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462 afleveringen, van nieuw naar oud
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#129 - Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology
21 september 2020 · 2 uur
World-renowned lipidologist Tom Dayspring returns to give an update on the current thinking in lipidology as a follow-up to his 2018 five-part podcast series. In this episode, Tom discusses the growing consensus that atherogenic lipoproteins are essential drivers of atherosclerotic vascular disease. Tom further emphasizes apolipoprotein B (apoB) and lipoprotein(a) (Lp(a)). He provides insights into risk assessment, including which lab metrics to use, how to interpret them, and the appropriate therapeutic targets. Additionally, Tom discusses the most recent developments in lipid-lowering drug therapies—from the continued evolution of PCSK9 inhibitors, to the latest understanding of EPA and DHA, and the most recent addition of bempedoic acid to the list of therapeutic agents. Lees meer
We discuss:
The latest in the field of lipidology and cardiovascular disease [3:45];
Apolipoproteins—the key to understanding lipid biology [9:30];
ApoB as a preferred metric over LDL-P [16:30];
Therapeutic goals for apoB concentration [21:45];
Drivers of atherosclerosis [34:15];
Overview and current thinking on high density lipoproteins (HDLs)—Is it a useful metric? [37:00];
Lipoprotein(a)—the most dangerous particle you've never heard of [55:00];
Are low density lipoprotein triglycerides (LDL-TGs) a useful metric? [1:13:15];
Tom's preferred lab measurements [1:17:45];
The latest in lipid-lowering therapies [1:21:30];
The different pathways among various lipid-lowering drugs [1:30:45];
The latest on EPA and DHA [1:38:15];
Fibrates—an underappreciated treatment for hypercholesterolemia [1:49:45] and;
More.
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Show notes page for this episode: https://peterattiamd.com/tomdayspring6
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#128 – Irene Davis, Ph.D.: The evolution of the foot, running injuries, and minimalist shoes
14 september 2020 · 1 uur 53 min
Irene Davis is the founding Director of the Spaulding National Running Center at the Harvard Medical School. In this episode, Irene describes how her research of biomechanics and clinical work with running injuries, as well as research by others, has shaped her views on maintaining body alignment and foot health. Irene discusses her argument for the role of modern footwear in running-related injuries and how minimalist footwear helps resolve the subsequent biomechanical issues. Lees meer
We discuss:
Irene's path to her Ph.D., her entry into physical therapy, and her interest in biomechanics [3:20];
How Irene's thinking about the use of orthotics has changed [7:15];
The evolution of the human foot and the transition from walking to running [10:30];
The evolution of shoes and its impact on running injuries [17:30];
An overview of running injuries [26:00];
Cushioned running shoes, heel striking and impact forces [29:30];
Shin splints [33:45];
How heel strike patterns promotes knee stress through rate of loading [35:30];
The critical importance of exercise [42:15];
Impact forces and injury potential [45:45];
How shoe cushioning alters impact forces despite forefoot striking [49:00];
An overview of minimalist shoes [52:30];
Irene's protocol for transitioning people out of orthotics [58:45];
Transitioning to minimalist shoes and a forefoot strike [1:05:30];
Foot muscle volume, minimalist shoes, and orthotics [1:07:00];
The recognition of the importance of foot strength in podiatry [1:09:45];
Minimalist shoes across the lifespan—from children to adults [1:12:30];
Why learning to forefoot strike on soft surfaces is not the best approach [1:20:00];
Knee valgus and factors related to knee injury [1:21:45];
IT band syndrome [1:28:30];
Physics and ground reaction forces [1:33:15];
Irene's approach to retraining a runner's gait [1:36:00];
Case study—How the transition to minimalist shoes decreased injury and improved performance [1:42:15];
Importance of proper mo…
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#127 - AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more
7 september 2020 · 16 min
In this special episode, Matthew Walker returns for his third AMA episode to provide his expert insight into numerous sleep-related questions directly from listeners. He explains how he adjusted his hypotheses on topics like blue light and caffeine, and why he is more bullish on the importance of REM sleep. Matt also answers questions about sleep wearables, how fasting affects sleep, how sleep deprivation impacts gut health, and magnesium as a sleep aid. Finally, Matt reveals what he believes is the next evolution in sleep science and technology. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website on the show notes page. Lees meer
We discuss:
Matt's framework for changing his mind when faced with new information [1:30];
Blue light—How Matt shifted his thinking [5:45];
Caffeine—How Matt has adjusted his hypothesis [12:00];
REM sleep—Why Matt is more bullish on the importance of dream sleep [16:30];
How to increase REM sleep [27:30];
Sleep tracking wearables—criteria for evaluation, and why Matthew favors Oura [35:00];
Does the electromagnetic force of devices have any impact on sleep? [40:15];
The relationship between fasting and sleep [46:15];
Restless leg syndrome [58:10];
Magnesium supplementation as a sleep aid [1:03:00];
The relationship between sleep deprivation and gut health [1:08:30];
The next evolution in sleep science and technology [1:16:30];
Questions Matt would like to explore if money was no issue [1:24:15]; and
More.
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Show notes page for this episode: https://peterattiamd.com/matthewwalkerama3
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#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book
31 augustus 2020 · 1 uur 42 min
In this episode, sleep expert Matthew Walker returns by popular demand to dive deeper into many sleep-related topics, starting with what we've learned about sleep through the lens of the COVID-19 pandemic and how sleep impacts the immune system. He then covers topics such as how dreaming affects emotional health, the different sleep chronotypes, the best sleep hygiene tips, and the pros and cons of napping. Matthew finishes by addressing several of the errors that readers have pointed out in his book, Why We Sleep. Lees meer
We discuss:
Three ways the coronavirus pandemic impacts sleep [3:30];
The importance of dreaming for emotional health, and how the coronavirus pandemic increases dreaming [11:45];
The impact of alcohol consumption on sleep quality and stress levels [20:00];
Sleep's impact on the immune system and implications for a future COVID-19 vaccine [27:45];
What determines how much deep sleep and REM sleep you need? [36:30];
Pros and cons of napping, and insights from the sleep habits of hunter-gatherer tribes [42:15];
Sleep hygiene, wind-down routine, and tips for better sleep [56:45];
Understanding sleep chronotypes and how knowing yours can help you [1:06:00];
Night terrors in kids—what they are and why they happen [1:16:30];
Addressing errors found in Matt's book, Why We Sleep [1:20:45]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/matthewwalker4
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#125 - John Arnold: The most prolific philanthropist you may not have heard of
24 augustus 2020 · 2 uur 28 min
John Arnold is widely regarded as the greatest natural gas trader of all time, but in his late 30's he walked away from it all and turned full-time philanthropist. He and his wife have committed to strategically give away most of their vast fortune in their lifetime and are already doing so at a staggering pace of nearly a half billion dollars a year. In this episode, John explains his quest to address the most challenging social programs plaguing the country, including criminal justice, health care policy, and K-12 education. John also shares self-identified attributes that contributed to his success in natural gas trading and how those same traits have translated to his philanthropic aspirations. Lees meer
We discuss:
John's background, upbringing, and early entrepreneurial tendencies [3:50];
John's time and rise at Enron [16:45];
Characteristics that made John an exceptional natural gas trader and how they translate to his philanthropic work [27:30];
The collapse of Enron [35:00];
The success of John's hedge fund, and his early interest in philanthropy [40:30];
The infamous 2006 trade that brought down Amaranth Advisors [55:45];
John's analytical prowess and emphasis on fundamentals [1:02:15];
The decision to become a full-time philanthropist and the founding of Arnold Ventures [1:09:00];
Education—John's quest to fundamentally change K-12 education [1:18:45];
Strategic philanthropy—preventing problems by attacking root causes and creating structural change [1:24:30];
The criminal justice system—structural changes needed to address mass incarceration, policing practices, and recidivism [1:31:45];
Re-imagining prisons to reduce recidivism [1:49:00];
US health care policy—John's focus on drug prices, and the severe consequences of not making system changes [1:56:15];
Climate change—the bipartisan role of John's foundation [2:13:45];
Advice for young adults interested in philanthropy [2:17:45]; and
More
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Show notes page…
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#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more
17 augustus 2020 · 17 min
As a follow up to AMA #14 where Peter explained his framework for analyzing labs, this "Ask Me Anything" (AMA) episode focuses on a number of real-world case studies exploring metabolic dysregulation, low testosterone, menopause, hypothyroidism, elevated uric acid, and more. From the examples discussed, you can follow along how our clinical team goes about interpreting diagnostic measures and applying relevant research findings. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #15 show notes page. Lees meer
We discuss:
Should you stop taking supplements before getting a lab test? [2:45];
Family history—Questions to ask and what to look for [5:30];
The purpose of an oral glucose tolerance test (OGTT) [12:15];
Case study—Insufficient muscle mass for proper glucose disposal [17:15];
Why hemoglobin A1c is a relatively unhelpful metric [24:00];
Case study—Exceeding carbohydrate tolerance [26:30];
Case study—Metabolic dysfunction and a framework for metabolic health [33:30];
Peter's ideal tracking of metabolic health for all his patients [43:30];
Contrasting presentations of hypogonadism—Low free testosterone [45:00];
How sleep, exercise, and alcohol affect testosterone levels? [56:20];
Case study—Surprisingly fast onset of menopause [59:25];
Case study—Hypothyroidism and high cholesterol [1:07:00];
Case study—Elevated uric acid and hypertension [1:10:55]; and
More.
