Alle afleveringen
290 afleveringen, van nieuw naar oud
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TWiP 90: A carbuncle is a large furuncle
30 mei 2015 · 2 uur 1 min
Vincent, Dickson, and Daniel discuss identification of an erythrocyte protein essential for invasion of Plasmodium falciparum, and introduce a new case study. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Dermatobia hominis (Wikipedia)
Plasmodium falciparum erythrocyte invasion (Science)
Plasmodium life cycle (TWiP #10)
Letters read on TWiP 90
Contact
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TWiP 89: Day TWiPers
16 mei 2015 · 1 uur 35 min
Vincent, Dickson, and Daniel reveal last week's case study and introduce a new one concerning a patient who traveled to Belize. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Neurocysticercosis (TWiP 6)
Cysticercosis (CDC)
Sarah Lane's neurocysticercosis
Letters read on TWiP 89
Contact
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TWiP 88: French foreign lesion
2 mei 2015 · 1 uur 54 min
Vincent, Dickson, and Daniel discuss how a secreted protein from the protozoan parasite Theileria transforms its host cells via a cellular proto-oncogene. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Leishmania (TWiP #14)
Transformation by a prolyl isomerase (Nature)
Theileria.org
Prolyl isomerase (Wikipedia)
Image from Transformation & Oncogenesis
Letters read on TWiP 88
Contact
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TWiP 87: Stumped by pinworm
21 april 2015 · 1 uur 17 min
Vincent, Dickson, and Daniel review new insight into antigenic variation in trypanosomes, reveal the difficult solution to the last case study, and present another mystery for your solving. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Pinworm (CDC)
Pinworm on TWiP #19
Dynamics of antigenic variation in T. brucei (Science)
Image credit
Letters read on TWiP 87
Contact
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TWiP 86: Worms Loa the immune response to mycobacteria
29 maart 2015 · 2 uur 5 min
Vincent, Dickson, and Daniel discuss how filarial infection modulates the immune response to mycobacterial infection, and reveal a new case study. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Filarial infection modulate immune response (J Immunol)
Memory T cells (Wikipedia)
Image: Loa loa microfilaria
Letters read on TWiP 86
Contact
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TWiP 85: Channeling tryps
14 maart 2015 · 1 uur 50 min
Vincent, Dickson, and Daniel explain how trypanolytic factor forms membrane channels to lyse trypanosomes, and present a new case study. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Human trypanolytic factor forms channels (PNAS)
Human paragonimiasis (MMWR)
Don't eat raw crawfish
Daniel and Dickson in studio (jpg)
Image credit
Letters read on TWiP 85
Contact
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TWiP 84: Bigfoot
28 februari 2015 · 1 uur 46 min
Vincent, Dickson, and Daniel consider the delivery of anti-trypanosome nanobodies to the tsetse fly via a bacterial symbiont, and present a new case study. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Delivery of a functional nanobody to tsetse flies (Microb Cell Fact)
Nanobodies (Wikipedia)
V.B. Wigglesworth (Wikipedia)
VB Nimble, VB Quick
Knott test
Mazzotti reaction
Image credit
Letters read on TWiP 84
Contact
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TWiP 83: Hidden costs of infection
23 februari 2015 · 1 uur 36 min
Vincent, Dickson, and Daniel present a new case study, and discuss the effect of chronic malaria infection on wild warbler life span and telomere degradation. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Effect of chronic malaria infection on wild warblers (Science)
Image credit
Letters read on TWiP 83
Contact
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TWiP 82: A NOD to helminths
7 februari 2015 · 1 uur 35 min
Vincent, Dickson, and Daniel solve last week's case study, present a new one, and reveal how secreted proteins from a helminth prevent diabetes in mice. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Babesiosis (CDC)
