Alle afleveringen
462 afleveringen, van nieuw naar oud
-
Qualy #89 - Cortisol and healthy aging
7 januari 2020 · 10 min
Today's episode of The Qualys is from podcast #31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#87 - Rick Johnson, M.D.: Fructose—The common link in high blood pressure, insulin resistance, T2D, & obesity?
6 januari 2020 · 1 uur 51 min
In this episode, Rick Johnson, Professor of Nephrology at the University of Colorado, explains how his research into the causes of blood pressure resulted in a change of research direction to focus more on how fructose has such profound metabolic effects. Rick discusses the relationship between salt and high blood pressure, provides a masterclass into uric acid, and expertly reveals the mechanisms and pathways by which sugar (specifically fructose) can profoundly impact metabolic health. From there, he explains how he applies this information to real life patients, as well as touches on some of the most promising ideas around pharmacotherapy that are being developed in response to the epidemics of fatty liver, insulin resistance, diabetes, and obesity. Furthermore, Rick gives his take on artificial sweeteners compared to real sugar, discusses cancer's affinity for fructose, and much more. Lees meer
We discuss:
The connection between blood pressure and fructose that shifted Rick's professional focus [4:00];
The relationship between salt and blood pressure (and the role of sugar) [5:45];
Defining fructose, glucose, and sugar [19:30];
An ancient mutation in apes that explains why humans turn fructose into fat so easily [23:00];
The problems with elevated uric acid levels, and what it tells us about how sugar causes disease [31:30];
How sugar causes obesity—explaining the difference in glucose vs. fructose metabolism and the critical pathway induced by fructose [40:00];
Why drinking sugar is worse than eating it [50:00];
Unique ability of sugar to drive oxidative stress to the mitochondria, insulin resistance, and diabetes [54:00];
Why cancer loves fructose [1:00:15];
The many areas of the body that can use fructose [1:05:00];
Fructokinase inhibitors—a potential blockbuster? [1:07:15];
Treating high uric acid levels—Rick's approach with patients [1:10:00];
Salt intake—what advice does Rick give his patients? [1:16:30];
How excess glucose (i.e., high carb diets) ca…
-
Qualy #85 - The past, present, and future of medicine, hospitals, and healthcare
31 december 2019 · 13 min
Today's episode of The Qualys is from podcast #06 – D.A. Wallach: music, medicine, longevity, and disruptive technologies. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#86 - Damon Hill: Overcoming loss, achieving success, and finding one's identity
30 december 2019 · 2 uur 27 min
In this episode, Damon Hill, 1996 Formula 1 World Champion, opens up about his personal struggles with depression, feelings of inadequacy, loss of identity, and his ultimate path to healing following his remarkable racing career. Damon's life was given a tragic jolt at 15 years of age when his father and legendary F1 driver Graham Hill died suddenly—the common string that ties together so much of his life and has forged so much of who he is to this day. We discuss Damon's unique and remarkable racing career including his legendary battles with Michael Schumacher as well as Damon's firsthand account of what happened that tragic day on May 1st, 1994, when his teammate, Ayrton Senna, died at Imola. But this is not just about racing; rather it's a human story that's cloaked in a racing one. Lees meer
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/damonhill/
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
-
Qualy #82 - What is the most common first presentation of heart disease?
25 december 2019 · 7 min
Today's episode of The Qualys is from podcast #03 – Ron Krauss, M.D.: a deep dive into heart disease. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
23 december 2019 · 2 uur 53 min
In this episode, Dr. Iñigo San Millán, Assistant Professor at the University of Colorado School of Medicine, explains the crucial role of mitochondrial function in everything from metabolic health to elite exercise performance. Iñigo provides a masterclass into the many different energy system pathways, the various fuel sources (including the misunderstood lactate), the six zones of exercise training, and the parameters he uses to measure metabolic health. Additionally, he highlights the power of zone 2 training in its ability to act as a powerful diagnostic tool, and perhaps more importantly as a treatment for mitochondrial and metabolic dysfunction. Lees meer
We discuss:
Iñigo's background in sports and decision to focus on education [7:15];
Explaining the various energy systems and fuels used during exercise [14:45];
Iñigo qualifies energy systems into six training zones [26:00];
Lactate is an important fuel source [33:00];
Zone 2 training—physiologic characteristics, fuel sources, lactate, and the transition into zone 3 [40:30];
Using blood lactate levels (and zone-2 threshold) to assess mitochondrial function [47:00];
Accessing mitochondrial function by looking at one's ability to utilize fat as fuel (with an RQ test) [55:00];
Athletes vs. metabolically ill patients—mitochondria, fat oxidation, muscle glycogen capacity, "fat droplets", and more [1:00:00];
Physiologic characteristics of zone 3, zone 4, and the lactate threshold [1:20:00];
Fueling exercise—dietary implications on glycolytic function [1:30:30];
Relationship between exercise and insulin sensitivity (and what we can learn from studying patients with type 1 diabetes) [1:46:30];
Metformin's impact on mitochondrial function, lactate production, and how this affects the benefits of exercise [2:04:15];
Raising awareness for risk of "double diabetes" [2:15:00];
How to dose zone 2 training, and balancing exercise with nutrition [2:18:00];
Proposed explanation of the Warburg Effect: Role of lactate i…
-
Qualy #80 - The four pillars of charity: water that helped it overcome the stigma of nonprofits and become successful
20 december 2019 · 12 min
Today's episode of The Qualys is from podcast #25 – Scott Harrison: transformation, finding meaning, and taking on the global water crisis. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#84 - AMA #10: Low testosterone, hypothyroidism, building muscle (and preserving it while fasting)
16 december 2019 · 11 min
In this "Ask Me Anything" (AMA) episode, Peter answers a wide range of questions from subscribers. Bob Kaplan, Peter's head of research, asks the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. Lees meer
If you're a subscriber, you can now listen to this full episode on your private RSS feed. You can also listen to this full episode on our website at the AMA #10 show notes page.
We discuss:
Does testosterone supplementation impact longevity? [2:40];
Under what conditions does Peter decide to treat patients who have low testosterone? [8:50];
Are there risks involved with testosterone replacement therapy? [17:10];
How does Peter diagnose and treat hypothyroidism? [21:30];
How might someone do time-restricted feeding while also adding muscle mass? [26:30];
If building muscle requires higher levels of IGF-1, should we be concerned about longevity? [34:45];
How to preserve muscle mass while fasting [41:45];
Is it possible to simultaneously lose fat and add muscle mass? [46:30]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/ama10
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
-
Qualy #73 - How can we change the food system when 10 companies control almost 90 percent of the calories we consume in the US?