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Show notes page for this episode: https://peterattiamd.com/ama15
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#123 - Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19
10 augustus 2020 · 2 uur 18 min
In this episode, Joan and Nir discuss their extensive research into rapamycin (including the category of analogs to rapamycin known as rapalogs) and metformin, respectively. Based on his work with metformin, Nir shares how he believes it could be a pro-longevity drug and the clinical trial he's leading to test this belief. Joan discusses her work with rapalogs, their ability to suppress the immune system as well as provide immune-enhancement, and the clinical trials she has led that inform her insights. We also talk about the potential beneficial roles of both metformin and rapamycin in reducing mortality from COVID-19, reducing the risk of neurodegenerative diseases, and delaying aging as well as its related diseases. Lees meer
We discuss:
Joan's career, interest in aging, and work with rapamycin analogs [3:45];
When Nir became convinced metformin could be a pro-longevity agent [15:00];
How metformin and rapamycin impact the hallmarks of aging and extend lifespan [24:15];
Enhancing the immune system with rapalogs and metformin [34:15];
Potential of metformin and rapamycin in reducing mortality from COVID-19 [41:30];
Insights from Joan's studies investigating the immune-enhancing effects of rapalogs [59:30];
Vaccines and treatments strategies for COVID-19, and the likelihood of long-term immunity [1:08:15];
The potential role of rapalogs and metformin in neurodegenerative disease [1:14:30];
Nir's TAME trial—primary objectives and latest updates [1:18:00];
Potential synergistic effect when combining metformin with rapamycin [1:25:45];
Why Peter stopped taking metformin and started taking rapamycin [1:27:30];
Story from Nir's book that demonstrates the challenge of doing good scientific studies [1:37:30];
The biology of aging—epigenetic clocks, proteomics, and Nir's centenarian data [1:42:00];
Joan's dream experiment to test immune-enhancing effect of RTB101 [1:57:15];
Concluding thoughts on COVID-19 [1:59:45]; and
More.
Learn more: https://peterattiamd.com/
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#122 - Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health
3 augustus 2020 · 1 uur 30 min
Lori Gottlieb is a psychotherapist and the bestselling author of Maybe You Should Talk to Someone. In this episode, Lori extracts important lessons from her experiences as both a therapist and a patient. The stories Lori shares has provided her the material for insights into living a more fulfilling life. In our conversation, Lori also dispels some misconceptions about therapy, explains the process of big therapeutic breakthroughs, and reveals the most important steps for enduring emotional health. Lees meer
We discuss:
Lori's unique path to becoming a therapist [3:00];
Dissecting cadavers—a profound experience during med school [12:30];
The sunk cost fallacy—How Lori was able to walk away from med school [17:15];
Being aware of the gift of life, and other lessons from Lori's terminally ill patient [24:00];
How underlying pain can manifest in obnoxious behavior [32:45];
Counseling versus therapy [36:15];
The story of John—why men hide their feelings, breaking down his shield, and uncovering his pain [38:30];
"Breaking open"—A shocking revelation about John that tests Lori's resolve as a therapist [46:30];
Rewriting your story, the recovery process, and the most important step for lasting change [49:00];
The process of many big therapeutic breakthroughs [56:00];
The 2 types of suicidal thoughts, and the importance of talking about it [1:01:00];
The most common issues that bring patients to therapy with Lori [1:02:45];
Clinging to the familiar—why change is so hard [1:05:15];
A story of shame, lack of self-compassion, and self-sabotage [1:07:00];
The importance of managing mental health to reduce unnecessary suffering [1:15:45];
Dispelling the misconceptions about therapy [1:23:15]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/LoriGottlieb
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#121 - Azra Raza, M.D.: Why we're losing the war on cancer
27 juli 2020 · 1 uur 55 min
Azra Raza is a physician, scientist, author, and outspoken advocate for reconfiguring the current model of research in cancer. In this episode, Azra discusses the content of her book, The First Cell, which takes a critical look at the outdated models being used to study cancer resulting in a lack of progress in survival rates for cancer patients. Azra offers a solution which focuses on early detection and prevention, and she concludes with an optimistic outlook for the future of cancer research. Lees meer
We discuss:
Azra's upbringing, interest in oncology, and the basis for writing her book [3:30];
The lack of progress in cancer treatment over the decades [18:45];
What is holding the oncology field back? [33:15];
Do the purported advances in oncology reflect the billions of dollars spent on cancer research? [40:00];
Economics of new cancer drugs—how small increases in survival come with staggering financial burdens [47:00];
How good intentions can still lead to misaligned incentives and a broken system [1:03:00];
Why 95% of new cancer drugs fail—a critical review of the cancer research model [1:11:15];
Early detection and prevention—a potential solution to the cancer problem [1:22:30];
Coping with the loss of her husband to cancer [1:46:00];
Azra's optimistic view of the future [1:49:30]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/azraraza
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#120 - AMA with Dom D'Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health
20 juli 2020 · 28 min
In part 2 of this special AMA episode, ketosis expert Dom D'Agostino once again joins Bob Kaplan, Peter's Head of Research, to discuss the impact of ketosis on various chronic diseases as well as the latest research on the metabolic management of cancer. Dom also discusses the numerous applications of hyperbaric oxygen therapy, provides insights into the application of ketosis on female health and performance, and much more. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on the website show notes page. Lees meer
We discuss:
Update on Dom's Press-pulse therapeutic strategy for the metabolic management of cancer [2:05];
Potential role for vitamin C in cancer treatment [12:45];
Glutamine targeting in cancer therapy—evidence that the mitochondria in cancer are damaged? [17:45];
Can a ketogenic diet lessen the toxicity of cancer therapies? [24:45];
3BP—a promising agent in cancer therapy [26:45];
The relationship between cancer and ketogenic diets [29:30];
Hyperbaric oxygen therapy (HBOT)—primer, protocols, and therapeutic uses [33:30];
Is there a potential role for HBOT in treating COVID-19 patients? [44:15];
Non-cancer applications of HBOT [47:30];
The inverse relationship between glucose and ketones [50:30];
Is a ketogenic diet appropriate for type 1 diabetics? [54:00];
How ketosis may reduce the risk for Alzheimer's disease and Parkinson's disease [1:00:30];
Ketosis for females—considerations, fertility, performance, and the latest research [1:11:00];
Low-carb diets during pregnancy and postpartum [1:17:00];
A high-protein diet to counteract common hormonal issues associated with the ketogenic diet [1:21:15];
Nutritional tips for remaining metabolically flexible [1:22:45];
What is one belief Dom has changed his mind about? [1:26:45];
In utero experiments, and other interesting questions Dom wants to exp…
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#119 - Terry Real: Breaking the cycle of shame, anger, and depression
13 juli 2020 · 1 uur 40 min
Terry Real, a renowned family therapist and best-selling author, helps people create the connections they desire in their relationships. In this episode, Terry describes how his upbringing with an abusive father forged his path to become a therapist, develop his Relational Life Therapy (RLT) framework, and write I Don't Want to Talk About It—a book that reveals the hidden legacy of male depression. Terry discusses the link between childhood trauma and the deep-rooted shame, anger, and depression, which can result in feeling disconnected. Using real-life examples, Terry explains how he implements RLT to confront trauma, discover its origin, and teach the skills to break the cycle of pain, in order to live a satisfying life. Lees meer
