This Week in Pediatric Oncology
Alle afleveringen
113 afleveringen, van nieuw naar oud
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TWiPO #63 - Dr. Javier Blanco discusses chemotherapy late effects and cardio-toxicity
17 juli 2017 · 24 min
Co-Hosts Dr. Timothy Cripe and Dr. Randal Olshefski (Nationwide Children's Hospital), interview Dr. Javier Blanco, Associate Professor at the Department of Pharmaceutical Sciences at SUNY Buffalo, about the late effects of chemotherapy. In this podcast, the participants discuss the role that chemotherapy, such as doxorubicin and other anthracycline drugs, often play in increasing cardio-toxicity. Lees meer
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TWiPO #62 - Interview with Dr. Uri Tabori
25 mei 2017 · 32 min
TWiPO hosts and cohosts interview Dr. Uri Tabori about the challenges that are unique to pediatric brain tumors, and how preventative treatment and early diagnosis can be largely beneficial.
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TWIPO #61 - Interview with Dr. Matthew Breen
25 mei 2017 · 31 min
TWIPO hosts and cohosts interview Dr. Matthew Breen, NC State Veterinary Medicine, to explore the question "Can dogs teach us new tricks when it comes to cancer treatment?"
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TWIPO #60 - Interview with Dr. Josua Mendell
25 mei 2017 · 33 min
TWIPO hosts and cohosts interview Dr. Joshua Mendell, UT Southwestern Medical Center, who shares his knowledge with regard to the relationship between innate RNA biology and how it influences human disease.
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TWiPo #59 ~ Interview with Dr. Sajid Qureshi
17 oktober 2016 · 33 min
Host Dr. Timothy Cripe and co-Host Nilay Shah interview Dr. Sajid Qureshi, a professor of Pediatric Oncology at the Tata Memorial Center, Mumbai, India. Dr. Qureshi is an Executive Committee Member of the International Society of Pediatric Surgical Oncology (IPSO). In this episode Dr. Qureshi provides a fascinating, first-hand glimpse into the successes and challenges of delivering quality care to larger, as well as remote, pediatric cancer populations. The episode concludes with Dr. Qureshi's thoughts on how international research collaboration could provide access to relapsed children worldwide. Lees meer
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TWiPO #58 ~ Interview with Dr. Damon Reed
17 oktober 2016 · 33 min
TWiPO Host Dr. Timothy Cripe, with co-hosts Dr. Nilay Shah and Dr. Bhuvana Setty welcome Dr. Damon Reed, Director of the Adolescent and Young Adult Program at Moffitt Cancer Center and Leader of the Pediatric Cancer Foundation's pediatric phase I consortium, the Sunshine Project. Dr. Reed shares his view points on how we can improve and accelerate the current trajectory with regard to pediatric therapy development. Lees meer
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TWIPO # 57 Interview with Dr. Elizabeth Lawlor
6 oktober 2016 · 29 min
TWIPO hosts Dr. Timothy Cripe and Dr. Nilay Shah (Nationwide Children's Hospital) along with guest
host Dr. Ryan Roberts (Nationwide Children's Hospital), interview Dr. Elizabeth Lawlor who is a Professor of Pediatric
Oncology at University of Michigan and the Director of the Cancer Biology
Training Program at University of Michigan Health System. Dr. Lawlor, a Ewing Sarcoma specialist, discusses
new approaches to the cellular eco-system of tumors and provides commentary on the growing
landscape for women in science. Lees meer -
TWIPO #56 ~ Interview with Dr. Mark Hatley
6 september 2016 · 28 min
On today's podcast, TWIPO host Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-host Dr. Ryan Roberts (Nationwide Children’s Hospital) interview Dr. Mark Hatley (St. Jude Children's Research Hospital). Dr. Hatley discusses how he got into the field of Biological Chemistry in Oncology. Also Dr. Hatley gives an indepth explaination about his research in G-Proteins. Lees meer
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TWiPO #55 ~ Interview with Dr. Chrystal Louis
3 juni 2016 · 34 min
On this episode of TWiPO podcast Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-host, Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri A. Streby (Nationwide Children's Hospital) interview Dr. Chrystal Louis (Assistant Professor, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine.) Dr. Louis talks to the hosts about her role in both the academic and industry side of oncology. Lees meer
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TWiPO #54 ~ Interview with Dr. Kim Kramer
3 juni 2016 · 21 min
On today's TWiPO Podcast host Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-host, Dr. Nilay Shah (Nationwide Children’s Hospital) interview Dr. Kim Kramer (Pediatric Oncologist of Memorial Sloan Kettering.) In this interview they discuss a new cutting edge therapy for treating brain tumors, which involves targeting the tumor intravenously just like any other tumor. Lees meer
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TWiPO #53 ~ Interview with Linda McAllister-Lucas
13 april 2016 · 25 min
On today's podcast TWiPO host Dr. Timothy Cripe (Nationwide Children’s Hospital) and co-hosts, Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Robyn Dennis (Nationwide Children’s Hospital) Interview Dr. Linda McAllister-Lucas (Chief of Service, Hematology/Oncology of Children's Hospital of Pittsburgh, Associate Professor of Pediatrics, University of Pittsburgh School of Medicine. In their discussion Dr. McAllister-Lucas talks about her research on MALT1 Lymphoma and how this research could advance the field of oncology Lees meer
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TWIPO #52 ~ Interview with Dr. James Geller
9 december 2015 · 26 min
On this TWiPO episode hosts, Dr. Timothy Cripe and Dr. Nilay Shah (Nationwide Children’s Hospital) interview Dr. James Geller (Medical Director at Kidney and Liver Tumors Program, Co-Medical Director at Retinoblastoma Program, Associate Director at Global Cancer Programs, Associate Professor at UC Department of Pediatrics.) Dr. James Geller was one of the original TWiPO members back in 2010. Today Dr. Geller talks about the battle to get access to potential drugs (Ex. Lorvotuzumab [IMGN901]) that can be beneficial to treating pediatric cancers. Lees meer
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TWIPO #51 ~ Interview with Dr. Gregory Armstrong
2 november 2015 · 7 min
This week
in pediatric oncology TWiPO hosts Dr. Timothy Cripe, Robyn Dennis, MD, Dr.
