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This Week in Cardiology

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This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.

Afleveringen

  1. Oct 30 2026 This Week in Cardiology

    30 oktober 2026 · 33 min

    Afspelen
    The ASPIRED syncope RCT, two studies in coronary artery calcium scoring, and the LEAP-Block trial of CSP vs RV pacing are the topics John Mandrola, MD, discusses in this week’s podcast. Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Syncope

    ASPIRED Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605812

    REMOSYNCED Trial https://clinicaltrials.gov/study/NCT05066347

    II TWO CAC Studies

    Atherosclerosis in Young Adults and Risk of Mortality Over 30 Years https://jamanetwork.com/journals/jamacardiology/fullarticle/2855732

    Predictive Utility of CAC Score Added to PREVENT Score https://jamanetwork.com/journals/jama/fullarticle/2853347

    III Conduction System Pacing vs Standard RV Pacing for AV block

    LEAP-Block Trial https://jamanetwork.com/journals/jama/fullarticle/2855975

    Meta-analysis: CSP vs RV Pacing in Preserved or Mildly Reduced EF https://doi.org/10.1016/j.cjca.2026.04.009

    You may also like:

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  2. Oct 23, 2026 This Week in Cardiology Podcast

    23 oktober 2026 · 33 min

    Afspelen
    Listener feedback on the nonobstructive HCM trials, AI-enhanced visits, timing of non-culprit PCI in STEMI, new tricuspid valve intervention, and EP at a crossroads are the topics John Mandrola, MD, discusses in this week’s podcast. Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Listener Feedback

    Koelemen meta-analysis https://www.medrxiv.org/content/10.64898/2026.09.08.26362195v1.full.pdf

    Improving SCD Risk Stratification in HCM https://pmc.ncbi.nlm.nih.gov/articles/PMC11026183/

    II More on Nonobstructive HCM

    Communication on Post-Hoc Analysis of ODYSSEY (mavacamten)

    Mavacamten in Nonobstructive HCM 10.1016/j.jacc.2025.12.092

    III Complete vs Staged PCI in STEMI With Multivessel Disease

    Immediate vs Staged CR in Multivessel Disease and STEMI: Meta-Analysis https://doi.org/10.1016/j.jcin.2026.07.033

    Timing of Nonculprit PCI for STEMI and Multivessel Disease: Editorial https://doi.org/10.1016/j.jcin.2026.08.009

    COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775

    FLOWER MI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2104650

    FRAME AMI Trial https://doi.org/10.1093/eurheartj/ehac763

    iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918

    COCUA Trial https://doi.org/10.1016/j.ahj.2023.01.020

    MULTISTARS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307823

    OPTION STEMI Trial 10.1016/S0140-6736(25)01529-6 External Link

    CULPRIT SHOCK Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1710261

    BioVasc Trial Substudy https://eurointervention.pcronline.com/article/immediate-versus-staged-complete-revascularisation-in-patients-presenting-with-stemi-and-multivessel-disease

    Main BioVasc Trial 10.1016/S0140-6736(23)00351-3 External Link

    FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149

    IV A Call to Action for Electrophysiologists

    Twenty Years at the Crossroads 10.1016/j.jacep.2026.09.023

    EP at a Crossroads - J…

  3. Oct 16, 2026 This Week in Cardiology Podcast

    16 oktober 2026 · 34 min

    Afspelen
    Some promising studies in amyloidosis, aficamten in nonobstructive HCM, costs of the microaxial flow pump in cardiogenic shock, and more on the VESALIUS trial of evolocumab are the topics John Mandrola, MD, discusses in this week’s podcast. Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Light Chain Amyloidosis – A Potentially Helpful Drug

    Anselamimab Does Not Reduce Light-Chain Amyloidosis Deaths

    https://www.medscape.com/viewarticle/anselamimab-does-not-reduce-light-chain-amyloidosis-deaths-2026a1000z79

    II Aficamten in Nonobstructive HCM: The ACACIA trial

    III Microaxial Flow Pump Cost Analysis of Danger Shock

    IV More on Evolocumab at ESC: Vesalius Trial Substudies

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

    https://www.medscape.com/viewarticle/1003092

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  4. Oct 09 2026 This Week in Cardiology

    9 oktober 2026 · 29 min

    Afspelen
    Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Listener Feedback

    POET II Response-Tailored or Standard-Duration ABX for Infectious Endocarditis

    POET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312

    POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887

    II PVI-SHAM-AF trial Back in the News

    GAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337

    PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link

    Why Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External Link

    The Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External Link

    III ICDs in HCM

    I CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597

    ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687

    IV Agenda Laundering

    How Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  5. Oct 02 2026 This Week in Cardiology

    2 oktober 2026 · 32 min

    Afspelen
    Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Listener Feedback

    DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7

    Identifying LV Posterior Wall Delay in RBBB Using Lead V8 https://doi.org/10.1016/j.jacep.2026.03.009

    Using Lead V8 as a Tool to Improve Patient Selection in CRT https://doi.org/10.1093/europace/euaf194

    II POET II Response-Tailored or Standard-Duration Antibiotics for Endocarditis

    POET I https://www.nejm.org/doi/10.1056/NEJMoa1808312

    POET II https://www.nejm.org/doi/full/10.1056/NEJMoa2607887

    III Obesity and AF – A Neat Study from the Team in Prague

    LA Remodeling and Functional Maladaptations in Obesity https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014509