We discuss:
Terry's upbringing with a depressed and abusive father [3:15];
The importance of the repair process, after relational disharmony, to break the trauma cycle [15:15];
The impact of a patriarchal society, and relational growth as the next step for feminism [19:00];
Origins of deep-rooted shame, and the difference between feeling ashamed and feeling guilty [27:15];
Preventing the propagation of trauma without over-coddling kids [35:30];
The one-up/one-down cycle from grandiosity to shame [37:30];
Covert depression—Steps to fixing the secret legacy of male depression [40:00];
Three forms of false self-esteem [50:00];
Narcissism—A misunderstood concept [51:45];
The interplay of shame, anger, and grandiosity, and how to break the cycle [54:15];
The Relational Life Therapy framework [1:06:30];
How the adaptive child becomes the maladaptive adult [1:15:30];
Speaking the language of social relationships [1:21:45];
When does it make sense for a couple to separate? [1:26:30];
Witness abuse—Consequences of screaming at your partner in the presence of children [1:28:15];
Cases of instantaneous change, and other behavioral changes that may take more time [1:30:45];
Reconciling with his father—Terry's final conversation with his dad…
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#118 - Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
6 juli 2020 · 2 uur 15 min
Lloyd Klickstein is the Chief Science Officer at resTORbio, a biopharmaceutical company that develops medications to target the biology of aging. In this episode, Lloyd discusses his company's clinical application of rapamycin and its derivatives. He also elucidates details of his 2014 paper—a paper that greatly influenced Peter's perspective of rapamycin in the context of longevity. Peter and Lloyd go on to discuss the dose-dependent effect of rapamycin on immune function and compare rapamycin, fasting, and caloric restriction. Lees meer
We discuss:
His background and decision to leave academia for translational medicine [6:15];
Translational medicine—bridging the gap between basic science and clinical medicine [10:30];
What prompted Lloyd to focus on mTOR inhibition? [18:00];
Defining mTOR, TORC1, and TORC2, and the consequences of inhibiting them with rapamycin [21:30];
Dose-dependent impact of rapamycin on immune function, mTOR inhibition, and toxicity [42:15];
Lloyd's 2014 experiment—mTOR inhibition improves immune function in the elderly [53:00];
Insights into autophagy, antigen presentation, and the pleiotropic benefits of a rapalog, and how it compares to fasting [1:13:00];
Lloyd's 2018 experiment—TORC1 inhibition enhances immune function and reduces infections in the elderly [1:18:45];
Creation of resTORbio, subsequent studies, and takeaways about dosing, TORC2 inhibition, and tissue selectivity [1:29:00];
Comparing the longevity effect of rapamycin, fasting, and caloric restriction [1:40:00];
Excitement around RTB101—resTORbio's mTOR inhibiting molecule [1:47:00];
Identifying rapalogs selective for TORC1 [1:56:15];
Treating depression with ketamine, an activator of mTOR [2:00:00];
Epigenetic clocks, rapalogs, and metformin [2:03:30]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/LloydKlickstein
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…
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#117 - Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19
29 juni 2020 · 1 uur 44 min
In this episode, Stanley Perlman shares insights from his impressive career studying coronaviruses—both the common and more deadly ones, like MERS and SARS. In comparing preceding coronaviruses with SARS-CoV-2, Stanley discusses how other coronaviruses can aid our current understanding of, and be used to infer about, COVID-19. He also gives his thoughts on durable immunity, therapeutic strategies, and future outbreak preparedness. Lees meer
We discuss:
His background and early work with coronaviruses [2:45];
The coronavirus family—various types, common traits, and scientific understanding [9:00];
The origin of viruses, animal to human transmission, R_0, immunity, and more [17:45];
Insights from the 2002 SARS outbreak [28:30];
Insights from the 2012 MERS outbreak [35:00];
Comparing SARS-CoV-2 to MERS, SARS, and other coronaviruses [42:00];
COVID-19 survivor potential for long-term damage [53:30];
Using the current pandemic for lessons on future preparedness [57:00];
Genetic drift and the potential for long-term immunity to COVID-19 [1:07:00];
Prevention and treatment strategies for COVID-19 and future diseases [1:22:30];
Alternative hypothesis to the origin of SARS-CoV-2 [1:32:30];
Determining durable immunity to COVID-19 and what a successful vaccine looks like [1:34:30]; and
More.
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Show notes page for this episode: https://peterattiamd.com/stanleyperlman
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#116 - AMA with Dom D'Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise
22 juni 2020 · 28 min
Back by very popular demand for a special AMA episode, ketosis expert Dom D'Agostino joins Bob Kaplan, Peter's Head of Research, to address many lingering questions about the ketogenic diet, exogenous ketones, and exercise for overall health. Dom also shares valuable insights from his personal experience with training, supplements, intermittent fasting, and other nutritional strategies to optimize his own health and performance. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on the website show notes page. Lees meer
We discuss:
Dom's recent and ongoing projects [3:00];
Benefits of a ketogenic diet for an otherwise healthy person [7:00];
Book recommendations to become more knowledgeable about a ketogenic diet [11:30];
Best devices for measuring ketones [13:45];
Genetic factors that influence how someone responds to the ketogenic diet [24:45];
Ketogenic diet for those with the APOE e4 allele [28:15];
Impact of long-term ketogenic diets on thyroid function [34:25];
Low-carb and ketogenic diets for appetite control and weight management [39:00];
Ketogenic diet and the microbiome [43:00];
Comparing monounsaturated fat versus saturated fat on the ketogenic diet [45:55];
Implications of long-term genetic and epigenetic adaptations to a ketogenic diet [47:45];
Why some people see a rise in LDL-C and LDL-P when on a ketogenic diet and what they can do about it [50:15];
Should someone with familial hypercholesterolemia consider a ketogenic diet? [55:00];
Exogenous ketones—benefits, therapeutic uses, and ketone supplements that Dom has tested [56:45];
Ketogenic protocols for management of traumatic brain injuries [1:06:00];
Comparing the benefits and therapeutic uses of various medium-chain fatty acids—caprylic acid (C8), capric acid (C10), MCT oil, and coconut oil [1:08:45];
Nootropics, caffeine, and other stimul…
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#115 - David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19
15 juni 2020 · 1 uur 38 min
In this episode, David Watkins, professor of pathology at George Washington University, shares how insights from his HIV and Zika virus research could apply to SARS-CoV-2 protection strategies. David introduces monoclonal antibodies as an intervention to prevent and treat COVID-19 infection, and also discusses how they could be used as a hedge to vaccine development. Additionally, David's immunology tutorial explains the innate and adaptive immune systems and their differentiated responses to viral infection. Lees meer
We discuss:
Background and current interest in immunology [4:30];
Immunology 101—The innate and adaptive immune system [10:15];
Defining antibodies, importance of neutralizing antibodies, and serology testing for COVID-19 [19:00];
B cells—How they fight viruses, create antibodies, and fit into the vaccine strategy [25:00];
T cells—Role in the adaptive immune system and ability to kill infected cells to prevent viral spread [36:15];
Valuable lessons from HIV applied to SARS-CoV-2 [51:00];
Lessons taken from the hepatitis C success story [1:01:30];
Monoclonal antibodies, vaccines, and the most promising strategies for preventing and treating COVID-19 infection [1:04:45];
COVID-19 vaccines in development [1:19:00];
How David's work with Zika virus informs his thinking on SARS-CoV-2 [1:25:20];
Why a vaccine for COVID-19 doesn't need to be perfect to be effective [1:27:45]; and
More.