10 december 2019 · 9 min
Today's episode of The Qualys is from podcast #14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#83 - Bill Harris, Ph.D.: Omega-3 fatty acids
9 december 2019 · 2 uur 2 min
In this episode, Bill Harris, Ph.D. in human nutrition and expert on omega-3 fatty acids, sets the table by clearly defining the families of fatty acids (saturated, monounsaturated, polyunsaturated) before diving into the current landscape of polyunsaturated fat (omega-6 and omega-3) with a particular focus on EPA and DHA (the two main elements of fish oil supplements). Bill gives a historical overview, updates us on the latest science related to the health benefits, and provides plenty of insights as to how we should think about increasing our EPA and DHA intake. Lees meer
We discuss:
Bill's long history of studying fatty acids [6:30];
Defining the fatty acids—SFA, MUFA, PUFA, omega-3, omega-6, and more [9:45];
What is the significance of fatty acids? Why should we care? [19:45];
History of fat phobia, saturated fat, and does PUFA reduce cholesterol? [23:45];
Breaking down the conversion process of omega-6 and omega-3 fatty acids including how we get to EPA and DHA [28:00];
Takeaway from Bill's 1980 study looking at how salmon oil affected cholesterol and triglyceride levels [36:15];
History of our understanding of omega-3 and its effect on LDL cholesterol [45:00];
Prescribed fish oil drugs vs. OTC supplements—Differences and recommended brands [52:00];
Health benefits of EPA [57:45];
Potential benefits of ALA and how it compares to taking EPA and DHA directly [1:12:45];
Health benefits of DHA [1:17:15];
Cell membrane omega-3 index—What is it, the role of genetics, how to increase it, and a recommended target [1:19:00];
Is EPA or DHA neuroprotective? Can it help with depression? [1:23:30];
Recommended fish to eat for EPA and DHA - Any mercury concerns? [1:25:45];
Can omega-3 mitigate risks associated with smoking? [1:29:15];
The problem with the omega-6 to omega-3 ratio [1:30:00];
The problem with labeling any kind of fatty acid as "bad" [1:36:00];
Why increasing EPA and DHA intake matters more than reducing omega-6 intake [1:38:00];
Important takeaway f…
-
Qualy #69 - Advice to parents and kids for creating a sustainable environment that's going to prevent them from running into metabolic problems
3 december 2019 · 9 min
Today's episode of The Qualys is from podcast #14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#82 - Mark Messier: Leadership, personal growth, and performing under pressure
2 december 2019 · 2 uur 10 min
In this episode, Mark Messier, six-time Stanley Cup champion, shares the most valuable lessons he picked up over 25+ years of professional hockey resulting in one of the longest and most decorated careers in hockey history. Mark shares what lead to his unique brand of humble leadership, how he was able to get talented individuals to effectively work as a team, the importance of maturing and evolving as a person, and how he was able to stay calm and perform at his best under enormous amounts of pressure. Additionally, we go through his favorite moments as a player, what it was like playing with and learning from The Great One, Wayne Gretzky, and much more. Lees meer
We discuss:
Overview of Mark's extraordinary 25+ year professional hockey career [7:15];
The trend towards kids focusing on one sport earlier and earlier—A good or bad thing? [12:00];
Mark's early passion for hockey, and when he realized it could be his "job" [14:15];
Going pro at age 17 [19:30];
Mark's favorite experience playing professional hockey [25:45];
Playing with (and learning from) the great Wayne Gretzky [26:40];
A hard lesson learned in his first year as a pro [32:00];
Lessons learned from losing his first Stanley Cup Finals [35:45];
Redemption—Winning his first Stanley Cup and the beginning of a dynasty in Edmonton [41:15];
Importance of team character [54:00];
The shocking trade of Wayne Gretzky, and Mark stepping up as the new leader and team captain [59:30];
Playing for the New York Rangers—the lure of the city and the pressure to perform [1:07:00];
Ending the 54-year championship drought for the New York Rangers [1:13:30];
Becoming a great leader [1:16:30];
How to win the mental war against your opponent [1:20:30];
Opposing players for which Mark had great respect [1:22:00];
Retiring after an unbelievably long and lustrous career [1:27:00];
How to leverage stress and nervousness into a positive force [1:32:45];
The most important quality—A willingness to learn, improve, and evo…
-
Qualy #65 - The three laws of medicine — Law #1: A strong intuition is much more powerful than a weak test
26 november 2019 · 6 min
Today's episode of The Qualys is from podcast #32 – Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing process. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#81 - Debra Kimless, M.D. & Steve Goldner, J.D.: Cannabis – the latest science on CBD & THC
25 november 2019 · 2 uur 12 min
In this episode, Dr. Debra Kimless and Steve Goldner share their knowledge on the science, policy, and market evolution of medicinal cannabis. We start with the differences between THC and CBD, how they work in the body, and how they act on the brain. We discuss the many potential benefits of using CBD, THC, hemp in the various forms of administration (smoking, vaping, edibles, oils, etc.) as well as some of the safety issues including the recent uptick in incidents of hospitalization and death linked to vaping. Debra and Steve are both involved with the company, Pure Green—Debra the Chief Medical Officer and Steve the founder and CEO—whose aim is to create the safest, most efficacious form of delivery of cannabis. Their bigger mission is to shift the perception of the cannabis plant, garner acceptance of its medicinal benefits, and ultimately get it descheduled on a federal level so more people can access cannabis for a range of chronic ailments. Lees meer
We discuss:
Debra and Steve's background reason for their interest in medical cannabis [7:00];
The history of medical use of cannabis [11:15];
How THC, CBD, and other cannabinoids work [16:00];
Hemp—What it is, special uses, and the 2018 farm bill [22:45];
The legal status of CBD, Deb and Steve's clinical trial, and how CBD differs from THC [30:15];
The safety profile of THC [35:00];
Is marijuana as a gateway drug? [45:30];
Smoking vs. vaping vs. edibles—Benefits, risks, and mechanistic differences [53:30];
Can you build up a tolerance to the effects of THC? [1:15:00];
What do people generally want to get from using marijuana? [1:17:15];
Cannabinoid synthetics [1:22:30];
Efficacy of CBD oils as a sleep aid [1:25:00];
Pure Green Cannabis [1:30:30];
Anecdotal evidence and managing the hype surrounding cannabis in medical treatment [1:38:45];
Aspirations for the future of medicinal cannabis, and the legal challenges that await them [1:45:15];
Descheduling cannabis: A human rights issue [2:04:00] and;
More.