    IV Reducing CAC: The DANCODE Trial

    DANCODE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.082363

    V Two Big RCTs of New GLP-1 Drugs

    TRIUMPH-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604169

    SYNCHRONIZE-2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607219

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  6. Sep 25 2026 This Week in Cardiology

    25 september 2026 · 34 min

    Afspelen
    Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Listener Feedback LBBP ICD Lead

    LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/

    TRIC-I-HF trial

    TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934

    Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030

    II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial

    PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012

    III Targeting CS leads in CRT devices – DANISH-CRT Trial

    DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7

    IV Exercise for AF, Especially When There Is LA Disease

    Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999

    V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX

    REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017

    ROTAS Trial https://heart.bmj.com/content/110/20/1223

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  7. Sep 18 2026 This Week in Cardiology

    18 september 2026 · 32 min

    Afspelen
    Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Correction on PROFID Trial

    II Listener Feedback

    III Fifth Universal Definition of MI

    Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101

    Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967

    IV New ESC HF Guidelines

    ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100

    Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20

    Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/

    V AIR STEMI Trial

    AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373

    CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051

    PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520

    COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775

    FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149

    VI GLP-1 News – A SELECT Trial Secondary Analysis

    Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

  8. Sep 11 2026 This Week in Cardiology

    11 september 2026 · 29 min

    Afspelen
    A second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola, MD Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Lp(a) Disappointment

    HORIZON https://clinicaltrials.gov/study/NCT04023552

    Press Release https://www.novartis.com/news/media-releases/novartis-announces-lpahorizon-phase-iii-topline-results-pelacarsen-patients-elevated-lpa-and-established-cardiovascular-disease-cvd

    Rationale paper https://doi.org/10.1016/j.ahj.2025.03.019

    II FDA Clears AI-ECG for Acute MI Detection

    Accuracy of cath lab activation decisions for STEMI-equivalent and mimic ECGs: Physicians vs. AI (Queen of Hearts by PMcardio) 10.1016/j.ajem.2025.07.061

    AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry https://www.jacc.org/doi/10.1016/j.jcin.2025.10.018

    Queen of Hearts™ AI ECG App https://www.powerfulmedical.com/pmcardio-stemi/

    III TARGET CTCA Trial

    Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain https://www.nejm.org/doi/10.1056/NEJMoa2608903

    IV CorCal trial

    Press release https://www.escardio.org/news/press/press-releases/new-data-presented-on-the-use-of-coronary-artery-calcium-for-cardiovascular-risk-assessment/

    CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics https://doi.org/10.1016/j.ahj.2026.107473

    V AMUNDSEN Trial

    LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial InfarctionThe AMUNDSEN Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2853274

    VI TRIC-I-HF trial

    Tricuspid Repair Cuts Death, HF Hospitalization in Severe TR https://www.medscape.com/vie…

  9. Sep 04 2026 This Week in Cardiology

    4 september 2026 · 41 min

    Afspelen
    ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I SINGLE-AF Trial

    To Anticoagulate or Not in Intermediate-Risk AF: The SINGLE-AF Trial https://www.medscape.com/viewarticle/anticoagulate-or-not-intermediate-risk-af-single-af-trial-2026a1000uko

    SINGLE-AF https://www.nejm.org/doi/10.1056/NEJMoa2607978

    II Scar as an ICD risk stratifier

    Is Scar on CMR an Indication for ICD? CMR Guide Leaves Doubts

    https://www.medscape.com/viewarticle/scar-cmr-indication-icd-cmr-guide-leaves-doubts-2026a1000ukq

    CMTR GUIDE Trial https://jamanetwork.com/journals/jama/fullarticle/2853395

    MADIT II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa013474

    III Single vs Dual Therapy in ATTR-CM

    HELIOS-B Trial Sub-analysis https://www.sciencedirect.com/science/article/pii/S0735109726072086

    HELIOS-B Sub-analysis Editorial https://www.sciencedirect.com/science/article/pii/S0735109726073766#bib8

    HELIOS-B main trial https://www.nejm.org/doi/10.1056/NEJMoa2409134

    CARDIO-TTRansform Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608510

    IV A Stunning Result of another Sham-controlled AF ablation trial

    Does AF Ablation Work? That's in Question After PVI-SHAM-AF https://www.medscape.com/viewarticle/does-af-ablation-work-s-question-after-sham-pvi-af-2026a1000uli

    PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link

    SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283

    PFA-Sham Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484

    V Should Older Adults Take Statins: The STAREE trial.

    STAREE Strengthens Case for Over-the-Counter Statins https://www.medscape.com/viewarticle/staree-strengthens-case-over-counter-statins-2026a1000vr…

  10. Aug 28 2026 This Week in Cardiology

    28 augustus 2026 · 26 min

    Afspelen
    Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Listener Feedback on Mechanical Compression Devices for OHCA

    Mechanical CPR Device Use and Cardiac Arrest Survival

    https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272

    PARAMEDIC trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext

    CIRC trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext

    LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037

    Cochrane Review – Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/

    II PFA and Stroke

    Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092

    AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/

    EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008

    III A New ICD Lead

    LEADR LBBAP Trial https://doi.org/10.1016/j.hrthm.2026.08.030

    IV ESC Preview

    Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi

    You may also like:

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Categorieën
Wetenschap , Gezondheid , Fitness , Geneeskunde
Status
Loopt nog
Verschijnt
Elke week
Lengte
Meestal 30 min
Afleveringen
427
Laatste aflevering
30 oktober 2026
Eerste aflevering
15 september 2017
Taal
Engels