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Show notes page for this episode: https://peterattiamd.com/davidwatkins
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#114 - Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
8 juni 2020 · 1 uur 59 min
In this episode, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, describes the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She also goes into detail about the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive—a discovery leading to new possibilities in cancer therapy. We also discuss fasting (and molecules that induce autophagy) and the critical need to decode the proper fasting "dose" in order to improve human health. Lees meer
We discuss:
Eileen's discovery that a specific oncogene blocks apoptosis [3:40];
Defining apoptosis and its role in cancer prevention [10:00];
How cancer cells use the autophagy pathway to survive [17:20];
Stressors that induce autophagy [29:15];
The importance of autophagy in the brain and liver [32:45];
The mechanisms that can trigger autophagy to support longevity [40:00];
Evidence for cancer treatment by blocking autophagy [42:30];
Types of cancer that are most autophagy-dependent [46:45];
The autophagy paradox [52:40];
Finding a molecular signal for autophagy [59:15];
Current knowledge gaps around fasting as a tool for longevity [1:13:00];
Rapamycin, metformin, and other molecules that may induce autophagy [1:22:15];
How to study fasting and exercise as longevity tools [1:32:50];
The Nobel Prize for autophagy research [1:36:45];
Eileen's future areas of research [1:38:25];
A fasting strategy for Alzheimer's Disease prevention[1:49:25];
Future study of metabolism and autophagy [1:51:30]; and
More.
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Show notes page for this episode: https://peterattiamd.com/eileenwhite
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#113: Normative errors—a conversation with my daughter about current events
3 juni 2020 · 22 min
In this episode, I sit down with my daughter to discuss the brutal death of George Floyd, and the aftermath we are watching unfold. Though I have no expertise in race relations, law enforcement, or police brutality, I do have some knowledge in the training of physicians, and it is that training of doctors that I've been thinking about lately as it may offer one small insight into this crisis. In this very short discussion, we speak about three types of errors in medicine (and medical training), how to distinguish between the two variants that are acceptable, and the one that is unacceptable. My question, ultimately, is if such a framework can be applied to law enforcement? Lees meer
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#112 - Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it
1 juni 2020 · 2 uur 16 min
Ned David is the co-founder of Unity Biotechnology, a company developing senolytic medicines—molecules that target and destroy senescent cells in the human body. In this episode, Ned explains the science of cellular senescence and how it impacts the aging process. Ned discusses how senolytics may delay, prevent, treat, or even reverse age-related diseases, including cancer, cardiovascular disease, and neurodegenerative disease. As a serial entrepreneur, Ned also provides advice on how to transform a simple idea into the creation of a company. Lees meer
We discuss:
Defining longevity and the principles of aging [2:50];
The control knobs of aging and how we can turn them [15:10];
Role of cellular senescence in aging and cancer [27:00];
History of senescence in scientific study [40:30];
The cellular senescence paradox [46:00];
Developing medicines that target cellular senescence [52:15];
Ned's lessons on risk analysis in business [1:05:15];
The search for a molecule that could eliminate senescent cells [1:15:15];
Senescent cell elimination example in osteoarthritic knees [1:30:30];
Extending lifespan by removing senescent cells [1:45:00];
Senolytic molecule example in macular degeneration reversal [1:52:30];
The future of senescent cell targeting [1:58:30];
The role of cellular senescence and metabolic syndrome [2:01:30];
The role of cellular senescence and brain health [2:03:30]
What prepared Ned to start Unity Biotechnology [2:05:45];
Advice for someone deciding between business and academics [2:08:50]; and
More.
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Show notes page for this episode: https://peterattiamd.com/neddavid
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#111 - AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity
18 mei 2020 · 17 min
In this "Ask Me Anything" (AMA) episode, Peter explains his framework for understanding what lab tests can (and cannot) inform us as it pertains to overall longevity, with a specific focus on atherosclerosis, cancer, Alzheimer's disease, and the physical body. Additionally, Peter shares details into two patient case studies around cardiovascular disease, including how the lab results influenced his diagnosis and treatment plan for the patients. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #14 show notes page. Lees meer
We discuss:
Important lab tests and reference ranges [2:35];
How lab testing fits into the overall objective of longevity [4:25];
A healthcare system set up to react to a disease rather than prevent it [8:00];
The four pillars of chronic disease, and the three components of healthspan [14:30];
Atherosclerosis—How much can labs tell us about risk? [18:00];
Coronary calcium score (CAC)—Interpreting results based on your age [24:15];
Cancer—What lab work can tell you, and the future of liquid biopsies [28:00];
Alzheimer's disease—What's driving Alzheimer's disease, and what labs can tell you about your risk [33:15];
Healthspan and the physical body—Where lab testing fits, the endocrine system, and zone 2 testing [39:00];
Summarizing the usefulness of lab testing—Where it gives great, reasonable, or lousy insight [43:15];
Patient case study—Elevated Lp(a): Understanding ApoB, and how cholesterol levels get reduced [45:30];
Patient case study—Familial hypercholesterolemia [59:30];
Coming up on a future AMA [1:10:30]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/ama14
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#110 - Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K
11 mei 2020 · 2 uur 11 min
In this episode, Lew Cantley, Professor of cancer biology and Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medical College in NYC, walks us through his amazing discovery of phosphoinositide 3-kinase (PI3K) and the implications for the care of patients with cancer. He explains various combinations of therapies being tested and used, including the possibility of pairing prescriptive nutritional therapies to increase the efficacy of drugs like PI3K inhibitors. Lew also explains the metabolic nature of cancer through the lens of his research into the connection between sugar consumption, insulin resistance, and tumor growth. Additionally, Lew provides some details about his exciting new clinical trial that is just now enrolling patients with stage 4 breast cancer and endometrial cancer. Lees meer
We discuss:
Teaching science through the lens of discovery—A better approach to learning science [5:15];
The metabolic nature of cancer, mitochondria, and a more nuanced explanation of the Warburg Effect [8:30];
The observation that convinced Lew to stop eating sugar [20:15];
The connection between obesity, insulin resistance, and cancer [25:30];
Sugar consumption and tumor growth—What did Lew's 2019 paper find? [32:00];
Natural sugar vs. HFCS, fruit vs. fruit juice, insulin response and cancer growth [43:00];
Increasing efficacy of PI3K inhibitors with ketogenic diets, SGLT2 inhibitors, and metformin [53:30];
Lew's clinical trial enrolling stage 4 breast cancer and endometrial cancer patients [1:07:30];
Pairing diet with drug could be the future of cancer treatment [1:09:30];
PI3K inhibitors on the market, alpha vs. delta isoform, and the possibility of pairing them with a food prescription [1:16:15];
What questions will Lew be focused on in the next chapter of his career? [1:22:15];
Lew's early work that ultimately led to the discovery of PI3K [1:27:30];
Studying the mechanism by which mitochondria make ATP [1:30:45];
How understanding the mech…
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#109 - John Dudley: The beauty in archery, the love of practice, and a model system for life
4 mei 2020 · 2 uur 17 min
In this episode, professional archer, John Dudley, shares the many insights he's gleaned through the process of not only becoming an elite competitor of archery but also an exceptional teacher. John describes how his desire for improvement has cultivated a sheer love of practice, and how pursuing mastery helped put into context how archery is an amazing model system for life. Additionally, John discusses the often misunderstood nature of hunting, but also makes the case as to why one should consider trying archery even if there is no desire to hunt. Lees meer
We discuss:
Why John loves archery, and what it means to be a professional archer [4:50];
How John's love of practice and training led to archery [10:45];
How an intense desire to improve drove John to quit football and pursue archery [22:00];
A traumatic childhood event that changed John's course from troublemaker to committed athlete [34:15];
The nuts and bolts of archery—Competitive events, types of bows, hunting, etc. [45:30];
The blissful nature of archery, and the uselessness of anger [57:15];
Hyper-focus and flow states—Did John's ADD and task-driven personality give him an advantage? [1:07:15];
The common traits found in the most successful people [1:12:45];
The keys to maintaining credibility as a salesman—Integrity, honesty, and straightforwardness [1:18:45];
The coaching technique that makes John a great teacher [1:28:30];
Why you should consider trying archery (even if you never want to hunt) [1:36:15];
Hunting discussion—The morality argument, hunting vs. commercial farming, managing overpopulation, and the unique emotional connection [1:45:00];
Resources for those interested in taking up archery [2:12:00]; and
More.