… -
Qualy #61 - Rapamycin in cancer treatment
19 november 2019 · 10 min
Today's episode of The Qualys is from podcast #10 – Matt Kaeberlein, Ph.D.: rapamycin and dogs — man's best friends? — living longer, healthier lives and turning back the clock on aging and age-related diseases. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#80 - Celebrity AMA #1: Fasting, rapamycin, performance vs. longevity, and more
18 november 2019 · 12 min
In this special, bonus celebrity AMA episode, Peter answers questions from former Olympians and past guests, Apolo Ohno and Sasha Cohen, on a wide range of subjects including fasting, learning, training for performance versus longevity, and much more. This bonus AMA is available in full to everyone. Lees meer
Apolo's questions begin [1:45];
Why women may have a harder time fasting, and tips for those who are struggling [2:10];
Is there any place for fasting as part of a nutritional strategy in adolescents? [6:15];
Tips for learning and retaining large amounts of new information (and the best nutritional approach) [9:15];
Must read books of 2019 [14:45;
If you could only keep a few watches for the rest of your life which would they be? [16:45];
What workout would Peter do inside a hotel room? [22:15];
What is Peter's ultimate gorge meal? [23:45];
How do you foresee fasting as a mechanism for performance in athletes? [25:30];
What is driving Peter to strive for excellence? [33:30];
Sasha's questions begin [38:40];
What are you most excited about in the longevity space? [38:45];
At what point do you see enough data or proof that a new drug, or type of fasting is worth trying it out for yourself? [41:30];
Is it possible to obsess so much about your health that it becomes a negative stressor? [46:45];
Which tests are worth doing if you want to be proactive about your health? [48:15];
Are there any supplements Peter things are beneficial to be taking? [55:15];
How does Peter's training differ when optimizing for performance versus longevity? [56:30];
How does taking testosterone and growth hormone affect performance versus longevity? [59:15]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode:https://peterattiamd.com/celebrityama01
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Fac…
-
Qualy #57 - A primer on NAD+/NADH, its effect on lifespan/healthspan, and a review of the supplements
12 november 2019 · 8 min
Today's episode of The Qualys is from podcast #02 – Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and more. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#79 - Ric Elias: Earning the gift of life
11 november 2019 · 1 uur 42 min
In this episode, Ric Elias, founder of Red Ventures, opens up about the fateful day he knew for certain that he was going to die as a passenger on US Airways Flight 1549. Ric dives deep into how that day impacted his life, greatly changed his perspective, and improved his relationship with his family and the broader community. We also talk about his incredible role as CEO of an enormous company, his remarkable work in philanthropy, and all the wisdom he has acquired in his extraordinary life. Lees meer
We discuss:
Ric's life leading up to the day of the plane crash [5:30];
The plane crash—What it's like knowing you're about to die, feelings of regret and sadness [11:15];
The improbable plane landing in the Hudson River [19:00];
Emotions after the safe landing (and a story he's never told before) [25:45];
A powerful story about Captain Sully [29:30];
Earning his second chance at life, and playing the "infinite game" [38:30];
Why time is the ultimate currency, and how (and why) to say "no" [46:15];
Raising kids in an achievement culture, Ric's definition of life success, and what Ric wants to instill in his kids [53:00];
What Ric believes is actually worth getting upset, and the organizations that are taking steps to help people [1:09:00];
The core principles of Red Ventures (Ric's company) [1:19:15];
Ric's tips for developing business acumen and negotiation skills [1:29:30];
What qualities does Ric look for in people he wants to work with? [1:32:50];
What is the next big problem that Ric wants to solve? [1:35:30];
What is the most challenging part of your business today? [1:37:30];
If Ric could go back and talk to himself in the morning before getting on that plane, what would he say? [1:39:15]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/ricelias
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://pet…
-
Qualy #53 - Screening for prostate cancer
5 november 2019 · 17 min
Today's episode of The Qualys is from podcast #39 – Ted Schaeffer, M.D., Ph.D.: How to catch, treat, and survive prostate cancer. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#78 - Sasha Cohen: The price of achievement, and redefining success
4 november 2019 · 2 uur 14 min
In this episode, Sasha Cohen, former US Olympic figure skater, discusses the most challenging things about life as an Olympian—the pressures, the expectations, years of sacrifice, but worst of all a loss of identity post-career resulting in many former Olympians suffering from depression. We begin by talking about everything that led up to her unforgettable moment from the 2006 Olympics, and how she handled herself so beautifully in the face of disaster. Most importantly, we talk about post-skating life when she shares many insights such as the downside of constantly striving for a moment, the hollowness of achievement, and the importance of redefining our definition of success. Lees meer
We discuss:
Sasha's mindset going into the 2006 Olympics as the favorite [6:30];
Figure skating basics, scoring, short program vs. long program, etc. [13:40];
Sasha's unforgettable performance at the 2006 Olympics [18:10];
Win, lose, or draw, why many Olympians suffer from a loss of identity [32:30];
Dealing with the disappointment of "losing the gold" [40:30];
The tiny window of opportunity for Olympians, and the overwhelming pressure to meet expectations [49:30];
Sasha's unique childhood, finding figure skating, and channeling her hyperactive personality into becoming an amazing skater [1:01:30];
The consequences of extreme training at a young age, and trying to control the uncontrollable [1:10:00];
What is driving extreme athletes and Olympians to be the best? [1:18:30];
Why many former Olympians and athletes struggle with depression [1:25:00];
Refining success—How Sasha overcame her own loss of identity [1:32:30];
What advice would Sasha give her 15-year-old self? [1:40:45];
Lessons we can learn from watching the rapid downfall of many former Olympians [1:45:00];
Advice for people who are tying their identity to being "successful" or striving to be "the best" [1:56:00];
Life lessons Sasha wants to apply to being a mother to her baby boy she is expecting [2:05:00]; and
M…
-
Qualy #52 - Insights about berberine
1 november 2019 · 5 min
Today's episode of The Qualys is from podcast #26 – AMA #3: supplements, women's health, patient care, and more. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#77 – AMA #2 with sleep expert, Matthew Walker, Ph.D.: short sleep mutants, optimal sleep environment, sleep apnea, & rapid fire questions
28 oktober 2019 · 29 min
In this special episode, Matthew Walker returns for his second AMA episode where he provides his expert insight on numerous sleep-related questions directly from listeners. He answers a wide range of questions from the gene that causes the short sleeping phenotype, to the ideal sleeping position, to the optimal temperature for best sleep, to how fasting affects sleep, plus a full dissertation on sleep apnea, and much, much more. Lees meer
We discuss:
DEC2—A genetic mutation that produces a short sleeping phenotype [11:00];
What is the best position to sleep in? [22:45];
Should you consider a "sleep divorce" with your partner? [27:00];
The challenge of kids wanting to sleep in bed with their parents [28:45];
Is there an ideal type of pillow? [32:30];
Any data on hammock sleeping? Should adults be rocked to sleep like a baby? [34:45];
The optimal room temperature and body temperature for the best sleep [38:30];
Do humidifiers help? [50:40];
How do high altitudes affect sleep? [53:15];
What is the data on weighted blankets (e.g., the Gravity blanket)? [57:00];
Caffeine—How much, and in what way, does it affect sleep? [58:15];
How does sexual activity relate to sleep quality? [1:04:00];
Should we be sleeping in two phases? First sleep & second sleep? [1:06:30];
Napping—Is there ideal duration? Should we be napping or not? [1:08:30];
Advice for new parents dealing with sleep deprivation [1:12:00];
Understanding your sleep chronotype [1:16:15];
If you drink too much alcohol in a given night, is there anything you can do to make sure your sleep isn't wrecked? [1:20:45];
How postmenopausal women can manage their sleep problems with (and without) hormone replacement therapy [1:23:00];
Could a daily practice of Wim Hof's breathing method help or hinder quality of sleep? [1:29:15];
Why do some people paradoxically feel more tired the more they sleep? [1:31:15];
Sleep apnea—How to know if you have it, the different types, the causes, and helpful resources [1:33:15]…
-
Qualy #46 - Rapamycin's effects on cancer, cardiovascular disease, and neurodegeneration
23 oktober 2019 · 8 min
Today's episode of The Qualys is from podcast #09 – David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#76 - Kyle Kingsbury: Finding meaning, depression, and psychedelics
21 oktober 2019 · 1 uur 42 min
In this episode, Kyle Kingsbury, retired UFC fighter and director of human optimization at Onnit, discusses the purpose and meaning that football and MMA gave him but which also acted as a distraction from his inner demons. Kyle opens up about his use of PEDs (steroids, testosterone, HGH) in college and talks about some of the misconceptions around them. Next, Kyle talks about his battle with depression and a close call with suicide that lead to life-changing experiences with psilocybin and ayahuasca—which really became the turning point in his own journey towards being more emotionally healthy, finding inner peace, and being a better husband and father. *DISCLAIMER: The substances spoken about in this episode are illegal and by no means are we advocating for anyone to use them or experiment with them. There are physical, physiological, psychological, and legal risks around the use of these plants. This conversation is purely informational only. Lees meer
We discuss:
Growing up in a volatile home [6:30];
Playing college football at ASU, and letting go of NFL aspirations [15:45];
Kyle's experience taking anabolics (steroids/testosterone), misunderstood science, and fear mongering [23:15];
Kyle's experience with taking HGH [35:30];
The Whizzinator [36:45];
Struggles with depression and drugs, and a lack of meaning after football [41:00];
Kyle's close call with suicide, and a spiritual experience [47:15];
Finding refuge with mixed martial arts, and Kyle's early success in cage fighting [52:30];
Lessons from Kyle's first loss in fighting, and training for the UFC [59:45];
First experiences with psilocybin and ayahuasca, quieting the monkey mind, and finding inner peace [1:07:15];
Overt vs. covert depression, depression in men vs. women, and the transition from adaptive to maladaptive behaviors [1:16:00];
Peeling back the layers with ayahuasca: Kyle tells stories about the most transformative experiences with psychedelics [1:19:00];
Does Kyle feel like he has lost h…
-
Qualy #43 - What are Peter's thoughts on fasting and ketosis for females?
17 oktober 2019 · 8 min
Today's episode of The Qualys is from podcast #26 – AMA #3: supplements, women's health, patient care, and more. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#75 - David Light: Zantac recall due to cancer concerns – what you need to know
14 oktober 2019 · 1 uur 38 min
In this episode, David Light, CEO of Valisure (the company which alerted the FDA to the Zantac cancer concerns), explains the story behind the recent recalls by manufacturers of ranitidine, a common heartburn medication, sold under the trade name Zantac, due to a potential link to increased cancer risk. David breaks down all the evidence, the role of his unique pharmacy company which tests all its drugs before being dispensed to consumers, and the reason behind the FDA's tempered reaction to the alarming study results. David makes the argument that Zantac/ranitidine is an inherently unstable molecule which explains the grossly excessive amounts of NDMA (a probable human carcinogen) as opposed to just a contamination for which there could be numerous causes. Finally, David and Peter both provide recommendations for what to do if you or someone you know is currently taking Zantac/ranitidine. Lees meer
We discuss:
The impetus for starting Valisure, a unique online pharmacy that tests all its medications [6:45];
The story behind the recall of valsartan, and the role which Valisure played [24:30];
Testing Zantac: The shocking results from Valisure's initial testing with major potential cancer implications [36:00];
NDMA - the probable human carcinogen found in Zantac/ranitidine [48:45];
The epidemiology question: Are we inferring too much from epidemiology? What can we take away from the existing studies? [53:30];
The staggering results from the 2016 Stanford study, why it didn't alarm more people, and how Valisure found the missing biological link [1:01:30];
Alerting the FDA, the FDA's tempered response, and question of contamination vs. inherent instability [1:07:30];
How confident is David that the elevated levels of NDMA being found in ranitidine are not due to instrumentation, human error, or temperature contamination? [1:24:15];
The massive risk being taken by the FDA by not doing more to keep ranitidine away from consumers [1:25:15];
If someone is taking Zantac/r…
-
Qualy #38 - Finding meaning in struggle and why we are less happy than ever (David Foster Wallace)
9 oktober 2019 · 7 min
Today's episode of The Qualys is from podcast #15 – Paul Conti, M.D.: trauma, suicide, community, and self-compassion. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#74 – Jason Fried: Optimizing efficiency and work-life balance
7 oktober 2019 · 2 uur 25 min
In this episode, Jason Fried, co-founder of Basecamp, shares his beliefs around achieving business success in a modern world which tends to disproportionately focus on the massive success stories (the outliers). Jason gives his honest take on companies like WeWork, Uber, and Lyft that may give off the appearance of wild success but may instead provide an example of the dangers of perverse incentives. We get into Jason's backstory, and how his affinity for optimizing efficiency and production in the workplace culminated with the creation of Basecamp, his very successful web-based project management software business. Perhaps most importantly, we get really deep into all aspects of work-life balance and what it really means to "work hard" (Stay tuned for an AMA-style deep dive into the topic of work-life balance with Jason in the near future). In addition, Jason provides many more valuable nuggets including thoughts on some common mistakes made by businesses today, the value of giving employees autonomy, how to take the right types of risks, why he doesn't set any goals, and much, much more. Lees meer
