Science In Action

Alle afleveringen

335 afleveringen, van nieuw naar oud

1. 2021: The year of variants

   30 december 2021 · 27 min

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   In our first programme of the year, we gathered a group of scientific experts directly involved in analysing the structure and impact of the SARS- Cov-2 coronavirus. There were concerns over the emergence of two new variants, Alpha and Beta, especially whether these variants might spread more quickly, or outmanoeuvre the suite of new vaccines that were about to be rolled out.
   Now the same questions are being asked about the Omicron variant’s ability to spread and overcome our defences. Lees meer

   We’ve invited the same scientists back to give us their assessment of our journey with Covid-19 over the past year, and discuss their findings on Omicron.

   The programme features:
   Ravi Gupta, Professor of Clinical Microbiology at the University of Cambridge
   Tulio de Oliveira, Professor of Bioinformatics, Stellenbosch University, South Africa
   Dr Allie Greaney from the Medical Scientist Training Program at the University of Washington School of Medicine
   Professor Jeremy Luban from the Broad Institute of MIT and Harvard

   Presenter: Roland Pease
   Producer: Julian Siddle

   Image: Local residents queue to receive a dose of the Covid-19 vaccine in Parkhurst, Johannesburg (Credit: Luca Sola/AFP via Getty Images)

2. Omicron – mild or monster?

   23 december 2021 · 28 min

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   Studies from South Africa and the UK suggest Omicron may be a mild infection for the majority of people. Hospital admissions are down when compared with other variants. However, the virus is replicating at a much faster rate than earlier variants and is able to overcome vaccines to some extent. Cases studies so far have mainly been in young people. There is concern over what will now happen as Omicron spreads across Europe and the US where there are older unvaccinated populations.
   Anne von Gottberg from South Africa’s National Institute for Communicable Diseases tells us what early results from studies there show and discusses the implications. Lees meer

   Typhoon Rai in the Philippines led to the loss of many lives and even destroyed buildings designed to resist such extreme weather events. Could more have been done either to predict the ferocity of the typhoon or to prepare for its impact?
   Liz Stephens, Associate Professor in Climate Risks and Resilience from the University of Reading discusses these issues.

   Beavers are making a comeback – in the Arctic. Their activity in engineering the landscape, building dams, and changing water courses is so widespread it can be picked out by satellites. However, this is not entirely welcome says Helen Wheeler Senior Lecturer in Zoology at Anglia Ruskin University. who has been working with local people concerned about the beavers impact on their livelihoods.

   And the James Webb telescope is finally launching. Heidi Hammel, who has been involved in the project for over 20 years tells us what it’s all about.

   (Image: Getty Images)

   Presenter: Roland Pease
   Producer: Julian Siddle

3. Omicron’s rapid replication rate

   16 december 2021 · 31 min

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   A study from Hong Kong university shows Omicron replicates 70 times faster than two earlier variants of the SARS-Cov-2 virus. Virologist Malik Peiris, explains how tests using cells from the wind pipe showed the dramatic difference, which supports observations of increased transmission. In contrast Omicron replicated less well than other variants on cells from dep in thre lung – offering some possibility that it may produce mild infections. Lees meer

   Tornados in the US do not normally occur in December. The one which swept across Kentucky and 3 other states was fuelled by weather patterns likely to have been influenced by long term climate change says Geographer James Elsner of Florida State University.

   The Parker Solar probe continues its mission of flying closer and closer to the sun. Results just published show what the data the probe picked up when it dipped into the surrounding plasma. NASA’s Nicky Fox is our guide.

   And how many legs does a millipede have? Until now not as many as you might think. Entomologist Paul Marek of Virginia Tech reveals the Australian specimen with more legs than ever seen before.

   (Image: Omicron variant (B.1.1.529): Immunofluorescence staining of uninfected and infected Vero E6 cells. Credit: Microbiology HKU/BSIP/Universal Images Group via Getty Images)

   Presenter: Roland Pease
   Producer: Julian Siddle

4. Can the weather trigger a volcano?

   9 december 2021 · 34 min

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   Which came first the volcano or the rain? Volcanic eruptions are known to influence global climate systems, even leading to the cooling of the planet. However local weather conditions can also influence the timing and ferocity of volcanic eruptions. As volcanologist Jenni Barclay explains rainwater can contribute to volcanic instability and even increase the explosiveness of eruptions. Lees meer

   Syria has been experiencing civil war for more than 10 years. Many people have left including many of the country's scientists. We speak with 3 exiled Syrian scientists Shaher Abdullateef, Abdulkader Rashwani, and Abdul Hafez about their current work, which involves working with other academics and students in Syria sometimes remotely and sometimes directly.

   New findings from Chile reveal an unknown Tsunami emanating from an earthquake there in the 1700s. Historical records mention other ones, but not this one. Geoscientist Emma Hocking found the evidence in layers of sand.

   And we discuss the development of tiny robot-like structures made from frog cells, they can move and build other copies of themselves. Sam Kreigman and Michael Levin explain how.

   (Image: Eruption of Semeru. Credit: Getty Images)

   Presenter: Roland Pease
   Producer: Julian Siddle

5. Omicron, racism and trust

   2 december 2021 · 30 min

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   South Africa announced their discovery of the Omicron variant to the world as quickly as they could. The response from many nations was panic and the closure of transport links with southern Africa. Tulio de Oliveira who made the initial announcement and leads South Africa’s Centre for Epidemic Response and Innovation tells us this is now having a negative effect on the country, with cases rising but vital supplies needed to tackle the virus not arriving thanks to the blockade. Lees meer

   Omicron contains many more mutations than previous variants. However scientists have produced models in the past which can help us understand what these mutations do. Rockefeller University virologist Theodora Hatziioannou produced one very similar to Omicron and she tells us why the similarities are cause for concern.

   Science sleuth Elisabeth Bik and Mohammad Razai, professor of Primary Care in St George’s University in London have just been awarded the John Maddox Prize for their campaigning investigations in science. Elisabeth is particularly concerned with mistakes, deliberate or accidental in scientific publications, and Mohammad structural racism in approaches to healthcare.

   Laura Figueroa from University of Massachusetts in Amhert in the US, has been investigating bees’ digestive systems. Though these are not conventional honey bees, they are Costa Rican vulture bees. They feed on rotting meat, but still produce honey.

   Presenter: Roland Pease
   Producer: Julian Siddle

   (Photo: Vaccination centre in South Africa administering Covid-19 vaccine after news of Omicron variant. Credit: Xabiso Mkhabela/Anadolu Agency/Getty Images)

6. Deliberately doomed dart

   25 november 2021 · 30 min

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   DART is a space mission designed to hit a distant asteroid and knock it slightly out of orbit. It’s a test mission, a pilot project for a way of potentially protecting the earth from a stray asteroid. We hear from mission coordinators Nancy Chabot and Andy Rivkin, both from the Applied Physics Labs, APL, of Johns Hopkins University. Lees meer

   A new kind of Covid-19 vaccine has successfully undergone preliminary tests. Tuebingen University’s Juliane Walz tells us about how it hopes to stimulate a longer lasting protective effect against the virus than current vaccines.

   And Haley Randolph of Chicago University sheds light on how our ancient ancestors’ exposure to viruses influences our susceptibility today.

   Historian Robert Schulmann gives us an insight into the significance of research notes by Albert Einstein and Michele Besso. Sold at auction in France the notes give an insight into the collaboration between the two scientists which led to much of what we now understand about the fundamentals of physics.

   Image: NASA's DART Spacecraft Launches in World's First Planetary Defense Test Mission
   Credit: NASA/Bill Ingalls

   Presenter: Roland Pease
   Producer: Julian Siddle

7. The end for coal power?

   18 november 2021 · 27 min

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   The political message from the COP meeting was a fudge over coal, but what does the science say? Surprisingly India seems to be on track to switch away from coal to renewables. We explore the apparent contradiction with Lauri Myllyvirta of the thinktank Centre for Research on Energy and Clean Air. Lees meer

   Also a synchrotron for Africa, how such a project would give a boost to scientific development across the continent, with Marielle Agbahoungbata from the X-tech Lab in Seme City in Benin.

   Moriba Jah, who leads the Computational Astronautical Sciences and Technologies Group, at the University of Texas, in Austin, tells us what he saw when an exploding Russian satellite sent a shower of debris into the path of the International Space Station.

   And the animals that carry SARS-Cov-2, an analysis from Barbara Han of the Cary Institute of Ecosystem Studies in New York shows there are many more than previously thought.

   Image: A coal-fired power station in Nanjing in east China
   Credit: Feature China/Barcroft Media via Getty Images

   Presenter: Roland Pease
   Producer: Julian Siddle

8. Bambi got Covid

   11 november 2021 · 27 min

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   Up to 8 percent of deer sampled in studies in the US were found to be infected with the SARS-Cov-2 Virus. Suresh Kuchipudi from the Department of Veterinary and Biomedical Sciences at Penn State University in the US says what they are seeing is a mixture of human to deer and deer to deer transmission of the virus. There is concern that its presence in animal reservoirs could lead to a new form of the virus emerging. Lees meer

   Tropical forests and spread of zoonotic diseases
   And as the Cop26 meeting in Glasgow draws to a close we ask how global policy on climate will impact the spread of zoonotic disease. Spill over of possible pandemic pathogens from animals to humans occurs with the destruction of tropical forests in particular and can expose people to previously unknown zoonotic diseases such as Covid 19.

