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364 afleveringen, van nieuw naar oud
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Ep. 200: “A Stem Cell Pioneer” Featuring Dr. Connie Eaves
24 augustus 2021 · 1 uur 25 min
Dr. Connie Eaves is a Distinguished Scientist at the Terry Fox Laboratory at the British Columbia Cancer Agency and a Professor of Medical Genetics at the University of British Columbia. Her research focuses on leukemia and breast cancer and the normal tissues in which these diseases originate. Her pioneering research in basic blood stem cell biology led to a breakthrough in treatment for leukemia. Lees meer
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Ep. 199: “Regeneration in Zebrafish” Featuring Dr. Ken Poss
10 augustus 2021 · 1 uur 8 min
Dr. Ken Poss is the James B. Duke Professor of Cell Biology and Head of the Duke Regeneration Center at Duke University. His lab investigates the initial morphogenesis and injury-induced regeneration of several tissues in zebrafish. He is also President of the newly-founded International Society for Regenerative Biology. Lees meer
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Ep. 198: “Printing Human Tissues” Featuring Dr. Anthony Atala
27 juli 2021 · 1 uur 6 min
Dr. Anthony Atala is the Founding Director of the Wake Forest Institute for Regenerative Medicine and the Chair of Urology at the Wake Forest School of Medicine. His team developed the first lab-grown organ to be implanted into a human and he currently oversees a team of over 400 researchers who are working to develop cell therapies and engineer replacement organs and tissues. Lees meer
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Ep. 197: “Policy, Regenerative Medicine, and Human Cloning” Featuring Bernie Siegel
13 juli 2021 · 1 uur 12 min
Bernie Siegel is an attorney and policy expert relating to stem cell research, regenerative medicine, and human cloning. He is the Executive Director of the Regenerative Medicine Foundation and the Founder of the World Stem Cell Summit.
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Ep. 196: “Human Brain Creation” Featuring Dr. Aparna Bhaduri
29 juni 2021 · 1 uur 8 min
Dr. Aparna Bhaduri is an Assistant Professor of Biological Chemistry at the David Geffen School of Medicine at UCLA. Her lab studies how the human brain is created, with billions of cells spanning hundreds or thousands of cell types. They also explore how the cell building blocks of development can reappear later in life in brain cancers such as glioblastoma. Lees meer
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“ISSCR 2021 Day 5” Featuring Dr. Nicolas Rivron
26 juni 2021 · 45 min
Dr. Nicolas Rivron is a Group Leader at IMBA. The Rivron group recreates embryonic development using mammalian stem cells in a dish to better understand the encoded principles of self-organization. They observe both blastocysts and blastoids to study how self-organization contributes to multicellular patterning and cellular decision making. Lees meer
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“ISSCR 2021 Day 4” Featuring Dr. Sheila Chari
26 juni 2021 · 45 min
In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting, featuring Dr. Sheila Charli from Cell Stem Cell. Lees meer
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“ISSCR 2021 Day 3” Featuring Dr. Shahin Rafii
25 juni 2021 · 42 min
Dr. Shahin Rafii is a Professor of Reproductive Medicine and the Arthur B. Belfer Professor in Genetic Medicine at Weill Cornell Medical College, as well as Director of the Ansary Stem Cell Institute. His research focuses on stem cell biology and angiogenesis. We discuss his research and thoughts on the meeting. Lees meer
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“ISSCR 2021 Day 2” Featuring Dr. Madeline Lancaster
24 juni 2021 · 34 min
In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting featuring Dr. Madeline Lancaster from the Medical Research Council (MRC) Laboratory of Molecular Biology, who was honored with the Dr. Susan Lim Award for Outstanding Young Investigator Lecture at the meeting. Lees meer
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“ISSCR 2021 Day 1” Featuring Dr. Chuck Murry
23 juni 2021 · 40 min
In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting featuring Dr. Chuck Murry from the University of Washington, who presented during the Presidential Symposium: What's in a Germ Layer session on the first day of the meeting. Lees meer