We discuss:
Jason's background and his early entrepreneurial spirit [9:45];
Views on completing higher education and the notion of hard work [24:00];
Beliefs around success in business [35:00];
WeWork, Uber, and Lyft: Poor business practices and the dangers of perverse incentives [41:30];
Jason's early career: his redesign approach and personal motivation [56:00];
The genesis of Basecamp [1:10:00];
Why Jason does not set goals but instead focuses on a vision [1:12:15];
Workplace motivation and hiring practice [1:20:30];
The importance of luck and not overworking [1:32:00];
A framework to work less and optimize for workplace autonomy [1:38:00];
The importance of saying 'no' more often (and tips for doing so) [1:55:00];
A shared passion for watches [2:03:30];
Guarding against the perils of phone addiction [2:08:45];
Jason's views on email and chat for communication […
-
Qualy #33 - How silent bravado and incessant striving can lead to a functional (and actual) death, and why Paul is critical of the current state of psychiatry
1 oktober 2019 · 9 min
Today's episode of The Qualys is from podcast #15 – Paul Conti, M.D.: trauma, suicide, community, and self-compassion. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#73 - AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and more
30 september 2019 · 16 min
In this "Ask Me Anything" (AMA) episode, Peter answers a wide range of questions from subscribers. Bob Kaplan, Peter's head of research, asks the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. Lees meer
If you're a subscriber, you can now listen to this full episode on your private RSS feed. You can also watch (or listen) to this full episode on our website at the AMA #9 show notes page.
Questions continue to be pulled from the AMA section on the website, and any subscriber is welcome to submit questions for future AMAs.
We discuss:
The story of how Peter almost worked for Theranos [2:00];
The trend of lower testosterone and higher estrogen in men: Why is it happening and what to do about it? [10:00];
Takeaways from Peter's recent hunting trip in Hawaii [14:45];
What books are you currently reading/listening to? [21:30];
What advice would you give to the 25 year-old Peter? [24:00];
What is your emergency protocol if you start getting sick? [27:45];
How have your thoughts changed on NAD precursors, and also on metformin, in the past year or so? [30:30];
What are your thoughts on "fat burning" zones for cardio workouts? — A lesson in relative vs. absolute fat combustion [34:15];
What mental models do you use and how do you go about solving problems and approaching difficult questions? [49:00];
Creatine supplementation—Yay or nay? Why? [49:30]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/ama09/
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
-
#72 - Dan Harris: 10% happier – meditation, kindness, and compassion
23 september 2019 · 2 uur 25 min
In this episode, Dan Harris, correspondent for ABC News and co-founder of the Ten Percent Happier meditation app, speaks openly about his struggles with self-centeredness, addiction, depression, emotional volatility, and the deep-rooted insecurities that drove him to career success. He tells the story of how a panic attack on live TV lead him down a path of self-discovery culminating in a meditation practice which has since transformed his life—in terms of his own personal suffering, his relationships with those closest to him, and his ability to be kind and compassionate (which has its own selfish advantages). Dan also shares some very practical advice and tips for new meditators, dispels some of the myths around meditation, and gives people some things to look forward to as they progress with their practice. Last but not least, we talk about the importance of not passing shame and trauma to our kids and the role that mindfulness and meditation plays in that. Lees meer
Dan's meditation book, and the panic attack on live TV that started it all [8:00];
Addiction: the spectrum of addiction, the socially acceptable forms, and Dan's own battle with addiction and depression [13:30];
Dan's drive for self-protection, a defining moment of childhood, and how his upbringing shaped him [20:30];
A selfish reason to be kind and compassionate [28:30];
Using mindfulness to avoid being controlled by your emotions such as anger and grandiosity [36:15];
How Dan found meditation, and how he went from skeptic to someone willing to try it [40:45];
Advice for new meditators, misconceptions about meditation, and the difference between changes in state vs. changes in trait [48:00];
Difference between being "mindful" versus being "present" [55:00];
The overlap between psychology and Buddhism, who is the real Buddha, and a Buddhism 101 lesson [57:45];
What convinced Dan to finally try meditation, and how did his first session go? [1:05:30];
Lessons from Dan's 10-day silent retreat: "You're…
-
Qualy #26 - What is Peter looking to achieve and monitor with his blood glucose monitor?
18 september 2019 · 13 min
Today's episode of The Qualys is from podcast #26 – AMA #3: supplements, women's health, patient care, and more. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#71 - Katherine Eban: Widespread fraud in the generic drug industry
16 september 2019 · 2 uur 42 min
In this episode, Katherine Eban, investigative journalist and author of Bottle of Lies, illuminates the prevalence of fraud in generic drug manufacturing which brings into question the idea that generics are identical to brand-name drug as we are lead to believe. Katherine walks us through how this widespread corruption came to be, including the shocking story of one particularly egregious (and unfortunately not uncommon) example of an Indian drug company, Ranbaxy, whose business model was completely dependent on falsifying data in their drug applications to the FDA. We then discuss the subsequent investigation into Indian and Chinese drug manufacturing plants which revealed that nearly 80% of them are tainted with fraud. We conclude this discussion on a positive note with i) how individuals can investigate their own drugs to protect themselves ii) an innovative pharmacy attempting to disrupt the market and iii) some ideas on how to reform to the regulations around generic drugs, the FDA, and more. Lees meer
We discuss:
How Peter found Katherine's book, and what convinced her to investigate the generic drug industry [5:45];
Branded vs. generic drugs: Why they aren't the same thing [11:15];
The Food and Drug Administration: Why it was originally created and what it does today [20:45];
How the generic drug industry really got its start in the U.S., and the flaw of the Hatch-Waxman Act [28:20];
PEPFAR: How a well-intentioned plan to help Africa with the AIDS epidemic laid the groundwork for corruption [36:30];
The story of Ranbaxy: An Indian drug company whose business model was fraud and deceit [40:45];
How the FDA approves drugs, the impact of "first to file", and Peter's tangent on moral corruption [47:30];
A booming generic drug market and the FDA struggling to keep up [57:15];
Dinesh's internal investigation finds widespread fraud and falsified data inside Ranbaxy [1:00:15];
Presenting the famous SAR document to Ranbaxy's board of directors which spells out the …
-
Qualy #24 - What are the "ABCs" of Alzheimer's prevention?