Nilay Shah interview Dr. Gregory Armstrong (Associate Professor in the
Department of pediatrics at the University of Tennessee health science center,
Associate member of in the department of epidemiology in cancer control in
Saint Jude's Children's Research Hospital, Director of CNS tumor after
completion of therapy clinic at Saint Jude). Dr. Armstrong and hosts discuss
the Childhood Cancer Survival Study (CCSS) and the advancements we have made in
the field of oncology. Along with problems that they are working to solve. Lees meer -
TWIPO #50 ~ Interview With Dr. Jonathan Finlay
8 mei 2015 · 37 min
In this most recent TWiPO podcast hosted by Dr. Timothy Cripe (Nationwide Children’s Hospital), he interviews Dr. Jonathan Finlay (Program Director of Neuro-Oncology at Nationwide Children’s Hospital) about sparked in research interest in brain tumors. One of Dr. Finlay’s mentors, helped launch a new treatment, which was able to rescue a proportion of newly diagnosed children who failed conventional chemotherapy, radiation, and surgery. That novel treatment is now a growing method of treating medulloblastoma. Lees meer
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TWIPO #49 ~ Interview With Dr. Robin Norris
20 april 2015 · 29 min
TWiPO host Dr. Timothy Cripe (Nationwide Children’s Hospital) and TWiPO co-host Dr. Nilay Shah (Nationwide Children’s Hospital) interview Robin Norris, MD, who is a pediatric oncologist and the Director of the Pediatric Developmental Therapeutics Program, Division of Pediatric Hematology and Oncology, at University Hospitals Rainbow Babies & Children's Hospital. Dr. Norris discusses the struggles that adolescents and young adult with cancer face and discusses her involvement in creating an antibody against TEM-1 in order to stop the metastasis of tumors. Lees meer
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TWIPO #48 ~ Interview With Dr. Michael D. Hogarty
20 april 2015 · 33 min
TWiPO host Dr. Nilay Shah (Nationwide Children’s Hospital) interviews Dr. Michael D. Hogarty, MD, an attending physician in the Division of Oncology at The Children's Hospital of Philadelphia. Dr. Hogarty recalls his efforts in finding a new way of tackling neuroblastoma by sending 17,000 tumor samples around the world. In this short interview, he discusses his current work in the lab, which involves testing the MYC gene found in children with high-risk neuroblastoma. Lees meer
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TWIPO #47 ~ Interview With Dr. Hiro Shimada
30 maart 2015 · 41 min
TWiPo co-hosts Dr. Keri Stretby
(Nationwide Children’s Hospital) and
Dr. Nilay Shah (Nationwide Children’s Hospital) interview Hiroyuki Shimada, MD,
PhD, Professor of Clinical Pathology at the Children’s Hospital of Lost
Angeles. Dr. Shimada developed the Shimada neuroblastoma classification system
for neuroblastoma, which was the basis of The International Neuroblastoma
Pathology Classification and now The International Neuroblastoma Risk Group
classification system. Lees meer -
TWIPO #46 ~ ANR Recap: Interview With Dr. Sue Cohn
30 maart 2015 · 52 min
TWiPO host Dr. Nilay Shah (Nationwide Children’s Hospital) interviewed Susan L. Cohn, MD, a Professor of Pediatrics, Dean of Clinical Research at the University of Chicago at the ANR meeting in Cologne, Germany last year for this episode of This Week in Pediatric Oncology. Dr. Cohn is a highly respected expert in pediatric cancers and blood diseases. She is a leading authority on neuroblastoma and actively researching several aspects of neuroblastoma. Her research has received generous support from the National Institutes of Health/National Cancer Institute and the National Institute of Neurological Disorders and Stroke. Dr. Shaw and Dr. Cohn discuss the future of neuroblastoma research and clinical trial design to create more effective treatment options for children with high-risk disease. Lees meer
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TWIPO #45 ~ Immunotherapy Vaccine for Immunotherapy Vaccine for High-Grade Gliomas
18 november 2014 · 57 min
In the most recent episode
of This Week in Pediatric Oncology, co-hosts Dr. Nilay Shah (Nationwide
Children’s Hospital), Dr. Timothy Cripe (Nationwide Children’s Hospital), and
Dr. Lionel Chow (Cincinnati Children’s) discuss the promising results of a
study published in the July issue of Journal
of Clinical Oncology among children with an aggressive brain tumor after receiving
immunotherapy. To see a summary of the study, click here. Lees meer -
TWIPO #44 ~ ANR Recap: Interview With Professor Michelle Haber and Professor Andrew Pearson
10 november 2014 · 44 min
In the most recent
episode of This Week in Pediatric Oncology (TWiPO), the first podcast focusing
on pediatric cancer research, co-hosts Dr. Keri Stretby (Nationwide Children’s
Hospital) and Dr. Nilay
Shah (Nationwide Children’s Hospital), caught up with Professor Michelle
Haber (Executive Director at Children’s Cancer Institute in Australia and Professor Andrew Pearson of
the Cancer Research UK. In this 26-minute podcast, both researchers
discuss the future of neuroblastoma, specifically looking at precision medicine,
the role of gene sequencing and the role of international collaboration to
bring new therapies into the clinic. Lees meer -
TWIPO #43 ~ Langerhans cell histiocytosis : Interview With Carl E. Allen
1 oktober 2014 · 36 min
New York, NY -- In the most recent episode of This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, co-hosts Dr. Edwin Horwitz (Nationwide Children’s Hospital), Dr. Nilay Shah (Nationwide Children’s Hospital), Dr. Robyn Dennis (Nationwide Children's Hospital), interview Dr. Carl E. Allen, (Texas Children’s Cancer and Hematology Centers) about his research in a rare pediatric blood disorder known as Langerhans cell histiocytosis (LCH). Lees meer
Dr. Allen is Assistant Professor, Department of Pediatrics, Section of Hematology-Oncology - Baylor College of Medicine, and the Co-Director of the Histiocytosis and Lymphoma Programs at Texas Children's Cancer and Hematology Centers. His primary research is focused on the clinical and biologic aspects of LCH. Along with Dr. Kenneth McClain, Dr. Carl Allen has developed the largest Histiocytosis Center in the world. Dr. Allen has developed gene expression and proteomic strategies to analyze the identity and function of the cells that cause LCH. The ultimate goal of these experiments is to identify genes, proteins, and pathways that may be used to diagnose and cure patients with LCH. These experiments may also provide insight into dendritic cell biology and tumor immunology.