Babesiosis blood smear with Maltese cross (NEJM)
Helminth proteins prevent diabetes in mice (PLoS One)
Letters read on TWiP 82
Contact
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TWiP 81: Living in a wormy world
24 januari 2015 · 1 uur 40 min
Vincent, Dickson, and Daniel provide the solution to last week's case study, present a new one, and discuss how immune suppression by nematodes increases tuberculosis fatality in African buffalo. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Consequences of living in a wormy world (Am Nat)
Opposite effects of antihelminthic treatment on microbial infection (Science)
Send your case study solutions to twip@twiv.tv
Daniel's cufflinks (jpg)
Daniel's TB bowtie (jpg)
Image credit
Letters read on TWiP 81
Contact
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TWiP 80: Daniel in the parasites' den
8 januari 2015 · 1 uur 58 min
Vincent and Dickson welcome new TWiP host Daniel to discuss the association of a new Mycoplasma with Trichomoniasis, and to introduce a new feature to the show, a case study. Lees meer
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Links for this episode:
Association of Mycoplasma with trichomoniasis (PLoS One)
Biggest DNA genomes (Wikipedia)
Send your case study solutions to twip@twiv.tv
Letters read on TWiP 80
Contact
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TWiP 79: Across the river and into the trees
22 november 2014 · 1 uur 31 min
Vincent and Dickson discuss the spread of P. knowlesi in Malaysia, and how Leishmania parasites protect the sandfly gut from bacterial infection. Lees meer
Hosts: Vincent Racaniello and Dickson Despommier
Links for this episode:
Spread of P. knowlesi in Malaysia (NY Times)
Climate change in Europe and vector transmitted disease (Infez Med)
Colonisation resistance in the sandfly gut (Parasites & Vectors)
Car Talk co-host dies
Early Career Scientists Symposium
Image credit: Anne Marie
Letters read on TWiP 79
Contact
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TWiP 78: Eau de rodent
29 oktober 2014 · 1 uur 11 min
Vincent and Dickson discuss how malaria parasites induce odors in their rodent hosts that attract mosquitoes. Lees meer
Hosts: Vincent Racaniello and Dickson Despommier
Links for this episode:
Visceral Leishmaniasis, South Sudan (ProMedMail)
Malaria-induced changes in host odors (PNAS)
Image credit
Letters read on TWiP 77
Contact
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TWiP 77: Mixed messages
19 september 2014 · 1 uur 6 min
Vincent and Dickson discuss the exchange of messenger RNAs between a parasitic plant and its hosts. Lees meer
Hosts: Vincent Racaniello and Dickson Despommier
Links for this episode:
Exchange of mRNAs between parasite and plant (Science)
White leaf rust (Wikipedia)
Cuscuta (Wikipedia)
Fungal haustoria (PNAS)
Image credit
Letters read on TWiP 77
Contact
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TWiP 76: Herpesvirus worms its way out
2 september 2014 · 1 uur 24 min
Vincent and Dickson discuss how infection of mice with helminths induces cytokines that reactivate a latent gamma-herpesvirus. Lees meer
Hosts: Vincent Racaniello and Dickson Despommier
Links for this episode:
Helminths reactivate herpesvirus (Science)
How helminths go viral (Science)
Herpesvirus latency protects from bacterial infection (Nature)
Image credit
Letters read on TWiP 76
Contact
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TWiP 75: Parasite wonders with Bobbi Pritt
21 juli 2014 · 1 uur 9 min
Bobbi Pritt joins Vincent and Dickson to talk about directing a clinical parasitology laboratory and her weekly case reports at Creepy Dreadful Wonderful Parasites. Lees meer
Hosts: Vincent Racaniello and Dickson Despommier
Guest: Bobbi Pritt
Links for this episode:
Creepy Dreadful Wonderful Parasites
Letters read on TWiP 75
Contact
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TWiP 74: Nature has all the answers, what is your question?
4 juli 2014 · 1 uur 26 min
Vincent and Dickson review a novel malaria vaccine candidate comprising a parasite protein involved in egress from red blood cells. Lees meer
Hosts: Vincent Racaniello and Dickson Despommier
Links for this episode:
Egress protein a malaria vaccine candidate (Science)
Human proteins (Wikipedia)
Plasmodium genomics resource
Image: P. falciparum ring forms and gametocytes in blood
Letters read on TWiP 74
Contact
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TWiP 73: I'm nibbling my way back to you
13 juni 2014 · 1 uur 7 min
Vincent and Dickson discuss how nibbling of human cells by Entamoeba histolytica, a process called amoebic trogocytosis, contributes to cell killing and tissue invasion. Lees meer
Hosts: Vincent Racaniello and Dickson Despommier
Links for this episode:
Trogocytosis by E. histolytica (Nature)
Trogocytosis
Entamoeba histolytica (TWiP 17)
Entamoeba histolytica life cycle (jpg)
Image: E. histolytica nibbling a green cell (credit)
Letters read on TWiP 73
Contact
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TWiP 72: Wormholes
24 mei 2014 · 1 uur 41 min
Vincent and Dickson discuss five ways that helminths manipulate host tissues to survive. Lees meer
Hosts: Vincent Racaniello and Dickson Despommier
Links for this episode:
Wormholes in host defense (PLoS Path)
Lung coin lesion (Wikipedia)
Granuloma (Wikipedia)
Jar that Dickson is holding (jpg)
Letters read on TWiP 72
Contact
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TWiP 71: Happy trails to you
10 mei 2014 · 1 uur 24 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson review the finding that urocanic acid in the skin is a chemoattractant for the parasitic nematode Strongyloides stercoralis.
Download TWiP #71 (60 MB .mp3, 84 minutes).
Links for this episode:
Strongyloides stercoralis (TWiP #71)
Urocanic acid is a S. stercoralis chemoattractant (PNAS)
Chemical trails of parasites (PNAS)
Urocanic acid (Wikipedia)
Candiru (Wikipedia)
Your Inner Fish (PBS)
Letters read on TWiP 71
Contact
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TWiP 70: Invasion of the swamp eels
12 april 2014 · 1 uur 23 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss the finding of Gnathostoma nematodes in Asian swamp eels from US live markets and wild populations.
Links for this episode:
Guinea worm eradication at risk (Science)
Gnathostomiasis (CDC)
Asian swamp eel
Gnathostoma in live swamp eels (EID)
Interview with Rebecca Cole (YouTube)
Letters read on TWiP 70
Contact
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TWiP 69: Malaria rising
29 maart 2014 · 1 uur 14 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss an increase in the altitude of malaria distribution in warmer years in the highlands of Colombia and Ethiopia.
Links for this episode:
Altitudinal changes in malaria incidence (Science)
El Niño (Wikipedia)
NOAA El Niño page
Image credit: Science
Letters read on TWiP 69
Contact
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TWiP 68: Sex and the single trypanosome
8 maart 2014 · 1 uur 23 min
Hosts: Vincent Racaniello Dickson Despommier, and Sagi Shapira Lees meer
Vincent, Dickson, and Sagi discuss evidence that the pathogen Trypanosoma brucei undergoes meiosis and sexual reproduction.
Links for this episode:
Meiosis and haploid gametes in T. brucei (Curr Biol)
Meiosis (Wikipedia)
Letters read on TWiP 68
Contact
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TWiP 67: They find each other delightful
22 februari 2014 · 1 uur 16 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson explain the genetic and molecular basis of drug resistance in Schistosoma mansonii.
Links for this episode:
Basis of resistance to oxamniquine (Science)
Oxamniquine (Wikipedia)
Letters read on TWiP 67
Contact
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TWiP 66: A nitrile warhead for Chagas disease
8 februari 2014 · 1 uur 43 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss reversible inhibitors of cruzipain as new drugs for treating Chagas disease.
Links for this episode:
Reversible cysteine protease inhibitors for Chagas (AAC)
New drug candidates for Chagas (ScienceDaily)
Pancake ice (YouTube)
Letters read on TWiP 66
Contact
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TWiP 65: The real world wide web
13 januari 2014 · 1 uur 23 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson consider the effects of climate change on parasitic diseases.
Links for this episode:
Climate change and infectious diseases (Science)
The more parasites the better? (Science)
Host and parasite control disease risk (PNAS)
Parasites dominate food web links (PNAS)
The World Without Us by Alan Weisman
Image credit: PLoS One
Letters read on TWiP 65
Dickson's Pick
Neglected by Shelly Xie (YouTube)
Contact
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TWiP 64: Three new ways to prevent malaria
19 december 2013 · 1 uur 37 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson review three novel approaches to antimalarial chemotherapy.