13 september 2019 · 11 min
Today's episode of The Qualys is from podcast #18 – Richard Isaacson, M.D.: Alzheimer's prevention. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#70 - David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD)
9 september 2019 · 2 uur 10 min
In this episode, David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, returns to the podcast to discuss the content of his new book, Lifespan: Why We Age - and Why We Don't Have To. This conversation focuses on the biological mechanisms involved in what David terms the Information Theory of Aging which provides insights into the "clock" that determines our aging and to what degree it can be manipulated. Our discussion on aging of course leads us into interconnected topics of epigenetics, sirtuins, cellular senescence, as well as what compounds David is personally taking for his own longevity. Additionally, we discuss the most up to date information related to NAD and longevity by looking at the potential benefits (if any) of supplemental agents (NAD precursors, NR, NMR, etc.) that pose a promise of increasing NAD. Lees meer
We discuss:
SIR genes and cellular identity [8:45];
Sirtuins regulate gene expression [14:30];
DNA is methylated at the deepest layer of the epigenome [17:45];
Methylation pattern and determining cellular age [20:15];
Cellular reprogramming [33:45];
Yamanaka factors to push cells "back in time" [41:00];
Human cellular reprogramming viability [57:00];
Measuring the rate of aging [1:02:45];
Cellular reprogramming for longevity [1:14:45];
Compounds David takes for his own longevity [1:29:15]
NAD precursors (NR, NMN) and pterostilbene [1:40:00];
The current field of sirtuin activators [2:03:15];
David's artistic work [2:05:15] and;
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode:https://peterattiamd.com/davidsinclair2/
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
-
Qualy #19 - A unifying theory of aging
5 september 2019 · 11 min
Today's episode of The Qualys is from podcast #27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#69 - Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly
2 september 2019 · 1 uur 59 min
In this episode, Dr. Ronesh Sinha, a physician, author, and educator based in Silicon Valley, shares his many insights into metabolic illness that he has gleaned from his South Asian patient population. In this conversation we focus on hyperinsulinemia, insulin resistance, metabolic dysregulation, inflammation, blood pressure, obesity, etc. and ways to address them with nutrition, sleep, exercise, stress management, and more. We also take a deep dive into insulin resistant phenotypes, evolutionary theory and geographic determinants of insulin resistance which provides insight into the genetic architecture and pathophysiology of metabolic syndrome. Additionally, we discuss the surprisingly interrelated topic of stress, and how we might be inadvertently passing this on to our children, leading to mental and physical sickness down the road. Lees meer
We discuss:
How a stubborn case of insulin resistance connected Peter with Ronesh [7:15];
Ronesh's clinical treatment focus of metabolic illnesses in South and East Asian patient populations [8:45];
The distinction between visceral fat and subcutaneous fat stores [15:00];
Shortcomings of a body mass index (BMI) calculator for evaluating metabolic disease risk [17:15];
Cortisol and blood glucose variability [28:30];
Insulin's role in elevated blood glucose: A symptom of metabolic syndrome [33:25];
Mechanistic explanations of insulin resistance (there may be more than one) [35:15];
Theories on origins and evolutionary reasons for insulin resistance [40:00];
The inverse relationship between the amount of brown adipose tissue and rates of insulin resistance, and the role of climate in patterns and prevalence of insulin resistance [49:50];
Vitamin D levels, hyperinsulinemia, and other effects [53:45];
The evolutionary benefit of being able to turn fructose into fat (and the price we are now paying for it) [58:00];
The VO2 max relationship to insulin resistance and familial metabolic health [59:30];
Using zone 2 fitness tes…
-
Qualy #16 - How much does cognitive activity ward off cognitive decline?
30 augustus 2019 · 7 min
Today's episode of The Qualys is from podcast #18 – Richard Isaacson, M.D.: Alzheimer's prevention. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#68 - Marty Makary, M.D.: The US healthcare system—why it's broken, steps to fix it, and how to protect yourself
26 augustus 2019 · 2 uur 50 min
In this episode, Marty Makary, Johns Hopkins surgeon and NYT bestselling author, discusses his ambitious attempt to fix the broken U.S. healthcare system through educating the public, changing the lexicon, encouraging radical transparency in pricing, and more. We go in detail into the main drivers of inflated health care costs, the money games being played making it hard to understand, and the unfortunate system structure that has resulted in one in five Americans finding themselves in medical debt collections which can ruin the lives of people and families seeking basic medical care. Marty also shares some very practical advice and tips if you find yourself a victim of predatory pricing and stuck with an outrageous medical bill. In the end, despite the current state of the system, Marty discusses the many exciting trends gaining traction in healthcare and why he is very optimistic and hopeful about the future. Lees meer
We discuss:
The science of delivering healthcare, how we need to do better as a system, and why no single person or entity fully to blame [10:15];
The stories that prompted Marty to write his first book (Unaccountable) [19:15];
The Surgery Checklist [26:15];
The problem is with the system (not any one person or entity) and the misaligned interests of all the parties involved [28:15];
Patients crave honesty and transparency, and the story of Peter's back surgery gone wrong [33:00];
Today's med students and young doctors have less tolerance for predatory pricing and healthcare industry BS [44:30];
Funny stories about John Cameron (legendary surgeon at Johns Hopkins) [48:00];
How doctors are trained to internalize traumatic experiences which can result in a misunderstood form of "burnout" [57:40];
The beat down of med students with traditional medical education and some exciting innovations to medical education [1:07:00];
Exciting trends in healthcare and an optimistic view of the future [1:11:30];
The Price We Pay (Marty's new book), an attempt to …
-
Qualy #9 - The importance of exercise for brain health
20 augustus 2019 · 9 min
Today's episode of The Qualys is from podcast #02 – Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and more. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#67 - AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more
19 augustus 2019 · 18 min
In this "Ask Me Anything" (AMA) episode, Peter answers a wide range of questions from subscribers. Bob Kaplan, Peter's head of research, asks the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. Lees meer
If you're a subscriber, you can now listen to this full episode on your private RSS feed. You can also watch (or listen) to this full episode on our website at the AMA #8 show notes page.
Questions continue to be pulled from the AMA section on the website, and any subscriber is welcome to submit questions for future AMAs.
We discuss:
Do DNA kits provide actionable info for cancer, CVD, diabetes, Alzheimer's, nutrition, or exercise? [1:45];
What genes increase longevity? And do those genes show up on genetic tests like 23andMe? [12:00];
Who are some people that Peter would like to have as guests on The Drive? [15:00];
Inflammation: Is CRP a useful marker? What can one do to reduce it? And what other inflammatory markers can I look at to gauge health? [18:30];
What lipid test does Peter now use on his patients? What are the three best cardiovascular laboratories? [28:00];
Metformin for longevity: What considerations should one think about before doing taking metformin for longevity purposes? [32:30];
What is Peter's take on salt and its role in things like high blood pressure and stomach cancer? [40:00];
What markers does Peter find most interesting (and surprising) during his quarterly fasts? [47:30]; and
More.
Learn more: https://peterattiamd.com/
Show notes page for this episode:http://peterattiamd.com/ama08
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
-
Qualy #6 - What are the best lab tests to request specifically for longevity
14 augustus 2019 · 10 min
Today's episode of The Qualys is from podcast #04 – AMA #1: alcohol, best lab tests, wearables, finding the right doc, racing, and more. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#66 - Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer's disease, and Parkinson's disease – do all roads lead to mitochondria?
12 augustus 2019 · 2 uur 28 min
In this episode, Dr. Vamsi Mootha, an expert in mitochondrial biology and investigator at the Howard Hughes Medical Institute, shares his breadth of knowledge on the mitochondrion organelle: its history, function, genome architecture, and his research of rare mitochondrial dysfunction. Vamsi is currently focused on finding clinical treatments for the 300-some identified rare disorders, but in this work there is a wealth of potential implications in the context of longevity and chronic disease. In this conversation, Vamsi elucidates how the latest research could give insight into conditions related to aging, including but not limited to Alzheimer's disease, Parkinson's disease, insulin resistance and type 2 diabetes, cancer, and much more. We also explore some of the most exciting potential therapies for mitochondrial diseases such as hypoxia (oxygen deprivation), how exercise affects the mitochondria, the use of hyperbaric chambers for cancer therapy, and the mechanisms by which Metformin might confer longevity benefits in a non-diabetic individual. Lees meer
We discuss:
The Broad Institute of MIT and Harvard [8:00];
Vamsi's academic background [10:30];
Advice for college students and med students considering a career in medicine and/or medical research [15:30];
Vamsi's focus on mitochondria and mitochondrial disorders [20:00];
The mitochondrial genome: Lineage, endosymbiosis, and reductive evolution [23:15];
How many diseases can be attributed to mitochondrial mutations? [28:45];
Nuclear DNA and mtDNA: Roles, interaction, communication, and biogenesis [31:30];
Which cells have the most mitochondrial DNA? And how often does mitochondria turn-over in a cell? [37:30];
Does ALL of your mitochondrial DNA come from your mother? [40:00];
Mitochondria 101: The powerhouse of the cell, electron transport chain, and the NADH/NAD ratio [44:00];
NAD and NADH: Role in the mitochondria, decline of NAD levels with age, and what it means to age at a mitochondrial level [51:30];
… -
Qualy #1 - What are Peter's thoughts on alcohol consumption and health?
6 augustus 2019 · 12 min
Today's episode of The Qualys is from podcast #04 – AMA #1: alcohol, best lab tests, wearables, finding the right doc, racing, and more. Lees meer
The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.
Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.
Learn more: https://peterattiamd.com/podcast/qualys/
Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/
Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD
-
#65 - Rick Doblin, Ph.D.: MDMA— the creation, scheduling, toxicity, therapeutic use, and changing public opinion of what is possibly the single most important synthetic molecule ever created by our species
5 augustus 2019 · 3 uur 1 min
In this episode, Rick Doblin, founder and executive director of MAPS, discusses MDMA, a molecule that has (at a minimum) revolutionary therapeutic benefits for PTSD, but arguably could have, at the highest order, a lasting impact on humanity's ability to peacefully coexist. Rick details the history of MDMA, what lead to its unfortunate criminalization, and his lifelong work trying to protect MDMA (and other psychedelics) from criminalization (and his subsequent attempt to decriminalize it). Through his founding of MAPS, Rick has made enormous progress in debunking many of the exaggerated risks being claimed against MDMA (neurotoxicity, memory loss, depression, Parkinson's, etc.), and is very close to getting FDA approval for a psychotherapy technique using MDMA. Additionally, in this discussion, you will learn about the history of LSD, psilocybin, and other psychedelics and how the combination of the misunderstanding of them with the crackdown on drug use in the 1970s lead to their designation of schedule 1 substances. But it's important to note that you will also realize from this discussion just how different MDMA is compared to the average psychedelic. We end this discussion with a message of hope: there are going to be many people who are going to wonder what can they do to receive this MDMA therapy. We talk about what those clinical trials look like, what the enrollment looks like, and perhaps more importantly, what a compassionate use license would look like, such that if there are patients who are in need of this therapy (prior to its approval) they can have an understanding of the legal paths to doing just that. Lees meer
We discuss:
Discovering MDMA, how Rick learned about it and his first experiences with it [9:45];
The timeline of MDMA's evolution, the reinvention in the 1970s, "ecstasy", the criminalization of MDMA [21:10];
Explaining the different "schedules" of drugs [30:55];
Rick's fight to protect it for therapeutic uses, losing to the DEA despite winnin…
-
#64 - Zol Kryger, M.D.: Navigating the sometimes shady world of plastic surgery—understanding potential complications of common procedures and how to reduce your risk by choosing the right doctor and asking the right questions
29 juli 2019 · 2 uur 13 min
In this episode, board-certified plastic surgeon, Zol Kryger, enlightens us about the frighteningly loose laws regulating the industry of plastic surgery, paving the way for a majority of cosmetic procedures being performed by doctors that are not board-certified plastic surgeons. We talk about some of the very serious complications that can occur even in "minimally invasive" procedures, where the incidence rate is only increased by the flood of non-certified doctors who want to offer these procedures to augment their income. Fortunately, Zol provides listeners with a very specific list of important questions to ask a surgeon when considering any of the many cosmetic procedures available. We then go into the specifics of the most common procedures and the risk of complications for each of them, including breast augmentation, tummy tucks, liposuction, Brazilian butt lifts, botox and fillers, facial peels and lasers, and more. By the end of this episode, you'll have a really clear understanding of what these risks are and how you can go about reducing those risks by choosing the right physician. Lees meer
We discuss:
Why Zol chose plastic surgery [7:30];
The shockingly high percentage of plastic surgery being done by non-board certified doctors, and the laws that allow it to happen [11:20];
10 Questions to Ask Your Cosmetic Surgeon (PDF Download) [21:00];
Complications: Why you must ask your doctor about potential complications and how they would deal with them [24:20];
Zol's first complication, how he dealt with it, and how having a partner to check your work is great for the doctor and patient [32:30];
Breast augmentation: What you need to know—types of implants, complication rates, and Zol's summary of the safest and most effective way to do it [39:10];
Breast reconstruction following a mastectomy [1:06:30];
Tummy tuck: How it's done, biggest risks involved, scarring, and how it can address hernias and diastasis [1:13:00];
Liposuction: How it works, the potential …
-
#63 - AMA #7: Exercise framework, deadlifting, lower back pain, blood pressure, nootropics, CGM, and more
22 juli 2019 · 13 min
In this "Ask Me Anything" (AMA) episode, Peter answers a wide range of questions from subscribers. Bob Kaplan, Peter's head of research, asks the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. Lees meer
If you're a subscriber, you can now listen to this full episode on your private RSS feed. You can also watch (or listen) to this full episode on our website at the AMA #7 show notes page.
