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364 afleveringen, van nieuw naar oud
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Ep. 333: “Shaping Cell Fate” Featuring Drs. Anupama Hemalatha and Verena Schwach
27 oktober 2026 · 1 uur 7 min
Guest: Lees meer
This special episode, created in partnership with the ISSCR Early Career Advisory Committee, features two rising leaders in stem cell research. Dr. Anupama Hemalatha, a Junior Group Leader at the Friedrich Miescher Institute for Biomedical Research, discusses how cellular metabolism shapes stem cell behavior, tissue homeostasis, and responses to cancer-associated mutations. Dr. Verena Schwach, an Assistant Professor at the University of Twente, explores how stem cell-derived tissues and organ-on-chip technologies can model heart–brain interactions and advance disease modeling and drug safety testing.
If you’d like to nominate yourself or a colleague for our Early Career Researcher Series, submit your nomination here.
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The Stem Cell Science Round Up
Mapping Early Human Organogenesis – Spatial transcriptomic and metabolomic profiling maps early human organ development, revealing distinct cell populations and molecular programs involved in tissue specification.
Totipotent-Like Cells Recreate Mouse Embryogenesis – Chemically induced totipotent-like stem cells generate self-organizing mouse embryo models that progress through gastrulation and early organogenesis, including the development of functional cardiac tissue.
Improving Organoid Models – A synthetic biology approach selectively eliminates abnormal cells from stem cell-derived multicellular models, improving liver organoid maturity and embryo model development.
Photo Reference: Courtesy of Drs. Anupama Hemalatha and Verena Schwach
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Ep. 332: Live Show at the Stem Cell and Developmental Biology Early Career Symposium
13 oktober 2026 · 1 uur 5 min
Guest: Lees meer
In this special episode recorded live in Seattle, Washington at the Allen Institute for the Early Career Development Symposium. Dr. Crystal Rogers, Associate Professor at the UC Davis School of Veterinary Medicine, and Dr. Ariel Waisman, CONICET Investigator at FLENI in Argentina, explore the unique career transitions and systemic challenges faced by early-career scientists. They discuss overcoming imposter syndrome, navigating funding cuts, and adapting to new leadership responsibilities. Emphasizing the importance of strong mentorship, scientific communication, and community, they highlight how peer support and resilience are essential for sustaining scientific progress in today’s economic landscape.
Photo Reference: Courtesy of Drs. Crystal Rogers and Ariel Waisman
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Ep. 331: “How the Heart Takes Shape” Featuring Dr. Lika Drakhlis
29 september 2026 · 1 uur 13 min
Guest: Lees meer
Dr. Lika Drakhlis is a Junior Group Leader at Hannover Medical School. She discusses how her lab uses human pluripotent stem cells to develop complex, multi-tissue organoids that model the co-development of the heart, vasculature, and foregut. She also explores how these models reveal the spatial organization and cellular interactions that shape early heart development, and how they can be used to study congenital disease and develop more human-relevant alternatives to animal models.
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The Stem Cell Science Round Up
Building a Human–Mouse Cortex – Human cortical organoids extensively integrate into the mouse brain, forming functional neural circuits that enable behavioral studies of human neurodevelopment and disease.
Connecting the Central and Peripheral – Self-organizing neural organoids recreate the coordinated development of the spinal cord and peripheral sensory nervous system, enabling studies of development, disease, and drug effects.
Tracing the Brain’s Origins – Lineage tracing and stem cell models reveal two distinct neural progenitors that separately give rise to the forebrain/midbrain and hindbrain.
Engineering Stem Cells for Bone – A first-in-human trial suggests that engineering patients’ own mesenchymal stem cells to better home to bone may provide a safe and durable approach to treating osteoporosis.