Links for this episode:
Targeting PI(4)K to eliminate malaria (Nature)
Antimicrobial peptides to target sporogonic stages of malaria (PLoS Path)
Small molecule blocks malaria invasion of mosquito (PLoS Path)
Photo credit
Letters read on TWiP 64
Contact
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TWiP 63: Plasmodium of the apes
12 november 2013 · 1 uur 37 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss evidence that the malaria parasite originated in gorillas.
Links for this episode:
Great apes and zoonoses (Science)
Source of human malaria (PNAS)
Origin of human malaria parasite in gorillas (Nature)
Ape Plasmodium in Cameroon not infecting humans (PNAS)
No Plasmodium in greater spot-nosed monkey (Int J Parasit)
TWiP 13: Toxoplasmosis
Image credit
Letters read on TWiP 62
Contact
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TWiP 62: More bats out of hell
1 november 2013 · 1 uur 36 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss the high diversity of malaria parasites in West African bats, and a vaccine against hookworm.
Links for this episode:
High diversity of West African bat malaria parasites (PNAS)
Human hookworm vaccine (Vaccine)
Gongylonema infection in human (Am J Trop Med Hyg)
Letters read on TWiP 62
Contact
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TWiP 61: Some creep crept into the crypt and crapped
15 oktober 2013 · 1 uur 15 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson review examples of paleoparasitology, the detection of parasites in archaeological material.
Links for this episode:
T. rex had Trichomonas (PLoS One)
King Richard III had worms (CNN)
Discovery of toilets in Japan (Mem Inst Os Cruz)
Paleoparasitology in the Old World (Mem Inst Os Cruz)
Soils from Seoul (J Arachael Sci)
Ancient parasite infections in Old World (pdf)
Ascaris in coprolites (Mem Inst Os Cruz)
Human intestinal parasites in the past (Mem Inst Os Cruz)
Letters read on TWiP 61
Contact
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TWiP 60: Urine a game of cat and mouse
25 september 2013 · 1 uur 10 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss how infection with Toxoplasma gondii causes mice to lose their aversion to cat urine, even after the parasites have been cleared.
Links for this episode:
T. gondii in mice causes loss of aversion to cat urine (PLoS One)
Cyclosporiasis update (CDC)
Letters read on TWiP 60
Listener Pick
Blaine - The Worm Within
Contact
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Subscribe (free)
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TWiP 59: Apicomplexity
9 september 2013 · 1 uur 24 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson update the multistate outbreak of cyclosporiasis, discuss the avian malaria parasite P. lophurae, and review protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine.
Links for this episode:
Cyclosporiasis outbreak in US (CDC)
Extraordinary history of REV (PLoS Biology)
Avian malaria (Ann NY Acad Sci)
P. lophurae (J Parasitol)
TWiP infects TWiV (TWiV 248)
Intravenous malaria vaccine (Science)
Unconventional malaria vaccine (Science)
Image of apicomplexan structure: Wikipedia
Letters read on TWiP 59
Contact
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TWiP 58: People, parasites, and plowshares
9 augustus 2013 · 1 uur 34 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Guest: Cali Despommier
Vincent and Dickson update the multistate outbreak of cyclosporiasis, and Dickson reads a chapter from his new book.
Links for this episode:
Dickson and Cali (jpg)
Cyclosporiasis keeps spreading (ProMedMail)
Cyclosporiasis is not a virus! (Gawker)
Cyclosporiasis is not a virus! (Yahoo)
The Global Dispatch
People, Parasites, and Plowshares by Dickson Despommier
Letters read on TWiP 58
Contact
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TWiP 57: An outbreak of cyclosporiasis
20 juli 2013 · 1 uur 17 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson review a multistate outbreak of cyclosporiasis caused by the single-celled coccidian parasite Cyclospora cayetanensis.
The day after recording this episode, ProMedMail reported that the outbreak of cyclosporiasis had spread to Texas.