In this 20-minute episode, Dr. Allen gives an overview of LCH, as well as treatment and the future of LCH research.
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TWIPO #42 ~ Advances in Neuroblastoma Research Meeting Recap: Interview With Frank Berthold
23 juli 2014 · 19 min
New York – This Week in Pediatric Oncology presents the third and final interview from the recent Advances in Neuroblastoma Research meeting, which was held in Cologne, Germany, in May. Co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri Stretby (Nationwide Children’s Hospital) talk with Frank Berthold, ANR2014 Local Chairman, to discuss meeting highlights in the short, 18-minute interview. Lees meer
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TWIPO #41 ~ Advances in Neuroblastoma Research Meeting Recap: Advances in Understanding MIBG Therapy
15 juli 2014 · 45 min
New York – This Week in Pediatric Oncology presents the second in a series of interviews from the recent Advances in Neuroblastoma Research meeting, which was held in Cologne, Germany, in May. Co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri Stretby (Nationwide Children’s Hospital) discuss MIBG therapy in treating children with high-risk neuroblastoma with Dr. Kate Matthay (UCSF Benioff Children's Hospital) and Dr. Gregory Yanik (C.S. Mott Children’s Hospital at the University of Michigan). In this 45-minute interview, both Drs. Matthay and Yanik, who have conducted extensive research in MIBG throughout their long careers, share their perspectives on what’s going on in the field now and opportunities to improve the therapy in the future. Lees meer
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TWIPO #40 ~ Advances in Neuroblastoma Research Meeting Recap: Advances in Understanding MYCN
10 juli 2014 · 28 min
New York – This Week in Pediatric Oncology presents the first of a series of interviews from the recent Advances in Neuroblastoma Research meeting, which was held in Cologne, Germany, in May. Co-hosts Dr. Nilay Shah (Nationwide Children’s Hospital) and Dr. Keri Stretby (Nationwide Children’s Hospital) caught up with two pediatric oncologists who’ve made significant advances in neuroblastoma research. In this 25-minute interview, Dr. Robert Seeger (Children's Hospital of Los Angeles) and Dr. Garrett Brodeur (Children’s Hospital of Philadelphia) discuss how the discovery of the MYCN gene 30 years ago has helped scientists better understand neuroblastoma and impacted treatment options. Lees meer
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TWIPO #39 ~ Declining Childhood Cancer Mortality & CAR123 T-cells
10 juli 2014 · 44 min
New York, NY -- In the most recent episode of This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, co-hosts Dr. Timothy Cripe (Nationwide Children's Hospital), Dr. Robyn Dennis (Nationwide Children's Hospital), Dr. Andy Kolb (A.I. Dupont) and Dr. Lionel Chow (Cincinatti Children's) discuss two recent papers on the declining mortality rate in childhood and adolescent cancers and a pre-clinical study using CAR123 T-cells. Lees meer
Saar Gill, Sarah K. Tasian, Marco Ruella, Olga Shestova, Yong Li, David L. Porter, Martin Carroll, Gwenn Danet-Desnoyers, John Scholler, Stephan A. Grupp, Carl H. June, and Michael Kalos. Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor–modified T cells. Blood. 2014, 10, April. http://www.ncbi.nlm.nih.gov/pubmed/24596416
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TWIPO #38 ~ Interview with John Goldberg, MD, on Phase I Clinical Trials
11 maart 2014 · 25 min
March 11, 2014 Lees meer
New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that John Goldberg, MD, from The Sylvester Comprehensive Cancer Center at the University of Miami, is a featured guest on its most recent episode. In this episode, Dr. Golberg talks about the challenges of phase I pediatric cancer clinical trials with hosts Dr. Tim Cripe (Nationwide Children's Hospital), Dr. Robyn Dennis (Nationwide Children's Hospital), and Mark Ranalli, MD (Nationwide Children's Hospital).
Dr. Goldberg is an Assistant Professor of Pediatrics and the Director of the Pediatric Oncology Early Phase Clinical Trials Program at The Sylvester Comprehensive Cancer Center, the University of Miami.
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TWIPO #37 ~ Interview with Patrick Brown, MD, on Infant Leukemia
26 februari 2014 · 26 min
February 26, 2014 Lees meer
New York, NY -- This Week in Pediatric Oncology (TWiPO), the first podcast focusing on pediatric cancer research, announced that Patrick Brown, MD, from The Sidney Kimmel Comprehensive Cancer Center, is a featured guest on its most recent episode. In this episode, Dr. Brown talks about treating infant leukemia and the challenges of doing clinical trials in this patient population with hosts Dr. Tim Cripe (Nationwide Children's Hospital) and Dr. Robyn Dennis (Nationwide Children's Hospital).
Dr. Brown is the Director, Pediatric Leukemia and Lymphoma Program and Associate Professor of Oncology and Assistant Professor of Pediatrics at The Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins School of Medicine.
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TWIPO #36 ~ Interview With Kathleen Neville, MD, on Pediatric Drug Development
10 februari 2014 · 28 min
January
27, 2014 Lees meerNew York, NY -- This Week in Pediatric Oncology
(TWiPO), the first podcast focusing on pediatric cancer research, announced
that Kathleen Neville,MD, from Children's Mercy Hospital in Kansas City, is a
featured guest on its most recent episode. In this episode, Dr. Kathleen
Neville talks about the challenges of drug development in pediatric cancer with
with host Dr. Tim Cripe (Nationwide Children's Hospital).Kathleen Neville is the Director of
Experimental Therapeutics in the pediatric cancer program at Children's Mercy
Hospital in Kansas City. She is an Associate Professor of Pediatrics in the
division of pediatric clinical pharmacology, medical toxicology and
hematology-oncology at the University of Missouri-Kansas City School of
Medicine. She is also the chair of the education committee of the American
Society for Clinical Pharmacology and Therapeutics, and a consultant on FDA
pediatric advisory committee, and serves on the FDA Pediatric Oncology
Subcommittee of the Oncologic Drugs Advisory Committee. -
TWIPO #35 ~ Interview With Robert Johnson, PhD
10 februari 2014 · 48 min
December
02, 2013 Lees meerNew York, NY -- This Week in Pediatric Oncology
(TWiPO), the first podcast focusing on pediatric cancer research, announced
that Robert Johnson, PhD, is a featured guest on its most recent episode, In
this episode, Dr. Johnson speaks with host Dr. Tim Cripe (Nationwide Children's
Hospital) and co-hosts Dr. Robyn Dennis (Nationwide Children's Hospital and Dr.
Lionel Chow (Cincinatti Children's) about the third most common type of brain
tumor in children, ependymomas.Robert A. Johnson, PhD, is a principal
investigator at The Research Institute at Nationwide Children’s Hospital and an
Assistant Professor of Pediatrics at The Ohio State University College of
Medicine. The primary focus of the Johnson laboratory is the development of
novel therapies for the treatment of ependymoma, the third most common
pediatric brain tumor, by identifying and targeting the genetic changes
responsible for the formation of the disease. -
TWIPO #34 ~Interview With Dr. Nancy Ratner
10 februari 2014 · 21 min
November
14, 2013 Lees meerNew York, NY -- This Week in Pediatric Oncology
(TWiPO), the first podcast focusing on pediatric cancer research, announced
that Nancy Ratner, PhD, is a featured guest on its most recent episode, In this
episode, Dr. Ratner speaks with host Dr. Tim Cripe (Nationwide Children's
Hospital) and co-host Dr. Robyn Dennis (Nationwide Children's Hospital).Dr. Ratner is interested in understanding
mechanisms of peripheral nerve tumor (neurofibroma) formation in
Neurofibromatosis type 1 (NF1), a common inherited disorder in which children
are predisposed to cancer of the nervous system, to learning problems, bone
disorders, and other cancers. She identified EGFR as a potential therapeutic
target in NF1 peripheral nerve tumorigenesis, and has developed cell culture
and mouse models of NF1 nerve tumorigenesis. Her laboratory has also used
analysis of gene expression to identify critical genes in neurofibroma and
their malignant derivatives, MPNST.Dr. Ratner is currently a professor in the Department of Pediatrics, Cincinnati
Children’s Hospital, University of Cincinnati, and the program leader for
Cancer Biology and Neural Tumors Program in the Cancer and Blood Disorders
Institute where she holds the Beatrice C. Lampkin Endowed Chair in Cancer
Biology and serves as PI of the NINDS P50 “Cincinnati Center in NF Research.” -
TWIPO #33 ~Effective Advocacy with Gavin Lindberg
10 februari 2014 · 22 min
October
31, 2013 Lees meerNew York, NY—This Week in Pediatric Oncology
(TWiPO), the first podcast focusing on pediatric cancer research, announced
that Gavin Lindberg is a featured guest on its most recent episode, entitled
Effective Advocacy. In this episode, Mr. Lindberg speaks with host Dr. Tim Cripe
(Nationwide Children’s Hospital), and co-host Dr. Robyn Dennis (Nationwide
Children’s Hospital), about his work to increase funding for childhood cancer
research.Mr. Lindberg is the President and Co-Founder of
The Evan’s Victory Against Neuroblastoma (EVAN) Foundation, which was
established in memory of his only child Evan Lindberg. Evan bravely battled
neuroblastoma for four years before passing away at the age of 7 in 2010. The
Foundation funds research aimed at fostering new therapies for children with
neuroblastoma, and sponsors patient-wellness programs for childhood cancer
patients enduring long and difficult stays in the hospital.While his son was in treatment, Mr. Lindberg
served as the founding president of the Band of Parents, an organization that
raised over $1 million to develop a new humanized antibody for neuroblastoma
currently used at Memorial Sloan-Kettering Cancer Center, in New York City. Mr.
Lindberg and his wife Wendy also work to increase awareness of neuroblastoma
among policymakers in Washington, DC and have successfully advanced new
opportunities for federal support of neuroblastoma research within the
Department of Defense. -
TWIPO #32 ~ Ethics in Childhood Cancer Clinical Trials
10 februari 2014 · 33 min
October
18, 2013 Lees meerEric Kodish, MD, is a featured guest on the
recent episode of This Week in Pediatric Oncology. In this episode, Dr. Kodish
speaks with host Dr. Tim Cripe (Nationwide Children’s Hospital), and co-host
Dr. Andy Kolb (AI DuPont), about informed consent and ethics surrounding
childhood cancer clinical trials. -
TWIPO #31 ~ Secondary Cancers in Childhood Cancer Survivors
10 februari 2014 · 32 min
October
03, 2013 Lees meerDr. Joseph Neglia (University of Minnesota) is
nationally and internationally recognized for his contributions to the field of
childhood cancer long-term effects. He is the featured guest in this week's
podcast episode, and answers questions from host Dr. Tim Cripe (Nationwide
Children’s Hospital), and co-hosts Dr. Robyn Dennis (Nationwide Children’s
Hospital), Dr. Andy Kolb (AI DuPont), and Donna Ludwinski (Solving Kids’
Cancer), about late effects and the risk of secondary cancers among childhood
cancer survivors. -
TWIPO #30 ~ Cancer Risk in Families
10 februari 2014 · 32 min
September
19, 2013 Lees meerRecently, several published papers have
discussed the risk of cancer among family members of children with
cancer. TWIPO host Dr. Timothy Cripe and fellow co-host Dr. Robyn Dennis
(Nationwide Children's) break down the topic of familial cancer risk with
certified genetic counselor Elizabeth Varga (Nationwide Children's) and Donna
Ludwinski (Solving Kids' Cancer) and what families should take away from these
studies. -
TWIPO #29 ~ Understanding the Circuitry Behind Pediatric Solid Tumors
10 februari 2014 · 36 min
September
05, 2013 Lees meerNew revelations in DNA damage and cell repair
mechanisms in childhood cancer may help scientists identify the underlying
cause of pediatric solid tumors and lead to the development of new therapies.
Dr. Peter Houghton (Nationwide Children's) speaks with TWIPO host Dr. Timothy
Cripe and fellow co-hosts Dr. Lionel Chow (Cincinatti Children's) and Dr. Robyn
Dennis (Nationwide Children's) about his recent paper published in the Proceedings
of the National Academy of Sciences on the mTOR pathway and role of
ATM. -
TWIPO #28 ~ Uniting the Childhood Cancer Community
10 februari 2014 · 40 min
August
15, 2013 Lees meerTWIPO host Dr. Tim Cripe (Nationwide
Children's) and co-hosts speak with Vickie Buenger from Texas A&M
University about her role as a childhood cancer advocate. A founding member of
the Coalition Against Childhood Cancer, Buenger discusses the organization's
principles and future projects to bring the childhood cancer community
together. -
TWIPO #27 ~ Advocating for Better Research for our Kids
10 februari 2014 · 32 min
August
01, 2013 Lees meerIn this new episode, host Dr. Tim Cripe
(Nationwide Children's) and co-host Dr. Jeffrey Auletta (Nationwide Children's)
interview Solving Kids' Cancer co-founder and Executive Director Scott Kennedy
and co-director of research programs Donna Ludwinski. Both Scott and Donna
share their personal stories that led them to Solving Kids' Cancer and their
shared passion to improve survival for children with the deadliest childhood
cancers through research advocacy. -
TWiPO #26 ~ Killer Immunoglobulin Receptor (KIR) Mismatch in Neuroblastoma
10 februari 2014 · 50 min
May
07, 2012 Lees meerIn this interesting episode, host Dr. Tim Cripe
(Nationwide Children's) and co-hosts Dr. Lionel Chow (Cincinnati Children's),
Dr. Andy Kolb (AI DuPont), and Donna Ludwinski (Solving Kids' Cancer) quiz Dr
Paul Sondel and Dr. Ken DeSantes (both from University of Wisconsin - Madison)
on NK cells and the implications of KIR/KIR-ligand mismatch (killer
immunoglobulin-like receptor) with regard to immunotherapy treatment of
neuroblastoma.References:
Delgado DC, Hank JA, Kolesar J, Lorentzen D, et
al. Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the
response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res.
2010 Dec 1;70(23):9554-61. Epub 2010 Oct 8.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999644/.
Venstrom JM, Zheng J, Noor N, Danis KE, et al.
KIR and HLA genotypes are associated with disease progression and survival
following autologous hematopoietic stem cell transplantation for high-risk
neuroblastoma. Clin Cancer Res. 2009 Dec 1;15(23):7330-4. Epub 2009 Nov 24.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788079/.
Alderson KL, Sondel PM. Clinical cancer therapy
by NK cells via antibody-dependent cell-mediated cytotoxicity. J Biomed
Biotechnol. 2011;2011:379123. Epub 2011 May 24.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110303/ -
TWiPO #25 ~ Histones in Pediatric Gliomas
10 februari 2014 · 46 min
April
05, 2012 Lees meerHost Dr. Tim Cripe welcomes back co-host Dr.
Lionel Chow to discuss somatic mutations in pediatric brain tumors. After
recapping the consensus paper on molecular subgroups in medulloblastoma
discussed in TWiPO episode 22 (Brain Tumor Round Robin) Dr Chow highlights the
significance of the driver mutations in histone H3.3 in pediatric glioblastoma.
Results of whole exome sequencing have shown that significantly more somatic
mutations are present in adult tumors compared to pediatric tumors. This
difference might suggest a reason for better success rates in pediatric tumors
and possibly more escape mechanisms in adult tumors. Dr. Chow also discusses a
paper published by the Pediatric Cancer Genome Project (a St. Jude Children's
Research Hospital–Washington University collaboration) on somatic histone H3
alterations in diffuse intrinsic pontine glioma (DIPG). The findings are
significant in showing that this mutation is present in 36% of non-brain stem
gliomas and in 78% of brain stem gliomas, but in none of the other pediatric
tumor types.Please send comments and questions to
twipo@solvingkidscancer.orgPapers discussed:
Taylor MD, Northcott PA, Korshunov A, et al.
Molecular subgroups of medulloblastoma: the current consensus. Acta
Neuropathol. 2012 Apr;123(4):465-72. Epub 2011 Dec 2.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306779/Schwartzentruber J, Korshunov A, Liu XY, Jones
DT, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in
paediatric glioblastoma. Nature. 2012 Jan 29;482(7384):226-31. doi:
10.1038/nature10833. http://www.ncbi.nlm.nih.gov/pubmed/22286061Wu G, Broniscer A, McEachron TA, Lu C, Paugh
BS, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic
pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012 Jan
29;44(3):251-3. doi: 10.1038/ng.1102. St. Jude Children's Research
Hospital–Washington University Pediatric Cancer Genome Project.http://www.ncbi.nlm.nih.gov/pubmed/22286216 -
TWiPO #24 ~ Cord Blood Banking: Interview with Machi Scaradavou
10 februari 2014 · 32 min
March
06, 2012 Lees meerDr. Tim Cripe welcomes Dr. Andy Kolb from AI
DuPont in this episode of TWiPO, and special guest Dr. Andromachi Scaradavou,
the Medical Director of New York Blood Center's National Cord Blood Program.NYBC is the world's oldest and largest public
cord blood bank, and collects, processes, tests and stores cord blood that
mothers donate shortly after birth. The cord blood is for children and adults
with no related donor available who need a hematopoietic stem cell transplant
for life-threatening illnesses. More than 60,000 units are stored at NYBC and
more than 4500 units have been provided for transplants worldwide. The variety
of ethic groups represented is much higher in cord blood banking than in bone
marrow donor programs. The percentage of use is climbing significantly for
pediatric transplants partly because of the small dose required.Discussants cover many aspects of this
fascinating subject: background and uses of cord blood, logistics of
collecting, processing, storing, and selecting units for transplants, as well
as the advantages and challenges currently faced in this field. For more on
NYBC seehttp://www.nationalcordbloodprogram.org/We welcome all questions or comments at
twipo@solvingkidscancer.org -
TWiPO #23 ~ Neuroblastoma Jeopardy 2011
10 februari 2014 · 41 min
January
26, 2012 Lees meerIn 2011 there were over 1300 new articles
published on neuroblastoma in the medical literature.Join Dr. Tim Cripe and his co-host Dr. Lars
Wagner in a fast-paced, in-depth, and comprehensive survey of 18 of the most
important papers on neuroblastoma published in 2011. Dr. Cripe and Dr Wagner
explore and discuss the compelling evidence reported on a variety of topics,
including epidemiology, risk stratification, clinical trials, ALK mutation and
expression, new targets, and genetics.All of the papers discussed are listed HERE with links to PubMed.
Please send all comments and questions to twipo@solvingkidscancer.org
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TWiPO #22 ~ Brain Tumor Year-End Round Robin
10 februari 2014 · 48 min
December
05, 2011 Lees meerJoin Dr. Tim Cripe and his co-host Dr. Lionel
Chow for a fast-paced, in-depth, and comprehensive survey of 15 important
recent papers on pediatric brain tumor research, addressing medulloblastoma,
ependymomas, and gliomas. Dr. Cripe and Dr. Chow explore and discuss the
compelling evidence reported on a variety of topics, including viral causes and
therapeutic implications, biomarkers, genomics, proteomics, targets, classification,
risk stratification, treatment side-effects, proton-beam radiation therapy, and
results of recent clinical trials.This robust review of current research includes
all of the following papers [click link], listed by timed location in the podcast.Please send all comments and questions to
twipo@solvingkidscancer.org -
TWiPO #21 ~ Interview with Dr. Beatrice Lampkin
10 februari 2014 · 38 min
November
29, 2011 Lees meerDr. Tim Cripe and co-hosts Dr. Maureen O'Brien
and Dr. Raj Nagarajan interview a pediatric hematology/oncology legend, Dr.
Beatrice Lampkin, who served as Director of Cincinnati Children's Division of
Hematology/Oncology in the 1970’s. This enlightening and inspiring discussion
explores her career and her contributions to leukemia therapy and the
challenges she faced as an early leader in the field as a female. She describes
her experience with polio, paralysis from the neck down, crutches for mobility,
and later, her confinement to a wheelchair. Revealing another era in
communications with parents and patients in the 1960s and 1970s, she explains
how parents were advised to use the term "anemia" to describe their
child's condition rather than "leukemia" to to explain why the child
would require periodic blood transfusions, in order to prevent shunning by
friends and family. Dr. Lampkin also shares her satisfaction in following the
earliest survivors of pediatric cancer she treated who are now in their 40s and
50s.As if all that isn't inspiring enough, she
describes her busy retirement in which she continues to teach the Cincinnati
Children's Hospital fellows how to examine blood and bone marrow smears under
the microscope and her work in the founding of the GLAD House (http://www.gladhouse.org/),
a sanctuary to help drug-addicted youth get off the streets.Please send all comments and questions to
twipo@solvingkidscancer.org. -
TWiPO #20 ~ The F-word in Pediatric Cancer Research
10 februari 2014 · 39 min
November
15, 2011 Lees meerToday’s episode features an impressive lineup
for a hot topic. Host Dr. Tim Cripe warns: “If your blood isn’t boiling by the
end, you weren't listening.” Hear Tim and co-host Dr. Lionel Chow discuss
pediatric cancer research funding with guests Dr. C. Patrick (Pat) Reynolds, Dr.
E. Anders (Andy) Kolb, and parent Joe McDonough.Dr. Pat Reynolds puts government spending on
the number one disease killer of children in the US in perspective, comparing
the tiny $200M spent on pediatric cancer research to the foreign aid budget of
$22B (less than 1%). For example, $1.6B goes to Egypt alone. The COG budget is
a mere $46M. The DOD budget is $700B. See his slides here. Dr. Lionel Chow mentions an enlightening fact
– private donations to St Jude exceed $600M per year, on top of the givers’
paying taxes. This is 3 times the entire NCI budget for pediatric cancer
research for all institutions in the US.Spending per Person Years Life Lost is compared
for childhood cancers and adult cancers, see graph here.Dr. C Patrick Reynolds is Director, Cancer
Center and Professor of Cell Biology & Biochemistry, Internal Medicine, and
Pediatrics, School of Medicine, Texas Tech University Health Sciences Center,
Lubbock TX. Dr. E Anders Kolb is the Director of Blood and Bone Marrow
Transplantation at Alfred I. duPont Hospital for Children, and Head of the
Cancer Therapeutics Laboratory at Nemours Biomedical Research, Wilmington, DE.
Joe McDonough is father to Andrew, and founder of The Andrew McDonough B+ (Be Positive)
Foundation, raising money for families and research.Please send comments to
twipo@solvingkidscancer.org -
TWiPO #19 ~ More on Hedgehog signaling, brain tumor risk from cell phone use, and FDA approval of cancer drugs
10 februari 2014 · 45 min
October
30, 2011 Lees meerSeveral just-published papers in the literature
relate to recent podcast episodes, and host Dr. Tim Cripe and co-host Dr. Lionel Chow review these interesting
developments.0:55 Hedgehog Signaling: Recent papers
discussing this pathway in neuroblastoma and rhabdomyosarcoma are discussed,
with implications for treatment in these tumor types with itraconozole.6:40 Cell phone and brain tumor risk: The
controversy concerning criticism by the Environmental Health Trust of a study
showing that cell phone use does not increase risk of brain tumors in children
is explored.Accelerated approval of cancer drugs by the FDA
and implications for pediatric cancers.15:30 Brentuximab for two types of lymphoma
21:20 Vemurafenib for melanoma
28:30 Crizotinib for non-small cell lung cancer
(and potential use in neuroblastoma)42:30 Response to email regarding personalized
medicine TWiPO episode #17 and lab blog for Dr Charles Keller at OHSUReferences:
Pediatr Blood Cancer. 2011 Dec 1;57(6):930-8.
doi: 10.1002/pbc.23174. Hedgehog pathway activity in
pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report
from the Children's Oncology Group.Int J Oncol. 2011 Oct;39(4):899-906. doi:
10.3892/ijo.2011.1076. Pharmacological inhibition of
the Hedgehog pathway preventshuman rhabdomyosarcoma cell growth.Cancer Lett. 2011 Nov 28;310(2):222-31. Inhibition of the sonic hedgehog
pathway by cyplopaminereduces the CD133+/CD15+ cell compartment and the in
vitrotumorigenic capability of neuroblastoma cells.Cell Phone Study Was Flawed, Say Some Experts by
Roxanne Nelson Medscape Oncology News.The JNCI Study by Aydin et al on Risk of Childhood Brain Cancer from
Cellphone Use Reveals Serious Health Problems, Environmental Health Trust.N Engl J Med. 2010 Nov 4;363(19):1812-21. Brentuximab
vedotin (SGN-35) for relapsed CD30-positive lymphomas.FDA Approves Brentuximab for Two Lymphomas By:
ELIZABETH MECHCATIE, Oncology Report Digital Network.Cl…
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TWiPO #18 ~ Targeting EWS-FLI1 in Ewing's Sarcoma: Interview with Dr Jeff Toretsky
10 februari 2014 · 22 min
October
18, 2011 Lees meerHost Dr. Tim Cripe and co-host Dr. Lionel Chow
welcome special guest Dr. Jeff Toretsky on TWiPO to discuss his clinical and
research interest in Ewing's sarcoma. Dr. Toretsky explains the challenges of
developing a clinical grade drug from a small molecule for a specific target
such as EWS-FLI1. The small market for a disease like Ewing's creates
formidable hurdles for researchers, yet Dr. Toretsky is driven on by the
question "If I don't do this, who will?" (17:54 mins)Dr. Jeff Toretsky is Professor of Oncology and
Pediatrics at Georgetown University. He graduated with BS in Biochemistry from
University of Wisconsin, Madison, WI, and recieved his MD from University of
Minnesota, Minneapolis, MN. He completed fellowship training at the NCI
Pediatric Branch.Please send any questions or comments to
twipo@solvingkidscancer.org -
TWiPO #17 ~ Personalized medicine: Interview with Dr Giselle Sholler
10 februari 2014 · 38 min
October
13, 2011 Lees meerHost Dr. Tim Cripe and co-hosts Dr. Lars Wagner
and Dr. Lionel Chow welcome guest Dr. Giselle Sholler on this episode of TWiPO.
Dr. Sholler gives the background to her current research interest in
neuroblastoma, and describes her nifurtimox trials and how she formed the
Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC).
The physicians also discuss the specifics of the personalized medicine
feasibility trial now open for neuroblastoma.Dr. Sholler is a Pediatric Oncologist with
Spectrum Health Medical Group, Helen DeVos Childrens Hospital, and directs the
Pediatric Oncology Therapeutic Discovery Clinic. She is also Co-Director of the
VARI/TGen Pediatric Oncology Research Program, and Associate Professor of the
Neuroblastoma Translational Research Laboratory at Van Andel Research
Institute. She has a faculty appointment within Michigan State University's
College of Human Medicine, and continues as adjunct faculty at University of
Vermont. Dr. Sholler is also a Guest Researcher in the Pediatric Oncology Branch
at the NCI.References:
J Clin Oncol. 2010 Nov 20;28(33):4877-83. Epub
2010 Oct 4. Pilot study using molecular profiling of patients' tumors to find
potential targets and select treatments for their refractory cancers.Science 16 Sept 2011: Vol. 333 no. 6049 pp.
1569-1571. Pushing the Envelope in Neuroblastoma TherapyMol Cancer Ther August 2011 10; 1311. A Pilot
Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with
Advanced Cancer -
TWiPO #16 ~ Genetic Underpinnings of Ewing Sarcoma: Interview with Dr Stephen L. Lessnick
10 februari 2014 · 38 min
October
07, 2011 Lees meerDr. Tim Cripe and co-hosts Dr. Lionel Chow and
Dr. Lars Wagner welcome special guest Dr. Stephen Lessnick for an in-depth
discussion on the progress to date in understanding the genetics of Ewing's
sarcoma. The challenges of interpreting the gene expression data as well as the
ethics of collecting tumor specimens for research purposes are also explored.
Dr.Stephen Lessnick is a Professor of Pediatrics and Oncological Sciences at
the University of Utah, where he also serves as an Attending Physician in
Pediatric Hematology/Oncology at Primary Children's Medical Center in Salt Lake
City, UT. He received his PhD in Molecular Biology from UCLA in 1994, and his
MD from UCLA in 1996, followed by a residency at Children's Hospital in Boston,
and a fellowship at the Dana-Farber Cancer Institute and Children's Hospital.
Currently, Dr. Lessnick is the Director of the Center for Children's Cancer
Research at Huntsman Cancer Institute, a Jon and Karen Huntsman Presidential
Professor in Cancer Research at the University of Utah, and is the Vice Chair
for Biology of the Bone Tumor Committee in the Children's Oncology Group.
Please send questions or comments to twipo@solvingkidscancer.org -
TWiPO #15 ~ MicroRNAs and hereditary cancer
10 februari 2014 · 46 min
September
28, 2011 Lees meerJoin host Dr. Tim Cripe with his co-hosts Drs.
Jim Geller, Lionel Chow, and Lars Wagner in a robust discussion with special
guest Dr. Kathryn Wikenheiser-Brokamp on the implications of DICER1, rare tumor
registries, and difficult issues surrounding genetic counseling.Kathryn A. Wikenheiser-Brokamp, MD, PhD, is an
Associate Professor in Pathology and Pulmonary Biology at Cincinnati Children's
Hospital Medical Center. Her research is focused on pediatric and adult lung diseases,
including cancer. She seeks to determine the molecular mechanisms underlying
Rb/p16, p53, and Dicer1 pathway function in lung development and the
pathogenesis of lung disease. Dr. Wikenheiser-Brokamp holds a PhD in
Developmental Biology, Developmental Biology and an MD from University of
Cincinnati.Papers discussed:
DICER1 syndrome: clarifying the diagnosis, clinical features and
management implications of a pleiotropic tumour predisposition syndrome.
J Med Genet. 2011 Apr;48(4):273-8.Extending the Phenotypes Associated with DICER1 Mutations.
Hum Mutat. 2011 Aug 31. doi: 10.1002/humu.21600.Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1
mutations: a report from the International Pleuropulmonary Blastoma Registry.
Gynecol Oncol. 2011 Aug;122(2):246-50.Please send questions or comments to
twipo@solvingkidscancer.org -
TWiPO #14 ~ Interview with Dr Kate Matthay
10 februari 2014 · 34 min
August
24, 2011 Lees meerIn this enlightening interview with Dr. Kate
Matthay, a reknown leader in the neuroblastoma research community, host Dr. Tim
Cripe draws out the inspiration for her early interest in medicine and why her
career grew with a focus on neuroblastoma. Dr. Matthay explains the history and
challenges of clinical research for neuroblastoma:10:00 challenges in planning and conducting the
CCG-3891 double randomized trial questioning the need for transplant and
cis-retinoic acid15:00 discussion of the COG-A3973 trial
questioning the need for purged stem cells15:50 rationale for the COG-ANBL0532 single
versus tandem transplant trial16:13 discussion of the COG-ANBL0032 ch14.18
with cytokines trial18:00 MIBG COG pilot trial
22:00 work with SIOP and NB protocol
development for children in Morocco (N Africa)Please send any questions or comments to
twipo@solvingkidscancer.org