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Ep. 195: “The Global Alliance for iPSC Therapies” Featuring Dr. Stephen Sullivan
15 juni 2021 · 1 uur 19 min
Dr. Stephen Sullivan is the Program Manager and International Liaison Officer at the Global Alliance for iPSC Therapies (GAiT), an international initiative to support the implementation and clinical application of therapies derived from pluripotent stem cells to the benefit of patients globally. Lees meer
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Ep. 194: “Evolution of Stemness Control and Multicellularity” Featuring Dr. Emma Hammarlund
1 juni 2021 · 1 uur 15 min
Dr. Emma Hammarlund is a Principal Investigator in the Division of Translational Cancer Research at Lund University Cancer Center and the Lund Stem Cell Center. Her lab investigates how the rise of animals on Earth relates to the evolution of stemness control. Lees meer
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Ep. 193: “From Academia to Venture Capital” Featuring Dr. Themasap Khan
18 mei 2021 · 1 uur 2 min
Dr. Themasap Khan is the Vice President at Civilization Ventures, a venture capital firm that invests in genomics, diagnostics, digital health, AI, and personalized and regenerative medicine. He leads the firm’s scientific due diligence and academic outreach programs. Dr. Khan earned his in PhD in stem cell biology and regenerative medicine in Dr. Sergiu Pasca’s lab at Stanford, where his research focused on genome engineering, cerebellar organoid models, and live imaging to elucidate biological mechanisms underlying neuropsychiatric disorders. Lees meer
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Ep. 192: “Gene Expression and the Brain” Featuring Dr. Johan Jakobsson
4 mei 2021 · 53 min
Dr. Johan Jakobsson is a Professor of Molecular Neurogenetics at the Lund Stem Cell Center. His research focuses on epigenetic mechanisms of the brain, including the role of microRNAs, long non-coding RNAs, and endogenous retroelements in neural stem cells and neurons. Lees meer
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Ep. 191: “Laser-Based Cell Manipulation” Featuring Dr. Marinna Madrid
20 april 2021 · 1 uur 6 min
Dr. Marinna Madrid is Co-Founder of Cellino, an early-stage biotechnology company seeking to make personalized, autologous cell therapies viable at large scale for the first time. Cellino’s platform combines label-free imaging and high-speed laser editing with machine learning to automate cell reprogramming, expansion, and differentiation in a closed cassette format, enabling thousands of patient samples to be processed in parallel in a single facility. Lees meer
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Ep. 190: “Immunology and Podcasts” Featuring Drs. Brenda Raud and Jason Goldsmith
6 april 2021 · 1 uur 6 min
Dr. Brenda Raud is a postdoctoral researcher at the Netherlands Cancer Institute and Dr. Jason Goldsmith is the Director of Donor Medical Sciences at Seres Therapeutics. In addition to their work as immunology researchers, Brenda and Jason are also hosts of the new Immunology Podcast, a sister podcast to the Stem Cell Podcast. Lees meer
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Ep. 189: “Stem Cells and Synthetic Biology” Featuring Dr. Krishanu Saha
23 maart 2021 · 1 uur 14 min
Dr. Krishanu Saha is an Associate Professor in the Department of Biomedical Engineering at the University of Wisconsin-Madison. His lab utilizes quantitative and bioengineering methods including genome editing, biomanufacturing, and disease modeling to advance the next generation of cell and gene therapies. Lees meer
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Ep. 188: “Discovery and Translation at CIRM” Featuring Dr. Kelly Shepard
9 maart 2021 · 1 uur 14 min
Dr. Kelly Shepard is the Associate Director of Discovery and Translation at the California Institute for Regenerative Medicine (CIRM). CIRM was created by the voters of California in 2004. The agency funds stem cell research at institutions and companies throughout California with the goal of accelerating treatments to patients with unmet medical needs. Lees meer
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Ep.187: “Stem Cell Education” Featuring Dr. Willy Lensch
23 februari 2021 · 1 uur 9 min
Dr. Willy Lensch is Strategic Advisor to the Dean at Harvard Medical School. Previously Executive Director of the Harvard Department of Stem Cell and Regenerative Biology, his experience in research, education, administration, science policy, intellectual property, science consulting, and outreach have combined to support and advance stem cell science and discovery at Harvard. Lees meer
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Ep.186: “Human Congenital Heart Disease” Featuring Dr. Sean Wu
9 februari 2021 · 1 uur 18 min
Dr. Sean Wu is an Associate Professor of Medicine at the Stanford School of Medicine. The Wu lab seeks to identify mechanisms responsible for human congenital heart disease, and uses mouse models and stem cells to study cardiovascular developmental biology, and to engineer cardiac tissue. Lees meer
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Ep. 185: “Cerebral Organoids” Featuring Dr. Jürgen Knoblich
26 januari 2021 · 1 uur 16 min
Dr. Jürgen Knoblich is Scientific Director of the Institute of Molecular Biotechnology at the Austrian Academy of Sciences. The Knoblich lab is known for the development of an organoid model of early brain development, and is currently using iPSCs and cerebral organoids to investigate inter-brain region interactions, neurodevelopmental disorders, and neuronal connections and functions. Lees meer
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Ep. 184: “Engineering Intestinal Grafts” Featuring Dr. Vivian Li
12 januari 2021 · 1 uur 13 min
Dr. Vivian Li is Group Leader of the Stem Cell and Cancer Biology Laboratory at the Francis Crick Institute. The Li lab investigates how Wnt signalling controls stem cells in the healthy gut and during colorectal cancer development. The lab also aims to engineer function intestinal constructs using patient-derived intestinal organoids. Lees meer
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Ep. 183: “Glomerulus-on-a-Chip” Featuring Dr. Samira Musah
15 december 2020 · 1 uur 18 min
Dr. Samira Musah is an Assistant Professor in the Department of Biomedical Engineering at Duke University. The Musah Lab applyies stem cell biology to engineer functional models of the human kidney and brain, with the goal of developing novel therapeutic modalities for human kidney diseases. Lees meer
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Ep. 182: “Stem Cells and Society” Featuring Dr. Christopher Scott
1 december 2020 · 1 uur 14 min
Dr. Christopher Thomas Scott is the Dalton Tomlin Professor of Medical Ethics and Health Policy at Baylor College of Medicine. Scott is also emeritus faculty of the Stanford University Center for Biomedical Ethics. His research centers on the ethical, legal, and social implications of emerging biotechnologies. Lees meer
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Ep. 181: “Printing Organoids” Featuring Dr. Matthias Lutolf
17 november 2020 · 1 uur 10 min
Dr. Matthias Lutolf is a Professor and Principal Investigator of the Laboratory of Stem Cell Bioengineering at the École Polytechnique Fédérale de Lausanne. His lab uses cutting-edge bioengineering strategies for guiding stem-cell-based development for the assembly of next-generation organoids with improved reproducibility and physiological relevance. Lees meer
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Ep. 180: “Next Generation Scientists” Featuring Naveed Tavakol, Nathasia Mudiwa Muwanigwa, and Sarthak Sinha
3 november 2020 · 1 uur 4 min
In this special episode of the Stem Cell Podcast, we speak with three PhD students — Nathasia Mudiwa Muwanigwa, Sarthak Sinha, and Naveed Tavakol — about their research into brain organoids, organ-on-chip systems, and regeneration in different mammals. Lees meer
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Ep. 179: “The Human Segmentation Clock” Featuring Dr. Miki Ebisuya
20 oktober 2020 · 1 uur 1 min
Dr. Miki Ebisuya is a Group Leader at the European Molecular Biology Laboratory in Barcelona. Her lab reconstitutes developmental mechanisms by making artificial gene circuits, and studies interspecies differences by comparing organoids of different animals. Lees meer
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Ep. 178: “Muscle Stem Cell Quiescence” Featuring Dr. Tom Cheung
6 oktober 2020 · 1 uur 7 min
Dr. Tom Cheung is the S H Ho Associate Professor of Life Science at the Hong Kong University of Science and Technology. His lab investigates the molecular pathways that control muscle stem cell quiescence and stem cell-mediated tissue regeneration.
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Ep. 177: “Molecular Mechanisms of Differentiation” Featuring Dr. Ludovic Vallier
22 september 2020 · 1 uur 10 min
Dr. Ludovic Vallier is a Professor of Regenerative Medicine at the Cambridge Stem Cell Institute and Director of the NIHR Cambridge Biomedical Centre hiPSC core facility. His lab studies the basic mechanisms controlling differentiation of pluripotent cells into endoderm progenitors from which the pancreas, lung, gut and liver originate. Lees meer
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Ep. 176: “Stem Cells and the Skin” Featuring Dr. Valerie Horsley
8 september 2020 · 1 uur 3 min
Dr. Valerie Horsley is an Associate Professor of Molecular, Cellular, and Developmental Biology, and Associate Professor of Dermatology at Yale University. Her lab studies how adult stem cells within epithelial tissues maintain tissue homeostasis, wound healing and can contribute to cancer formation. Lees meer
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Ep. 175: “Human Colon Organoids” Featuring Dr. Henner Farin
25 augustus 2020 · 1 uur 4 min
Dr. Henner Farin is a Young Investigator in the German Cancer Consortium, and a Junior Research Group Leader at the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy. His group uses organoids to study cell signaling in intestinal stem cells and colorectal cancer. Lees meer
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Ep. 174: “Functional Human Brain Models of Disease” Featuring Dr. Sergiu Pașca
11 augustus 2020 · 1 uur 10 min
Dr. Sergiu Pașca is an Assistant Professor of Psychiatry and Behavioral Sciences at Stanford University, and the Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program. His team has developed methods for generating human brain organoids, and uses them to study the programs underlying brain development, assembly and dysfunction. Lees meer
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ISSCR 2020 with Dr. Martin Pera
4 augustus 2020 · 25 min
Dr. Martin Pera is a Principal Investigator at the Jackson Laboratories and Editor-in-Chief of the ISSCR's journal Stem Cell Reports. His lab studies the regulation of self-renewal and pluripotency, heterogeneity in pluripotent stem cell populations, and neural specification of pluripotent stem cells. Lees meer
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Ep. 173: “Blood Cells and the Bone Marrow” Featuring Dr. Dominique Bonnet
28 juli 2020 · 1 uur 11 min
Dr. Dominique Bonnet is the Group Leader of the Hematopoietic Stem Cell Laboratory at the Francis Crick Institute. Her lab is interested in the extrinsic mechanisms that regulate hematopoietic stem cells, and how they can intervene in order to eradicate the leukemic stem cell. Lees meer
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ISSCR 2020 with Dr. Kristy Red-Horse
21 juli 2020 · 41 min
Dr. Kristy Red-Horse is an Associate Professor of Biology at Stanford University. Her lab uses cardiovascular development as a model to study the signals that instruct cell fate and guide morphogenesis during organ formation in the mammalian embryo.
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Ep. 172: “Organ Regeneration” Featuring Dr. Valentina Greco
14 juli 2020 · 1 uur 3 min
Dr. Valentina Greco is the Carolyn Slayman Professor of Genetics at Yale University. Her lab has developed novel live imaging approaches to track and manipulate stem cells in live animals, allowing them to study the complex orchestration of tissue regeneration using the skin as a model system. Lees meer
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ISSCR 2020 with Dr. Madeline Lancaster
7 juli 2020 · 32 min
Dr. Madeline Lancaster is a Group Leader at the MRC Laboratory of Molecular Biology in Cambridge, UK. The Lancaster lab has developed cerebral organoids as a model system to better understand human brain evolution, development, and neurodevelopmental disorders. She joined us to discuss her research presentated at the ISSCR 2020 conference. Lees meer
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Ep. 171: “The Heart and Human Development” Featuring Dr. Benoit Bruneau
30 juni 2020 · 1 uur 13 min
Dr. Benoit Bruneau is the Director of the Gladstone Institute of Cardiovascular Disease. His lab uses mouse models and human iPSCs to investigate the transcription factor networks that regulate sets of genes critical for heart development.
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Ep. 170: “Human Skin Organoids” Featuring Dr. Karl Koehler
16 juni 2020 · 1 uur 3 min
Dr. Karl Koehler is an Assistant Professor of Otolaryngology at Harvard Medical School. His lab focuses on using human organoid systems as a platform to model congenital diseases and develop regenerative medicine therapies for the inner ear and various craniofacial tissues. Lees meer
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Ep. 169: “The Mammalian Nervous System” Featuring Dr. Freda Miller
2 juni 2020 · 1 uur 24 min
Dr. Freda Miller, from the Hospital for Sick Children Research Institute and the University of Toronto, studies the cellular mechanisms that regulate development of the mammalian nervous system, with a particular interest in stem cells and trophic factors. Lees meer
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Ep. 168: “Adult Stem Cell-Based Organoids” Featuring Dr. Hans Clevers
19 mei 2020 · 1 uur 18 min
Dr. Hans Clevers from the Hubrecht Institute for Developmental Biology and Stem Cell Research is a pioneer in the field, studying the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. Lees meer
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Ep. 167: “From Scientist to Editor-in-Chief” Featuring Dr. Sheila Chari
5 mei 2020 · 1 uur 13 min
Dr. Sheila Chari is the Editor-in-Chief at the journal Cell Stem Cell, and Executive Editor at Cell Press. As the Editor-in-Chief, Dr. Chari’s primary responsibilities are knowing and publishing the top stem cell discoveries, driving journal publishing strategy, and managing a global editorial staff. Lees meer
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Special Episode: “COVID-19 Research Updates” Featuring Dr. Josef Penninger
28 april 2020 · 1 uur 15 min
Dr. Josef Penninger is from the University of British Columbia and the Institute for Molecular Biotechnology of the Austrian Academy of Sciences in Vienna, Austria. He was previously on the podcast to talk about his research developing human blood vessel organoids. Dr. Penninger’s team has identified a trial drug that can significantly block early stages of COVID-19 in human blood vessel and kidney organoids. Lees meer
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Ep. 166: “Lung Regeneration” Featuring Dr. Darcy Wagner
21 april 2020 · 1 uur 7 min
Dr. Darcy Wagner from the Lund Stem Cell Center uses a multidisciplinary approach to understand how the extracellular environment directs stem cell behavior for endogenous and exogenous lung tissue regeneration.
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Ep. 165: “Tackling Heart Disease” Featuring Dr. Deepak Srivastava
7 april 2020 · 1 uur 26 min
Dr. Deepak Srivastava is the President of the Gladstone Institutes and the International Society for Stem Cell Research, and the co-founder of Tenaya Therapeutics. His lab investigates the gene networks that guide cardiogenesis by developing models of heart disease using patient-derived iPSCs and CRISPR technology. Lees meer
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Ep. 164: “iPSCs and Highly Endangered Species” Featuring Dr. Jeanne Loring
24 maart 2020 · 1 uur 1 min
Dr. Jeanne Loring is a Professor Emeritus and Director of the Center for Regenerative Medicine at the Scripps Research Institute, and the co-founder of Aspen Neuroscience. Her lab works on a diverse range of projects using iPSCs, including developing cell replacement therapies for Parkinson’s disease, sending neural organoids into space, and partnering with the San Diego zoo to make iPSCs from engangered species. Lees meer
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Ep. 163: “Bone Tissue Regeneration” Featuring Dr. Joy Wu
10 maart 2020 · 1 uur 2 min
Dr. Joy Wu is an Associate Professor of Medicine at Stanford University, and a a board-certified endocrinologist. With both basic and translational research, her lab studies stem cell therapies for bone formation and the prevention of cancer metastases to bone, as well as the bone marrow hematopoietic niche. Lees meer
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Ep. 162: “The Human Fetal Retina” Featuring Dr. Thomas Reh
25 februari 2020 · 1 uur 11 min
Dr. Thomas Reh is a Professor of Biological Structure at the University of Washington School of Medicine. His research is aimed at stimulating more effective regeneration in the retina to restore vision in people that have lost their sight.
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Ep. 161: “Generation of Functional and Mature Beta Cells” Featuring Priye Iworima
11 februari 2020 · 1 uur 15 min
Priye Iworima is a PhD student at the University of British Columbia. Her project is focused on developing and optimizing a differentiation protocol for generating insulin-producing cells derived from stem cells that could be used as a potential therapy for type 1 diabetes. Lees meer
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Ep. 160: “Engineering Human Cardiac Muscle” Featuring Dr. Kacey Ronaldson-Bouchard
28 januari 2020 · 1 uur 7 min
Dr. Kacey Ronaldson-Bouchard is an Associate Research Scientist at Columbia University focusing on biomedical engineering. She is also the co-founder of TARA Biosystems, which offers physiologically relevant human “heart-on-a-chip” tissue models for cardiac risk assessment and drug discovery applications. Lees meer