Links for this episode:
Cyclosporiasis (CDC)
Cyclospora life cycle (CDC)
Cyclosporiasis (Wikipedia)
Cyclosporiasis outbreak, US (one, two, three) (ProMedMail)
Cyclosporiasis outbreak moves to Texas (ProMedMail)
Notifiable diseases, US, 2011 (CDC)
Federal funding for science research (virology blog)
Oculus of Singapore (YouTube)
Dickson recording TWiP 57 (jpg)
Dickson's stuff (jpg)
People, Parasites, and Plowshares by Dickson Despommier
Letters read on TWiP 57
Contact
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TWiP 56: Whirling disease
3 juli 2013 · 1 uur 33 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss Myxobolus cerebralis, the parasite that causes whirling disease of salmonids.
Links for this episode:
Myxobolus cerebralis (Wikipedia)
Fish migration (Wikipedia)
Trout with whirling disease (YouTube)
Letters read on TWiP 55
Listener Pick
Amanda - Pandemic: On the Brink
Contact
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-
TWiP 55: A ladybird's weapon
15 juni 2013 · 1 uur 14 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson reveal how invasive harlequin ladybirds use biological weapons against their competitors.
Links for this episode:
Invasive Harlequin Ladybirds' biological weapon (Science)
Immunity an invasive success (Science)
Invading ladybugs carry bioweapons (C&EN)
Ladybird Ladybird (Wikipedia)
G. Evelyn Hutchinson (Wikipedia)
Letters read on TWiP 55
Dickson's Pick
An Inordinate Fondess for Beetles by Arthur V. Evans, Charles L. Bellamy
Listener Pick
Jessie - Pandemic, the board game
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv
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TWiP 54: Unde venis?
23 mei 2013 · 1 uur 26 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson consider a case history of a young man with Blastocystis hominis - is it causing his disease?
Links for this episode:
Blastocystis (Wikipedia)
Blastocystis review (Trends Parasitol)
Letters read on TWiP 54
Contact
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TWiP 53: Anti-saliva immunity
21 april 2013 · 1 uur 11 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss the finding that immunity to a sandfly salivary protein protects against fatal visceral leishmaniasis in hamsters.
Links for this episode:
Immunity to a salivary protein protects against leishmaniasis (PNAS)
Image of blood-fed Lutzomyia longipalpis (right) credit
Short history of Leishmania vaccines
Leishmania on TWiP #14
Letters read on TWiP 53
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv
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TWiP 52: Not your ordinary unsegmented roundworm
16 maart 2013 · 1 uur 10 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson review the life cycle and pathogenesis of the giant kidney worm, Dioctophyme renale.
Links for this episode:
Dioctophymiasis (CDC)
Dioctophyme renale (Wikipedia)
Fatal bilateral dioctophymiasis (J Parasitol)
Clinical Parasitology by Paul C. Beaver
D. renale in a dog (Vet. Parasitol.)
Surgical removal of D. renale (YouTube)
Letters read on TWiP 52
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv
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TWiP 51: Modifying mosquitoes with Anthony A. James
2 maart 2013 · 1 uur 12 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Guest: Anthony A. James
Special guest Anthony A. James joins Vincent and Dickson to discuss how mosquitoes can be genetically modified to control infectious diseases.
Links for this episode:
Field cage studies of modified mosquitoes (PLoS NTD)
Flightless mosquitoes (PNAS)
When mutant mosquitoes attack (NY Times)
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv
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TWiP 50: Antagonism in the mosquito midgut
16 februari 2013 · 1 uur 11 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson reveal how malaria parasites avoid lysis by complement in the mosquito.
Links for this episode:
Malaria parasites co-opt factor H (Cell Host Microbe)
Complement system (Wikipedia)
Letters read on TWiP 50
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv
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TWiP 49: Making sense of toxo and heme
26 januari 2013 · 1 uur 34 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss innate immune sensing of Toxoplasma gondii in mice, and heme metabolism in protozoan parasites.
Links for this episode:
Sensing Toxoplasma in mice (Cell Host Microbe)
Make it, take it, or leave it (PLoS Path)
Heme (Wikipedia)
Letters read on TWiP 49
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv
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TWiP 48: A parasitic cloaking device
19 december 2012 · 1 uur 7 min
Hosts: Vincent Racaniello, Dickson Despommier, and Josef Sabo Lees meer
Vincent, Dickson, and Josef discuss tetraspanins on the surface of schistosomes as vaccine candidates and immune evasion proteins.