Questions continue to be pulled from the AMA section on the website, and any subscriber is welcome to submit questions for future AMAs.
We discuss:
What can I do to prevent/reduce interruptions in sleep due to needing to get up to urinate at night? [3:00];
Peter's note card system for organizing his to-do lists [7:15];
How do I get smarter at reading/understanding the studies (or the media's interpretation of them) that get the headlines on health and/or disease? [11:15];
How can I obtain a continuous glucose monitor (CGM) as a non-diabetic individual? [11:55];
What is the most effective way to bring blood pressure down? [15:00];
Does Peter use any nootropics? [28:10];
Peter's thoughts pertaining to concussions and head trauma [33:00];
Does Peter structure his exercise plan for lifespan or healthspan? [36:45];
How did Peter rebuild his lower back strength after his devastating injury during med school? [38:15];
Peter's approach to deadlifting with a bad lower back [43:25];
Did Peter cave and buy a dog? [51:50]; and
More.
Learn more at www.PeterAttiaMD.com
Connect with Peter on Facebook | Twitter | Instagram. -
#62 - Keith Flaherty, M.D.: Deep dive into cancer—History of oncology, novel approaches to treatment, and the exciting and hopeful future
15 juli 2019 · 2 uur 57 min
In this episode, Keith Flaherty, director of clinical research and targeted cancer therapy at Massachusetts General Hospital, shares his vast wealth of knowledge in cancer starting with the history of treatment from chemotherapy to radiation to surgical therapy and where those methodologies seemed to have leveled off. He also walks us through the timeline of advancements (and lack there of) from when the War on Cancer was declared in the 1970s, through the sequencing of the entire human genome, and all the way to today. Keith dives into the topic of immunotherapy, probably the most exciting recent development in cancer therapy, and also provides us a rundown of his notion of a different approach to cancer that attacks all the essential pillars of cancer growth and survival. Finally, we talk a little bit about liquid biopsies, we discuss the roles of CRISPR and other potentially over-hyped therapies with respect to cancer. We also touch on stem cell therapy a bit, as well as some other common cancer-related questions such as the role of vitamin D and sun exposure in melanoma, and much more. Lees meer
We discuss:
Growing up around medicine, and finding a career that you love [7:30];
Medicine as a career, limitations of the med school teaching approach, and the dynamic and accelerating field of medicine and technology [16:30];
Explaining chemotherapy, radiation, and how a cancer develops [23:45];
Surgical oncology, cure rate of solid tumors, and survival rate after tumor removal [33:15];
25 years after the War on Cancer is declared, gene sequencing, and why Keith's was fascinated by the HIV case study [37:15];
Cancer immunotherapy: History, how it works, and why some cancers respond and others don't [46:00];
MHC complexes, and cancer cloaking mechanisms [56:00];
Comparative biology of cancer: Why some cancer can evade immune detection better than others [1:03:00];
What we learned from the Cancer Genome Atlas Project [1:07:00];
Defining targeted therapy, HER2 breast c…
-
#61 - Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiology
8 juli 2019 · 2 uur 13 min
In this episode, radiologist/engineer, Raj Attariwala, explains how he was able to apply his engineering background to create a unique MRI scanner that is capable of constructing whole-body images with a resolution that is unmatched in the industry. Peter and Raj discuss the implications of such a robust, radiation-free imaging tool on the early detection of cancer. They dive deep into cancer screening and define terms such as sensitivity and specificity that are necessary to really understand this complex space. They then describe the biggest risks involved in this type of screening (false positives) and how Raj's unique technology and process might drive down this risk substantially. But before that, they discuss all the common imaging technology from X-ray, to CT scan, to PET scans, to ultrasound, to MRI, and more. They touch on the history of each, how they work, the usefulness and limitations of each of them, as well as the varying risks involved such as radiation exposure. If you are interested in cancer screening and/or you've ever wondered how any radiology tool works, this episode is for you. Lees meer
We discuss:
Raj's road from engineering to radiology [7:45];
How X-ray works, the risk of radiation exposure, and the varying amounts of radiation associated with the different imaging technologies [18:00];
Computed tomography scans (CT scans): The history of CT, how it works, and why we use contrast [27:45];
Ultrasound: Benefits and limitations, and a special use for the heart [40:45];
Detecting breast cancer with mammography: When is works, when you need more testing, and defining 'sensitivity' and 'specificity' [51:15];
Magnetic resonance imaging (MRI): How it works, defining terms, and looking at the most common types of MRI [1:03:45];
Brain aneurysms: Using MRI to find them and save lives [1:23:45];
Raj's unique MRI technology [1:30:00];
The risk of false positives in cancer detection, and how Raj's MRI can reduce the number of false positives (i.e., in…
-
The one-year anniversary episode with Olivia Attia: Reflecting on the past year and looking forward to exciting times ahead
2 juli 2019 · 17 min
In this anniversary episode, Olivia, Peter's daughter who initially kicked off The Drive podcast with her sneak peek episode, returns to ask Peter the tough questions on how the podcast is going, what he has learned along the way (and how he plans to make it better), what exciting things are in store for the future, and plenty more. Lees meer