Photo Reference: Courtesy of Dr. Lika Drakhlis
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Ep. 330: “Decoding Cell Fate” Featuring Dr. Yonatan Stelzer
15 september 2026 · 1 uur 20 min
Guest: Lees meer
Dr. Yonatan Stelzer is a Principal Investigator at the Weizmann Institute of Science. He discusses how his lab combines developmental biology, epigenetics, and single-cell technologies to understand how cells acquire distinct identities during embryonic development. He also explores building quantitative models that track development across space and time, how extracellular signals and epigenetic mechanisms shape cell fate, and the opportunities and limitations of using AI to uncover the underlying logic of biology.
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The Stem Cell Science Round Up
Stem Cells Drive Spinal Stenosis – Researchers identified tendon/ligament stem cells and showed that their abnormal differentiation contributes to ligament thickening and lumbar spinal stenosis.
Building Better Bones – Engineered vascularized callus organoids act as temporary biological templates that promote blood vessel formation and regeneration of large bone defects.
Regenerating Beta Cells – Loss of ALDH3B2 converts human pancreatic duct cells into insulin-producing β-like cells capable of improving blood glucose in diabetic mice.
Controlling Organ Size – A Hippo–IGF2 signaling pathway controls organ growth and liver regeneration, with IGF2 restoring impaired regenerative capacity in aged mice.
Photo Reference: Courtesy of Dr. Yonatan Stelzer
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Ep. 329: “Decoding Spermatogenesis” Featuring Dr. Charles Easley
1 september 2026 · 1 uur 13 min
Guest: Lees meer
Dr. Charles Easley is an Associate Professor and Associate Dean for Research at the University of Georgia. He discusses how his lab uses pluripotent stem cells and in vitro models of spermatogenesis to investigate how environmental exposures affect male fertility. He also explores efforts to generate functional sperm from stem cells, develop regenerative therapies for male infertility, and use human-based models to advance drug discovery and male contraception.
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The Stem Cell Science Round Up
Tracking Brain Organoid Maturation – Scientists have found that human brain organoids cultured for five years continue to mature and retain a molecular memory of time spent in culture.
Oligodendrocytes and Cognitive Aging – Changes in oligodendrocytes and reduced NRF2 signaling are linked to cognitive decline during aging, identifying a potential therapeutic target.
Maturing iPSC-Derived Cardiomyocytes – Generating tetraploid iPSCs produces cardiomyocytes with more mature molecular, metabolic, and functional properties than conventional iPSC-derived cardiomyocytes.
Embryo Mechanics and Fertility – Reproductive aging increases embryo contractility and alters tissue mechanics, reducing the ability of embryos to implant successfully.
Photo Reference: Courtesy of Dr. Charles Easley
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Ep. 328: “Modeling Human Microenvironments” Featuring Dr. Abdullah Khan
18 augustus 2026 · 1 uur 6 min
Guest: Lees meer
Dr. Abdullah Khan is an Associate Professor of Tissue Engineering at the University of Oxford and a Group Leader at the MRC Weatherall Institute of Molecular Medicine. He discusses how his lab engineers complex human tissue models to study the cellular interactions that drive development, aging, and disease. He also explores how multi-organoid systems can model interactions between tissues such as the bone marrow and heart, and how these platforms could advance disease modeling, drug discovery, and preclinical research.
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The Stem Cell Science Round Up
Rescuing hPSC Differentiation – A chemical chromatin restoration approach reverses differentiation defects in human pluripotent stem cells, restoring their ability to generate diverse cell types and brain organoids.
A Tumor Organoid Atlas – Patient-derived tumor organoids reveal cancer-specific gene dependencies and therapeutic vulnerabilities, providing a resource for advancing precision oncology.
Mapping New Cancer Vulnerabilities – CRISPR screening of organoids and spheroids expands the Cancer Dependency Map, revealing cancer vulnerabilities and molecular subtypes missed by traditional cell lines.
Building Better Cancer Models – A large collection of next-generation cancer models captures much of the genetic and epigenetic diversity of patient tumors, creating a resource for studying cancer biology and treatment response.
Modeling Heart Valve Disease – Human iPSC-derived valve assembloid models heart valve development and reveals how mechanical forces and fluid flow shape valve formation and disease.