   Aaron Bernstein from the Coalition to Prevent Pandemics at the Source says healthcare initiatives designed to reduce the potential spread of such diseases need to be designed to work in tandem with conservation and climate change impact reduction initiatives, essentially tackling both problems simultaneously.

   LED lighting
   Researchers in South Africa are looking into ways of making LED lighting both cheaper and more efficient. This should help reduce energy consumption, a prerequisite for effective policy on climate change.

   In addition, as Professor Odireleng Martin Ntwaeaborwa tells us, the technology now has many applications in places where access to electricity is limited, including South Africa which currently has regular power outages.

   Personalised medicine
   And personalised medicine based on our genes took a further step forward this week. Richard Scott, Chief Medical Officer for Genomics England discusses new findings which reveal the genetic basis for a range or rare diseases.

   Image: Bambi, lobbycard, 1942
   Photo by LMPC via Getty Images

   Presenter: Roland Pease
   Producer: Julian Siddle

9. Jet fuel from thin air

   4 november 2021 · 32 min

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   Scientists in Switzerland have developed a system which uses solar energy to extract gases such as hydrogen and carbon dioxide from the air and turns them into fuels for transport. So far they have only made small quantities in experimental reactors, however they say with the right investment their alternatives to fossil fuels could be scaled up to provide a climate friendly way to power transport, particularly aviation and shipping. We speak to Aldo Steinfeld and Tony Patt from ETH Zurich and Johan Lilliestam from the University of Potsdam. Lees meer

   And what will rises in global temperature mean where you live? An interactive model developed by Bristol University’s Seb Steinig shows how an average global rise of say 1.5C affects different regions, with some potentially seeing much higher temperatures than others. Dan Lunt – one of the contributing authors to this year’s IPCC report discusses the implications.

   We also look at racism in science, with problems caused by decisions on the naming of ancient bones more than 200 years ago. As more is known about human evolution, the way we classify the past seems to make less sense says Mirjana Roksandic.

   And the issue of colonialism looms large in the international response to conservation. Its legacy has been discussed at COP26 and as Lauren Rudd, author of a new study on racism in conservation tells us, this hangover from colonial times is limiting the effectiveness of current conservation initiatives.

   Image: President Biden and his wife travelling to the G20 summit in Rome and COP26 in Glasgow.
   Photo by BRENDAN SMIALOWSKI/AFP via Getty Images.

   Presenter: Roland Pease
   Producer: Julian Siddle

10. Can we still avoid climate catastrophe?

    29 oktober 2021 · 26 min

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    Just a few days before COP26 opens in Glasgow, the World Meteorological Organisation reported record greenhouse gas levels, despite a fall in CO2 due to pandemic restrictions. The UN Environment Programme’s Emissions Gap Report also revealed that current country pledges will only take 7.5% off predicted greenhouse gas emissions by 2030, well below the 55% needed to limit global warming to 1.5C. Worse still, many large emission producers are not on track to meet their countries’ pledges. Lees meer

    Rachel Warren, Tyndall Centre for Climate Change Research, tells us the 1.5C limit is still achievable if we work in tandem with nature. Research by Sara Mikaloff-Fletcher, National Institute of Water and Atmospheric Research (NIWA), illustrates this. Her contribution to the WMO Greenhouse Bulletin revealed that New Zealand’s indigenous forests play a bigger role in absorbing carbon from the atmosphere than previously thought.

    Also on the programme, Abinash Mohanty, Council on Energy, Environment and Water, has been mapping climate vulnerability in India and explains why communities should be at the forefront of climate adaptation and mitigation strategies. And particle physicist Claire Malone shares her insights on how we can help women thrive in science, technology, engineering and mathematics (STEM) fields.

    Picture: Aerial shot at the edge of Lake Carezza showing storm damaged forest, Dolomites, Italy, Credit: Abstract Aerial Art/Getty Images

    Presenter: Roland Pease
    Producer: Samara Linton

11. Red blood cells’ surprising immune function

    21 oktober 2021 · 27 min

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    We’ve talked a huge amount the past 18 months, for obvious reasons, about the way that white blood cells protect us from infection. But red blood cells – it’s probably among the earliest things I learned in human biology that they’re simple bags for carrying oxygen around the body. But over recent years, immunologist Nilam Mangalmurti, University of Pennsylvania, has been finding several clues to challenge that dogma – including molecules on the surface of red blood cells known from other parts of the immune system. Lees meer

    The Last Ice Area, home to the oldest and thickest ice in the Arctic, is expected to act as the last refuge for ice-dependent wildlife as the rest of the Arctic melts. Kent Moore, University of Toronto-Mississauga, tells us that the formation of a 3,000 square kilometre rift in the area means the ice is not as resilient as we once thought.

    Also on the programme, an obituary for the renowned Dutch climate scientist and physicist Geert Jan van Oldenborgh (October 22, 1961 – October 12, 2021), and, Dominique Gonçalves, Gorongosa National Park, explains how ivory poaching during the Mozambican civil war led to the rapid evolution of tusklessness in African elephants.

    Image: Confocal microscopy of CpG-treated human RBCs stained for Band 3. Credit: Mangalmurti Lab / Nilam Mangalmurti, MD)

    Presenter: Roland Pease
    Producer: Samara Linton

12. Wetlands under attack

    14 oktober 2021 · 28 min

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    Since its introduction four decades ago, Spartina alterniflora, a salt-water cordgrass from the USA, has been spreading along China’s coasts. Today, it covers nearly half of the country’s salt marshes. As the UN Biodiversity Conference COP 15 kicks off in China, we look at how this invasive plant species threatens native species in protected coastal wetlands. Featuring Yuan Lin, East China Normal University, and Qiang He, Fudan University. Lees meer

    In January 2020, Barney Graham and Jason McLellan teamed up to engineer a coronavirus spike protein that now powers the COVID-19 vaccines for Moderna, Pfizer, Johnson & Johnson and Novavax. They discuss their work, a next-generation vaccine using chicken eggs, and the future of pandemic preparedness.

    Also, a recent Nature survey reveals the extent of abuse against scientists who speak about COVID-19 publicly. Deepti Gurdasani, Queen Mary University of London, shares her experiences of trolling and online abuse and discusses the implications for academia and scientific discourse going forward.

    And Tom Scott explains how his team uses novel robots and sensors to go into and create 3D digital radiation maps of the Chornobyl Nuclear Power Plant and surrounding areas.

    (Credit: Getty Images)

    Presenter: Roland Pease
    Producer: Samara Linton

13. Youngest rock samples from the moon

    7 oktober 2021 · 29 min

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    In December 2020, China's Chang'e-5 mission returned to earth carrying rock samples collected from the moon – the first lunar samples to be collected since the American Apollo and Luna missions to the moon in the 1970s. Laboratory analysis has revealed that these are the youngest samples of rocks to be collected from the moon. Lunar geologist Katherine Joy explains what this tells us about the moon’s volcanic past. Lees meer

    Also on the programme, a recent study reveals that the hepatitis B virus has been infecting humans for at least 10,000 years. Denise Kühnert from the Max Planck Institute for the Science of Human History shares what the evolution of the virus tells us about human evolution, as well as the rise and fall of civilisations.

    In the wake of Cyclone Shaheen, we also speak to Princeton University’s Ning Lin about how climate modelling can help us predict tropical storms in the Arabian Sea, and Fredi Otto joins us to discuss the 2021 Nobel Prizes for Science.

    (Image: Getty Images)

    Presenter: Roland Pease
    Producer: Samara Linton

14. Drug resistant malaria found in East Africa

    30 september 2021 · 29 min

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    Since their discovery in the 1970s, artemisinin-based drugs have become the mainstay of treatment for malaria caused by the Plasmodium falciparum parasite. Researchers have identified artemisinin-resistant malaria parasites in Southeast Asia since the early 2000s, but now, there is evidence of resistance in Rwanda and Uganda. Dr Betty Balikagala of Juntendo University tells us how this resistance developed and what it means for managing malaria in Africa, which carries the greatest burden of malaria cases and deaths worldwide. Lees meer

    We hear from some of the scientists from COVID Moonshot, a non-profit, open-science consortium which has just received key funding to develop affordable antivirals to stop SARS-CoV-2 in its tracks.

    Also on the programme, Dr Rakesh Ghosh from the University of California, San Francisco tells us how air pollution is contributing to 6 million preterm births globally each year, and Dr Catherine Nakalembe of the University of Maryland and Africa Lead for NASA Harvest returns to the programme as NASA/USGS launches Landsat 9.

    Presenter: Roland Pease
    Producer: Samara Linton

    Image: Mosquito net demonstration in a community outreach centre in Kenya
    Credit: Wendy Stone/Corbis via Getty Images

15. New evidence for Sars-CoV-2’s origin in bats

    23 september 2021 · 30 min

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    Researchers studying bats in Northern Laos have found evidence that brings us closer than ever to understanding the origin of Covid-19. Since the beginning of the coronavirus pandemic scientists have tried to pin-point the exact origin of Sars-CoV-2. But recent evidence from the Institut Pasteur has identified several novel coronaviruses with similarities to the current coronavirus in bats. Professor Marc Eliot spoke to Roland Pease about how this research could give us a better idea where Covid-19 came from. Lees meer

    Could an oral Covid-19 treatment be available soon?
    Daria Hazuda, responsible for infectious disease and bacteria research at MSD tells us about their clinical trials for an oral antiviral drug that could combat Covid-19: Molnupiravir.

    Early Diagnosis of Alzheimer's
    Roland Pease travels to Bath to meet scientists who may have developed a way to diagnose Alzheimer's in the earlier stages of the disease. Dr George Stothart, has led the team from Bath university in the development of this simple 2 minute test.

    Inducing Earthquakes
    Scientists are experimenting with artificially managing earthquakes by injecting fluid into fault lines. Professor Derek Elsworth at Pennsylvania State University explains his research into how these induced earthquakes can be more tightly controlled.

    Presenter: Roland Pease
    Producer: Ania Lichtarowicz

    (Photo: Bats hanging in a cave. Credit: Getty Images)

16. Ebola can remain dormant for five years

    16 september 2021 · 28 min

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    An international team of researchers has discovered that an outbreak of Ebola in Guinea in February this year was the result of re-activated Ebola virus in someone who’d been infected at least five years ago during the earlier large Ebola epidemic that swept through Guinea, Sierra Leone and Liberia. This means the virus can remain dormant in some Ebola survivors for five years or more. Virologists Alpha Kabinet Keita and Robert Garry talk to Roland Pease about the research and its implications. Lees meer

    Also in the programme:

    The eruption of lavas from Iceland’s newest volcano Fagradalsfjall continues six months on. Geochemist Ed Marshall tells us how he gets up close to sample the molten rock with a long scoop and a bucket of water, and what he’s learning about this remarkable eruption.

    NASA’s Katie Stack Morgan updates Science in Action on the Perseverance rover’s successful sampling of rocks from Jezero crater on the planet Mars. When the specimens are eventually returned to Earth, she says they may turn out to contain tiny samples of Mars’ water and atmosphere from early in the Red Planet’s history.

    (Image credit: Getty Images)

    Presenter: Roland Pease
    Producer: Andrew Luck-Baker

17. Keep most fossil fuel in ground to meet 1.5 degree goal

    9 september 2021 · 29 min

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    For the world to have a decent chance of limiting global temperature rise to 1.5 degrees, 90% of remaining coal reserves and 60% of unexploited oil and gas have to stay in the ground. These are the stark findings of carbon budget research by scientists at University College London. Dan Welsby spells out the details to Roland Pease. Lees meer

    Virologist Ravi Gupta of the University of Cambridge describes his latest research that explains why the Delta variant of SARS-CoV-2 is much more infectious and more able to evade our immune systems and covid vaccines than other variants.

    When dense fog rises from the Pacific ocean into the foothills of the Andes, oases of floral colour bloom for a few weeks or months. When the fog goes, the plants die and disappear for another year or maybe another decade. The true extent of these unique ecosystems (known as fog oases or Lomas) has now been revealed by researchers at the Royal Botanic Gardens at Kew in the UK and their colleagues in Peru and Chile. They have discovered that the Lomas are much more extensive than suspected. Ecologist Carolina Tovar explains why the fog oases are threatened and need to be protected.

    A species of duck can now be added to the list of birds such as parrots and starlings that mimic human speech and other sounds in their environment. Listen to Ripper, the Australian musk duck who was hand-reared on a nature reserve where he learnt to imitate his keeper say ‘You bloody fool’ and imitate the sound of an aviary door closing. Animal behaviour researcher Carel ten Cate of Leiden University says that Ripper is not the only mimicking musk duck, but why this duck species has evolved this trick remains a mystery.

    Presenter: Roland Pease
    Producer: Andrew Luck-Baker

    (Image credit: Getty Images)

18. Hurricane season intensifies

    2 september 2021 · 32 min

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    When hurricane Ida struck the coast of Louisiana last weekend, almost to the day that Katrina did 16 years ago, comparisons between the two events were soon to follow. As the latest storm continues to wreak havoc and death further north in the US, Suzana Camargo of Columbia university talks to Roland Pease about the similarities and differences, the better forecasting available now, and the grim reality that climate change suggests for this and future hurricane seasons. Lees meer

    A couple of weeks ago, Science in Action looked at the carbon accounting of Blue Hydrogen (hydrogen manufactured from fossil fuels). Listener Nick Arndt got in touch to say we were wrong when we stated that hydrogen can’t be piped out of the ground from natural sources. His company, Sisprobe, plans to use its passive seismic prospecting technology to work with an international consortium that aims to unlock a new “hydrogen Rush” – commercialising what they suspect to be a near-ubiquitous source of genuinely carbon-free fuel - to supply the world economy of the near future. Viacheslav Zgonnik - CEO of start-up Natural Hydrogen Energy LLC - has been working on hydrogen for 10 years, has written a recent review of the science, and tells Roland about current and future studies into finding the best way to tap this simplest of molecules before it escapes into space.

    In Chile, the recent megadrought has led to fears that hydroelectric damns may become so drained that power-outs may occur in the coming months. This will not help Chile to achieve its target of carbon-neutrality by 2050. Apt, then, that a new Concentrated Solar Power plant (CSP) is now up and running in the north of the country. Reporter Jane Chambers has been to visit Cerro Dominador – the spectacular new array of 10,600 mirrors that focus sunshine onto a molten salt target, heating it up to 560C, and generating up to 210 MW electricity.

    Meanwhile archaeologists have been doing a molecular analysis of a protein found to survive in the bo…

19. World’s first DNA Covid vaccine

    26 augustus 2021 · 37 min

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    Indian authorities have approved the world’s first DNA-based Covid vaccine for emergency use. Not all the data that has led to the opening of the phase 3 trials is yet publicly available, but as public health policy expert Chandrakant Lahariya explains to Roland, it could be a real help in India’s, and the world’s, fight to get things under control. Lees meer

    The origins of the Covid virus were investigated last winter by a WHO team sent to Wuhan – where the first cases were discovered – earlier this year. Their work has since become the subject of intense political scrutiny and some criticism. This week, members of the team including Marian Koopmans have written a rebuttal, setting out the original terms of the investigation and urging the continuation of the process, as she explains to Victoria Gill.

    Most of the science written by people from or about the African continent is written in English. Many local African languages do not currently have a meaningful vocabulary for many of the scientific terms and concepts researchers use. This week a team of scientists, journalists, and translators are completing the launch of a project called Decolonise Science, which will take 180 nominated papers posted on the website AfricaArxiv, translate them into 6 African languages including isiZulu, Sothu, and Hausa, and then use Machine Learning methods to build resources for science communication and education in people’s home languages. Project partner Sibusiso Byela explains the thinking.

    This week the UK’s Royal Society announced its annual awards. Kenya’s George Warimwe has taken the Africa Award for his work creating vaccines for a virus that creates disease in livestock and humans – Rift Valley Fever. His promising approach stems from years of working with adenovirus technology akin to the AstraZeneca covid virus. But as he explains, his One Health approach is to learn from the immune response in humans and apply it to animals, and vice-versa. The grant associated with the awar…

20. Seismic citizen science in Hispaniola

    19 augustus 2021 · 39 min

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    The epicentre of the tragic earthquake in Haiti last week was just 100km from that of the even more deadly 2010 one. Unlike then, a network of small cheap seismic detectors run by volunteers is currently monitoring the aftershocks. As Eric Calais says, the suspicion is that this could be the latest in a sequence of quakes, echoing previous clusters over the last few hundred years. Lees meer

    Hydrogen is being much touted as an alternative to natural gas as a source of fuel for homes in a low-carbon world. In particular, “blue” hydrogen – hydrogen made from fossil fuels but with the carbon dioxide being captured at the point of production – is said to be some sort of transitional fuel that could be introduced into current infrastructure with little stress. But Robert Howarth is less optimistic. He is co-author on a paper published last week analysing the net carbon impact of blue hydrogen production. He argues that not only are there hidden greenhouse gas emissions in production, but that in fact burning blue Hydrogen at home could have a worse impact than burning the natural gas from which it is made.

    Meanwhile, physicists at the US National Ignition Facility are rumoured to have made a huge stride in the quest for controlled, sustained nuclear fusion. Using a barrage of powerful lasers to heat indirectly a tiny hydrogen isotope target, on the 8th of august, they briefly got 70% of the energy back from one of their runs. It is a huge leap in returns, and tantalisingly suggests some sort of runaway fusion reaction occurred. Around the world, hopes of laser-driven fusion energy generation are soaring, but as an ecstatic Kate Lancaster of the University of York cautions, even if it does represent ignition, we are still a long way from “plug socket efficiency” or net energy gain.

    Meanwhile, scientists of the Leibniz Institute evolution and Biodiversity have been eavesdropping on bats in Panama. Human babies babble when they are learning how to talk. It’s been shown before that…

21. Methane: A climate solution?

    12 augustus 2021 · 29 min

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    The latest IPCC assessment raised alarm about the rate at which manmade emissions are contributing to climate change. Much of the focus for action is on reducing levels of carbon dioxide, however there is a more potent greenhouse gas, methane, produced by natural and industrial processes which, says Drew Shindell of Duke University and lead author on the Global Methane Assessment, is relatively easy to target for reduction. Lees meer

    Neuroscientist John Cryan of University College, Cork in Ireland is interested in the effects our gut microbes can have on our behaviour. It’s an unusual connection and one which he’s been experimenting on in mice. By feeding the faeces of younger mice to older ones he has found that the older ones’ took on some of the younger ones’ behaviour.

    Ball lightning is the stuff of legend and the supernatural. And yet there are many reported sightings of this phenomenon. Texas State University's Karl Stephan is keen to uncover the science behind these observations. He’s running a crowd sourcing project encouraging people to contribute video recordings of any ball lightening events they might observe.

    And Chile is home to the oldest known mummies in the World. UNESCO world heritage status has been given to a collection of around 300 mummies from Chile’s northern deserts. The mummies of babies, children and adults are thought to have been created in response to arsenic poisoning in the region around 7,000 years ago.

    Image: Livestock farm in Brazil
    Credit: Photo by Igor Do Vale/NurPhoto via Getty Images

    Presenter: Roland Pease
    Producer: Julian Siddle

22. Record-shattering weather

    5 augustus 2021 · 30 min

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    July 2021 saw temperatures in the western US and Canada smash previous records by 5 degrees. And that’s what we should expect, according to a study prepared much earlier but published, coincidentally, just a few days later. A hallmark of rapid climate change, says author Erich Fischer of ETH Zurich, will be an accelerating number of record-shattering, and socially disruptive, events. Lees meer

    A large new study on communications and hierarchy across a large range of our ape and monkey relatives has just been published. Lead author Katie Slocombe of the University of York explains the findings: like us, the primates live socially in groups, and there are leaders, but the more tolerant ones are also the more communicative ones. In species with ‘despotic’ leaders, order seems to be maintained with more menacing silence.

    The double helix of all DNA on earth twists in one direction. But researchers at Tsinghua University in China have made some important steps towards making mirror life, in which the DNA twists in the opposite direction. Chemistry journalist Mark Peplow discusses the significance of this discovery with Roland Pease.

    One of the benefits of science’s ability to read normal DNA has been to compare human genomes from across the globe – for example in the Human Genome Diversity Project – for what they reveal about both our health – and our past. But sequences from the Middle East have been sadly lacking. The Sanger Institute’s Mohamed Almarri and colleagues have just rectified that, saying that the Middle East played such a key role in the human story.

    (Photo By Tom Williams/CQ-Roll Call, Inc via Getty Images)

    Presenter: Roland Pease
    Editor: Deborah Cohen

23. The earliest traces of animal life on earth.

    29 juli 2021 · 36 min

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    Do rocks found in Canada show animal life 350 million years older than any found before?
    And, delving to the core of Mars, the guts of cats, and into the life of Steven Weinberg. Lees meer

    Prof Elizabeth Turner of Canada's Laurentian University reports in the journal Nature structures in some of the oldest sedimentary rocks that resemble the residue left by sponges such as the sort you might find in a bath. 350 million years older than the oldest such fossils yet identified, if they are left by such animals, they represent a complex life that existed some 90 million years before - it has been supposed - there was even enough oxygen to support such development. As she tells us, rather like previous geologists investigating the deep history of life, Elizabeth has been sitting on this idea since she was a young researcher.

    Since 2019 NASA's InSight probe has been on the surface of Mars listening for seismic waves from below to try to form a picture of the planet's internal structure. Last week in the journal Science, three papers presented data and analysis and some surprises for planetary scientists trying to work out how a planet that began almost, but not quite, so similar to earth could have turned out so different today. Cambridge University's Dr Sanna Cottaar gives us her take on the exciting findings.

    Most of our understanding of genetics – diseases and heritability – is derived from decades of deep studies into just a few model species besides humans. But Prof Lesley Lyons runs a lab at the University of Missouri focusing almost entirely on cats. She describes to Roland a proclamation she makes this week to her fellow scientists to do more work into cat genetics and how, because of the similarities between cats and human genomes, that will bring all sorts of benefits to human (and cat) health.

    Earlier this week we heard of the death of physicist Steven Weinberg - one of the giants of 20th century particle physics and cosmology. Roland presents recordings and reminis…

24. Your molecular machinery, now in 3D

    22 juli 2021 · 34 min

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    Back in November it was announced that an AI company called DeepMind had essentially cracked the problem of protein folding – that is they had managed to successfully predict the 3D structures of complex biochemical molecules by only knowing the 2D sequence of amino acids from which they are made. Lees meer

    They are not the only team to use machine learning to approach the vast amounts of data involved. But last week, they released the source code and methodology behind their so called AlphaFold2 tool. Today, they are publishing via a paper in the journal Nature, a simply huge database of predicted structures including most of the human proteome and 20 other model species such as yes, mice. The possibilities for any biochemists are very exciting.

    As DeepMind CEO Demis Hassabis tells Roland Pease, they partnered with the European Molecular Biology Laboratory to make over 350,000 protein predictions available to researchers around the world free of charge and open sourced. Dr Benjamin Perry of the Drugs for Neglected Diseases Initiative told us how it may help in the search for urgently needed drugs for difficult diseases such as Chagas disease. Prof John McGeehan of the Centre for Enzyme Innovation at Portsmouth University in the UK is on the search for enzymes that might be used to digest otherwise pollutant plastics. He received results (that would have taken years using more traditional methods) back from the AlphaFold team in just a couple of days.

    Prof Julia Gog of Cambridge University is a biomathematician who has been modelling Covid epidemiology and behaviour. In a recent paper in Royal Society Open Science, she and colleagues wonder whether the vaccination strategy of jabbing the most vulnerable in a population first, rather than the most gregarious or mobile, is necessarily the optimal way to protect them. Should nations still at an early stage in vaccine rollout consider her model?

    And did you know that elephants can hear things up to a kilometre away through t…

25. Science when the funding dries up

    15 juli 2021 · 31 min

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    This week the UK parliament voted to accept the Government’s continued cap on Official Development Aid. This disappointed many researchers around the world, funded directly and indirectly through various scientific funding structures enabling international collaboration on some of the global challenges facing all of us. These funding mechanisms make for a small fraction of the overall amount, but they have been hit hard, with many projects closing altogether. Lees meer

    There had been hope amongst the scientific community that the cap – from 0.7% down to 0.5% of the UK’s Gross Domestic Income – might have been in place just for a year. But it seems like the criteria set to judge when the level of aid might rise again imply that it is unlikely to happen for several years at the earliest.

    What, asks Science in Action, does that mean to the world of scientific collaboration on such topics as climate change, contagious disease, and emergency planning?

    Researchers Chris Trisos and Jenni Barclay, with journalist Robin Bisson of Research Professional News, update us on the story.

    In Zambia, where covid testing remains scarce, a project run by Boston University’s Christopher Gill has been estimating the prevalence of covid in the capital Lusaka by taking nasal swab samples from the noses of around one in five of those recently deceased, in the morgue of a major hospital. Tantalisingly, his team have seen over the last few months a sharp rise in cases to the extent that in June, nearly 90 percent of the cadavers tested positive for covid. But as Chris describes, unrelated to the UK cuts, their funding has now run out, so where the graph leads from here we may not learn for a long time.

    Presented by Roland Pease
    Produced by Alex Mansfield.

    (Image: Getty Images)

26. Human induced climate change heats up fast

    8 juli 2021 · 34 min

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    Scientists say the record-breaking Pacific North-West heatwave of recent weeks must have been caused by human induced climate change, but as Geert Jan van Oldenborgh explains to Roland Pease, despite a herculean effort to analyse the event in just a week, the precise mechanism to cause such an extreme and sudden event is so far bewildering climate modellers, exceeding even worst expectations. Lees meer

    Looking to the skies, Rosita Kokotanekova of the European Southern Observatory and colleagues have been getting excited about the discovery of a comet maybe twice as large as any observed before. Being so big, it has been spotted much further out from the sun and – if the best telescopes can be convinced to join the fun – will provide astronomers a chance to observe the core of the comet before the solar heat induces a gaseous coma to form as it nears the point in its orbit closest to the sun. It will be around for the next decade before continuing its several million year journey around our mutual star.

    But it won’t get terribly close to earth, at least not as close as lumps of an asteroid that fell onto a driveway in the UK earlier this year. Dr Ashley King of the UK’s Natural History Museum is leading a consortium of scientists (benefitting from a rapid research grant by the UK’s STFC) who have now officially classified it and named it. The Winchcombe meteorite is a CM carbonaceous chondrite, meaning it represents the unspoilt early building blocks of the solar system. Falling like 4.5 billion year old leftover celestial lego, only a few are known around the world but perhaps none have been in scientists hands in such a short period of time, continuing its pristine survival.

    Dr Pablo Tsukayama has published a preprint paper announcing a new variant of interest in the ongoing evolution of the SARS-CoV2 virus. Now named by the WHO as the Lambda variant, it seems it has driven the pandemic for much of this year in Peru – as much as 80% of cases – and large fractions of the …

27. Insects in incredible detail

    1 juli 2021 · 33 min

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    The Natural History Museum in London holds a massive collection of insects. It asked researchers at the Diamond light source, a facility near Oxford, to develop a high throughput X-ray microscope to take 3D scans of them all. Roland Pease has been to see the new technology in action. Lees meer

    Many people seeking compensation for the impacts of climate change are turning to the law courts. Successes so far have been few. Oxford University’s Friederike Otto, who specialises in connecting weather extremes to the greenhouse effect, has just published a paper looking at the challenge in bringing successful climate lawsuits.

    Spacecraft will be returning to Venus in the next decade with the recent approval of two NASA missions to the planet, and one from the European Space Agency, ESA. Philippa Mason of Imperial College is a planetary geologist on that mission, Envision. She plans to use radar to peer through that dense and interesting atmosphere to follow up evidence of volcanic activity and tectonics on the surface beneath.

    A few years ago synthetic biologist Jim Collins of Harvard found a way to spill the contents of biological cells onto … basically … blotting paper, in a way that meant by just adding water, all the biochemical circuitry could be brought back to life. With a bit of genetic engineering, it could be turned into a sensor to detect Ebola and Nipah viruses. His team have kept developing the idea, and this week they report success in a smart face mask that can detect SARS-CoV-2 in your breath.

    (Image: Hairy Fungus Beetle - Prepared by Malte Storm. Credit: Diamond light Source Ltd)

    Presenter: Roland Pease
    Producer: Alex Mansfield

28. Tales of unexpected DNA data

    24 juni 2021 · 40 min

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    This week Jesse Bloom of Seattle’s Fred Hutchinson Cancer Research has published an account of some DNA sequence data he located in an internet archive, despite it having been removed from the US NIH’s Sequence Read Archive. He tells Roland Pease of its significance to our understanding of the beginning of the Covid pandemic, but also, of more general interest, to what it might tell scientists about the full availability of relevant virological evidence. Lees meer

    Elsewhere, Elena Zavala of the Max Planck Institute for Evolutionary Anthropology in Leipzig has been using new techniques for sequencing tiny fragments of mitochondrial DNA found in layers of mud to trace a long narrative of different evolutionary species of human and animal and their changing fortunes. As she describes in a paper published in Nature, sediments from different depths of the floor of the famous Denisova cave tell a long story of different humans (Denisovan and Neanderthal), bears, hyenas and other animals living there over different periods in the last 250 thousand years.

    Over in the journal Science, several papers describe a new type of early hominin found in Nesher Rambla, Israel, that may be yet another instance of a human species that didn’t quite make it. As Marta Lahr, professor in human evolutionary biology at Cambridge University tells Roland the new findings all point to the bigger question – given the similar ages, technologies, and even neighbourhoods that all these types of hominin shared, just what was it about our own direct ancestor species that enabled us to take over the world?

    Since almost the beginning of the Covid pandemic, in some parts of the world, the drug Ivermectin has been repurposed as a therapy against the disease, with some even believing it to convey protection against infection – a situation not without tragic consequences. The evidence for any meaningful effect has been less than obvious to most scientists and health authorities. Not the first controversial drug i…

29. Doubling Earth’s energy imbalance

    17 juni 2021 · 38 min

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    Nasa scientists have observed that the Earth’s energy imbalance has doubled in just 15 years. As greenhouse gas atmospheric concentrations have risen, so too has the difference between the total amount of energy being absorbed from the sun, and the total amount being reradiated back into space. Meanwhile, as we all heat up, scientists at the LIGO Gravitational Wave Observatory have managed to do something very cool with their mirrors. Such is the precision with which the detectors have been engineered, they have managed to effectively reduce the temperature of one of the big 10kg reflectors to such an extent that it betrays its quantum state, as if it were simply one big subatomic particle. So what? Roland Pease finds out. Lees meer

    Presenter: Roland Pease
    Producer: Alex Mansfield

    (Photo: Giant sun in the horizon. Credit: Getty Images)

30. Evolving viral variant trickery

    10 juni 2021 · 33 min

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    Dr. Clare Jolly and colleagues have been looking at how the first of the major covid variants – alpha - evolved to be more transmissible. Whilst a lot of attention has been on the spike binding areas of the virus and the effectiveness of antibodies from either vaccine or prior infection, their preprint paper this week reports how the virus evolved an ability to inhibit our bodies innate virus response once it has infected a cell. Lees meer

    Prof Dan Shugar and colleagues have been studying the conditions that led to the tragic rock and ice avalanche in February in Chamoli, Uttarakhand. 27 million cubic meters of rock and ice broke off the steep mountainside and plummeted almost 2km down into the valleys below. Using satellite, seismic and video data the scientists have investigated the sequence of events that led to the tragic deaths of 204 people in the floods that followed.

    It was a thankfully rare combination of geography and geology and events, but highlights the care that should be taken when building the growing number of hydroelectric plants in high mountainous areas.

    But avalanches don’t just happen in mountains. A year before, in a canyon under the sea near the outflow of the Congo river, a sediment avalanche rumbled on for almost two days along some 1,100km of the ocean floor. And as Prof Pete Talling describes, whilst it didn’t trigger a tsunami, it did sever cables supplying internet connectivity between South Africa and Nigeria.

    And the BBC’s Samara Linton reports on research into a type of DNA you perhaps haven’t heard of – Z-DNA. It winds the other way to what we consider normal DNA, and scientists are finally beginning to understand its role in many human diseases, including cancer, with some future promise of novel therapeutics.

    Presented by Roland Pease
    Produced by Alex Mansfield

    (Image: Getty Images)

31. Zoonotic hotspots and where to find them

    3 juni 2021 · 36 min

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    Researchers map where the riskiest areas are for viruses to jump from bats into humans. Also, synthetic bacteria with unnatural DNA, and the origin of the humble watermelon. Lees meer

    David Hayman of Massey University in NZ and colleagues have published in the journal Nature Food a study highlighting areas of the world where zoonotic transmission of coronaviruses are most likely to occur between humans and bats of the type most suspected of being the origin of the current SARS CoV2 virus. There are a lot of hotspots combining fragmented forest, livestock farming, human habitation, and populations of horseshoe bats. It is, as he says, just part of the evidence suggesting a natural origin in the areas of northern south-east Asia and southern China.

    Jason Chin, Wes Robertson and team at the Laboratory of Molecular Biology have been tinkering with their work on synthetic organisms. By rewriting the dictionary of DNA itself, their new molecular alphabet is able to encode far more elaborate and innovative functions than even nature has ever produced. Publishing this week in the journal Science, their latest bacterium is even capable of being completely immune to viral infection. But as they describe, this could be just the start of what the new technology could deliver in terms of new materials and medicines.

    Meanwhile, Susanne Renner has been tracking down some of human beings’ earliest genetic engineering. The selection and breeding of various fruits to produce sweet, sweet watermelon was long suspected to have originated in Africa, the question was where and when? Using a combination of genetic sequencing, ancient Egyptian art, and early modern paintings, she describes to Roland how what we now know as Sudan likely played a part in the story.

    (Image: Horseshoe bat Credit: Getty Images)

    Presented by Roland Pease
    Produced by Alex Mansfield

32. Nyiragongo eruption

    27 mei 2021 · 27 min

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    The latest Nyiragongo eruption was not entirely unexpected, the volcano’s lava lake inside the crater had been building up for years. Local volcanologists say it was only a matter of time before an eruption occurred. The big concern was where the flank of the volcano would be breached as the city of Goma rests under the volcano and there are potential fissures even within the town.
    However there are still questions over the effectiveness of seismic monitoring in the area, North Kivu. The Goma observatory has been unable to carry out this work due to a lack of funding. And monitoring is further complicated by the region’s long running civil war, with rebel groups often camped around the volcano.
    We hear from Dario Tadesco and Cindy Ebinger. Who have both been monitoring developments. Lees meer

    Cyclone Yass was the second Cyclone to hit India within a week. Are these events becoming more common and are they related to rises in global temperatures? Climatologist Roxy Koll has been monitoring the situation.

    Greenland’s pristine glaciers might not be so pristine. Jemma Wadham from Bristol university and her team have found unexpectedly high levels of Mercury in meltwaters - similar to those from industrial pollution. They say research now needs to focus on the impact for wildlife and people in the Arctic region.

    And the elusive Sowerby’s beaked Whale doesn’t travel very much despite pockets of the species being found across the Atlantic. Kerri Smith has been researching this species, which is rarely seen alive. Using samples from whales beached or caught accidentally she was able to build up a picture of their distribution.

    Presenter: Roland Pease
    Producer: Julian Siddle

    (Photo: Nyiragongo volcano erupting. Credit: Getty images)

33. Robot revolution

    20 mei 2021 · 36 min

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    A brain-computer interface allows a severely paralysed patient not only to move and use a robotic arm, but also to feel the sensations as the mechanical hand clasps objects . We hear from Jennifer Collinger at Pittsburgh University’s Rehab Neural Engineering Labs. And Nathan Copeland, who has been controlling the robotic arm with his thoughts via a series of brain implants. Lees meer

    Ralph Baric of the University of North Carolina tells us about the development of a multi-component vaccine that would be effective not just against the current coronavirus outbreak and its variants, but also future outbreaks from SARS-like coronaviruses that we don’t even know about yet.

    Blood clots, thromboses, have been a problem for a small number of people following Covid vaccination Paul Knöbl, and a team of medics in Vienna have worked out the link between vaccination and clot development. They now have a method to treat such clots – so they should not be fatal.

    And how did fungi and plants come to live together? Symbiotic relationships between the two are a key component of the evolution of life. Melanie Rich of the University of Toulouse has been looking at the present day genetic markers which allowed plants and fungi to help each other as they first colonised land millions of years ago.

    (Image: Artificial tactile perception allows the brain-computer interface user to transfer objects with a
    robotic arm at twice the speed of doing it without the feedback.
    Credit: UPMC/Pitt Health Sciences Media Relations)

    Presenter: Roland Pease
    Producer: Alex Mansfield

34. Covid and clean air

    13 mei 2021 · 32 min

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    We wouldn’t drink dirty water so why do we put up with polluted air? Researchers are calling for a major rethink on our attitude to air quality. Professor Lidia Morawska, from the Queensland University of Technology, says attention to air quality during the Covid pandemic has shown how levels of airborne disease can be reduced. Lees meer

    Sam Wilson from the UK Medical Research Council, University of Glasgow Centre for Virus Research has been investigating genetic mechanisms associated with susceptibility to Covid infection. His team has identified a molecule that detects SARS-COV-2 when it starts to replicate in our cells. However, not all humans have this protective mechanism, which may help explain why some people become very ill with Covid and others have little if any symptoms.

    Many Europeans lack this protective molecule, whereas the vast majority of Africans have it. The difference can be seen in cell cultures. However, the lack of diversity in the cells used in experiments worldwide can be a serious problem when looking at genetic differences as Samara Linton reports.

    Nuclear material buried beneath the doomed Chernobyl nuclear power plant is becoming more active
    Neil Hyatt Professor of Nuclear Materials Chemistry at Sheffield University says it’s a small increase but needs to be monitored.

    (Photo by Sean Gallup/Getty Images)

    Presenter: Roland Pease
    Producer: Alex Mansfield

35. Africa’s oldest burial

    6 mei 2021 · 29 min

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    Analysis of the 78,0000-year-old fossil of a Kenyan boy reveals he was likely buried with care and attention, the body wrapped and laid to rest supported on a pillow. Maria Martinon-Torres, of the National Research Centre on Human Evolution in Burgos, Spain, and a team from Kenya and Germany used techniques from paleontology and forensic science to reveal his story from the fragile remains. Lees meer

    A promising malaria vaccine is to enter trials which could lead to it being used globally to vaccinate children. Merheen Datoo, Oxford University’s Jenner Institute, explains malaria vaccines have been in development for 100 years. Research from these helped covid vaccine development and the success of covid vaccines may now help to speed up the rollout of malaria vaccines.

    Covid vaccines may also help to treat those who have symptoms of long covid – a range of immune system issues that develop sometimes months after the initial infection. Yale University immunologist Akiko Kawasaki is embarking on a research project to assess the impact. If you’d like to take part, have yet to be vaccinated, and live in Connecticut in the US, email covidrecovery@yale.edu.

    And in India scientists are calling on the government to make all data on Covid more widely available. At present Indian bureaucracy means statistics on infection rates, variants and recovery are not distributed widely. Science journalist TV Padma says greater access to the data could help more scientists come together to work on solutions to India’s Covid crisis.

    (Image: An artist’s interpretation of Mtoto’s burial Credit: Fernando Fueyo)

    Presenter: Roland Pease
    Producer: Julian Siddle

36. Melting glaciers, warming coffee and a Dragonfly on Titan

    29 april 2021 · 37 min

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    When Apollo 11 astronaut Michael Collins – who passed away this week – looked down on the earth from lunar orbit during those days in 1969, he saw more ice and a smaller liquid ocean than you would see today. Of the 200,000 glaciers outside of the polar and Greenland ice sheets, their melting in the last two decades accounts for about a fifth of the sea level rise we are also seeing. Thus according to a paper published this week in the journal nature by, amongst others Bob McNabb of Ulster University who describes to Roland how and why these numbers are more certain than others before. As fellow earth observation expert Anna Hogg adds, the work synthesises years of data from almost half a million images of glaciers taken from space, and provides our best handle yet on our accelerating loss of this finite and dwindling natural feature. Lees meer

    Researchers at Kew in the UK and in Sierra Leone have rediscovered a species of coffee plant once thought lost. As Marnie Chesterton reports, climate change threatens many coffee crops around the world as the most popular variety – arabica – needs cool high altitude conditions which are going to become more scarce. But after a long and arduous search, the researchers have discovered a more resilient variety that might not only save the morning brew for many, it may even prove agriculturally and even economically transformative for some African economies.

    And whilst many of us watch the antics of NASA’s Martian helicopter, Ingenuity, as it whizzes across the distant plains of “Wright’s Field” aerodrome on Mars, some are watching with more trepidation than others. In 6 years’ time, Zibi Turtle, Principle Investigator of NASA’s Dragonfly mission, hopes to launch a much larger octocopter drone to Titan, moon of Saturn. As she describes to Roland, the challenges are huge, not least because dragonfly will carry all its instruments on board as it hops around, finding new landing sites autonomously. And communicating with Earth will take a …

37. Exponential increase in Indian covid cases

    22 april 2021 · 47 min

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    As Covid cases surge almost beyond belief in India, how much is to do with social distancing, and how much to do with the mutations to the original virus? Lees meer

    Ramanan Laxminarayan talks to Roland from Delhi about ways in which the huge second wave could and could not have been predicted and avoided. Suggestions of the latest variant to make the headlines, B1.617, have got virologists such as Ravindra Gupta working hard to identify the clinical significance of the latest combinations of mutations.

    In the journal Science, Stephen Chanock of the US Cancer program reports work with colleagues in Ukraine looking at the long footprint of radiation dosing from the Chernobyl nuclear disaster, 35 years ago this week. In the first of two papers, they find a definite footprint of radiation damage accounting for the many sad cases of thyroid cancer in people alive in the region at the time. But in another study, they looked at whether any higher level of mutations could be detected in the germlines of children conceived subsequently to parents who had experienced radiation in the disaster. While the parents' own health is often affected, 35 years on, thus far their offspring show no widespread elevated levels of disease, as was commonly expected.

    And in the week that the world witnessed a guilty verdict delivered in the trial for the murder of George Floyd in the US, David Curtis of the University of Utah and colleagues report in the journal PNAS a study that suggests the widespread media coverage of acts of racial violence, including deaths at the hands of police, leads to poorer mental health in Black Americans. As the BBC’s Samara Linton reports, the study involved google search data over five years up to 2017, and nearly 2.3 million survey respondents.

    Image: NurPhoto/Getty Images

    Presenter: Roland Pease
    Reporter: Samara Linton
    Producer: Alex Mansfield

38. Rolling out the vaccines faster

    15 april 2021 · 45 min

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    Two weeks ago several G7 leaders called for an international treaty on Pandemic Preparedness for the future. This week 175 prominent leaders called for lifting the IP on vaccine design. And former UK PM Gordon Brown called on the G7 to finance vaccines for the world in the next two months. But are there technical difficulties that limit the pace of manufacture? Lees meer

    Anthony McDonnell is an economist at think tank Centre for Global Development who has been looking at the problem since last year. He suggests, amongst other things, one limit is the human expertise in manufacturing these brand-new technologies, with another being a level of vaccine nationalism that is seeing a lack of exports of components involved in manufacture.

    Professor Trudie Lang heads the University of Oxford’s Global Health Network, and looks at health research across the world. She says in most countries there is no lack of public health or infrastructure potential for rolling out the vaccines, if only the supply existed.

    The volcano that erupted explosively on St Vincent last week has led to many thousands of people being evacuated. Dr Joan Latchman of the University of West Indies Seismic Research Centre - who has monitored Caribbean volcanos for several decades - describes from Trinidad how the layers of ash mean recovery will take a long time, even if the explosions and pyroclastic dangers subside reasonably soon. Back in The UK, Prof Jenni Barclay and colleagues are examining rocks from the early part of the eruption, before the explosive phase began, to see if there are clues in the microstructure that could provide clues to the future.

    And how do our brains so quickly tell a scream of delight from a scream of horror? Or of pain? Prof Sascha Frühholz of the University of Geneva has written in the journal PLOS Biology this week about work looking at how we identify the nature of different human screams. One finding is that we perceive joy quicker than fear..

    (Image: Getty Images)

    Present…

39. On the trail of rare blood clots

    8 april 2021 · 34 min

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    On Wednesday the EU’s EMA and UK’s JCVI announced a suspected correlation between vaccination and an extremely rare type of blood clot. Prof Sabine Eichinger is a co-author of a new paper suggesting a link with vaccination or the immune response to Covid vaccination and suggests the name VIPIT for the condition. One of her patients died at the end of February having presented with a rare combination of symptoms – blood clots and a low blood platelet count. Sabine tells Roland the dots they have managed to join in the story so far. Lees meer

    Scientists at Fermilab in the USA posted four papers and announced an exciting development in particle physics that might lift the curtain on science beyond the Standard Model. Their measurement of something known as g-2 (“gee minus two”, just fyi), by measuring with phenomenal accuracy the magnetic properties of muons flying round in circles confirms a 20-year old attempt at a similar value by colleagues at Brookhaven. At the time, it was breathtaking but suspicious. Muons, rather like heavy electrons, don’t quite behave as the Standard Model might have us believe, hinting at fields and possibly particles or forces hitherto unknown. Dr. Harry Cliffe – a member of the LHCb team who found something similarly weird two weeks ago - describes the finding and the level of excitement amongst theorists worldwide.

    Superfans around the world have learned to speak fluent Klingon, a fictional language originating from Star Trek. In a quest to understand the science behind these languages often dismissed as gobbledygook, Gaia Vince has been speaking to some of the linguists responsible for creating these languages. It’s time for her to relax the tongue, loosen those jaw muscles and wrap her head around the scientific building blocks embedded in language and what languages like Klingon tell us about prehistoric forms of communication.

    Meanwhile, primatologist Edward Wright of the Max Plank Institute has been hanging out with mountain gorillas in Rw…

40. Post-Covid outcomes after release from hospital

    1 april 2021 · 37 min

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    After last year’s first wave of covid-19 in the UK, individuals who had been discharged after hospitalisation suffered higher rates of coronary and respiratory disorders, and even diabetes subsequently over 140 days. As Dr Ami Banerjee of University College London explains, out of 48,000 cases, patients who had had acute covid-19 were four times more likely to be readmitted and 8 times more likely to die. Ami’s team suggests in their paper published in the British Medical Journal that diagnosis, treatment and prevention of post-covid syndrome needs an integrated approach. Lees meer

    In France, researcher Xavier Montagutelli describes how his team has observed that unlike the original virus, some of the newer Variants of Concern can infect mice in laboratories. They do not show serious illness, but nevertheless host the virus in their lungs. Whilst infection is unlikely in natural environments and not yet observed in the wild, it does show how the viral variants can extend the host range, perhaps leading to more opportunities for mutation. But this finding, posted as a pre-print, also perhaps represents an avenue for deeper gene-specific research that has not so far been possible.

    Over in Colombia, Monica Carvalho of the Smithsonian Tropical Research Institute describes her team’s findings regarding the origins of the diversity and habitat of rainforests in south America. Looking at leaf fossils and pollen grains from 60 million years ago, they have found significant differences between the forests of the dinosaurs, and the ones we see today. As they write in the journal Science, it all changed when the Chixulub meteor hit the Gulf of Mexico and the global lights went out. The rainforests that grew back were simply not the same.

    But much further back in time, some billion years ago, the forests of the world that were changing the chemistry and making seas inhabitable allowing complex multicellular life, consisted of pencil-lead sized algae quietly photosynthesizing in the s…

41. Science on the side of a new volcano

    25 maart 2021 · 42 min

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    Sightseers and social media scrollers have flocked to the slopes of Fagradalsfjall, a volcano erupting 40 kilometres west of the Icelandic capital Reykjavik. Having produced less than 1 square kilometre of lava this eruption could be deemed relatively minor, allowing bystanders to get up close and personal. Among the hubbub, you might also spot Dr Evgenia Ilyinskaya from University of Leeds, just one of the researchers measuring and observing the event from an alarmingly small distance. Her interest is more in the invisible toxic gases and trace elements being emitted from one of the deepest magma eruptions in recent times than the more cinematic molten rock. Lees meer

    This week scientists working on results from the Large Hadron Collider at CERN announced intriguing evidence (NB “evidence” – not yet a definite discovery) of physics beyond our current understanding. Everything we can detect directly in the universe is made from a few basic building blocks, fundamental particles. These particles are governed by four universal fundamental forces. Our best understanding of these forces and particles are sewn together in the Standard Model of particle physics. Since the 1970s this model has been able to explain most of our experimental results, but not all. Professor Gudrun Hiller from Technische Universität Dortmund has been theorizing as to what sort of experiments might lead to evidence of where the model might be incomplete. And this week, she has reason to feel a little bit proud. As she and her fellow member of the LHCb consortium, Harry Cliff, explain, a mysterious asymmetry in the way certain quarks – beauty quarks – have been seen to decay could be pointing at a deeper, more sophisticated, picture of the nature of the universe. Theorists are theorizing all around the world: could this be a new class of particle called a “leptoquark” that mediates a whole new type of force?

    The new results have been submitted for publication in the journal Nature, but have also been ma…

42. International science at sea

    18 maart 2021 · 35 min

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    In the UK thousands of scientists have signed open letters to the UK government protesting cuts to international funding announced this week. Abruptly and severely, the cuts may end hundreds of international collaborations between UK scientists and colleagues around the world working on health, climate change, disaster resilience, sustainability and many development topics. Lees meer

    Professor Jenni Barclay is a volcanologist at the University of East Anglia, and is one of the organisers of the protest. At the University of Cape Town, Dr Chris Trisos is the director of the Climate Risk Lab at the African Climate and Development Initiative, one of the authors of the IPCC 6th assessment, and has just learned his funding will be terminated, as the UK’s Royal Society must trim its output in this area by two thirds. Professor Otteline Leyser is CEO of UKRI – the UK’s main research funding agency, and will have to work out what will happen to over 900 projects currently under way.

    Antarctica Iceberg A74 break away
    Earlier this week German Research Vessel Polarstern released images from its remarkable circumnavigation of Antarctica’s latest iceberg, known as A74. This is the largest chunk of ice to break away from this sector of Antarctica since 1971, approaching the same size of Greater London. Dr Autun Purser describes a hair-raising voyage between the narrow gap left between the berg and the shelf, including the first images of life that have spent at least 50 years in total darkness, hundreds of miles from the open sea.

    Image: Polarstern between Brunt and iceberg A74, Antarctica
    Credit: RalphTimmermann

    Presented by Roland Pease
    Produced by Alex Mansfield

43. A shooting star parked on your driveway

    11 maart 2021 · 34 min

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    Last week a fireball lit up the sky of western England. Locals and professionals scoured the countryside for any surviving precious fragments of meteorite, and thanks to them some bits of the earliest solar system are now in London’s Natural History Museum. And as an excited Sara Russell, Merit Researcher in Cosmic Mineralogy tells us, examples of carbonaceous chondrite – the soft, loamy type that fell in Winchcombe – such as this, are a rare and special chunk of luck. Lees meer

    10 years on from the Japanese Tsunami
    Exactly a decade ago the disastrous huge wave caused by an earthquake at sea struck the coast of Japan, causing death and devastating consequences. The flood defences have been rebuilt to replace the ones swept away. But could new ways of spotting tsunamis beyond the horizon be, well, just over the horizon? Giovanni Occhipinti of the Paris Geophysics Institute tells Roland about his technique of looking at disruptions in the highest levels of the atmosphere - using the slight twinkle in a beam from a GPS or GNS satellite - to infer that a massive wave may be on its way.

    Hacked EMA emails and mRNA vaccine stability
    This week a piece in the British Medical Journal provides some insight into how the medical regulatory bodies scrutinised the novel RNA vaccines that were the science marvels of 2020. Investigative journalist Serena Tinari was one of the people who received anonymously a large, though selective, bundle of hacked emails and documents dating back to November copied from the servers of the European Medicines Agency. They make mention of concerns the Agency had over the levels of effective RNA contained in some batches of the industrially produced Pfizer Biontech Covid vaccine compared to the laboratory produced doses. The EMA did subsequently licence the vaccine - the problem having presumably been solved. However, as Serena describes, she was then surprised that the companies and agencies she and the BMJ approached would not tell her what the threshold …

44. Uncovering history with Little Foot's skull

    4 maart 2021 · 27 min

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    One of our most complete ancient ancestor’s fossils has been transported to the UK from South Africa in order to be scanned at the Diamond Light Source. Roland Pease investigates what these scans could reveal about the human story. Lees meer

    Professor Corinne Le Quéré explains how she managed to look past the 7% reduction in human emissions caused by the pandemic in 2020 to reveal the impact of the Paris Climate agreements, and explains what more needs to be done. Roland speaks with anthropologist Dr. Rolf Quam, who has studied the inner ears of fossilised Neanderthal skulls to reveal they may have evolved the ability to hear the complex sounds of spoken language separately to our own species. Dr. Emma Hodcroft discusses the Brazilian P1 COVID 19 variant that is spreading around the world.

    (Image: Little Foot Skull. Copyright: Diamond Light Source Ltd)

    Presenter: Roland Pease
    Producer: Rory Galloway

45. Waste not, want not

    25 februari 2021 · 31 min

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    Although vaccines will go a long way to reducing the number of cases of Covid, there’s still a need for other approaches. One of these could be an engineered biomolecule, designed by virologists Anne Moscona and Matteo Porotto, that blocks SARS-CoV-2 precisely at the moment it tries to enter cells in the nose and upper airways. Roland Pease talks to Anne Moscona about this “molecular mask”. Lees meer

    We’re already beginning to see really encouraging analyses showing that Covid vaccines are performing as well in the real world as was promised by last year’s trials. Shane Crotty of the La Jolla Institute for Immunology discusses progress so far and the question of one dose or two with Roland.

    Lives can be saved if there’s an early warning system for earthquakes and tsunamis. Seismologist Zhongwen Zhan at CalTech has been experimenting with a newly installed 10,000 km cable laid along the Pacific coasts of north and south America by Google, all the way from Los Angeles to Santiago. What he was looking for were subtle changes in a property of light that’s important to IT engineers, and can detect subsea earthquakes.

    We are still sending too much waste to landfill sites. At the Commonwealth Science Conference this week Veena Sahajwalla of the University of New South Wales explained how she is creating small scale factories that can use discarded objects such as ceramics and textiles to make new products.

    (Image: Getty Images)

    Presenter: Roland Pease
    Producer: Deborah Cohen

46. Weird weather

    18 februari 2021 · 33 min

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    A paper in the BMJ shows that deaths from Covid 9 are being massively overlooked in Zambia. The new data come from post-mortem tests at the University Hospital mortuary in Lusaka, showing that at least 1 in 6 deaths there are due to the coronavirus; many of the victims had also been suffering from tuberculosis. Chris Gill of Boston University’s Department of Global Health, and Lawrence Mwananyanda, chief scientific officer of Right to Care, Zambia, discuss their findings with Roland Pease. Lees meer

    New variants of concern continue to be reported, such as the one labelled B 1 1 7 in the UK, or B 1 351 identified in South Africa. Geneticist Emma Hodcroft, of the University of Bern, talks about seven variants that have been found in the US. Although all these variants are evolving from different starting points, certain individual mutations keep recurring – which suggests they have specific advantages for the virus.
    Her co-author Jeremy Kamil, of Louisiana State University Health Sciences Center in Shreveport, explains how he can watch the viruses replicating inside cells.

    Much of the United States, as far south as Texas, and Eurasia, has been gripped by an extraordinary blast of Arctic weather. Roland hears from climatalogist Jennifer Francis, of the Woodwell Climate Research Center, about the Arctic’s role in this weird weather.

    Life, in the form of sponges, has been discovered hundreds of metres under the thick ice surrounding Antarctica, where it’s dark, subzero and barren. The British Antarctic Survey’s Huw Griffiths reveals how it was spotted unexpectedly in pictures colleagues took with a sub-glacial camera.

    (Image: A man walks to his friend's home in a neighborhood without electricity as snow covers the BlackHawk neighborhood in Pflugerville, Texas, U.S. Credit: Reuters)

    Presenter: Roland Pease
    Producer: Deborah Cohen

47. Perseverance approaches Mars

    11 februari 2021 · 33 min

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    On 18th February the Perseverance rover should land on Mars. Katie Stack-Morgan of NASA’s Jet Propulsion Lab tells Roland Pease about the technological advances that mean that the spacecraft should be able to land in Jezero Crater. Imperial College geologist Sanjeev Gupta discusses what this crater can reveal about the history of life on the red planet. Lees meer

    After months of negotiations, and weeks of work on the ground, a team brought together by the World Health Organisation has just concluded its first attempts to find out the origins of SARS-Cov2 in Wuhan. Peter Daszak, who has worked closely with Chinese virologists in the past, briefed Roland Pease on what had been discovered.

    The South African government has announced that it will not be rolling out the Astra Zeneca Covid vaccine as it appears it is not very effective against the dominant strain in the country. Helen Rees, of Witwatersrand University and a member of South Africa’s Health Products Regulatory Authority, explains that the ‘ban’ is an overstatement.

    At least 35 people died in a flood disaster in the Himalayan state of Uttarakhand in India on February 6th. The details are still unclear, but the trigger seems to be associated with a glacier overhanging an upstream lake in the steep valley. Rupert Stuart-Smith of Oxford University, who has just published an analysis of a glacier melting disaster in waiting in the Andes, talks about the impacts of climate change on the stability of mountain glaciers.

    (Image: An illustration of NASA’s Perseverance rover landing on Mars.
    Credit NASA/JPL-Caltech)

48. Mixing Covid vaccines

    4 februari 2021 · 30 min

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    A new trial is about to start in the UK, seeing if different vaccines can be mixed and matched in a two-dose schedule, and whether the timing matters. Governments want to know the answer as vaccines are in short supply. Oxford University’s Matthew Snape takes Roland Pease through the thinking. Lees meer

    Despite the numbers of vaccines being approved for use we still need treatments for Covid-19. A team at the University of North Carolina is upgrading the kind of manufactured antibodies that have been used to treat patients during the pandemic, monoclonal antibodies. Lisa Gralinski explains how they are designing souped-up antibodies that’ll neutralise not just SARS-CoV-2, but a whole range of coronaviruses.

    Before global warming, the big ecological worry that exercised environmentalists was acid rain. We’d routinely see pictures of forests across the world dying because of the acid soaking they’d had poisoning the soil. In a way, this has been one of environmental activism’s success stories. The culprit was sulphur in coal and in forecourt fuels – which could be removed, with immediate effect on air quality. But biogeochemist Tobias Goldhammer of the Leibniz Institute in Berlin and colleagues have found that sulphur, from other sources, is still polluting water courses.

    There’s been debate over when and where dogs became man’s best friend. Geoff Marsh reports on new research from archaeology and genetics that puts the time at around 20,000 years ago and the place as Siberia.

    (Image: Getty Images)

    Presenter: Roland Pease
    Producer: Deborah Cohen

49. New Covid vaccine

    28 januari 2021 · 34 min

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    Researchers at Imperial College have been working on a strategy that can make RNA vaccines stretch further. Anna Blakely explains how the new approach works and why RNA vaccines are adaptable to a changing disease.
    In January 2019 a dam collapsed in Brazil, spilling 10 million cubic metres of red sludge down nearby rivers, claiming the lives of at least 259 people. An engineering report into the collapse looked at data from safety sensors around the site, and said they’d not revealed any weakening of the dam prior to the failure. But a new study using data from Earth observing satellites has found signs of subtle movement starting weeks earlier. Stephen Grebby of Nottingham University and Roland Pease discuss this finding.
    An international collaboration led by Kew Gardens has just set out a list of ten golden rules for maintaining and restoring forests. The main author, Kate Hardwick talks about why the rules are necessary and why it isn’t as simple as planting any old trees.
    There’s been a lot of debate about whether being bilingual is good for the brain. Does knowing more than one language take up precious capacity that could be used for better things? Or does it sharpen it, all the better to take on more challenges? Dean d’Souza of Anglia Ruskin University has been addressing this question by comparing the behaviour of infants brought up in monolingual and multilingual homes. Lees meer

    (Image: Getty Images)

    Presenter: Roland Pease
    Producer: Deborah Cohen

50. Saving the Northern White Rhino

    21 januari 2021 · 28 min

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    Northern white rhinos are extinct in the wild and there are just two females in captivity in Kenya. Conservationists are working on an artificial breeding programme, using eggs from the females and sperm from a deceased male. Now five embryos have been created. Thomas Hildebrandt of the Leibniz Institute for Zoo and Wildlife Research in Berlin explained the research. Lees meer

    President Biden’s first executive order was what’s being called the hundred-day mask mandate. The day before the inauguration a massive analysis of mask-wearing and COVID rates demonstrated a clear, if small, benefit. Epidemiologist Ben Rader told Roland Pease that it got over 300,000 opinions by using the online questionnaire, SurveyMonkey.

    After the alarming series of record-breaking heatwaves last year, global warming is causing specific problems in the innumerable lakes around the world. Lakes are ecologically particularly vulnerable to extremes. The European Space Agency’s Yestyn Woolway has been analysing past trends, and modelling the future.

    2020 delivered a record year in hurricanes, which caused around $60 billion dollars in damage to the US alone, according to one estimate. A new technology called Airborne Phased-Array Radar promises to improve the measurements that are currently made by planes that fly right into the eye of the hurricanes, and make the missions safe. It’s being developed at the National Centre for Atmospheric Research and Roland discussed the new technology with the Director of NCAR, Vanda Grubišić.

    (Image; Najin and Fatu, the only two remaining female northern white rhinos graze in their paddock. Credit: Tony Karumba/AFP via Getty Images)

    Presenter: Roland Pease
    Producer: Deborah Cohen