Links for this episode:
S. japonicum tetraspanin-2 as a vaccine target (PLoS NTP)
Protection with S. mansoni tetraspanin-2 (PLoS NTP)
S. mansoni tetraspanins confer protection (Nat Med)
Tetraspanins
Letters read on TWiP 48
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv.
Subscribe (free)
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TWiP 47: For whom the trich tolls
28 november 2012 · 1 uur 9 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson review evidence that a virus of the protozoan parasite Trichomonas vaginalis may exacerbate disease.
Links for this episode:
Endobiont viruses sensed by the human host (PLoS One)
Letters read on TWiP 47
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv
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TWiP 46: Malaria gets the (zinc) finger
17 oktober 2012 · 1 uur 4 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson meet with Judith Straimer and Marcus Lee to discuss their method for site-specific genome editing in Plasmodium falciparumusing zinc finger nucleases.
Right-click to download TWiP #46 (46 MB .mp3, 64 minutes).
Links for this episode:
Judith Straimer and Marcus Lee
Genome editing in P. falciparum with zinc finger nucleases (Nature Methods)
Zinc finger nucleases (Sigma-Aldrich)
Gene-editing nucleases (Nature Methods)
Illustration by Andrew Lee
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv.
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TWiP 45: Free range Toxoplasma with John Boothroyd
26 september 2012 · 1 uur 1 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson discuss Toxoplasma biology with Stanford University Professor John Boothroyd.
Links for this episode:
T. gondii and free range animals
Kiss and spit: Toxoplasma rhoptries (Nat Rev Micro)
Toxoplasma cell invasion (Curr Opin Micro)
Loading of IRG onto parasitophorous vacuole (Cell Micro)
Toxoplasma gondii on TWiP #12
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv.
Subscribe (free)
Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email
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TWiP 44: Parasites provide a cricket subsidy for trout
8 september 2012 · 1 uur 20 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson explain how a nematode manipulates cricket behavior and alters the food web of a stream.
Links for this episode:
Nematomorph parasites alter food web of streams (Ecol Lett)
Manipulation of cockle behavior by a trematode (Parasitology)
Cockles infected by one parasite are more susceptible to a second (J Parasitol)
Letters read on TWiP 44
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv.
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TWiP 43: Two remarkable host-parasite conflicts
23 augustus 2012 · 1 uur 32 min
Vincent and Dickson review how sickle cell microRNAs contribute to malaria resistance, and inhibition of innate immune responses by an enzyme from trypanosomes. Lees meer
Links for this episode:
microRNAs involved in sickle cell resistance to Plasmodium (Cell Host Microbe)
Trypanosome adenylate cyclases modulate innate immune response (Science)
Letters read on TWiP 43
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv.
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TWiP 42: The tick keeps on ticking
10 augustus 2012 · 1 uur 15 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson answer listener emails about Leishmania, dual infection of vectors, tapeworms, liver flukes, toxoplasmosis, and much more.
Links for this episode:
Metabolic pathways required by Leishmania (Ann Rev Micro)
Tapeworms in people's brains (Carl Zimmer)
Poison Ivy
Bovine tuberculosis disguised by liver fluke (Nature)
Giant kidney worm (YouTube)
Crowd-sourced games for telepathology
Ivermectin for alcohol abuse
Ivermectin and alcohol abuse in mice (Neuropharm)
Etymology of Loa
Worm removed from man's eye (BBC)
Ticks keep on ticking (PLoS One article)
Letters read on TWiP 42
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv.
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TWiP 41: Flying and crawling beasts
27 juni 2012 · 1 uur 34 min
Hosts: Vincent Racaniello and Dickson Despommier Lees meer
Vincent and Dickson review medically important arthropods.
Links for this episode:
Thomas Eisner
Incomplete metamorphosis in insects (jpg)
Complete metamorphosis in an insect with aquatic immature stages (jpg)
Complete metamorphosis in an insect with terrestrial immature stages (jpg)
Letters read on TWiP 41
Contact
Send your questions and comments (email or mp3 file) to twip@twiv.tv.