Alle afleveringen
367 afleveringen, van nieuw naar oud
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TWiM #166: Dark fermentation
7 december 2017 · 51 min
Vincent and Elio discuss the reason for poor efficacy of one of the influenza virus vaccines, and using a hyperthermophilic anaerobe to produce hydrogen from fruit and vegetable wastes in seawater. Lees meer
Hosts:
Vincent Racaniello and Elio Schaechter.
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Links for this episode
Glycosylation site on influenza H3N2 viruses (PNAS)
Biohydrogen production by Thermotoga (Waste Man)
Image credit
Letters read on TWiM 166
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #165: Pumping Copper
30 november 2017 · 1 uur 3 min
The TWiM team discusses the use of copper on exercise weights to reduce bacterial burden, and the mechanism of antigenic variation by which a fungus that causes severe pneumonia escapes the immune system. Lees meer
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson
Links for this episode:
Reducing bacteria on exercise weights with copper (Am J Inf Contr)
Antigenic variation in Pneumocystis jirovecii (mBio)
Letters read on TWiM 165
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TWiM #164: Indiana Quorum
16 november 2017 · 59 min
From Indiana University, Vincent speaks with Ankur, Julia, and Xindan about their careers and their work on horizontal gene transfer, quorum sensing, and chromosome organization in bacteria. Lees meer
Guests: Ankur Dalia, Julia Van Kessel, and Xindan Wang
Watch the video version! https://www.youtube.com/watch?v=ifGCe-qfnA0
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Links for this episode:
Dalia laboratory
Van Kessel laboratory
Wang laboratory
Indiana U Dept of Biology
Vibrio DNA uptake and chitin (Environ Micro)
Activation of quorum-sensing genes (Mol Micro)
Structural maintenance of chromosome complexes (Science)
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TWiM #163: Saliva and sptR/S
2 november 2017 · 1 uur 6 min
This episode is all about saliva: how certain bacteria survive in it, and how swallowing saliva might cause intestinal inflammation. Lees meer
Links for this episode:
Genes for the Streptococcus pyogenes fitness in human saliva (mSphere)
Swallowed bacteria drive colonic inflammation (Science)
Intestinal inflammation induced by oral bacteria (Science)
Human oral microbiome (J Bact)
T cell subsets (Nat Rev Imm)
Image credit
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TWiM #162: Intracellular bacteria with flagella
13 oktober 2017 · 53 min
The TWiM hosts and associated microbiomes review a fungus destroying salamanders in Europe, and genes for flagella in intracellular bacteria. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Fungus killing fire salamanders (Nature)
Chlamydia with flagella (ISME J)
Flagellar movement in rickettsia (PLoS One)
Image credit
Letters read on TWiM 162
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency's Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
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TWiM #161: Eros, a bacterial aphrodisiac
22 september 2017 · 56 min
From the TWiM team, a discussion of Hurricane Harvey microbiology, and a bacterial enzyme that induces eukaryotic mating. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
Tainted Houston floodwaters (NYTimes)
Peter Hotez on TWiP 29
FAQ: Microbiology of Built Environments, American Academy of Microbiology
Microbiomes of the Built Environment: A Research Agenda for Indoor Microbiology, Human Health, and Buildings, The National Academies of Sciences
Eukaryotic mating induced by bacterial enzyme (Cell)
Image credit: Arielle Woznica
Nicole King on TWiEVO 11
Letters read on TWiM 161
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency's Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
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TWiM #160: On the road to virus
8 september 2017 · 1 uur 7 min
The TWiM team provides an update on Zika virus, and reveals a plasmid on the road to becoming a virus. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, and Michele Swanson.
Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
Regional Zika update, Americas (PAHO, WHO)
FGCU, Zika (TWiV 454)
CDC Graphic of US zika cases as of May 2017
Archaeal plasmid travels cell to cell via vesicles (Nature Micro)
Letters read on TWiM 160
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency's Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
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TWiM #159: Immunophage synergy
31 augustus 2017 · 1 uur 1 min
The TWiM team pays a tribute to Chris Condayan, and investigates the synergy between virus and the innate immune system for clearing bacterial pneumonia by phage therapy.