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Show notes page for this episode: https://peterattiamd.com/johndudley
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#108 - AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity
21 april 2020 · 16 min
In this "Ask Me Anything" (AMA) episode, Peter explains some observations he's noticed since switching to a 3-day fasting cycle from the longer fasts, the various things he's measuring, and some helpful tips for getting through a prolonged fast. He also discusses the role of exogenous ketones in fasting and ketogenic diets as well as their impact on autophagy, specifically. Finally, Peter provides some practical advice for those looking to fit exercise for longevity into their busy life. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. Lees meer
If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #13 show notes page. If you are not a subscriber, you'll be able to listen to a sneak peak of this episode.
We discuss:
Peter's observations since switching from a 7-day to a 3-day fasting regimen [1:25];
Ketone measuring devices—blood and breath [7:40];
Can zero-calorie sweeteners affect ketone production? [10:40];
Will there be a continuous insulin monitor anytime soon? [11:55];
Exogenous ketones—Role in fasting and ketogenic diets and their effect on insulin, blood glucose, and autophagy [14:10];
5 tips to help you get through a multi-day fast [25:55];
Relationship between BHB levels, glucose levels, and autophagy—Are high levels of ketones enough to produce autophagy? [34:10];
Why is measuring blood insulin so much harder than blood glucose? [36:55];
Advice and resources for people wanting to stay up to date on developments related to health and longevity (and how to quickly sift through all the bad science) [40:10];
Advice for those looking to fit exercise for longevity into their busy life [51:10]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/ama13
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#107 - John Barry: 1918 Spanish flu pandemic—historical account, parallels to today, and lessons
17 april 2020 · 1 uur 22 min
n this episode, John Barry, historian and author of The Great Influenza: The Story of the Deadliest Pandemic in History, describes what happened with the 1918 Spanish flu pandemic, including where it likely originated, how and why it spread, and what may have accounted for the occurrence of three separate waves of the virus, each with different rates of infection and mortality. While the current coronavirus pandemic pales in comparison to the devastation of the Spanish flu, John highlights a number of parallels that can be drawn and lessons to be learned and applied going forward. Lees meer
We discuss:
What got John interested in the Spanish flu and led to him writing his book? [2:45];
Historical account of the 1918 Spanish flu—origin, the first wave in the summer of 1918, the death rate, and how it compared to other pandemics [10:30];
Evidence that second wave in the fall of 1918 was a mutation of the same virus, and the immunity immunity protection for those exposed to the first wave [18:00];
What impact did World War I have on the spread and the propagation of a "second wave"? [21:45];
How the government's response may have impacted the death toll [26:15];
Pathology of the Spanish flu, symptoms, time course, transmissibility, mortality, and how it compares to COVID-19 [29:30];
The deadly second wave—The story of Philadelphia and a government and media in cahoots to downplay the truth [35:50];
What role did social distancing and prior exposure to the first wave play in the differing mortality rates city to city? [44:45];
The importance of being truthful with the public—Is honesty the key to reducing fear and panic to bring a community together and combat the socially-isolating nature of pandemic? [46:15];
Third wave of Spanish flu in the spring of 1919 [51:30];
Global impact of Spanish flu, a high mortality in the younger population, and why India hit so much harder than other countries [55:15];
What happened to the economy and the mental psyche of the public …
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#106 - Amesh Adalja, M.D.: Comparing COVID-19 to past pandemics, preparing for the future, and reasons for optimism
13 april 2020 · 44 min
In this episode, infectious disease and pandemic preparedness expert, Amesh Adalja, M.D., puts the current pandemic into context against previous coronaviruses as well as past influenza pandemics. Amesh also provides his interpretation of the evolving metrics which have contributed to big variations in modeling predictions, whether this will be a seasonally recurring virus, and perhaps most importantly—how we can be better prepared for the inevitable future novel virus. Finally, Amesh explains where he sees positive trends which give him reasons for optimism. Lees meer
We discuss:
Amesh's background in infectious disease [2:40];
When did the virus actually reach the US? And when did Amesh realize it would pose a real threat to the US? [4:00];
Comparing and contrasting COVID-19 to previous pandemics like the Asian flu of 1958 and the Spanish flu of 1918 [8:00];
Will COVID-19 be a recurring seasonal virus every year? [14:00];
Will a future vaccine be specific to this COVID-19 or will it also cover previous coronaviruses as well? [15:15];
What does Amesh think might be the true case fatality rate of SARS-CoV-2? [16:15];
Why did early models over predict infections and deaths by order of millions? [18:30];
Role of government—How does Amesh view the role of local versus central government in dealing with a future pandemic? [21:50];
What went wrong with testing and how could we have utilized it more effectively? [25:15];
Future pandemic preparedness—why Amesh is cautiously optimistic [27:30];
Should there be different policies and restrictions for places like New York City compared to less populated and less affected places across the US? [30:15];
Why mass gatherings might be disproportionately driving the spread of the virus [32:30];
Learning from HKU1, a lesser-known novel coronavirus from 2005 [34:00];
Thoughts on Sweden's herd immunity approach [36:10];
The efficacy of masks being worn in public and what role they will play as restrictions are slowly lifted [37…
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#105 - Paul Conti, M.D.: The psychological toll of a pandemic, and the societal problems it has highlighted
10 april 2020 · 1 uur 27 min
In this episode, psychiatrist Paul Conti, M.D. discusses the impact of the fear and uncertainty surrounding the COVID-19 pandemic and the resulting stress, anxiety, and trauma it may impart on the population. Paul examines how this situation has highlighted the challenges we face at the societal level as well as the individual level, and stresses the importance of seeking absolute truth above personal truth and taking action as individuals as a means to combat many of these pervasive problems. Lees meer
We discuss:
Paul's personal experience with a presumptive case of COVID-19 [2:15];
Through the lens of trauma, Paul's overall take on the lasting effects of this pandemic on society [4:30];
The imperative to unite as a species given the isolating and suspicious nature of an invisible enemy [8:15];
The indigent population and the affluent population—The commonalities and differences in how both populations have been affected [16:15];
The prevailing feeling of demoralization spanning the population [25:30];
Health care workers—What lingering psychological effects might they suffer from this? [35:00];
Could this pandemic be a catalyst for changing the way people think about science, truth, and logic? [46:30];
How our inability to deal with uncertainty exacerbates the problem, and the need for humility [58:00];
What has been Paul's recipe for self care during this time? [1:06:45];
The forthcoming challenge of reintegrating back into the world when the quarantines lift [1:14:45];
An urgent need for change which must come through individuals seeking absolute truth and taking action [1:19:15]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/paulconti2
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#104 - COVID-19 for kids with Olivia Attia
8 april 2020 · 34 min
In this episode, Peter sits down with his daughter to answer questions from her and other kids about COVID-19. Lees meer
We discuss:
What is a virus? [1:45];
How did this version of coronavirus (SARS-CoV-2) start? [4:30];
How does COVID-19 compare to SARS and MERS (previous coronaviruses)? [6:00];
Will COVID-19 come back again after we resolve the current issue? [7:15];
When will kids go back to school? [7:45];
How has the US surpassed China in total cases, and how could we have been better prepared for this? [8:30];
Should have we started to quarantine sooner than we actually did? [11:45];
What about herd immunity? Would it be easier if we all just got the virus so we could be immune? [13:45];
Which age groups are the least and most at risk for getting a deadly version of the virus? [15:00];
