Talk Python To Me
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Talk Python to Me is a weekly podcast for Python developers, data scientists, and AI builders, hosted by developer and entrepreneur Michael Kennedy. We dive deep into the packages, tools, and people shaping Python, from web development and data science to AI and LLMs. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from its leaders. And if you've been Pythoning for years, you'll hear about your favorite packages and the hot new ones coming out of open source.
Afleveringen
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#568: Cloudflare Python Workers
3 november 2026 · 1 uur 2 min
Where does your Python code actually run? A server in Virginia? A container in Frankfurt? Pyodide put Python into the browser. Cloudflare put the browser into the server. Combine the two and you get Python Workers, now generally available. My guests are Hood Chatham, Gyeongjae Choi, and Dominik Picheta from Cloudflare. Hood and Gyeongjae maintain Pyodide. Dominik got Python running in Cloudflare Workers in the first place. Your FastAPI app ships as plain Python files. It runs on CPython compiled to WebAssembly, inside V8, at over 350 locations worldwide. Lees meer
Episode sponsors
Talk Python Membership
Talk Python Membership
Talk Python Courses
Links from the show
Guests
Gyeongjae Choi: linkedin.com
Hood Chatham
Dominik Picheta
Pyodide: pyodide.com
Python Everywhere: The State of Python on WebAssembly - Hood Chatham, Gyeongjae Choi: www.youtube.com
PEP 783: peps.python.org
D1 Databases: www.cloudflare.com
Hyperdrive: www.cloudflare.com
R2 Object Storage: www.cloudflare.com
Queues: developers.cloudflare.com
AI: www.cloudflare.com
now generally available: blog.cloudflare.com
Memory Snapshots for CPython (Python Language Summit 2026\): blog.python.org
Cloudflare Worker Limits: developers.cloudflare.com
Litestream: litestream.io
workerd: github.com
Are we PEP 783 yet?: pyodide.github.io
The Birth & Death of JavaScript: www.destroyallsoftware.com
Watch this episode on YouTube: youtube.com
Episode #568 deep-dive: talkpython.fm/568
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy
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#567: Personal AI Agents for Pythonistas
27 oktober 2026 · 1 uur 7 min
The most popular Python project you've probably never heard of has 252,000 GitHub stars and merged over 1,800 pull requests in a single week. It's Hermes, a self-hosted AI agent you program just by talking to it. And it never clocks out. It runs 24/7 on a box in your house, wakes up every 15 minutes, keeps your YouTube channel in sync, and has your morning briefing ready before you're up. Mine started as a few config files. A few months later, it's 16,000 files of skills, memories, and tools it built for itself, all while I wasn't watching. Jeff Triplett joins me to explore this honestly weird but kind of amazing world. And yes, Hermes has a few words for you, too. Lees meer
Episode sponsors
Talk Python Membership
Talk Python Membership
Talk Python Courses
Links from the show
Talk Python Tech Talks: talkpython.fm/meetups
Hermes: github.com
Ollama cloud models: ollama.com
https\://hermes-agent.nousresearch.com: hermes-agent.nousresearch.com
Hermes Web UI: get-hermes.ai
built my own UI: blobs.talkpython.fm
the Hermes Dashboard: blobs.talkpython.fm
the audio from the chat example: blobs.talkpython.fm
the CLI: blobs.talkpython.fm
Tailscale: tailscale.com
Hindsight: hindsight.vectorize.io
trmnl display: trmnl.com
JEV: typesafe.ai
Home Assistant Green: www.home-assistant.io
QMD - Query Markup Documents: github.com
OrangePi: www.orangepi.org
Watch this episode on YouTube: youtube.com
Episode #567 deep-dive: talkpython.fm/567
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy
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#566: State of the art in Python 2026
17 oktober 2026 · 1 uur 5 min
Which of your Python tools would you still pick if you started fresh today? For a long time, the answer was easy. The stack felt settled. AI has reopened almost every one of those choices. Some tools got faster. Others got replaced outright. On this episode, a panel takes stock of the state of the art in Python for 2026. Calvin Hendryx-Parker is CTO and co-founder of Six Feet Up. Pat Decker works in DevOps at Hibu. Reuven Lerner has trained Python developers for 15 years. Sydney Runkle does product management for open source at LangChain. One of them barely opens an editor anymore. Listen in to hear the surprising replacement. Lees meer
Episode sponsors
Talk Python Membership
Talk Python Membership
Talk Python Courses
Links from the show
Guests
Pat Decker
Reuven Lerner: github.com
Calvin Hendryx-Parker: linkedin.com
Sydney Runkle: github.com
Talk Python Membership: talkpython.fm/community
This Reddit post: www.reddit.com
PSF+Jetbrains survey: blog.jetbrains.com
vscode: code.visualstudio.com
pycharm: www.jetbrains.com
cmux: cmux.com
warp.dev: www.warp.dev
herdr: herdr.dev
Royal TS: apps.microsoft.com
Tailscale: tailscale.com
uv: docs.astral.sh
FastAPI: fastapi.tiangolo.com
Litestar: litestar.dev
Django: www.djangoproject.com
httpx2: github.com
ty: github.com
pyrefly: pyrefly.org
postgres: www.postgresql.org
sqlite: www.sqlite.org
duckdb: duckdb.org
Hetzner: www.hetzner.com
DigitalOcean: www.digitalocean.com
AWS: aws.amazon.com
Great Docs: posit-dev.github.io
Zensical: zensical.org
Vue.js: Vue.js
AgentsView: www.agentsview.io
LangChain Blog: www.langchain.com
Umami Example of Great Docs: mkennedy.codes
Mintlify: www.mintlify.com
DuckLake: ducklake.select
Robyn Web Framework: robyn.tech
Django Ninja: django-ninja.dev
Talk Python CLI: talkpython.fm
KEdit: www.kedit.com
Kitty: sw.kovidgoyal.net
Watch this episode on YouTube: youtube.com
Episode #566 deep-dive: talkpython.fm/566
Episode transcripts: talkpython.fm
Theme Song: Develo…
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#565: Tachyon, Python 3.15's Built-in Sampling Profiler
2 oktober 2026 · 1 uur 28 min
Do you know what's actually slow in your Python app? Or are you guessing? Until now, profiling Python meant a tracing profiler that made your code 2 to 3 times slower. Or a third-party tool that broke with every new release. Python 3.15 fixes that. It ships Tachyon, a sampling profiler built into the standard library. It attaches to live production apps with almost zero overhead. My guests are Pablo Galindo Salgado, CPython core developer and Steering Council member, and László Kiss Kollár from Bloomberg's Python infrastructure team. Their first prototype ran at two samples a second. Now it does over a million hz. And it lands in Python 3.15 this October. Lees meer
Episode sponsors
Sentry Error Monitoring, Code talkpython26
Python in Production
Talk Python Courses
Links from the show
Guests
László Kiss Kollár: linkedin.com
Pablo Galindo Salgado
3.11: talkpython.fm
Memray: talkpython.fm
PyStack: talkpython.fm
profile and cProfile: docs.python.org
py-spy: github.com
Austin: github.com
PEP 799: peps.python.org
PEP 768: peps.python.org
PyCon US 2026 talk: us.pycon.org
The docs: docs.python.org
Backport to 3.14: github.com
Watch this episode on YouTube: youtube.com
Episode #565 deep-dive: talkpython.fm/565
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy
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#564: EVE Online Departs for Python 3
22 september 2026 · 1 uur 8 min
Every ship in EVE Online eventually undocks and leaves the station. This time, it's the whole game. EVE has run on Python 2 since it launched in 2003, all 2.4 million lines of it, on a custom Stackless interpreter that stopped at 3.8 and was archived last year. Destination: Python 3.12. The route runs through 6,500 lines of division that decide who wins a fight, and 100 gigabytes of pickled Python objects that have to survive the jump intact. Kristinn Sigurbergsson was on this show ten years ago. He's back, with Jamie Bannister, who is flying the EVE Online migration right now, and Thomas Dähling, who took EVE Frontier through first. In EVE, a destroyed ship is gone for good. There are no do-overs, and the universe has to stay online the whole way. Lees meer
Episode sponsors
Sentry Error Monitoring, Code talkpython26
Talk Python Courses
Links from the show
Guests
Jamie Bannister: linkedin.com
Thomas Dähling: linkedin.com
Kristinn Sigurbergsson: linkedin.com
EVE Online: www.eveonline.com
EVE Frontier: evefrontier.com
2.4 million lines of Python: www.eveonline.com
Example of graphics, ships walk-through: www.youtube.com
Stackless: www.stackless.com
futurize: python-future.org
blue: github.com
Dev blog on the Frontier upgrade: evefrontier.com
Upgrading CARBON to Python 3: www.youtube.com
carbon-scheduler: github.com
Scheduling in Carbon: Leaving Stackless Python Behind: www.youtube.com
All of Carbon is on GitHub now: github.com
did a whole course: training.talkpython.fm
Trade Wars BBS (Wikipedia): en.wikipedia.org
TW 3002 - TradeWars 2002, reimagined as a modern browser game: www.reddit.com
Watch this episode on YouTube: youtube.com
Episode #564 deep-dive: talkpython.fm/564
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mk…
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#563: Getting Started with Rust as Python Devs
16 september 2026 · 1 uur 11 min
Lint the entire CPython code base from scratch. It takes 0.3 seconds. Three blinks of an eye. Lees meer
That is ruff, and it is written in Rust. So are Pydantic, Polars, uv, and Granian. Rust shows up in Python three ways: tools that happen to be Rust, libraries Python imports, and servers that run Python inside Rust. This is Rust for Python developers, not Rust experts.
Christopher Trudeau is back on Talk Python to discuss Rust and his latest course Up and Running with Rust. The core rule is that only one thing can own a value at a time. Pass it around freely in Python and the garbage collector cleans up. Do that in Rust and it will not compile.
Episode sponsors
Sentry Error Monitoring, Code talkpython26
Python in Production
Talk Python Courses
Links from the show
Up and Running with Rust course: training.talkpython.fm
Rust: rust-lang.org
pydantic: pydantic.dev
ruff: docs.astral.sh
granian: github.com
By example: doc.rust-lang.org
rust-lang.org: rust-lang.org
rustup.rs: rustup.rs
crates.io: crates.io
main.rs: main.rs
PyO3: github.com
https://github.com/ritwiktiwari/awesome-python-rs: github.com
ty: docs.astral.sh
pyrefly: pyrefly.org
uv: github.com
polars: pola.rs
Watch this episode on YouTube: youtube.com
Episode #563 deep-dive: talkpython.fm/563
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy
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#562: DuckLake: The Lakehouse That's Just SQL and Parquet
10 september 2026 · 1 uur 11 min
How many files does your query read before it reads any data? On some data lakes, you go through JSON and metadata files first, just to learn which Parquet files matter. DuckLake asks one SQL question instead. The metadata lives in a real database. The data stays in plain Parquet. That's the entire format. Lees meer
Pedro Holanda joined DuckDB in 2018, when it was still a research prototype at CWI. He's the lead DuckLake developer. Guillermo Sanchez Dionis works on DuckLake and the new Quack protocol.
With Quack as the catalog, DuckLake handles 200 transactions a second under heavy contention. No other open table format comes close.
Episode sponsors
Six Feet Up
Talk Python Courses
Links from the show
Guests
Pedro Holanda: pedroholanda.org
Guillermo Sanchez: linkedin.com
PhD on progressive indexes: ir.cwi.nl
SQLite: www.sqlite.org
Litestream: litestream.io
boring hardware: talkpython.fm
DuckDB: duckdb.org
episode 491: talkpython.fm
Iceberg: iceberg.apache.org
manifesto: ducklake.select
DuckLake: ducklake.select
spec: ducklake.select
this diagram: blobs.talkpython.fm
Data inlining: ducklake.select
ducklake-dataframe: github.com
Polars course: training.talkpython.fm
CSV parser: duckdb.org
Zero-copy Arrow: duckdb.org
ART index: duckdb.org
async I/O: duckdb.org
v1.0: ducklake.select
Git-like branching: ducklake.select
Watch this episode on YouTube: youtube.com
Episode #562 deep-dive: talkpython.fm/562
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy
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#561: TonIO, a Multi-threaded Async Runtime for Python
4 september 2026 · 1 uur 16 min
How many cores does your machine have, 10, 18? Your async Python code uses just one of them. That isn't a bug in asyncio. That's the design, and optimizing event loops to be faster by 20% doesn't change it. So Giovanni Barillari started over. Joe is the creator of Granian, the Rust-based server that powers Talk Python. His new project is TonIO, an async runtime written from scratch for free-threaded Python. Real threads, a handful of primitives instead of asyncio's pile of them, and it flat out refuses to start if the GIL is on. Lees meer
Episode sponsors
Sentry Error Monitoring, Code talkpython26
Python in Production
Talk Python Courses
Links from the show
Guest
Giovanni Barillari: github.com
Granian: github.com
Hyper: github.com
Free threaded Python: docs.python.org
Sort of: labs.quansight.org
did a whole course: training.talkpython.fm
uvloop: github.com
rloop: github.com
TonIO: github.com
your EuroPython 2026 talk: www.youtube.com
Michael's Cutting Python Web App Memory Over 31% Article: mkennedy.codes
Watch this episode on YouTube: youtube.com
Episode #561 deep-dive: talkpython.fm/561
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy
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#560: Building a Research OS: From Django to 30,000 Samples
26 augustus 2026 · 1 uur 3 min
In 2020, a gastroenterologist in Glasgow did the math on his new research study and came up with 30,000 samples, arriving over two years from three cities and a dozen hospitals. He asked around about how researchers keep track of that. The answer was Microsoft Excel. Shaun Chuah had written some HTML by hand in Notepad back in high school and that was about the whole of his programming experience, so he opened the Django tutorial and started reading. Six years later that app is Foundry120, holding 10 terabytes of clinical and genomics data with an agentic AI running on top of it. Lees meer
Episode sponsors
Sentry Error Monitoring, Code talkpython26
Talk Python Courses
Talk Python Courses
Links from the show
Guest
Shaun Chuah: github.com
Up and Running with Rust Course: talkpython.fm
Foundry120: www.foundry120.com
Designing Data Intensive Applications: www.oreilly.com
Microsoft Foundry: ai.azure.com
ChatIBD: www.chatibd.com
Blog: shaunchuah.github.io
@drshaunchuah: x.com
github.com/shaunchuah: github.com
Watch this episode on YouTube: youtube.com
Episode #560 deep-dive: talkpython.fm/560
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython
Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy
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#559: 12 Things You Should (and Shouldn't) Do in AWS
19 augustus 2026 · 1 uur 8 min
Your site is down. It's 3am. Is it a bug, a bill, or a breach? You can't tell yet, and everyone is watching you find out. Matt Lea has spent fifteen years being the person companies call when an outage is costing them real money per hour, and his whole argument is that everything you'd want in that moment gets decided months earlier, on ordinary afternoons, when someone chose the convenient thing. We walk his top twelve dos and don'ts in AWS - infrastructure as code, IAM roles instead of access keys, private subnets, no wildcards, no public buckets - and I push on which of them actually matter if you're one person on a small VPS. Then we get to Cloud War Games, where Matt breaks things on purpose so your team's first real incident isn't their first incident. Let's get into it. Lees meer
Episode sponsors
Sentry Error Monitoring, Code talkpython26
Talk Python Courses
Talk Python Courses
Links from the show
Guest
Matt Lea: linkedin.com
Talk Python Certificates: training.talkpython.fm/certificates
Schematical: schematical.com
CloudWarGames.com: cloudwargames.com
Zero to Hero on AWS Security: www.oreilly.com
Repo: github.com
Custom Wheel Offset: customwheeloffset.com
2012 TechCrunch Disrupt Hackathon: techcrunch.com
tech comics: schematical.com
shhgit: github.com
Zero Trust in 200ms: Implementing Identity-Per-Transaction: us.pycon.org
Coolify: coolify.io
returned to full GA Nov 2025: aws.amazon.com
Signed URLs/cookies: docs.aws.amazon.com
Cloudflare: www.cloudflare.com
Bunny Shield: bunny.net
Cloud War Games One: www.youtube.com
Cloud War Games Two: www.youtube.com
LinkedIn: linkedin.com
YouTube: youtube.com
KnocKnoc: knocknoc.io
Watch this episode on YouTube: youtube.com
Episode #559 deep-dive: talkpython.fm/559
Episode transcripts: talkpython.fm
Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong
---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython
Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X…
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- Categorieën
- Technologie
- Verschijnt
- Elke week
- Lengte
- Meestal 1 uur 5 min
- Afleveringen
- 567
- Eerste aflevering
- 21 maart 2015
- Taal
- Engels