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TWiM #158: The bottom line
10 augustus 2017 · 1 uur 5 min
The TWiM team considers a report on prokaryotic viral DNA in mammalian brain, and how diarrhea is beneficial, by clearing enteric pathogens. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
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Links for this episode
Prokaryotic viral sequence in the brain (PNAS)
Diarrhea clears enteric pathogens (Cell Host Microbe)
Tight junction biology (Turner Laboratory)
Letters read on TWiM 158
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #157: Back to the ancestor
27 juli 2017 · 57 min
The TWiMbionts explore the role of bacteria in the genesis of moonmilk, and how ancient host proteins can be used to engineer resistance to virus infection. Lees meer
Hosts:
Vincent Racaniello, Michele Swanson and Elio Schaechter.
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Links for this episode
Role of Streptomyces in moonmilk (bioRxiv)
TWiM 51: Cave science with Hazel Barton
Moonmilk (Wikipedia)
Ancient proteins for virus resistance (Cell Rep)
Image credit
Letters read on TWiM 157
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #156: Gifted microbes and defensive symbiosis
13 juli 2017 · 58 min
The TWiM team explains the use of microbial genome mining to identify new drugs, and how a bacterial symbiont protects flies against parasitoid wasps. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
Molecular beacons identify gifted microbes (J Antibiot)
Defensive symbiosis (PLoS Path)
Letters read on TWiM 156
Image
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #155: Living in the stomach of a cell
30 juni 2017 · 57 min
Michele updates the TWiMers on Legionella in the Flint water supply, and Elio informs us about how horizontally acquired biosynthesis genes boost the physiology of Coxiella burnetii. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
Legionella in Flint water (The Scientist)
Q fever with Robert Heinzen (TWiM Special)
Horizontally acquired genes boost C. burnetii (Front Cell Inf Micro)
Image credit
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #154: Rigor, lotteries, and moonshots
15 juni 2017 · 1 uur 14 min
At Microbe 2017 in New Orleans, the TWiM team speaks with Arturo Casadevall about his thoughts on the pathogenic potential of a microbe, rigorous science, funding by lottery, and moonshot science. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
Watch the video version recorded live at ASM Microbe 2017!
Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
Pathogenic potential of a microbe (mSphere)
Rigorous science (mBio)
Funding by lottery (mBio)
Moonshot science (mBio)
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #153: Covert pathogenesis
30 mei 2017 · 58 min
The TWiM team ventures into preprint space with an analysis of type VI secretion across human gut microbiomes, and provide insight into urinary tract infection: how bladder exposure to a member of the vaginal microbiota triggers E. coli egress from latent reservoirs. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.
Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Become a patron of TWiM.
Links for this episode
ASM Microbe 2017
TWiM Live from ASM Microbe 2017
Landscape of type VI secretion (BioRxiv)
Type VI secretion structure (jpg)
Activation of dormant E. coli in urinary tract infection (PLoS Path)
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #152: Wooden steps
19 mei 2017 · 51 min
The TWiMmers get cozy with symbionts: the bacteria that allow a giant shipworm to oxidize sulfur, and algae that live within salamander cells. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
ASM Microbe 2017
Chemoautotrophic symbiosis in giant shipworm (PNAS)
There's gold in them hills (TWiM 97)
Vertebrate-algal symbiosis (eLife)
Letters read on TWiM 152
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #151: Bat and moth antimicrobials
4 mei 2017 · 1 uur
The TWiMsters discuss potential new sources of antimicrobial compounds from unusual places: the skin of bats and the intestines of moths. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
JMBE science communication issue
Bat sources of novel antifungals (AEM)
White nose syndrome in US (jpg)
White nose syndrome fact sheet (pdf)
Symbiont-derived antimicrobials (Cell Chem Cell)
Bacteriocins (Wikipedia)
Letters read on TWiM 151
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #150: Microbiology is where it's at
21 april 2017 · 1 uur 1 min
In recognition of National Medical Laboratory Professionals Week, Robin Patel speaks with the TWiM team about directing a clinical bacteriology laboratory, and how an observation made by a laboratory technologist lead to the finding that Ureaplasma species can cause a system metabolic disturbance, hyperammonemia. Lees meer
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson
Guest: Robin Patel
Links for this episode:
National Laboratory Professionals Week
Mayo Clinic Clinical Microbiology Laboratory
Infectious Diseases Laboratory, Mayo Clinic
Murine model of Ureaplasma hyperammonemia (Eur J Clin Microbiol Infect Dis)
Ureaplasma and human hyperammonemia (Sci Transl Med)
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TWiM #149: You're going to learn R
6 april 2017 · 1 uur 3 min
The TWiM team speaks with Pat Schloss about assigning sequence data to operational taxonomic units, and his experience with mSphere Direct, a new way of submitting papers for publication. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
Special guest: Pat Schloss
Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
Schloss Laboratory
OptiClust (mSphere)
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Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #148: Neanderthal Dentistry
23 maart 2017 · 55 min
Vincent, Elio, and Michael reveal what Neanderthals ate from analysis of DNA in their teeth, and new CRISPR-Cas systems found in the genomes of uncultured microbes. Lees meer
Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt.
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Links for this episode
Ancient DNA in Neanderthal teeth (Nature)
New CRISPRs from metagenomics (Nature)
CRISPR/cas explained (Wikipedia)
ASM Conference for Undergraduate Educators
Image credit
Letters read on TWiM 148
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #147: The Public Goods Dilemma
10 maart 2017 · 1 uur 7 min
The TWiM hosts reveal why phosphorus is essential for fungal brain disease, and how bacteria kill local competitors to favor the evolution of public goods cooperation. Lees meer
Hosts:
Vincent Racaniello, Michele Swanson, Michael Schmidt, and Elio Schaechter.
Links for this episode
Phosphate needed for Cryptococcus brain disease (mSphere)
Type VI killing drives phase separation (Nat Rep)
Type VI secretion review (Phil Trans Roy Soc)
Microbial cooperation and conflict (TedX)
Image credit
Letters read on TWiM 147
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Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #146: Viral arbitrium
23 februari 2017 · 54 min
Vincent, Elio and Michael discuss the finding of a prion in bacteria, and how communication between bacteria guides the decision between lysis and lysogeny. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, and Elio Schaechter.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
ASM 2017 Election is Open! VOTE HERE
Prions in bacteria (Science)
Communication guides lysis-lysogeny decisions (Nature)
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim
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TWiM Special: Q fever with Robert Heinzen
16 februari 2017 · 1 uur 5 min
Host: Vincent Racaniello Lees meer
Guest: Robert Heinzen
At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Robert Heinzen about the work of his laboratory on Q fever and its causative microbe, Coxiella burneti.
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Links for this episode
Rocky Mountain Laboratory
Heinzen Laboratory
Small town, big science (TWiM 140)
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to twim@microbe.tv
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TWiM #145: Anything but academic
10 februari 2017 · 1 uur 3 min
Vincent meets up with Catharine Bosio, Michael Merchlinsky, and Shilpa Gadwal at the ASM Biothreats meeting to talk about careers for scientists outside of the ivory tower. Lees meer
Become a patron of TWiM.
Links for this episode:
ASM Biothreats 2017
Rocky Mountain Laboratory
BARDA
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TWiM #144: Did eukaryotes invent anything?
26 januari 2017 · 1 uur 6 min
The TWiMers discuss how changes in domestic laundering affect the removal of microorganisms, and assembly of a nucleus-like structure during viral replication in bacteria. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
Laundry hygiene (J Appl Micro)
Nucleus-like structure in infected bacteria (Science)
Video of nucleus assembly in bacteria (YouTube)
Image credit
Letters read on TWiM 144
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #143: E-scaffolds and receptor transfer
12 januari 2017 · 1 uur 6 min
Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, and Michele Swanson.
Right click to download TWiM#143 (32 MB .mp3, 66 minutes).
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
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Links for this episode
Electrochemical scaffold to eliminate persistent biofilms (npj Biofilms Microbiomes)
Experimental setup for electrochemical treatment of biofilm (pdf, from article)
Acquisition of phage sensitivity by transfer of cell receptors (Cell)
Image credit
Letters read on TWiM 143
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Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #142: A membrane-thickness caliper
29 december 2016 · 59 min
Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness. Lees meer
Hosts:
Vincent Racaniello, Elio Schaechter, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Phenylpyrroles: Nearly no resistance (Front Micro)
Membrane-thickness caliper (J Bact)
Letters read on TWiM 142
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv
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TWiM #141: Nutritional immunity and polymicrobial infections
16 december 2016 · 1 uur 6 min
Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity. Lees meer
Hosts:
Vincent Racaniello, Elio Schaechter, and Michael Schmidt.
Guest: Jennifer Bomberger
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Links for this episode
Virus dysregulation of nutritional immunity (PNAS)
Podcast article mentioned by Michael
Compromised defenses (PLoS Path)
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TWiM 140: Small town, big science
1 december 2016 · 1 uur 20 min
Host: Vincent Racaniello Lees meer
Guests: Marie Antonioli, Bryan Hansen, Forrest Jessop, Kyle Shifflet and Jim Striebel
At the Hamilton, Montana Performing Arts Center, Vincent speaks with three local high school graduates and two high school teachers about how Rocky Mountain Laboratories influenced school science programs and opened up career opportunities.
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Links for this episode
Poster of this event (jpg)
Rocky Mountain Laboratories
Hamilton, MT high school
Video of this episode on YouTube
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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to twim@microbe.tv
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TWiM #139: Frackibacter and sticky fingers
18 november 2016 · 1 uur 11 min
The TWiM team discusses microbial DNA found on ATM machines in New York City, and how hydraulic fracturing, or fracking, alters microbial ecosystems deep in the Earth. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Microbial DNA on ATM machines in NYC (mSphere)
NYC OpenData
Altering deep microbial ecosystems by fracking (Nat Micro)
Marcellus Shale Energy and Environment Laboratory
Chemicals used for fracking (FracFocus)
Marcellus and Utica shale formation map
Consequences of fracking (GasBuddy)
Image credit
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #138: Learning to love uranium and the A-baum
3 november 2016 · 1 uur 2 min
The TWiM team brings you a bacterium from a Colorado field site that grows on uranium, and copper resistance in the emerging pathogen Acinetobacter baumannii. Lees meer
Hosts:
Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Kavli Microbiome Ideas Challenge
Uranium-respiring bacterium from a field site (PLoS One)
Acid mine drainage (Wikipedia)
Copper resistance of Acinetobacter baumannii
ASM Grant Writing Online Course
TWiM #132: Bacteria learn long division
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This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #137: The battle for oxygen
20 oktober 2016 · 1 uur 9 min
Highlights of the Recent Advances in Microbial Control meeting in San Diego, and expansion of a gut pathogen by virulence factors that stimulate aerobic respiration. Lees meer
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Fred Neidhardt obituary
Recent Advances in Microbial Control
Science hero Bill Fenical
Virulence factors and aerobic respiration (Science)
Image credit
Letters read on TWiM 137
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #136: Diderms and then monoderms
7 oktober 2016 · 49 min
Them TWiM team discusses the importance of neutrophils in microbial infections, and evidence that ancient bacteria had two cell walls. Lees meer
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Conquering neutrophils (PLoS Path)
Ancestral outer membrane in firmicutes (eLife )
Were gram positive rods the first bacteria? (Cell)
Image credit
Letters read on TWiM 136
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
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Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #135: Unruly individuals and their unruly friends
23 september 2016 · 1 uur 7 min
Links for this episode Lees meer
Dysbiosis of microbiome in critical illness (mSphere)
Consequences of sewage spill into aquatic environment (App Env Mic)
EPA recreational water guidelines (pdf)
VRE following sewage spill (Outbreak Radio)
FAQ: Human microbiome
American gut project
British gut project
Rob Knight on human microbiome (TED)
Rob Knight on TWiM
Image credit
TWiM 135 Letters
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #134: Lipids that live forever
8 september 2016 · 1 uur 4 min
Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM. Lees meer
Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Bacterial lysis for in vivo delivery (Nature)
Coley's toxins (Iowa Orthop J)
Hopanoids, stress tolerance, and nutrient storage (Geobiol)
Lipids that last forever (STC)
Fattening up microbial geological biomarkers (STC)
Money spreads infection (Fut Micro)
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #133: Right under our noses
20 augustus 2016 · 1 uur 1 min
Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM. Lees meer
Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Cryo-EM of viruses and vaccine design (PNAS)
Atomic structure of rhinovirus C (PNAS)
Opening windows into the cell (STC)
Human commensals produce novel antibiotic (Nature)
The nose knows (Nature)
Letters read on TWiM 133
Image in audio player: Molecular surface of a Human rhinovirus, showing protein spikes. By: Wiki user: Robin S
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #132: Bacteria learn long division
6 augustus 2016 · 57 min
Vincent, Elio, and Michele present cell division by longitudinal scission in an insect symbiont, and thermally activated charge transport in microbial nanowires. Lees meer
Hosts: Vincent Racaniello, Michele Swanson and Elio Schaechter.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Cell division by longitudinal scission (mBio)
Bacterium learns long division (STC)
Charge transport by microbial nanowires (Sci Rep)
Mechanism of nanowire conductance (Nat Comm)
Using nature to grow batteries (TED)
SEM of Y-shaped S. poulsonii (above) - Image credit
Extracellular electron transport (below) - image credit
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM 131: Mice behaving badly
20 juli 2016 · 1 uur 22 min
Hosts: Vincent Racaniello and Michael Schmidt Lees meer
Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.
Links for this episode
Protein secretion in E. coli (J Bacteriol)
Plague pathogenesis (J Bacteriol)
Reversal of diet induced social defects (Cell)
Letters read on TWiM 131
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments to twim@microbe.tv
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TWiM #130: Interkingdom interactions at ASM Microbe
24 juni 2016 · 1 uur 17 min
Filmed live in Boston, MA at Microbe 2016, David S. Schneider and Vanessa Sperandio talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover. Lees meer
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TWiM #129: Dried and wrinkled, smooth and mucoid
7 juni 2016 · 1 uur 11 min
The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele. Lees meer
Image: Etest used to determine the minimum inhibitory concentration of an antibiotic for a particular bacterium.
Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
E. coli with mcr-1 on a plasmid in the US (AAC)
Emergence of plasmid mediated colistin resistance in China (The Lancet)
Major breach in last line of defense (The Lancet)
Resistance plasmid families in Enterobacteriaceae (AAC)
EUCAST MIC breakpoints (ClinCalc)
Role of ASM in microbial resistance one, two (bLogphase)
Quorum sensing in fungi (Cell Host Microbe)
Image credit
Letters read on TWiM 129
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #128: A moonlighting phage protein
21 mei 2016 · 1 uur 18 min
A eukaryote without a mitochondrion, and using a phage enzyme to eliminate intracellular bacteria are two topics discussed by the TWiMers on this episode. Lees meer
Image (right): An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one of the TWiM hosts.
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Copper and Michael Schmidt in the news (The Scientist)
Fair Pay for Postdocs (Huff Post)
National Microbiome Initiative (White House)
The shrinking mitochondrion (The Scientist)
Eukaryote without a mitochondrion (Curr Biol)
Why have organelles retained genomes? (Cell Sys)
Bugs as drugs (Amer Acad Micro)
Phage encoded lysin eliminates intracellular bacteria (eLife)
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #127: Subway Snowblowers and Men in Black
5 mei 2016 · 54 min
The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease. Lees meer
Image (right): Photograph of the 'Subway' snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white 'snow' in the vent and orange floc on the seafloor. Credit: Canadian Scientific Submersible Facility and the University of Washington
Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Happy Birthday, Elio!
In the Company of Microbes
Snowblower vents (Front Micro)
Deep-sea snowblower vents video (YouTube)
Visions 11 cruise photos
Mycoplasma capture and cleave IgG (PNAS)
Snowblower image (large)
Letters read on TWiM 127
This episode is sponsored by ASM Agar Art Contest and ASM Grant Writing Course
Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv
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TWiM #126: I'm not scared of zebrafish and mice and bears (oh my!)
22 april 2016 · 1 uur 7 min
The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele. Lees meer
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Microbiome of hibernating brown bear and energy metabolism (Cell Rep)
Ten animals that hibernate (Cons Inst)
Zebrafish model of sepsis (mSphere)
Image credit
Letters read on TWiM 126
This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016
Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
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TWiM #125: A minimal cell operating system
8 april 2016 · 58 min
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. Lees meer
A deep sequencing study of commercially available probiotics, and design and synthesis of a minimal bacterial genome are the topics tackled by Vincent, Michael, and Michele on this episode of TWiM.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Culture-independent surveillance of probiotics (mSphere)
Design and synthesis of a minimal bacterial genome (Science)
J. Craig Venter Institute
Image credit
Letters read on TWiM 125
This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016
Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
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TWiM #124: Fungal pirates
24 maart 2016 · 1 uur 3 min
Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. Lees meer
Vincent, Michael, and Michele reveal how a fungal protease blunts the innate immune response and promotes pathogenicity.
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Michele on Flint Legionella outbreak (Detroit News)
Fungal mimicry of a mammalian aminopeptidase (Cell Host Micr)
This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016
Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
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TWiM #123: A microbial MAGE
9 maart 2016 · 1 uur 15 min
Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Lees meer
Guest: Harris Wang
Harris joins Vincent, Elio, and Michael to describe multiplex automated genome engineering, a method for targeting many modifications in a population of bacterial cells.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
MAGE - Multiplex automated genome engineering (Nature)
Genome-scale promoter engineering (Nat Methods)
Manipulating microbial communities in situ (Trends Genet)
Engineering human microbiomes (Meth Mol Biol)
Genome-scale engineering (Mol Syst Biol)
Economic framework of microbial trade (PLoS One)
Tardigrade t-shirt
Image credit
This episode is sponsored by Microbe Magazine Podcast and ASM Microbe 2016
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.
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TWiM #122: Mayonii, microRNAs and the microbiome
25 februari 2016 · 1 uur 4 min
Vincent, Michele, and Michael reveal the discovery of a new species of the spirochaete that causes Lyme disease, and fecal microRNAs that shape the gut microbiome. Lees meer
Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Identification of a novel Borrelia species causing Lyme disease (Lancet Inf Dis)
Parasite wonders with Bobbi Pritt (TWiP 75)
Reported cases of Lyme disease (CDC)
Signs and symptoms of Lyme disease (CDC)
Multilocus sequence typing
Borrelia MLST database
American Academy of Microbiology FAQ Human microbiome
Host fecal microRNA shapes gut microbiota (Cell)
Image credit
C.U.R.E. the game
Live Tiny, Die Never - Tardigrade T-shirt
This episode is sponsored by Microbe Magazine Podcast and ASM Microbe 2016
Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
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TWiM #121: A plague of pathogens
11 februari 2016 · 58 min
Host: Vincent Racaniello Lees meer
Special guests: Rebekah Kading and Wyndham Lathem
From the ASM Biodefense and Emerging Diseases Research meeting, Vincent speaks with Rebekah and Wyndham about their work on Rift Valley Fever virus and other vector-borne pathogens, and the evolution and pathogenesis of Yersinia pestis, the agent of plague.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Rift Valley fever virus risk (Emerg Micr Inf)
Predicting Rift Valley fever virus transmission (PLoS NTD)
Culex in New York City (BioOne)
Early emergence of Y. pestis (Nature Comm)
Pneumonic plague (Trends Micro)
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
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TWiM #120: Snakes in trouble
2 februari 2016 · 49 min
Hosts: Vincent Racaniello and Elio Schaechter. Lees meer
Vincent and Elio marvel in the finding that a phage tail-like structure from a marine bacterium stimulates tubeworm metamorphosis, and reveal Ophidiomyces as a cause of snake fungal disease.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Tubeworm metamorphosis by phage tail-like structures (Science)
Cell enzyme becomes viral capsid protein (virology blog)
Snake fungal disease in the laboratory (mBioi)
Snake fungal disease in cottonmouths (PLoS Biol)
Snake fungal disease (pdf)
Image credit
This episode is sponsored by ASM Grant Writing Institute Online Webinar and 32nd Clinical Virology Symposium
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.
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TWiM #119: Power of one
16 januari 2016 · 1 uur 3 min
Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Lees meer
The microbophiles investigate the ratio of bacterial to human cells in our bodies, and how placing solar panels on a bacterium enables it to carry out photosynthesis.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Revised estimates of human and bacterial cells in the body (biorxiv)
Power of ten (Small Things Considered)
Solar-to-chemical production in bacteria (Science)
Letters read on TWiM 119
This episode is sponsored by ASM Grant Writing Institute Online Webinar and 32nd Clinical Virology Symposium
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.
Thumbnail image: Cell structure of a gram positive bacterium. This vector image is completely made by Ali Zifan - Own work; used information from Biology 10e Textbook (chapter 4, Pg: 63) by: Peter Raven, Kenneth Mason, Jonathan Losos, Susan Singer · McGraw-Hill Education.
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TWiM #118: Spore-drops keep fallin' on my head
1 januari 2016 · 1 uur 6 min
Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson Lees meer
On the last episode for 2015, Vincent, Elio, and Michele discuss how soil amoeba hunt nematodes in packs, and the role of mushrooms as rainmakers.
Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.
Links for this episode
Pack hunting by a common soil amoeba on nematodes (Environ Micro)
Mushrooms as rainmakers (PLoS One)
Mushroom by Nicholas Money
In the Company of Mushrooms by Elio Schaechter
Image credit
Letters read on TWiM 118
This episode is sponsored by ASM Microbe 2016 and ASM Biodefense
Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.
Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.