Why do we have to wipe down packages that are delivered to our homes? [16:30];
How a lack of preparation and discipline led to this troubling situation [18:45];
Is China to blame for all of this? [24:15];
What did Olivia think when her parents pulled her out of school before it was mandated? [26:30];
What's been the hardest part of this for Olivia? [27:50];
What does Olivia appreciate now that she probably didn't appreciate in the past? [28:50];
How are Olivia's zone 2 workouts going? [30:00]; and
More
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Show notes page for this episode: https://peterattiamd.com/covid-19-for-kids
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#103 - Looking back on the first 99 episodes: Strong Convictions, Loosely Held
6 april 2020 · 1 uur 17 min
In this episode, originally recorded to be the 100th episode of The Drive, Peter discusses topics that he has changed his mind about since starting the podcast as a result of preparing for interviews as well as from the actual conversations. Peter also reviews some of his favorite moments from the first 99 episodes, shares what books he's currently reading, and much more. Initially scheduled to be released as episode 100, this was delayed due to recent podcasts covering COVID-19. Lees meer
We discuss:
Definition of "strong convictions loosely held," and the value in trying to shoot down your own hypotheses [2:20];
Metformin—How Peter's strong convictions have changed since 2018 [8:00];
Getting a dog—Why Peter caved and how it's going so far [15:45];
Rapamycin—How Peter's feelings have evolved, and the questions still needing to be answered [20:45];
Archery, the joy of pursuing mastery, and the importance of stillness [26:50];
Zone 2 training—Why Peter has made it a big component of his exercise regimen [37:30];
Deadlifts—Why Peter now believes it's extremely beneficial to longevity when done properly [41:45];
Read any good books lately? [50:00];
Baby aspirin for preventing blood clotting—Why Peter no longer takes it, and a few alternative options [53:15];
Generic drugs—How and why Peter's mind has shifted on generic drugs [55:45];
Omega-3 fatty acids, EPA and DHA—How Peter's long-held views have changed [58:15];
How Peter got better at saying "no" [1:02:30];
Does Peter have any favorite episodes of The Drive? [1:07:15]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/strong-convictions-loosely-held
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#102 - Michael Osterholm, Ph.D.: COVID-19—Lessons learned, challenges ahead, and reasons for optimism and concern
31 maart 2020 · 1 uur 22 min
In this episode, Michael Osterholm, Director of the Center for Infectious Disease Research and Policy at the University of Minnesota and author of Deadliest Enemy: Our War Against Killer Germs, provides an overview on the COVID-19 pandemic in regards to what has happened to date, what we've learned about how the disease spreads, and his optimism and pessimism about what potentially lies ahead. Michael gives his take on the true case fatality rate, why it differs around the world, and which underlying conditions, such as obesity, impact risk of severe illness and death. We also discuss the outlook regarding vaccines, repurposed drugs/antivirals for treatment, and Michael's growing concern about supply chain limitations with respect to drugs, vaccines, n95 masks, and testing kits. Lees meer
We discuss:
Recapping the brief history of COVID-19 and what potentially lies ahead [2:15];
Some positive news about immunity and reinfection [10:45];
Case fatality rate—The challenge in finding the true rate, difference by country, and the impact of age, underlying conditions, and obesity [13:00];
What has to be true for less than 100,000 Americans to die from COVID-19? [24:30];
How do we best protect healthcare workers? [29:45];
Concerns about testing capability—Reagent shortfall and a supply chain problem [39:30];
Vaccines and antivirals—The outlook, timing, and challenges [47:45];
Long term health of survivors of COVID-19 [56:45];
The impact of comorbidities—Diabetes, obesity, and immunosuppressed patients [59:30];
Understanding R0 and how the disease spreads [1:01:30];
The challenge of forecasting with so many unknown [1:08:00];
What explains the difference in cases and fatalities in different parts of the world? [1:14:30];
Repurposed drugs/antivirals being considered for treatment options—any optimism? [1:16:45];
A parting message from Michael about what lies ahead [1:18:30]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://pe…
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#101 - Ryan Holiday: Finding stillness amidst chaos
27 maart 2020 · 1 uur 23 min
Ryan Holiday, bestselling author and author of Daily Stoic, discusses practical ways to find stillness and apply the insights of stoic philosophy in the midst of COVID-19 chaos. Ryan discusses the importance of taking back a feeling of control, the benefits of structure and routine, and the idea of being prepared for anything. Lees meer
We discuss:
Using times of adversity to evaluate and reflect how you've set up and prioritized your life [2:30];
What insights might the famous stoics provide amidst this COVID-19 pandemic? [8:15];
The possible consequences of the socially isolating nature of a pandemic (and why we need good leaders) [13:00];
Stoicism—what it means and how to apply it [18:45];
Lessons taken from the life of Winston Churchill—stillness, structure, routine, hobbies, empathy, forward thinking, and more [23:30];
Alive time vs. dead time—taking control of your time and making it count [38:45];
Auditing how the world (and its leaders) are handling the COVID-19 pandemic through the lens of stoic philosophy [44:15];
Asserting control and using routine to find stillness in an environment not conducive for it [52:15];
Why you should find a way to exercise, especially now [58:30];
How to find purpose during this time—goal setting, having a project to work on, and the benefits of keeping a journal [1:02:00];
What is Ryan most optimistic about and what is he most concerned about over the next few months? [1:08:45];
How can you follow Ryan's work and messages about stoicism and stillness? [1:17:45].
And more.
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Show notes page for this episode: https://peterattiamd.com/ryanholiday2
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#100 - Sam Harris, Ph.D.: COVID-19—Comprehending the crisis and managing our emotions
24 maart 2020 · 1 uur 32 min
In this episode, Sam Harris, neuroscientist, author, and host of the Making Sense Podcast, joins Peter to discuss this unprecedented coronavirus (COVID-19) crisis. The discussion includes the important distinction between COVID-19 and influenza, the impact on the economy, the dire situation in New York, and the challenge of creating a safe and effective vaccine. Additionally, Sam brings insights from his extensive meditation practice to help those struggling with stress, anxiety, and fear in this extraordinary situation. Lees meer
We discuss:
A time unlike any other—why many people don't seem to fully grasp the magnitude of this situation [2:00];
Why comparing COVID-19 to influenza is a bad analogy [10:45]
The impact on the economy of measures like shelter-in-place—Is the "cure" worse than the disease? [16:45];
Why are some places, like New York, getting hit so much worse? [24:45];
The trickle down effect of an overrun healthcare system on non-COVID-19 related health issues [34:45];
How to calm our minds and manage our emotions during this craziness [38:00];
Talking to kids about this situation without burdening them with undue stress [50:15];
Insights from meditation practice—Recognize and unhook yourself from a heightened emotional state [52:00];
How to make the most of a situation where you let your emotions get the best of you [59:15];
What are some potential positive things that Sam hopes could be learned from this crisis and applied to the future? [1:09:30];
The unfortunate politics being layered on top of this crisis [1:15:30];
The challenge of creating a safe and effective vaccine for COVID-19 [1:20:00]; and
More.
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Show notes page for this episode: https://peterattiamd.com/samharris2
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#99 - Peter Hotez, M.D., Ph.D.: Continuing the conversation on COVID-19
21 maart 2020 · 1 uur 6 min
In this episode, Dr. Peter Hotez M.D., Ph.D., Dean for the National School of Tropical Medicine Baylor College of Medicine, returns to continue the conversation on COVID-19. Dr. Hotez informs us on how we can gauge the number of infected people, behaviors to reduce the probability of becoming infected, and the inconsistency of hospitalizations among young adults between different countries. Dr. Hotez underscores the continued uncertainty in many virus-related developments, but ends with some points of optimism. Lees meer
Disclaimer: This is information accurate as of March 19, 2020, when it was recorded.
