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367 afleveringen, van nieuw naar oud
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316: Food Addiction and the Gut Microbiome
23 augustus 2024 · 56 min
TWiM describes experiments to explore gut microbiota signatures of vulnerability to food addiction in mice and humans, and how a phage tail-like protein suppresses competitors in populations of bacteria of plants. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episode
Gut microbiota and food addiction (Probiotics)
Blautia may have probiotic properties (Gut Microbes)
Blautia wexlerae ameliorates obesity and type 2 diabetes (Nat Commun)
Phage tail–like bacteriocin suppresses competitors (Science)
What is a bacteriocin? (Front Micro)
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315: How Pseudomonas Became A Global Pathogen
10 augustus 2024 · 58 min
TWiM explores evolution and host adaptation of Pseudomonas infections of plants, and the impact of COVID-19 on ESBL-producing E. coli on urinary tract and blood infections. Lees meer
Hosts: Vincent Racaniello and Michael Schmidt.
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Links for this episode
Evolution and host adaptation of Pseudomonas (Science)
Type III secretion system, infection by injection (Nat Comm)
Demographic inference with skyline plots (Peer J)
Skyline plots (Taming the Beast)
Panaroo, a bacterial genome analysis pipeline (Wellcome Sanger Inst)
Impact of COVID-19 on ESBL-producing E. coli infections (Antimicro Resist Inf Control)
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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314: Microbes Sculpt Our Planet and Manage Inflammation
27 juli 2024 · 53 min
TWiM explores the deep-dwelling microbes that sculpt our planet, and the use of microbes in bioelectronics to manage inflammation. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episode
Deep-dwelling microbes that sculpt our planet (NY Times)
Living bioelectronics resolve inflammation (Science)
Active biointegrated living electronics for managing inflammation (Science)
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313: Could Fungal Pathogens Outsmart US?
11 juli 2024 · 44 min
From ASM Microbe in Atlanta, Georgia, Arturo joins TWiM to reveal the threats that fungi pose to human health, including the notorious Candida auris and many more and how committed experts are researching ways to save us and our food supplies. Lees meer
Hosts: Michael Schmidt, Mark O. Martin
Guest: Arturo Casadevall
Watch this episode: https://youtu.be/nKJe5xNUocU
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Links for this episode
Disaster mycology (Biomedica)
Emergence of C. auris (mBio)
What if fungi win? (JHU Press)
Thinking about Science: Good Science, Bad Science, and How to Make It Better (Amazon)
Recorded at ASM Microbe 2024 in Atlanta, Georgia. Join us at the next ASM Microbe by visiting us at asm.org/microbe
Matters Microbial
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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312: Cry Havoc!, and Let Slip the Phages of Healing
28 juni 2024 · 53 min
TWiM explains a new mechanism for preventing lysogeny through temperate phage-antibiotic synergy, and Salmonella expansion in the murine gut dependency on aspartate derived from reactive oxygen species-mediated microbiota lysis. Lees meer
Hosts: Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episode
Temperate phage-antibiotic synergy (mBio)
Salmonella expansion dependent on aspartate (Cell Host Micr)
Arrowsmith by Sinclair Lewis (Wiki)
A Genetic Switch by Mark Ptashne
Lysis timing and bacteriophage fitness (Genetics)
HK97 capsid assembly (Ad Exp Med Biol)
Mode of action of fluoroquinolones (Drugs)
Salmonella a foodborne pathogen (CDC)
Freeman Hrabowski Scholars Program (HHMI)
Sam Kaplan - 30 years of Microbiology (McGovern Medical School)
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311: Bacteria, beware of siderophore-antibiotic hybrids
13 juni 2024 · 44 min
TWiM explores how climate change may be increasing our risks to infectious disease and then how the Odyssey literally comes alive in our microbial world but fear not, unlike the Trojans, the bacteria are fighting back and have developed resistance to this novel class of newly developed antimicrobials. Lees meer
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Links for this episode:
Environmental changes fueling diseases (NY Times)
Global change drivers and risk of infectious diseases (Nature)
First reported cefiderocol-resistant E. coli in Canada (Clin Micro)
E. coli cells explode (YouTube)
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to twim@microbe.tv
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310: Starvation vs Dehydration: Who Loses, Who Wins?
12 mei 2024 · 59 min
TWiM explores the plasticity of the adult human small intestinal stoma microbiota, and survival and rapid resuscitation that permit limited productivity in desert microbial communities. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episode
Plasticity of small intestinal stoma microbiome (Cell Host Micr)
Desert microbial communities (Nat Comm)
How soil microbes survive in the desert (Science Daily)
Negev Desert (WikiCommons)
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309: Stomach Acid Can Be Your Friend
27 april 2024 · 46 min
Today on TWiM, a charcuterie invasion, and how that acid in your stomach may protect from the invading hordes of microbes. Lees meer
Hosts: Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episode
2024 Salmonella outbreak linked to charcuterie meats
Multitier regulation of the E. coli extreme acid stress response by CsrA
Commentary: Peeling the onion: additional layers of regulation in the acid stress response
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308: Living in a Community World
13 april 2024 · 1 uur 7 min
TWiM reviews a case of E. faecium bacteremia treated with combination bacteriophage and antibiotic therapy, and how dopamine receptor D2 confers colonization resistance via microbial metabolites. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
Guest: Mark O. Martin
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Links for this episode
Matters Microbial
Distinct Fusobacterium dominates colorectal cancer (Nature)
Bacterial subspecies that might drive colon cancer (Nature)
A bacterial strain linked to colon cancer (Nature)
Spatial perspective on bacteria in tumors (Nature)
Colorectal cancer in the young (Yale Med)
Surface colonization by Flavobacterium johnsoniae promotes its survival (mBio)
THOR, a model microbiome (mBio)
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307: Attaching and Effacing on a Pedestal
30 maart 2024 · 50 min
TWiM reviews a case of E. faecium bacteremia treated with combination bacteriophage and antibiotic therapy, and how dopamine receptor D2 confers colonization resistance via microbial metabolites. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episode
Vincent's interviews at SXSW
Bacteriophage and antibiotic therapy for E. faecium bacteremia (mBio)
Dopamine receptor D2 confers colonization resistance (Nature)
CDC's Reports of Selected E. coli Outbreak Investigations
Brett Finlay's narrated EPEC animation
Colonization resistance by gut microbial metabolome (ACS Chem Biol)
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306: Spirulina Smoothies
16 maart 2024 · 53 min
TWiM discusses the identification of natural products from reconstructed ancient bacterial genomes, and how plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin.
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Links for this episode
Natural products from ancient bacterial genomes (Science)
Plant mRNAs move into fungal pathogens (Cell Host Microb)
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305: The Marvel of MAC
2 maart 2024 · 50 min
TWiM reviews the ongoing cholera outbreak in Africa, and research showing that gut complement induced by the microbiota blocks pathogens and spares commensal bacteria. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
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Links for this episode
Cholera in Southern Africa (Africa CDC)
Deadly cholera outbreak in Africa (NY Times)
Pediatric cholera in sub-Saharan Africa (Curr Op Ped)
Gut complement spares commensals (Cell)
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304: A New blue cheese-making fungus
17 februari 2024 · 58 min
TWiM reveals a new population in the blue cheese-making fungus Penicillium roqueforti and identification of a quorum-sensing autoinducer and siderophore in uropathogenic Escherichia coli. Lees meer
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Links for this episode
New blue cheese-making fungus (Evol Appl)
Threat to Camenbert cheese (Guardian)
French Cheese Under Threat (CNRS News)
Fungadapt project (YouTube)
Microbes Make the Cheese (ASM)
Yersiniabactin in uropathogenic Escherichia coli (mBio)
Public goods and cheating in microbes (Curr Biol)
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303: Can Our Microbiome Break Our Hearts?
3 februari 2024 · 57 min
TWiM reveals a database of genome sequences of thousands of Mycobaterium tuberculosis, allowing association with resistance phenotypes to 13 antibiotics, and microbe-derived uremic solutes that enhance thrombosis potential in the host. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Links for this episode
M. tuberculosis genomes and antimicrobial resistance (PLoS Biol)
The CRyPTIC consortium
BashTheBug
Zooniverse
Microbial solutes enhance thrombosis (mBio)
Can our microbiome break our heart? (mBio)
Pathogenesis of cardiovascular disease (EJIFCC)
How Kidneys Work Video (Mayo Clinic)
What is a metaorganism? (Zoology)
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302: Itching and Scratching and New Antibiotics
20 januari 2024 · 55 min
TWiM describes the mechanism for the S. aureus itch and scratch induced skin damage, and discovery of a novel class of antibiotics that targets the lipopolysaccharide transporter. Lees meer
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Links:
S. aureus drives itch and scratch behavior (Cell)
Staph scratches its itch (Cell)
A new class of antibiotics (Nature)
A new type of antibiotic (Nature)
Novel antibiotic targets LPS transporter (Nature)
New antibiotic traps LPS (Nature)
Macrocyclic peptide drugs (Science)
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to twim@microbe.tv
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301: Another Year is Microbial
3 januari 2024 · 47 min
A highly reduced TWiM team presents a study of the use of phage diversity in cell-free DNA to identify bacterial pathogens in human sepsis cases, and the evolution, persistence, and host adaptation of a gonococcal antimicrobial resistance plasmid that emerged in the pre-antibiotic era. Lees meer
Hosts: Vincent Racaniello and Petra Levin
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Links for this episode
Phages identify sepsis pathogens (Nat Micro)
Gonococcal AMR plasmid from pre-antibiotic era (PLoS Genetics)
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Music used on TWiM is by Ronald Jenkees.
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300: Marvels of Microbiology
17 december 2023 · 40 min
On the occasion of TWiM's 300th episode, we discuss how two college students found a new antibiotic in soil, Barbara Iglewski's passing, and Elio returns for an appearance. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
Guest: Elio Schaechter
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Links for this episode
Barbara Iglewski dies
Antimicrobial activity of P. nicotinovorans (MicroPubl Biol)
2 NWTC students found a new antibiotic in soil (Green Bay Press Gazette)
ESKAPE bacteria group (Clover)
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299: Teaching with TWiM
2 december 2023 · 51 min
From ASM's Conference for Undergraduate Educators 2023 in Phoenix, TWiM speaks with Amaya Garcia Costas and Gwendolyn Knapp about their approaches to undergraduate microbiology education, and how they use TWiM as part of their curricula. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.
Guest: Amaya Garcia Costas and Gwendolyn Knapp.
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Links for this episode
ASMCUE 2023
Teaching in the time of COVID-19 (J Microbiol Biol Edu)
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298: Impact of Lung Microbiome and Racial Disparities on Asthma
16 november 2023 · 1 uur
TWiM provides thoughts on providing better training for a non-academic career, and help celebrate Black in Microbiology Week with a 2023 paper by Ari Kozik, a co-founder of Black Microbiologists Association and Assistant Professor at the University of Michigan Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin,
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Links for this episode
Better training for a non-academic career (Nat Micro)
Nature career site
ASM career site
Prosper - Unlocking postdoc career potential
Airway microbiota in obesity and asthma (J Allerg Clin Immunol)
A vision for human microbiome research (mSphere)
Microbes in Models (ASM)
Climate change and microbes (ASM)
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297: Bacterial-electronic Sensor Pill
4 november 2023 · 59 min
TWiM reviews how a coating of lipoproteins provides a stabilizing environment on the inner membrane of Bacillus subtilis spores, and a miniaturized device that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip to track mediators of inflammation in the gastrointestinal tract Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin,
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Links for this episode
Lipoproteins stabilize germination apparatus (J Bacteriol)
A coating of liposomes (J Bacteriol)
Biosensor to detect inflammatory molecules in the gut (Nature)
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296: Bacterial Channels in Plant Cells
7 oktober 2023 · 47 min
TWiM discusses a dispute about whether the mycobiome plays a role in the development of cancer, and the structure and function of channels that are delivered to plant cells by pathogenic bacteria. Lees meer
Hosts: Vincent Racaniello, and Michael Schmidt.
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Links for this episode
Cancer microbes disputed (Carl Zimmer)
Fungal mycobiome and cancer (Nature)
Revisiting fungal mycobiome and cancer (Nature)
Bacteria deliver channels to plant cells (Nature)
Ice nucleation by bacteria (YouTube)
Gram-negative bacterial porins (Curr Protein Pept Sci)
Xenopus oocyte toolbox (Cold Spring Harb Protocols)
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295: Uncultured and Unmutable
22 september 2023 · 1 uur 7 min
TWiM explains how phages avoid tRNA-targeting host defenses, and discovery of a new antibiotic from an uncultured bacterium that binds to an immutable target. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin,
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Links for this episode
Phages avoid tRNA-targeting host defenses (eLife)
Sea phages
Actinobacteriophage database
New antibiotic from uncultured bacterium (bioRxiv)
The age of infection (For Policy)
Killing bacteria by teixobactin (Nature)
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294: You'll Scream After Ice Cream
8 september 2023 · 53 min
TWiM reveals that the ice cream manufacturing environment harbors psychrotrophic bacteria, and identification of a deadly bacterial strain causing widespread deaths of newborns in Uganda. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, & Michele Swanson.
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Links for this episode
Pyschrotrophic bacteria in ice cream plants (Appl Environ Micro)
Creamery pays fine for contaminated ice cream (US DOJ)
Paenibacillus infection of infants in Uganda (The Lancet)
Deadly bacterial strain identified (Yale SOM)
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293: Aerosol phage therapy, alpha-gal aptamers for MRSA
23 augustus 2023 · 1 uur 10 min
TWiM explains personalized aerosilized phage therapy for a chronic lung infection, and using the combination of antibiotic and a DNA molecule that binds alpha-gal to reduce S. aureus infection in vivo. Lees meer
Hosts: Vincent Racaniello and Michael Schmidt
Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email.
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Links for this episode:
Aerosolized phage therapy (Nat Comm)
Alpha-gal aptamer and vancomycin for MRSA (Microorg)
Alpha-gal syndrome (Front Allergy)
Natural antibody protects against viral infection (virology blog)
Oil pulling for improving oral health (Healthcare)
Music used on TWiM is by Ronald Jenkees.
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292: Breast Milk Bioactives
12 augustus 2023 · 59 min
TWiM reveals that breast milk bioactives are essential for development of the infant microbiome and immunity, and how capsule mutants of Klebsiella pneumoniae can affect bacterial pathogenesis. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin,
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Links for this episode
Diet-microbe-host interaction in early life (Science)
Human Milk: An Ideal Food (Front Ped)
Determinants of Diabetes in the Young (Ann NY Acad Sci)
Gut microbiome in early childhood (Nature)
Probiotics Infloran and Labinic
Cell envelope defects of Klebsiella pneumoniae (Mol Micro)
A cautionary tale (Mol Micro)
Global mortality associated with bacterial pathogens (Lancet)
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Music used on TWiM is composed and performed by Ronald Jenkees
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291: Biogeography of Tectonics and Teeth
29 juli 2023 · 1 uur 1 min
TWiM explains how photoferrotrophic bacteria initiated plate tectonics over 2500 million years ago, and how two bacteria work together to cause childhood tooth decay. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin,
Guest: Mark O. Martin
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Links for this episode
Bacteria initiated plate tectonics (Geophys Res Lett)
Medea hypothesis (Sci Am)
Earth's ferrous wheel (Nature)
The Great Dying (Nova)
The Great Oxidation Event (ASM)
Banded iron formations (EarthSphere)
S. sputigena and tooth decay (Nat Comm)
Acid tolerance mechanisms of S. mutans (Fut. Micro.)
Halitosis patients' tongue biofilm (Microbiol. Open)
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Music used on TWiM is by Ronald Jenkees
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290: Houston, We Have Mimi Goldschmidt
14 juli 2023 · 47 min
From ASM Microbe 2023 in Houston, TWiM speaks with Mimi Goldschmidt about her remarkable career in microbiology which included training astronauts to safely bring moon rocks back to Earth. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin.
Guest: Mimi Goldschmidt
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Links for this episode
Mimi Goldschmidt (Wikipedia)
Dr. Millicent "Mimi" Goldschmidt - Women in Microbiology (YouTube)
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Music used on TWiM is by Ronald Jenkees
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289: Viral Defense and Counter-Defense
30 juni 2023 · 58 min
TWiM highlights viral defense and counter-defense: cGAS mediated ubiquitination to counter infection, and viral sponges that sequester nucleotide signals to inactivate immunity. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin.
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Links for this episode
Ubiquitin-like conjugation by bacterial cGAS (Nature)
Jumpin' Jack Flash (TWiV 222)
Viral sponges inactivate anti-phage immunity (Trends Micro)
cGAS and CD-NTase enzymes (Curr Opin Struct Biol)
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Music used on TWiM is by Ronald Jenkees
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288: Cancer and E. coli
10 juni 2023 · 1 uur 7 min
TWiM describes a potential connection between a bacterial protein that damages DNA, and human cancers, and how to synthesize antimicrobial natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin
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Links for this episode
Colorectal cancer and E. coli (Nature)
Natural products from ancient bacterial genomes (Science)
Underexplored bacteria reservoirs of antimicrobial lipopeptides (Front Chem)
Fries With That Mammoth Burger? (Mother Jones)
25-40 million year old spores (Science)
250 million year old bacterium from salt crystal (Nature)
1918 influenza with Jeffery Taubenberger (TWiV 966)
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Music used on TWiM is by Ronald Jenkees
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287: When Replicas Do Not Replicate
20 mei 2023 · 51 min
TWiM investigates the high variability in the rate and amount of current production from microbial fuel cells, and how bacteria link their growth rate to external nutrient conditions via a protein that functions as a cellular rheostat. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin
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Links for this episode
Variability in microbial fuel cells (Appl Environ Micro)
Electrodes for microbial fuel cells (Chemosphere)
Microbial | electrochemical CO2 reduction (Joule)
Growth rate and cell wall precursors (Nat Micro)
Bacterial growth physiology (Front Micro)
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Music used on TWiM is by Ronald Jenkees.
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286: Integrons and Invasion
6 mei 2023 · 53 min
TWiM reveals environmental integrons, bacterial genetic elements notorious for their role in spreading antibiotic resistance, and how Salmonella invasion is controlled by competition among intestinal chemical signals. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Links for this episode
Environmental integrons (Trends Micro)
Integrons: agents of bacterial evolution (Nat Rev Micro)
Rethinking microbial infallibility in the metagenomics era (Fems Micro
Music used on TWiM is by Ronald Jenkees.
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285: How Plague Got Deadly
23 april 2023 · 1 uur 11 min
TWiM reveals a new type of satellite virus that requires only phage tails for producing infectious virus particles, and that highly virulent plague bacteria differs from its innocuous enteric predecessor by its resistance to lysis by human complement. Lees meer
Hosts: Vincent Racaniello and Michael Schmidt.
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Links for this episode
Viruses that steal bacteriophage tails (Cell Host Microbe)
Y. pestis not susceptible to human complement (Appl Environ Micro)
How Y. pestis got its pathogenic groove (Appl Environ Micro)
Risks of another pandemic (TedEd)
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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284: Flies, Pigs, and Squid
8 april 2023 · 55 min
TWiM reveals housefly dispersal of antimicrobial resistant bacteria, and a reproductive organ in squid linked to symbiotic bacteria. Lees meer
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Links for this episode
Housefly dispersal of antimicrobial resistant E. coli (Appl Micro Int)
Antibiotic use in farming (Nature)
Antimicrobial use in food producing animals (PLoS Glob Pub Health)
Reproductive organ linked to symbiotic bacteria (mBio)
Skype a Scientist
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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283: Quorum Sensing In The Gut
24 maart 2023 · 58 min
TWiM reveals quorum-sensing systems that regulate intestinal inflammation and permeability caused by P. aeruginosa, and how plasmids manipulate bacterial behavior through translational regulatory crosstalk. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin.
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Links for this episode
Quorum-sensing in the intestine (mBio)
Block quorum sensing, block biofilm (Antimicrob Agents Chemother)
Plasmids manipulate bacterial behavior (PLoS Biol)
Regulatory genes associated with integrative conjugative elements (J Bact)
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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282: At-home evolution with yeast
10 maart 2023 · 54 min
TWiM presents a protocol for evolving caffeine-tolerant yeast by high school students in the home, and how predator-prey dynamics change when multiple bacteria grow together in biofilms. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin.
Guest: Mark O. Martin
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Become a patron of TWiM.
Links for this episode
Caffeine-tolerant yeast selected at home (microPub Biology)
yEvo Lab
Vision and change in undergraduate biology (NAS)
CURE in a box (JMBE)
EvolvingStem
EvolvingStem: Evolution-in-action curriculum (BMC)
Spatial ecology of predation (PNAS)
Predatory bacteria: From curiosity to curative (Trends Micro)
Combating antimicrobial resistance with predatory Bdellovibrio (YouTube)
Bdellovibrio attacking E.coli (YouTube)
From one, many (YouTube)
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281: Microbes Making Jet Fuel
17 februari 2023 · 1 uur
TWiM explains the synthesis in bacteria of new energy-dense biofuels that can replace rocket and jet fuels, and the use of nanopore sequencing to improve diagnosis and treatment of patients with serious infections. Lees meer
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Links for this episode:
Biosynthesis of high energy biofuels (Joule)
Polyketide synthases in bacteria (PNAS)
Sequencing for diagnosis of serious infections (mBio)
Nanopore sequencing video (YouTube)
Emerging human pathogen Kodamaea ohmeri (Front. Micro)
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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280: They Forget To Divide
28 januari 2023 · 59 min
TWiM explains how magnesium modulates cell division frequency of a soil bacillus, and killing of fungi by Acinetobacter baumannii via a Type VI DNase Effector. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin
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Links for this episode:
•Magnesium modulates cell division frequency (J Bacteriol)
•A. baumannii kills fungi (mBio)Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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279: A Road Map For Successful Phage Therapy
13 januari 2023 · 1 uur 2 min
TWiM describes successful phage therapy against a mycobacterial lung infection, and how encapsulation of the cell wall protects S. pneumoniae from its major peptidoglycan hydrolase and host defenses. Lees meer
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Links for this episode:
Phage therapy against M. abscessus lung infection (Cell)
Encapsulation of the septal cell wall protects S. pneumoniae from host defenses (PLoS Path)
Letters read on TWiM 279
Music used on TWiM is by Ronald Jenkees.
Send your microbiology questions and comments to twim@microbe.tv
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278: Bacteria Sing The Blues
29 december 2022 · 59 min
TWiM explores the relationship between the gut microbiome and depressive symptoms, and how purine nucleotides act as adjuvants to antibiotics. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson
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Links for this episode:
Gut microbiota and depressive symptoms one and two (Nat Commun )
Microbiome influences depression (Phys.org)
Gut bacteria and depression (Med Press)
Mice behaving badly (TWiM 131)
Gut microbiome in ASD (Front Cell Inf Micro)
Transferring the blues (J Psych Res)
Nucleotides as adjuvants to antibiotics (mBio)
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to twim@microbe.tv
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277: To Stop or Not To Stop
8 december 2022 · 59 min
On this episode of TWiM, we reveal widespread stop-codon recoding in bacteriophages that may regulate translation of lytic genes, and how Staphylococcus aureus inhibits Pseudomonas aeruginosa growth. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
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Links for this episode
Stop codon recoding in bacteriophages (Nat Micro)
How S. aureus inhibits P. aeruginosa growth (J Bact)
S. aureus small colony variants (Front Cell Infect Micro)
Ken Timmis retires as journal editor (YouTube)
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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276: Bacterial Multicellularity Near An Underground Stream
24 november 2022 · 1 uur 7 min
TWiM presents evidence that over half of human pathogenic diseases are impacted by climate change, and considers how a novel prokaryote discovered next to an underground stream illuminates the pathway to multicellularity. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Mark Martin.
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Links for this episode
Climate change and pathogenic diseases (Nat Climate Change)
Impacts of climate change on human diseases (MoraLAB)
Cave bacteria illuminate pathway to multicellularity (eLife)
Commentary on novel cave bacteria (eLife)
Karst landscapes (National Park Service)
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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275: The Myth of Clonality
11 november 2022 · 1 uur 6 min
TWiM reveals high rates of co-transformation of plasmids in E. coli overturns the clonality myth, and bacterial membrane vesicles as a novel strategy for extrusion of the antimicrobial bismuth in H. pylori. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin
Links for this episode
The myth of clonality (Sci Rep)
Bacterial membrane vesicles extrude bismuth (mBio)
Gastric acid levels must decrease (World J Gastroenterol)
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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274: Bacterial Endosymbionts Block Giant Viruses
21 oktober 2022 · 58 min
Mark Martin returns to TWiM to join the discussion of how to design a complex gut microbiome, and protection of protists from virus infection by intracellular bacterial symbionts. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin
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Links for this episode
Design of a complex gut microbiome (Cell)
Defensive symbiosis against giant viruses (PNAS)
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Music by Ronald Jenkees.
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273: The Value of Wiping
30 september 2022 · 1 uur
TWiM reveals how to inactivate norovirus on formica surfaces, and how to achieve antibiotic resistance by suppression of a frameshift mutation in an essential gene. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin
Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email.
Become a patron of TWiM.
Links for this episode
Effect of wiping on norovirus inactivation (Appl Env Micro)
Chlorine dilution calculator (Ontario Pub Health)
Antibiotic resistance by frameshift suppression (PNAS)
Resistance to rifampicin (Nature)
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Music by Ronald Jenkees.
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272: Metabolism's Got Rhythm
17 september 2022 · 52 min
TWiM explores the activation of natural product synthesis using CRISPR interference in Streptomyces, and how light/dark and temperature cycling modulate Electron Flow in Pseudomonas aeruginosa biofilms. Lees meer
Hosts: Vincent Racaniello, Michele Swanson, and Petra Levin
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Links for this episode
Activating natural product synthesis (Nucleic Acids Res)
Light and temperature modulate biofilm electron flow (mBio)
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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271: Microbe vs Microbe
26 augustus 2022 · 1 uur 4 min
TWiM presents a novel mucosal COVID-19 vaccine based on a bacteriophage capsid, and potentiation of C. difficile infection severity by the gut bacterial community. Lees meer
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Links for this episode:
Bacteriophage based COVID-19 vaccine (mBio)
Gut microbiome potentiates C. difficile disease (mBio)
Letters read on TWiM 271
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to twim@microbe.tv
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270: Magnets and Salt Improve Plastics Production by Archaea
10 augustus 2022 · 53 min
TWiM explores the use of Archaea to produce plastics from molasses wastewater, and a bacterial defense against bacteriophage infection that involves depletion of deoxynucleotides. Lees meer
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Links for this episode
Improving plastics production by Archaea (Appl Environ Micro)
Biodegradability of PHA (Green Chem)
What does tesla mean for an MRI and its magnet? (GE)
Bacteria deplete nucleotides to block phages (Nat Micro)
Antiphage hotspots in bacteria (TWiM 265)
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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269: Bacterial But Not Microbial
22 juli 2022 · 1 uur 10 min
TWiM reviews discovery of a bacterium that is visible to the naked eye, and reversible resistance to bacteriophage by shedding of the bacterial cell wall. Lees meer
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Links for this episode
A bacterium that is not a microbe (Science)
Overwhelming microbial greatness (TWiM 261)
Medical illustrator Kellie Holoski
Bacteriophage resistance by shedding cell wall (Open Biol)
Who came first, monderms or diderms? (Nat Ecol Evol)
Letters read on TWiM 269
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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268: Aspergillus and Aspergillum
8 juli 2022 · 1 uur 6 min
TWiM discusses citizen science surveillance of drug-resistant Aspergillus in garden soil, and the mechanism of action of a copper dependent antibiotic. Lees meer
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Links for this episode
Fanny Hesse (Microbial Menagerie)
Citizen science surveillance of Aspergillus (App Envir Micro)
Aspergillum (Wikipedia)
DMDC, copper dependent antibiotic (Infect Immun)
National Summer Undergraduate Research Project
Letters read on TWiM 268
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
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267: The Honey Badger of Pathogens With Heran Darwin
24 juni 2022 · 47 min
From ASM Microbe 2022 in Washington, DC, Heran joins TWiM to discuss her career and her work on the agent of tuberculosis, Mycobacterium tuberculosis. Lees meer
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson
Guest: Heran Darwin
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Links for this episode
Honey badger of pathogens (EMBO Rep)
Pup-proteasome system (PNAS)
Cytokinin signaling in M. tuberculosis (mBio)
Bandwagoning (EMBO Rep)
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv