Neurotech Pub – Podcastlijstje

Paradromics Founder and CEO Matt Angle hosts an informal salon with some of the most influential figures in neurotechnology.

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Engineering Mental Health

27 augustus 2024 · 51 min
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This episode features Paradromics CEO Matt Angle in a compelling discussion with Amit Etkin, Founder and CEO of Alto Neuroscience; Maryam Shanechi, Dean's Professor in Electrical and Computer Engineering, Neuroscience, Computer Science, and Biomedical Engineering at USC; and Prasad Shirvalkar, Associate Professor of Neurological Surgery, Neurology and Anesthesia at UC San Francisco. They delve into the intersection of neurotechnology and psychiatry, discussing innovative approaches to treating mental health disorders, the potential of machine learning models, and the challenges associated with obtaining and analyzing brain data. The discussion emphasizes the importance of interdisciplinary collaboration and the promising future of personalized therapies for psychiatric conditions. They also address the limitations of current diagnostic tools like the DSM and the need for scalable, real-world solutions. Lees meer

Guest Quote:

“There's artificial intelligence and there's actual intelligence. And that actual intelligence, when it comes to analyzing data, I feel goes a really, really long way. True subject matter expertise.” - Amit Etkin

Timestamps:

*(00:00) Welcome to Neurotech Pub

*(00:45) Icebreaker: Unpopular Beliefs

*(05:36) Non-surgical brain activity recording and diagnostics

*(13:32) Understanding pain: Subjective reports vs. physical representations

*(16:33) Rethinking psychiatry and DSM alignment

*(21:07) Determining brain data needs and tool validation

*(26:47) The need for explainability in AI algorithms

*(35:49) Timescales in mental health interventions

*(41:22) Advice for aspiring neurotech researchers

*(46:25) Closing Thoughts

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Where There's Blood, There's Signal

30 juli 2024 · 1 uur 49 min
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This episode features Paradromics CEO Matt Angle in a compelling discussion with Sumner Norman, Co-founder & CEO at Forest Neurotech; Ryan Field,CEO at Kernel; and Mary Lou Jepsen, Founder and CEO of Openwater. They share their career influences, discuss the challenges of managing interdisciplinary teams, and explore the future of neuroimaging and brain-computer interfaces (BCIs). Delving into ultrasound and optical-based techniques, they highlight the transformative potential of non-invasive methods for diagnosing and treating brain conditions. Furthermore, they addresses regulatory hurdles, the evolution of focused research organizations, and offers valuable advice for early-career researchers on leveraging industry trends and fundamental research to drive technological advancements. Lees meer

Guest Quote:

“And I think what we're trying to work on is the silicon hospital of the future with this capability, like the modern smartphone, that can reach everybody, regardless of income levels or borders.” - Mary Lou Jepsen

Timestamps:

*(00:00) Welcome to Neurotech Pub

*(00:06) Meet the Guests

*(02:48) Balancing Mentorship and Startup Demands

*(05:36) Interdisciplinary Challenges in Neurotech

*(07:11) Hardware Development and Efficiency

*(18:12) Medical Device Development and Regulatory Challenges

*(23:37) Technical Deep Dive: Optical and Acoustic Signatures

*(24:00) Ultrasound in Brain-Computer Interfaces

*(34:57) Near-Infrared Spectroscopy and Mental Health

*(55:55) Understanding Stroke and Thrombectomy

*(56:51) Innovations in Cancer Treatment and Blood Flow Analysis

*(57:39) Challenges and Trials in Medical Technology

*(58:42) Open Source Medical Technology and Global Collaboration

*(58:59) The Evolution of Brain-Computer Interfaces

*(01:02:42) Advancements in Ultrasound Technology

*(01:03:39) The Role of MEMS and Silicon in Medical Devices

*(01:09:29) The Importance of Fundamental Research

*(01:14:48) The Future of Neurotechnology and Industry Trends

*(0…
Now That’s a Lot of Power

2 juli 2024 · 1 uur 14 min
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This episode features Paradromics CEO Matt Angle in a compelling discussion with Grayson Zulauf, CEO of Resonant Link; Alex Yeh, CTO and VP of R&D at Neuspera Medical; and Jacob Robinson, Founder and CEO of Motif Neurotech. They explore the latest advancements in neurotechnology, focusing on wireless power transfer, implantable devices, and brain-computer interfaces (BCIs). The conversation highlights transformative innovations in treating mental health conditions like major depressive disorder, OCD, and ADHD with less invasive wireless devices, enhancing patient care and acceptance. Personal stories and insights on market expansion and patient-friendly treatments are shared, along with valuable advice for investors on the potential of neurotechnology in improving overall mental health and medical care. Lees meer

Guest Quote:

“The message that I would want to send is, there is a future in which we look at neurotechnologies no differently than we look at cardiac pacemakers.

These are life saving devices, in many cases less invasive than a device that goes in your heart. There's no reason why anybody wouldn't want to feel better. To be healthier mentally and just live a better quality of life. So that's what we're trying to enable” - Jacob Robinson

Show Notes:

*(00:00) Welcome to Neurotech Pub

*(00:46) Meet the Guests

*(02:45) Discussing Industry Competitors

*(09:54) Wireless Power Transfer in Medical Devices

*(16:38) Exploring Inductive and Magnetoelectric Power

*(27:35) Ultrasound in real-world devices

*(33:31) Patient Experience and Device Miniaturization

*(36:24) Designing for Patient Comfort and Practicality

*(38:20) Innovations in Power and Data Transmission

*(39:32) Miniaturization and Its Impact

*(41:12) Battery Technology in Medical Devices

*(43:19) Future of Implantable Batteries

*(45:16) Implanted Battery Companies Integer and Resonetics

*(46:31) Intermittent Stimulation and Therapy

*(49:28) Power Consumption in Future Implants

*(59:52) Data Tran…
Your Future Self Will Thank You | Connectomics Part II

22 maart 2023 · 1 uur 1 min
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We’re back with Part II of our two-part series on Connectomics! Lees meer

In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome.

Our guests are:

Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC)

Robert McIntyre, CEO at Nectome

Jeremy Maitin-Shepard, PhD, Software Engineer–Connectomics at Google

In this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy’s recent paper on BioRxiv, as well as his published work at Google.

If you missed part one, you can listen and explore the show notes here. Cheers!

Show Notes:

0:00 | Intro

1:03 | Kenneth Hayworth, PhD

1:12 | Robert McKintyre, CEO, Nectome

1:17 | Jeremy Maitin-Shepard, PhD

1:51 | Setting the record straight

3:09 | The nucleotide sequence of bacteriophage φX174

4:22 | Frozen Zoo at San Diego Zoo

12:01| Glutaraldehyde and reduction techniques for immunolabeling

17:39 | SWITCH Framework

19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude

Enhanced mirror neuron network activity and effective connectivity during live interaction among female subjects

Permeabilization-free en bloc immunohistochemistry for correlative microscopy

19:57 | Synaptic Signaling in Learning and Memory

Structure and function of a neocortical synapse

Engineering a memory…
We're in Heated Agreement Over Here | Connectomics Part I

15 maart 2023 · 49 min
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Welcome back to Neurotech Pub! Lees meer

In this first installment of two episodes on Connectomics, host and Paradromics CEO Matt Angle kicks off a lively discussion on the rapidly accelerating research in the mapping, preservation, and reconstruction of the human connectome. We explore the ethical and legal ramifications of disruptive technology, and some of the unique challenges faced when driving innovation in emerging industries.

Our guests are:

Nita Faraheny, JD, PhD, Everett Distinguished Professor of Law & Philosophy at Duke Law School, the Founding Director of Duke Science & Society, the Faculty Chair of the Duke MA in Bioethics & Science Policy, and principal investigator of SLAP Lab.

Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC)

Robert McIntyre, CEO at Nectome

As an exciting new development since the recording of this episode, Nita recently published a book, The Battle for Your Brain, which examines many topics in neuroethics, from Connectomics to Brain-Computer Interfaces. It is currently available on Amazon.

Keep an eye out for part two in this series, which will take a deep dive into the latest technical and engineering innovations in the connectomics ecosystem. Coming soon!

Please be advised that this episode contains a brief discussion of assisted suicide in a medical setting.

Show Notes:

0:00 | Episode Intro

1:16 | Nita A. Farahany, JD, PhD

1:21 | Kenneth Hayworth, PhD

1:27 | Robert McKintyre, CEO, Nectome

1:56 | Meeting of the minds

2:53 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize

3:56 | The Brain Preservation Foundation

4:09 | Documentary series on the Brain Preservation Foundation

5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps’ caveats)

5:51 | Nita's 2018 Neuroethics Ted Talk

5:54 | International Neuroethics Society

6:25 | Connec…
Neuro Mapping & Napping

25 augustus 2022 · 1 uur 6 min
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Welcome back to Neurotech Pub! In this episode we’re talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity. Lees meer

Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine.

This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you’re unfamiliar with the stages of sleep and want to follow along later in the episode.

Cheers!

Show Notes:

00:00 | Episode intro with Matt Angle and Amy Kruse

1:07 | StimScience in Fast Company

5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep

6:43 | Connect with Prime Movers Lab

7:01 | PML on Medium

7:45 | Introduction to Sleep Stages

References:

Stages of Sleep Overview

REM vs Non-REM Sleep

Sleep Walking

Benefits of REM Sleep

Consequences of low REM sleep

Importance of Deep Sleep

Check out Zoe’s nonprofit organization, ALS Heroes, and her Ted Talk

12:24 | Pulling all-nighters

12:50 | Amy Kruse, PhD

13:00 | Ram Gurumoorthy, PhD

13:07 | Stimscience, now Somnee

13:30 | Luis de Lecea, PhD

18:26 | Gordon Rule, PhD

18:40 | Knights of the Old Republic II: The Sith Lords (2004)

19:50 | Why do we sleep?

20:26 | Sleep drives metabolite clearance from the adult brain

20:35 | Sleep & DNA Repair

22:13 | Neural Activity can cause DNA damage

23:22 | Jerry Seigal

24:26 | DARPA Sleep Research

24:55 | Fur seals and sleep

25:08 | How do Whales and Dolphins Sleep Without Drowning?

25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars

27:36 | Sleep and Mortality

28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices

28:27 | Giulio Tononi, MD, PhD

28:45 …
BCI Pioneers Part II

12 juli 2022 · 44 min
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The Panel: Lees meer

Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn.

Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram.

Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin.

00:00 | Intro

0:14 | Neurotech Pub Episode 13: BCI Pioneers Part I

0:47 | Neurotech Pub Episode 10: Business Models in Neurotech

1:30 | BCI & Identity

1:30 | New Yorker - Do Brain Implants Change Your Identity?

2:09 | The Utah Array (Blackrock Neurotech)

16:05 | Learn more about Hector in Part 1
…
BCI Pioneers Part I

16 juni 2022 · 49 min
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In this very special two part series in collaboration with Blackrock Neurotech, Paradromics CEO Matt Angle and Blackrock Creative Director Taryn Southern co-host a discussion with BCI research pioneers Jan Scheuermann, Ian Burkhart, and Nathan Copeland. In part one, we discuss their personal journeys to becoming BCI pioneers, implant experiences with the Utah Array, their time in the lab, and some of their current projects. Learn more about Jan, Ian, and Nathan below and stay tuned for part two, coming in July 2022! Lees meer

The Panel:

Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn.

Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram.

Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publicati…
Mind Control with Lasers: Optical Recording Part II

13 mei 2022 · 1 uur 44 min
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Welcome back to Neurotech Pub! Lees meer

This episode is part two of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD, Mark Schnitzer, PhD, and Jacob Robinson, PhD. Last time we talked about optical recording methods, but in this episode we focus on optical stimulation methods.

Cheers!

Check out video and full transcript here: https://www.paradromics.com/podcast/episode-12-mind-control-with-lasers

00:00 | Intro

1:37 | Aspirational Papers

1:56 | Packer Lab

2:10 | What is the claustrum?

2:30 | Ian's paper (but only part of it!)

3:02 | Two-Photon Bidirectional Control and Imaging In Vivo

3:29 | Inferring Spikes from Calcium Imaging

5:45 | Neuropixels are now in humans

7:12 | Paper by Pachitariu et al

7:55 | Ian Oldenburg

10:02 | Kaufman Lab

11:21 | Cortical activity in the null space: permitting preparation without movement

12:08 | Motor cortical dynamics shaped by multiple distinct subspaces during naturalistic behavior

12:33 | Tickling Cells with Light

14:41 | Light-activated ion channels for remote control of neuronal firing

14:50 | Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons

15:20 | Millisecond-timescale, genetically targeted optical control of neural activity

16:03 | Red-shifted Opsins

16:52 | eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications

17:26 | Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

18:16 | Neural Dust

18:41 | Wireless magnetothermal deep brain stimulation

19:05 | Neural Stimulation Through Ultrasound

19:20 | Methods and Modalities: Sculpting Light

21:35 | Recent advances in patterned photostimulation for optogenetics

22:50 | Two-photon microscopy is now over 30 years old (Denk 1990)

25:22 | Optical Recording State of the Art

27:06 | Challenges of Deep Tissue 2-Photon Imaging

28:21 | Deisseroth Lab

28:29 | Temporal Precision of Optical Stimula…
Let there be Light: Optical Recording Part I

11 april 2022 · 1 uur 29 min
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Welcome back to Neurotech Pub! Lees meer

This episode is one of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD, Mark Schnitzer, PhD, and Jacob Robinson, PhD. So far, our technical dives have focused mainly on direct electrical recording and stimulation of neural activity, but in this episode we deep dive into advantages that all-optical interfaces might have over electrical interfaces, and the challenges in developing them.

In addition, we talk about running highly collaborative, interdisciplinary projects that span traditional physics and engineering with biology, a theme that is ever-present in neurotech and is also highlighted in part two of this series.

Cheers!

Check out full video with transcript here: https://www.paradromics.com/podcast/episode-11-let-there-be-light

Show Notes

Latest news & publications since recording:

>> Hillman Lab: New publication on SCAPE in Nature Biomedical Engineering

>> Robinson Lab: Review article in Optica on Recent advances in lensless imaging

>> Robinson Lab: BioRxiv pre-print on in vivo fluorescence imaging

1:23 | The Heart and Soul of a Paper

2:32| Ultrasmall Mode Volumes in Dielectric Optical Microcavities

3:01 | Robinson Lab

4:01 | Hillman Lab

4:07 | Zuckerman Institute

4:15 | Schnitzer Lab

4:25 | Howard Hughes Medical Institute

4:41| Miniature Fluorescence Microscope

9:02 | Discovery of DNA Structure and Function

10:25 | Hodgkin–Huxley Equations

13:49 | Vessel Dilation in the Brain

16:03 | State of the art of Neural Optical Recording

18:03 | Long-Term Optical Access to an Estimated One Million Neurons in Mouse Cortex

24:56 | Watch the Crystal Skull video

27:45 | High-Speed Cellular-Resolution Light Beads Microscopy

29:54 | Relationship between spiking activity and calcium imaging

32:50 | Analytical & Quantitative Light Microscopy [AQLM]

32:59 | Imaging Structure & Function in the Nervous System

35:22 | NIH Brain Initi…

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