We discuss:
How to gauge true number of infected people [5:45]
Reducing the probability of getting infected [22:45]
Inconsistency by country in infected young people [27:15]
Conferred immunity, seasonality, and repurposed therapeutics [30:30]
Vaccine development [39:30]
Practical behaviors to reduce risk of transmission [46:00]
Mental Health resource and funding [51:00]
Points of optimism [56:00]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/peterhotez-2
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Qualy #129 - Evolutionary reasons to sleep
17 maart 2020 · 10 min
Today's episode of The Qualys is from podcast #47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of poor sleep, Alzheimer's risk, mental health, memory consolidation, and more. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
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#97 - Peter Hotez, M.D., Ph.D.: COVID-19: transmissibility, vaccines, risk reduction, and treatment
14 maart 2020 · 57 min
In this episode, Dr. Peter Hotez M.D., Ph.D., Dean for the National School of Tropical Medicine Baylor College of Medicine, shares his expertise on viral disease and how it applies specifically to the coronavirus disease (COVID-19) and the virus that causes it (SARS-CoV-2). Dr. Hotez informs us about the current state of disease progression, which has many unknowns, but has thus far been greatly determined by the delayed response time and lack of testing. Moreover, we discuss what we can do on a country, state, community, and individual level in order to collectively slow transmission of the disease. He shares with us a potential hope in convalescent plasma therapy and underscores the need for US federal involvement - particularly in the creation of a specialty task force to address areas of concern and unknowns. Lees meer
Disclaimer: This is information accurate as of March 13, 2020, when it was recorded.
We discuss:
The disease and the virus: transmissibility and lethality [04:30];
Disease transmission: US playing catch-up [12:00];
Convalescent plasma coronavirus therapy [16:00];
Remdesivir drug treatment and vaccination challenges [19:45];
Disease mechanism and reported pathology [27:45];
Most concerning geographic regions in the US [39:00];
Risk reduction [46:30]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/peterhotez
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Qualy #125 - Hierarchies in healthcare, physician burnout, and a broken system
10 maart 2020 · 13 min
Today's episode of The Qualys is from podcast #37 – Zubin Damania, M.D.: Revolutionizing healthcare one hilariously inspiring video at a time. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
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#96 - David Epstein: How a range of experience leads to better performance in a highly specialized world
9 maart 2020 · 2 uur 37 min
In this episode, David Epstein, best-selling author of Range and The Sports Gene, discusses the evidence around the most effective ways to improve long-term performance and learning in our specialties, our sports, our careers, and our lives. David makes a compelling case that a range of experiences and skills are more likely to lead to expert performance compared to early specialization, and offers an in-depth critique of the much-publicized 10,000-Hour Rule. David also provides insights into our role as parents in the process of encouraging exposure to many things, the concepts of when to push them, when to give them space, and when to allow them to quit. Furthermore, David goes into many other fascinating topics such as the role of talent, genetics, and practice in reaching expert status, what differentiates a kind vs. wicked learning environment, the importance of "informal training," and many case studies that suggest strategies for short-term success may not be best for long-term development. Lees meer
We discuss:
A shared interest in Ayrton Senna, and pondering the value in participating in sports [2:30];
Examining the 10,000-Hour Rule, and the importance of questioning existing dogma [15:00];
How the medical profession is affected by bad science, and the importance of understanding individual variation [28:00];
David's most surprising findings when writing The Sports Gene [35:45];
Kind versus wicked learning environments [40:45];
How and why strategies for short-term success may not be best for long-term development [47:30];
Contrasting the success stories of Tiger Woods and Roger Federer—which path is more common, and an argument for diversified training and experiences [59:15];
Is there an age-range or "critical window" during which exposure is necessary to reach a certain level of proficiency or mastery of a skill or knowledge? [1:14:00];
How diversifying your interests and unraveling your identity from your speciality could lead to more enjoyment and act…
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Qualy #121 - The "art" of longevity: the challenge of preventative medicine and understanding risk
3 maart 2020 · 10 min
Today's episode of The Qualys is from podcast #52 – Ethan Weiss, M.D.: A masterclass in cardiovascular disease and growth hormone – two topics that are surprising interrelated. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
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#95 - Luke Bennett, M.D.: The emotional, cognitive, and physical demands that make Formula 1 a unique and special sport
2 maart 2020 · 1 uur 39 min
In this episode, Luke Bennett, Medical and Sports Performance Director for Hintsa Performance, explains the ins and outs of Formula 1 with a focus on the behind-the-scenes human element, and what makes it so emotionally, cognitively, and physically demanding for the drivers as well as the many team members. Luke first talks about his fascinating background with the Royal Flying Doctor Service in Australia, which lead to his current position with Hintsa working closely with F1 drivers to improve their health and performance despite jet-lag and sleep constraints due to an unrivaled travel schedule. Luke also sheds light on the underappreciated level of sheer physical strength and endurance it takes to drive an F1 car combined with the extreme cognitive aptitude, spatial awareness, and ability to navigate a socially complex environment that is needed to be successful as a driver. Additionally, Luke gives an overview of how the F1 season and races work, the incredible advances in car technology and safety measures, and what Luke and Hintsa hope to bring in the near future to the unique and special sport that is Formula 1. Lees meer
We discuss:
What it's like to be a "flying doctor" in Australia, and how Luke ended up working in Formula 1 with Hintsa [3:10];
Behind the scenes of Formula 1—crazy travel, jet lag, massive teams, and fascinating human storylines [10:45];
The incredible physical strength and cognitive aptitude needed to be a F1 driver [19:00];
The technological leap to hybrid electric engines [29:30];
The trend towards younger drivers in F1 [32:30];
Advancements in safety—the history and recent upgrades [36:00];
How Hintsa manages the athletes through the incredible social complexity of the sport [41:45];
Explaining the difference between F1, F2, F3, and F4, and the path to reaching the F1 [47:30];
Comparing F1 in the 60s & 70s to today—Incidences of deaths, number of crashes, physicality of driving, new regulations, and more [53:45];
Women in F1—Past, pres…
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Qualy #120 - What is the difference between ketone salts and esters?
28 februari 2020 · 6 min
Today's episode of The Qualys is from podcast #05 – Dom D'Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
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#94 - Mark Hyman, M.D.: The impact of the food system on our health and the environment
24 februari 2020 · 1 uur 50 min
In this episode, Mark Hyman, M.D., director of the Cleveland Clinic Center for Functional Medicine and the author of Food Fix, discusses that if we can fix the food system, we can solve many big problems—namely the chronic disease/obesity epidemic, the rising costs of healthcare, as well as the big problems facing the environment. Mark first briefly lays out the health consequences of processed food with a focus on the gut microbiome. From there, Mark discusses the environmental consequences of industrial farming and lays out how we can affect change on the individual level, through policy and regulations, and perhaps most importantly through regenerative agriculture. Additionally, Mark talks about the potential health risks of consuming GMO foods, herbicides, and other chemicals used in industrial farming as well as the environmental consequences, such as the loss of soil, caused by those same fertilizers and methods of farming. Lees meer
We discuss:
The negative consequences of the existing food environment [3:25];
What makes processed food so unhealthy? [9:00];
The gut microbiome: Inflammation from gut permeability and how to measure gut health [18:30];
Steps to fixing a bad gut—The Five R's [24:30];
Some staggering health statistics, and which races might be more genetically susceptible [27:15];
An argument for government regulations and policies to fight back against a massive food industry with unlimited resources (and what we can learn from the tobacco story) [29:00];
Industrial farming and climate change: The degradation of soil and use of fertilizer [41:45];
Regenerative agriculture: Could it be the answer to food waste, our health problems, and the environment? [51:45];
Comparing the Impossible Burger to regeneratively raised beef [1:06:00];
GMO and Roundup—The potential health risks of consuming GMO foods sprayed with Roundup (glyphosate) and other herbicides and pesticides [1:08:15];
How the livelihood of farmers are being affected by big ag companies…
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Qualy #116 - Dealing with anger in spots where you know it's coming
21 februari 2020 · 9 min
Today's episode of The Qualys is from podcast #34 – Sam Harris, Ph.D.: The transformative power of mindfulness. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
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#93 - AMA with Jason Fried: Work-life balance, avoiding burnout, defining success, company culture, and more
17 februari 2020 · 2 uur 8 min
In my first interview with Jason Fried, Jason explained his overall philosophy about work-life balance and how exactly he optimizes for efficiency. For this special follow-up AMA, we've decided to release the full episode to everyone (including non-subscribers), so all can hear Jason answer questions from listeners that dive deeper into topics such as work-life balance, the role of luck versus hard work in success, specifics around Basecamp's unique process-oriented approach to projects, 4-day work weeks, practical tips for people searching for the right company culture, tips on writing and parenting, and a whole bunch more. Lees meer
If Jason had taken his own advice about work-life balance at the start of his career, would he have achieved the same level of success? [2:05];
What is Jason's definition of success, and what is he optimizing for? [10:10];
Basecamp's policy on email and expectations for a quick response, and why Jason believes in sleeping on big decisions [14:30];
How Jason implements "true" work-life balance in his life and at Basecamp [19:15];
Does work and life have to be separated in order to have balance? [32:00];
How Jason makes time the fixed component to avoid the compulsion to keep pushing forward on a project perpetually [34:15];
Jason's tip for physicians who may be facing burnout [45:00];
Signs of "burnout" if you do the same thing for work and pleasure, and tips to avoid and manage that feeling [49:45];
Is a 40-hour work week the correct amount? [53:45];
How to evaluate a company's culture when looking for a job with the right work environment [59:00];
Jason's take on salaries and alternate incentives like equity, profit sharing, etc. [1:06:45];
What traits does Jason look for when hiring new employees? [1:13:45];
Does Jason believe in process-oriented work or outcome-driven work, and Basecamp's unique process for completing projects [1:16:15];
How does Jason handle a project that results in a failure? [1:20:00];
Advice for people in…
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Qualy #109 - How does one select the right physician as a patient?