Heart Valves in the Lab – Stem cell-derived 3D heart valve tissues recapitulate key features of valve maturation and provide a human platform for studying inflammation and calcific valve dise…
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Ep. 327: “The iPSC Revolution” Featuring Dr. Shinya Yamanaka
5 augustus 2026 · 1 uur 12 min
Guest: Lees meer
Nobel Laureate Dr. Shinya Yamanaka is the Director Emeritus of the Center for iPS Cell Research and Application (CiRA), President of the CiRA Foundation, Professor at Kyoto University, and Senior Investigator at the Gladstone Institutes. 20 years after the discovery of iPSCs, he discusses how his lab is advancing iPSC therapies toward the clinic while continuing to investigate the basic mechanisms underlying pluripotency, stem cell biology, and translation initiation. He also shares his vision for the future of regenerative medicine, the ethical challenges posed by emerging stem cell technologies, and the opportunities created by combining iPSC with advances such as CRISPR and organoids.
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The Stem Cell Science Round Up
Elephant iPS Cells – Researchers have generated the first induced pluripotent stem cells from Asian elephants, providing a new platform for conservation and disease research.
Epigenetic Cell Counter – Intestinal stem cells use an epigenetic division-counting mechanism to precisely control cell fate decisions during tissue maintenance.
Reversing Bone Marrow Aging – Long-term vitamin C supplementation partially reverses age-related changes in primate bone marrow and hematopoietic stem cell function.
Human Heart Atlas – A comprehensive atlas of human cardiac organoids reveals how signaling molecules regulate heart function and identifies pathways linked to heart failure.
Photo Reference: Courtesy of Dr. Shinya Yamanaka.
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Ep. 326: “ISSCR 2026: On the Ground”
21 juli 2026 · 33 min
Guest: Lees meer
In July 2026, we attended ISSCR 2026, the annual meeting of the International Society for Stem Cell Research, in Montreal. We spoke with delegates about their research, the scientific advances that stood out to them, and the emerging trends shaping the future of stem cell biology. They also reflect on their own conference highlights and the unique opportunities that meetings like ISSCR provide for collaboration, networking, and scientific discovery.
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Ep. 325: “Live at ISSCR 2026: Scaling and Manufacturing of PSC-Derived Therapies” Featuring Drs. Michael May and Janet Rothberg
14 juli 2026 · 48 min
Guest: Lees meer
In this special episode recorded live in Montréal, Canada at ISSCR 2026, Dr. Michael May, President and CEO of the Centre for Commercialization of Regenerative Medicine (CCRM), and Dr. Janet Rothberg, Senior Director of Process and Analytical Development at CCRM, explore how stem cell discoveries can be translated into commercially viable therapies through scalable manufacturing, company creation, investment, automation, and artificial intelligence. They emphasize the importance of considering manufacturing, quality control, market selection, reimbursement, and the evolving standard of care much earlier in the development process. They also share their vision for a future in which robust bioprocessing, better use of data, and improved regulatory and reimbursement models make iPSC-derived therapies more affordable and widely accessible.
Photo Reference: Courtesy of Drs. Michael May and Janet Rothberg
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ISSCR 2026: Day 4
12 juli 2026 · 35 min
Guest: Lees meer
In July 2026, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Montreal, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four episodes from the meeting, where they discuss the challenges of making advanced cell and gene therapies accessible, the latest progress in organoids and regenerative medicine, and the importance of balancing ambitious clinical goals with rigorous scientific evidence. They also reflect on the meeting’s broader themes, from the enduring role of developmental biology and patient advocacy to the achievements of award recipients and the growing integration of new technologies such as AI, machine learning, and advanced imaging in stem cell research.
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ISSCR 2026: Day 3
11 juli 2026 · 34 min
In July 2026, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Montreal, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four episodes, where Daylon and Arun discuss advances in synthetic biology, organoid engineering, regenerative medicine, developmental biology, and AI-driven approaches to stem cell research. They also reflect on inspiring plenary talks covering topics from pregnancy-associated tissue adaptation and lung development to AI-powered drug discovery, while sharing their excitement about conversations with conference delegates and the rapidly evolving future of the field. Lees meer
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ISSCR 2026: Day 2
10 juli 2026 · 36 min
In July 2026, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Montreal, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four episodes, where Daylon and Arun discuss promising stem cell clinical trial updates for Parkinson's disease, advances in cardiac, thymus, and vascular organoid research, and new technologies that are reshaping developmental biology and regenerative medicine. They also reflect on inspiring patient stories, tributes to stem cell pioneer Sir John Gurdon, and the growing role of AI and engineering in the future of stem cell research. Lees meer
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ISSCR 2026: Day 1
9 juli 2026 · 24 min
In July 2026, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Montreal, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four episodes, where Daylon and Arun discuss the opening plenary, major advances in iPSC research, organoids, CRISPR, and space biology, as well as their live podcast recording on translating stem cell research into real-world therapies. They also share their impressions of the meeting, memorable sessions, and the excitement of reconnecting with colleagues and the stem cell community. Lees meer
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Ep. 324: “From Stem Cells to Living Tissues” Featuring Drs. Yifei Miao and Anca Pasca
7 juli 2026 · 1 uur 14 min
This quarterly special episode, created in partnership with the ISSCR Early Career Advisory Committee, features two rising leaders in stem cell research. Dr. Yifei (Simon) Miao, a Professor at the Chinese Academy of Sciences, discusses engineering vascularized organoids and integrating bioengineering approaches to build more physiologically relevant human tissues. Dr. Anca Pașca, an Assistant Professor at Stanford Medicine, explores how stem cell-derived brain organoids and assembloids are advancing our understanding of neonatal brain injury and neurodevelopmental disorders, with the goal of developing new therapies for vulnerable infants. If you'd like to recommend yourself or a colleague for a future episode, we'd love to hear from you. Submit a nomination here. Lees meer
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Ep. 323: “Building the Blastema” Featuring Dr. Mekayla Storer
23 juni 2026 · 1 uur 15 min
Dr. Mekayla Storer is an Associate Professor at the University of Cambridge and a Principal Investigator at the Cambridge Stem Cell Institute. She discusses how mammalian digit tips regenerate after injury, focusing on the formation of the blastema and the cellular and molecular mechanisms that distinguish regeneration from scarring. She highlights the role of the extracellular matrix, tissue mechanics, and regenerative microenvironments in directing tissue repair, and explores how insights from digit tip regeneration may inform strategies to promote regeneration in other organs. Lees meer
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Ep. 322: “Healing Hearts with Macrophages” Featuring Dr. Filipa Simões
9 juni 2026 · 1 uur 22 min
Dr. Filipa Simões is a Group Leader at the University of Oxford and Co-Director of the Oxford Organoid Hub. She discusses how macrophages shape heart development, repair, and regeneration, and how cellular crosstalk within the cardiac niche influences tissue outcomes after injury. Using zebrafish models, stem cell–derived cardiac organoids, and spatial genomics approaches, she explores the molecular signals that govern macrophage identity and function, with the goal of uncovering new strategies to promote cardiac regeneration and limit fibrosis. Lees meer
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Ep. 321: “Decoding Blood Stem Cells” Featuring Dr. Vijay Sankaran
26 mei 2026 · 1 uur 14 min
Dr. Vijay Sankaran is a Professor at Harvard Medical School and Investigator at the Howard Hughes Medical Institute. He discusses how his lab uses human genetics and stem cell biology to uncover mechanisms regulating hematopoiesis and blood disease, including the discovery of key regulators such as BCL11A and HOTSCRAMBL. He also explores how advances in genome editing, stem cell engineering, and single-cell genomics are shaping new therapies for disorders such as sickle cell disease, thalassemia, and leukemia, while highlighting the challenges of translating these breakthroughs into scalable patient treatments. Lees meer
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Ep. 320: “Cancer Under Pressure” Featuring Dr. Meenal Datta
12 mei 2026 · 1 uur 31 min
Dr. Minal Datta is an Associate Professor at the University of Notre Dame and leader of the Tumor Immune Microenvironment Mechanics (TIME) Lab. She discusses how mechanical forces within tumors shape cancer progression and immune responses, with a focus on glioblastoma. She highlights how immunomechanics and mechanobiology influence tumor growth, treatment resistance, and immune cell function, and explores how space-based research and microgravity models can uncover new insights and therapeutic strategies for cancer. Lees meer
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Ep. 319: “Building Better iPSCs” Featuring Dr. Andrew Gaffney
28 april 2026 · 1 uur 12 min
Dr. Andrew Gaffney is Vice President, iPSC Platform at STEMCELL Technologies. In this episode, he discusses how his team is advancing pluripotent stem cell applications through high-quality iPSC line development, gene editing, organoid production, and GMP manufacturing for translational and clinical use. He also highlights key challenges in the field, including reproducibility, standardization, genetic diversity, and freedom-to-operate considerations, and explains how these factors impact the path from basic research to commercialization. Lees meer
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Ep. 318: “Modeling Reproduction and Endocrinology” Featuring Dr. Kotaro Sasaki
14 april 2026 · 1 uur 34 min
Dr. Kotaro Sasaki is an Associate Professor at the University of Pennsylvania. He discusses how his lab uses human pluripotent stem cells to model germ cell development and endocrine organs such as the testis and adrenal gland. He highlights progress toward in vitro gametogenesis, including generating spermatogonial-like cells and reconstructing testicular environments, as well as recent advances in building adrenal organoids with zonal architecture. He also explores the scientific, translational, and ethical challenges of creating functional human gametes, and emphasizes the importance of developmental biology in guiding stem cell-based approaches. Lees meer
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Ep. 317: “Engineering the Human Heart” Featuring Dr. Aitor Aguirre
31 maart 2026 · 1 uur 21 min
Dr. Aitor Aguirre is an Associate Professor at Michigan State University and Director of the Stem Cell Core. In this episode, he discusses how his lab uses pluripotent stem cells and cardiac organoids to model human heart development and disease. He highlights the role of self-organization and bioengineering in building complex heart models, including assembloids with immune and neural components, and their applications in studying conditions like atrial fibrillation. He also shares perspectives on open science, collaboration, and training the next generation of scientists. Lees meer
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Ep. 316: “Primate Embryogenesis” Featuring Dr. Thorsten Boroviak
17 maart 2026 · 1 uur 25 min
Dr. Thorsten Boroviak is an Assistant Professor at the University of Cambridge and a member of the Cambridge Stem Cell Institute. He discusses how stem cell–based embryo models are helping researchers study early human and primate development, including implantation and gastrulation. He also talks about using primate systems such as marmoset to understand human development, the role of biomechanics and extraembryonic tissues in embryogenesis, and the ethical considerations surrounding embryo models and emerging technologies like in vitro gametogenesis. Lees meer
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Ep. 315: “Advanced Stem Cell-Based Models” Featuring Drs. Shuibing Chen and Hans Clevers
3 maart 2026 · 1 uur 12 min
Drs. Shuibing Chen and Hans Clevers, members of the Steering Committee for the ISSCR Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development, explore how stem cell–derived organoids and other new approach methodologies (NAMs) can complement or replace animal models in preclinical research. The discussion highlights the need for standardization, regulatory alignment, and industry collaboration to improve reproducibility, accelerate drug development, and ultimately create more human-relevant and effective therapies. Lees meer
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Ep. 314: “ISSCR 2026: Real Discoveries, Real Collaboration, Real Potential” Featuring Drs. Fiona Doetsch & Nozomu Yachie
18 februari 2026 · 1 uur 11 min
Drs. Fiona Doetsch and Nozomu Yachie, Co-Chairs of the ISSCR 2026 Annual Meeting Program Committee, join the podcast to discuss what to expect at the upcoming ISSCR 2026 meeting taking place in Montreal, Canada from July 8 - 11, 2026.
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Ep. 313: “Cardiovascular Disease Mechanisms” Featuring Dr. Joseph Wu
3 februari 2026 · 1 uur 28 min
Dr. Joseph Wu is a Professor of Medicine and Radiology and the Director of the Stanford Cardiovascular Institute. He talks about the importance of pharmacology knowledge in drug discovery. He also discusses his early iPSC research, investigating vaccine-induced myocarditis, and embracing New Approach Methodologies (NAMs). Lees meer
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Ep. 312: “Biomanufacturing in Space” Featuring Dr. Pinar Mesci
20 januari 2026 · 1 uur 28 min
Dr. Pinar Mesci is the Global Head of Biomanufacturing and Biotechnology at Axiom Space, where she manages a portfolio focused on biomedical research programs including stem cells, tissue engineering, disease modeling, cancer research, and DNA-inspired nanomaterials. She talks about her early career developing brain organoid models, transitioning to the space industry, and how microgravity affects biological systems. She also discusses the future of low Earth orbit research and how new technologies can be transferred back to Earth. Lees meer
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Ep. 311: “Congenital Heart Disease” Featuring Dr. Deepak Srivastava
23 december 2025 · 1 uur 28 min
Dr. Deepak Srivastava is the President of the Gladstone Institutes and Director of the Roddenberry Stem Cell Center. His lab is focused on the gene networks that guide cardiac development. He talks about their recent work investigating heart defects in Down syndrome and strategies for delivering therapies to the heart. He also talks about how to incentivize the development and commercialization of cell and gene therapies. Lees meer
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Ep. 310: “Epithelial Organoids” Featuring Dr. Hans Clevers
9 december 2025 · 1 uur 29 min
Dr. Hans Clevers is a Professor of Molecular Genetics and Distinguished Group Leader at the University of Utrecht. In this episode, he discusses snake gut and lung organoids, transitioning from academia to industry, and the challenges and complexities of creating a cell therapy. Lees meer
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Ep. 309: “Neuronal Cell Fate and Function” Featuring Dr. Thomas Vierbuchen
25 november 2025 · 1 uur 20 min
Dr. Thomas Vierbuchen is Assistant Professor of Developmental Biology at Memorial Sloan Kettering Cancer Center. In this episode, he talks about using PSCs to model neurodevelopmental processes. He also discusses his direct reprogramming work and his lab's recent study on OTX2 in gastrulation. Lees meer
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Ep. 308: “Regeneration in the Cerebellum” Featuring Dr. Sumru Bayin
11 november 2025 · 1 uur 31 min
Dr. Sumru Bayin is a Group Leader at the Gurdon Institute at the University of Cambridge. She talks about her work on regeneration in the neonatal mouse cerebellum and how cerebellar interneurons differentiate. She also discusses organizing a workshop to facilitate collaborations in regenerative biology, and her memories of the late Sir John Gurdon. Lees meer
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Ep. 307: “Vascular Biology” Featuring Dr. Juan Melero-Martin
28 oktober 2025 · 1 uur 37 min
Dr. Juan Melero-Martin is an Associate Professor and the Endowed Chair in Cardiac Surgery at Boston Children's Hospital. His lab uses bioengineering principles to understand how vascular networks are formed and the mechanisms by which the vasculature modulates the engraftment and activity of various human stem cells. Lees meer
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Ep. 306: “Vertebrate Development” Featuring Dr. Carole LaBonne
14 oktober 2025 · 1 uur 12 min
Dr. Carole LaBonne is the Erastus Otis Haven Professor of Molecular Biosciences at Northwestern University. Her lab studies the genesis of neural crest stem cells at the level of the signaling pathways and transcription factors that comprise the neural crest gene regulatory network. They also study how these mechanisms contribute to exit from pluripotency and the subsequent lineage restriction of neural crest cells to their derivative cell types that collectively define vertebrates. Lees meer
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Ep. 305: “Glial Cell Fate” Featuring Dr. Paul Tesar
30 september 2025 · 1 uur 24 min
Dr. Paul Tesar is the Director of the Institute for Glial Sciences and the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at Case Western Reserve University. His lab uses PSCs to model neurological development and disease with a specific focus on oligodendrocytes and astrocytes. He talks about his work on oligodendrocyte maturation, advancing research into the commercial and clinical sectors, and mentoring the next generation of scientists. Lees meer
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Ep. 304: “Gene Regulation” Featuring Dr. Lars Velten
16 september 2025 · 1 uur 15 min
Dr. Lars Velten is a Group Leader at the Centre for Genomic Regulation in Barcelona. He talks about his research on cell-state-specific enhancers in hematopoiesis and lineage tracing techniques to study blood aging. He also discusses combining generative AI with wet lab techniques and the advantages of risk-taking in basic research. Lees meer
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Ep. 303: “Organoid Models of Cancer” Featuring Dr. Alice Soragni
2 september 2025 · 1 uur 35 min
Dr. Alice Soragni is an Associate Professor at the University of California, Los Angeles. She talks about her work on patient-derived organoids and how they can be adapted for drug screening. She also discusses how she transitioned from structural biology to research on protein aggregation and rare diseases, and the current social media landscape for scientists. Lees meer
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Ep. 302: “Kidney Organoids” Featuring Dr. Zhongwei Li
19 augustus 2025 · 1 uur 19 min
Dr. Zhongwei Li is an Associate Professor at the University of Southern California. His lab focuses on kidney organogenesis with translational applications of kidney regeneration and disease modeling. He talks about his work on PSC-derived nephron progenitors and drug discovery applications for polycystic kidney disease. Lees meer
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Ep. 301: “Cell Fate Decisions in Cancer” Featuring Dr. Mark Hatley
5 augustus 2025 · 1 uur 20 min
Dr. Mark Hatley is an Associate Faculty Member and Director of the Division of Molecular Oncology at St. Jude Children's Research Hospital. His research focuses on the developmental origins and genetic mechanisms of pediatric rhabdomyosarcoma. He talks about his work on pediatric oncology and the mechanisms that differentiate normal development from cancer. He also discusses the role of PAX3-FOXO1 and DICER1 in tumorigenesis. Lees meer
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Ep. 300: “Autologous Cell Therapy” Featuring Dr. Jeanne Loring
22 juli 2025 · 1 uur 35 min
Dr. Jeanne Loring is a Co-Founder of Aspen Neuroscience and Professor Emeritus at Scripps Research. She talks about generating gametes from the functionally extinct northern white rhinoceros, Aspen's early days and its recent clinical trial results for Parkinson's cell therapy, and sending her own stem cells into space. She also discusses the need for genetic variation in iPSC lines. Lees meer
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Ep. 299: “Spinal Cord Development” Featuring Dr. James Briscoe
8 juli 2025 · 1 uur 23 min
Dr. James Briscoe is a Group Leader at the Francis Crick Institute and Editor-In-Chief of Development. His lab uses an interdisciplinary approach, including mice, chicks, and other models, to study developmental dynamics. He discusses his lab's work on human trunk formation and his role as an Editor-In-Chief. Lees meer
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Ep. 298: “ISSCR 2025: On the Ground”
24 juni 2025 · 59 min
In June 2025, we attended ISSCR 2025, the annual meeting of the International Society for Stem Cell Research, in Hong Kong. We spoke with delegates about their research, their impressions of the meeting, and the most memorable research presented. They also discussed their experiences exploring Hong Kong. Lees meer
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Ep. 297: “Live at ISSCR 2025: Advancing Regenerative Medicine with CiPSCs” Featuring Drs. Hongkui Deng and Candice Liew
17 juni 2025 · 1 uur
Dr. Hongkui Deng is the Director of the Institute of Stem Cell Research at Peking University and Dr. Candice Liew is a Senior Scientist at Reprogenix Bioscience. In this special episode recorded in front of a live audience at ISSCR 2025 in Hong Kong, they discuss their groundbreaking study transplanting CiPSC-derived islets into a patient with type 1 diabetes. They talk about their approach to chemical reprogramming, immune tolerance, and the therapy's impact on the first patient. Lees meer
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ISSCR 2025: Day 4
14 juni 2025 · 29 min
In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four episodes from the meeting. Sessions focused on cell therapy for spinal cord injury, immunocompatible pig organs, and community engagement. Lees meer
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ISSCR 2025: Day 3
13 juni 2025 · 34 min
In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four episodes, where Daylon and Arun discuss research on cell therapy for inflammatory bowel disease and hearing loss. They also talk about Dr. Jacob Hanna's work on ex utero embryo culture, Dr. Paola Arlotta's research on long-term brain organoids, and Di Pan's insights into sponge regeneration. Lees meer
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ISSCR 2025: Day 2
12 juni 2025 · 35 min
In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four episodes, where Daylon and Arun cover talks on animal models of regeneration and the public perception of in vitro gametogenesis. They also discuss work on CiPSCs for Type 1 diabetes therapy and growing pig-human chimeric embryos. Lees meer
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ISSCR 2025: Day 1
11 juni 2025 · 30 min
In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four episodes, where Daylon and Arun discuss updates from clinical trials for ALS, congenital heart disease, and Parkinson's disease. They also talk about the Presidential Plenary session, chaired by Dr. Valentina Greco. Lees meer
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Ep. 296: “Cardiovascular Development” Featuring Dr. Maneesha Inamdar
10 juni 2025 · 1 uur 34 min
Dr. Maneesha Inamdar is the Director of the Institute for Stem Cell Science and Regenerative Medicine and Professor at Jawaharlal Nehru Centre for Advanced Scientific Research. Her lab uses comparative models, including mice, Drosophila, stem cell lines, and gastruloids, to study developmental biology. She talks about using embryo models to investigate teratogenicity, prioritizing ethnically diverse cell lines, and representing Indian scientists in global discussions. Lees meer
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Ep. 295: “Roadmap for Cell Therapy Development” Featuring Drs. Jacqueline Barry, Kapil Bharti, and Jack Mosher
27 mei 2025 · 1 uur 26 min
Dr. Jacqueline Barry is the Chief Clinical Officer at Cell and Gene Therapy Catapult, Dr. Kapil Bharti is a Senior Investigator at the National Eye Institute at the National Institutes of Health, and Dr. Jack Mosher is the Scientific Director at the International Society for Stem Cell Research (ISSCR). They discuss their work on the ISSCR's Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies. They talk about the need for consistency and rigor in cell therapy development, and how the document can be navigated and applied across jurisdictions. Lees meer
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Ep. 294: “HSC Development and Regulation” Featuring Dr. Margaret Goodell
13 mei 2025 · 1 uur 27 min
Dr. Margaret "Peggy" Goodell is the Vivian L. Smith Chair in Regenerative Medicine and Director of the Stem Cell and Regenerative Medicine Center at Baylor College of Medicine. Her research focuses on HSC regulation and aging. She talks about her discovery of a side population of HSCs, as well as her work on DNMT3A mutation and clonal hematopoiesis of indeterminate potential. Finally, she discusses the rich research environment in Houston. Lees meer
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Ep. 293: “Cell Atlases” Featuring Dr. Sarah Teichmann
29 april 2025 · 1 uur 32 min
Drs. Sarah Teichmann is a Member of the Department of Medicine and Professor of Stem Cell Medicine at the Cambridge Stem Cell Institute. She talks about the plasticity of different cell types and developing whole-organ cell atlases for organs such as the thymus. She also discusses Human Cell Atlas project and overcoming skepticism in its early days. Finally, she talks about integrating computational and wet lab biology, and running an interdisciplinary research group. Lees meer
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Ep. 292: “Biomedical Ethics” Featuring Prof. Hank Greely
15 april 2025 · 1 uur 28 min
Professor Hank Greely is the Deane F. and Kate Edelman Johnson Professor of Law and Professor, by courtesy, of Genetics at Stanford University. He is also the Director of the Stanford Center for Law and the Biosciences. He talks about his career path into bioethics and ethical considerations for organoids, bodyoids, and embryo models. He also discusses the potential future of reproduction, including gametogenesis, ectogenesis, and genetic selection and editing of embryos. Lees meer