11 februari 2020 · 10 min
Today's episode of The Qualys is from podcast #04 – AMA #1: alcohol, best lab tests, wearables, finding the right doc, racing, and more. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
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92 - AMA #12: Strategies for longevity (which don't require a doctor)
10 februari 2020 · 15 min
In this "Ask Me Anything" (AMA) episode, Peter explains the various levers one can pull to affect longevity with a specific focus on the strategies and tactics one can implement that do not require the help of a physician. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. Lees meer
If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #12 show notes page.
We discuss:
The five levers you can pull to affect longevity [1:15];
Nutritional biochemistry: Framework, 3 nutritional interventions, and how to approach your goals, and what you should be tracking [4:30];
Exercise for brain health, and the 4 components of exercise [20:45];
Exercise component—Stability [24:30];
Exercise component—Strength [29:00];
What is Peter optimizing for with his exercise? [30:30];
Exercise components—Zone 2 and zone 5 training [33:15];
More about DNS, and why we need to be careful with rushing kids through neuromuscular development stages [45:00];
Sleep: How to improve quantity and quality [48:15]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/AMA12
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
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Qualy #106 - Does LDL cause heart disease?
5 februari 2020 · 10 min
Today's episode of The Qualys is from podcast #03 – Ron Krauss, M.D.: a deep dive into heart disease. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
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#91 – Eric Topol, M.D.: Can AI empower physicians and revolutionize patient care?
3 februari 2020 · 2 uur 1 min
In this episode, Dr. Eric Topol, founder and director of the Scripps Research Translational Institute, shares how artificial intelligence and deep learning is currently impacting medicine and how it could transform the healthcare industry, not only in terms of the technological advancements, but also in restoring the patient-doctor relationship for better patient outcomes and experiences. We also discuss Eric's rich and fascinating career in cardiology as well as his involvement as one of the first outspoken researchers to question the cardiovascular safety of Vioxx. Lees meer
We discuss:
Eric's background and his source of interest in cardiology [3:15];
The US medical field's resistance to technological change and learning from other healthcare models [11:15];
Eric's mission at the Cleveland Clinic [20:15];
How Eric helped to elucidate the issues with Vioxx (and why he came to regret it) [29:45];
How Eric came to found one of the most influential research centers in the world [47:30];
How AI and deep learning is currently impacting medicine, and the future possibilities [56:30];
Gut microbiome—Its role in health, impact on glycemic response and fuel partitioning, and how deep learning could improve our research and treatment [1:17:45];
Why machines combined with human doctors is superior to one without the other [1:32:00];
How AI and machines can reinstate medicine as an attractive career (and alleviate physician burnout) [1:36:45];
Eric's dream experiment [1:47:15] and;
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/erictopol
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
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Qualy #102 - Is the food industry still saying that all calories contribute equally to adiposity and insulin resistance?
29 januari 2020 · 8 min
Today's episode of The Qualys is from podcast #14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
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#90 - Ryan Holiday: Stillness, stoicism, and suffering less
27 januari 2020 · 2 uur 16 min
In this episode, Ryan Holiday, author of Stillness is the Key, shares the profound impact that stoic philosophy has had on his personal life and his career as a successful writer. Ryan stresses the importance of stillness in a modern world set up to encourage the opposite and lays out the best strategies to develop stillness in your life. He also explains the destructive nature of being driven by ego, as well as the perils of jealousy and anger, and provides practical steps you can take to avoid those harmful states. Lees meer
We discuss:
Has a more connected world improved or worsened our lives? [2:15];
Consequences of an overly secure life, living in the present, & the misconception of unlimited time [5:45];
Stoicism 101: The definition and origins of stoic philosophy [15:45];
Ryan's career transition into writing, and his take on what makes a book or business successful [26:45];
Storytelling—The upside and downside of telling stories and self-narrative [36:15];
Does achieving success have to come from a place of craving and proving others wrong? And what are the costs of building a legacy? [38:45];
Ego—confusing ego with confidence, signs your ego is showing, & antidotes to the negative effects of ego [52:45];
Ryan's advice to Peter about writing (and finishing) his book [1:06:30];
Stillness—what it is, how it compares to meditation, & the obstacles to achieving stillness [1:10:30];
Ryan's morning routine, relationship with his smartphone, and how he avoids falling victim to the trappings of technology and a hyperconnected world [1:17:40];
The perils of jealousy and envy [1:24:15];
How to live in the moment in a modern world not designed for stillness [1:32:15];
How the idea of "dying well" can help you live better [1:36:00];
How has fatherhood impacted Ryan's philosophies on stillness and living in the moment? [1:39:45];
How to make your favorite day your every day [1:42:00];
The most reliable strategies for developing stillness [1:47:30];
Anger—what th…
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Qualy #99 - The steroid controversy: Mark's use of them and Peter's perspective
23 januari 2020 · 11 min
Today's episode of The Qualys is from podcast #28 – Mark and Chris Bell: steroids, powerlifting, addiction, diet, training, helping others, documentaries, and living your best life. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
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#89 - AMA #11: All things fasting
20 januari 2020 · 15 min
In this "Ask Me Anything" (AMA) episode, Peter answers a wide range of fasting-specific questions from subscribers. Peter starts by defining the various fasting protocols, details his own personal fasting regimen, explains his revised plan for 2020, and provides a ton of value to anyone interested in fasting. Once again, Bob Kaplan, Peter's head of research, will be asking the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. Lees meer
If you're a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #11 show notes page.
We discuss:
Defining the various fasting protocols [1:00];
Why Peter plans to switch to a 3-day fast once per month in 2020 [11:00];
How Peter uses his CGM to gain insights into the depth of fast [13:15];
Peter's supplement protocol during fasting, and why he eats a ketogenic diet leading up to a prolonged fast [17:00];
Peter's exercise regimen during a fast [23:30];
Peter's hunger levels during a typical 7-day fast [26:45];
Fasting observations—Core body temperature and thyroid hormone [30:30];
Fasting observations—Glucose, BHB, and hunger levels [33:15];
Peter's sleep protocol during a fast [40:15];
Does Peter observe any differences between men and women in their ability to fast? [47:00];
How Peter prefers to break a long fast [50:15];
Importance of community support while fasting, and is there a perfect fasting protocol? [52:00]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/ama11/
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
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Qualy #94 - Comparing the two broad types of meditation, and Peter's favorite meditation apps
15 januari 2020 · 7 min
Today's episode of The Qualys is from podcast #34 – Sam Harris, Ph.D.: The transformative power of mindfulness. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD