Alle afleveringen
364 afleveringen, van nieuw naar oud
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Ep. 159: “Stem Cell Patterning by Automated Design” Featuring Dr. Todd McDevitt
14 januari 2020 · 1 uur 38 min
Dr. Todd McDevitt is a Senior Investigator at the Gladstone Institutes and a Program Director and Professor at UCSF. His research focuses on engineering 3D, multicellular systems that can be used to study principles of stem cell and developmental biology. Lees meer
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Ep. 158: “Science Communication in Industry” Featuring Dr. Nicole Quinn
24 december 2019 · 1 uur 22 min
Dr. Nicole Quinn is the Associate Director of Scientific Communications at STEMCELL Technologies, and one of the people hard at work behind the scenes of the Stem Cell Podcast. After completing her PhD in genomics and discovering her love of communicating science, Nicole left the bench to pursue a science communications career in the biotech industry. Lees meer
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Ep. 157: “Secrets of Hematopoiesis” Featuring Dr. Camilla Forsberg
10 december 2019 · 1 uur 1 min
Dr. Camilla Forsberg is the Co-Director of the Institute for the Biology of Stem Cells, and a Professor of Biomolecular Engineering at the University of California, Santa Cruz. Her lab seeks to understand the molecular determinants of hematopoietic stem cell fate decisions. Lees meer
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Ep. 156: “Engineering the Stem Cell Niche” Featuring Dr. Peter Zandstra
26 november 2019 · 1 uur 6 min
Dr. Peter Zandstra is the Director of the School of Biomedical Engineering at the University of British Columbia. His lab applyies engineering design principles, computational modeling, and fundamental stem cell biology to study the mechanisms that control stem cell fate, and to develop technologies for the propagation of stem cells and their derivatives. Lees meer
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Ep. 155: “Mapping Hydra Development” Featuring Dr. Celina Juliano
12 november 2019 · 1 uur 6 min
Dr. Celina Juliano is an Assistant Professor at the University of California, Davis. Her lab studies development and regeneration in the aquatic animal Hydra, which undergoes continual self-renewal, lacks senescence and has incredible regenerative capabilities. Lees meer
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Ep. 154: “Cardiac Development and Disease” Featuring Dr. Rameen Shakur
29 oktober 2019 · 1 uur 24 min
Dr. Rameen Shakur is a Jansen Fellow in Cardiology and Personalized Medicine at the Koch Institute for Integrative Science at MIT, and the Founder of the medical device and algorithm company Cambridge Heartwear Ltd.
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Ep. 153: “Signal Transduction in Stem Cells and Cancer” Featuring Dr. Stephane Angers
15 oktober 2019 · 1 uur 26 min
Dr. Stephane Angers is a Professor at the University of Toronto. He is an expert in the field of signal transduction, working to understand the signaling mechanisms underlying the Wnt and Hedgehog families of growth factors and the large family of G protein-coupled receptors. Lees meer
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Ep. 152: “Chemotherapy-Induced Cardiomyopathy” Featuring Dr. Paul Burridge
1 oktober 2019 · 1 uur 19 min
Dr. Paul Burridge from Northwestern University talks about his work using human iPSCs to model cardiomyopathy and heart failure.
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The Stem Cell Podcast Does ISSCR – Part 3
24 september 2019 · 1 uur 19 min
Back in June 2019, we attended the ISSCR annual conference in Los Angeles, California! Here is the last of three special episodes featuring some of the top researchers in the field, and junior trainees.
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Ep. 151: “Stem Cells and Aging” Featuring Dr. Pekka Katajisto
17 september 2019 · 1 uur 24 min
Dr. Pekka Katajisto studies the mechanisms that lead to the decline in tissue regeneration during aging.
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The Stem Cell Podcast Does ISSCR – Part 2
10 september 2019 · 1 uur 23 min
Back in June 2019, we attended the ISSCR annual conference in Los Angeles, California! Here is the second of three special episodes featuring some of the top researchers in the field, and junior trainees.
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Ep. 150: “Brain Organoids in Space” Featuring Dr. Alysson Muotri
3 september 2019 · 1 uur 23 min
Guest:
Dr. Alysson Muotri is a Professor in the Departments of Pediatrics and Cellular & Molecular Medicine at the University of California, San Diego (UCSD) School of Medicine, and Co-Director of the UCSD Stem Cell Program. His research focuses on modeling neurological diseases using human iPSCs, and he is leading a project investigating the effect of microgravity on human brain organoids.
Featured Products and Resources: Lees meerSTEMdiff™ Cerebral Organoid Kit
Organoid Research ResourcesResources and Links
Detecting an Unreported Zika Outbreak using Genetics - By sequencing Zika virus and analyzing travel patterns, a previously unreported 2017 Zika outbreak in Cuba has been identified.
Ketogenic Diet Supports Intestinal Stem Cell Proliferation - Researchers have found that ketone bodies enhance the activity of intestinal stem cells, while a glucose-rich diet has the opposite effect.
Cancer Cells 'Corrupt' Their Healthy Neighbours - Scientists have developed a technique whereby metastatic cancer cells release a cell-penetrating fluorescent protein, allowing them to study the tumor microenvironment.
3D Heart Cell-on-Chip Platform - Investigators have developed an organ-on-an-electronic-chip platform, which uses biosensors to measure the electrophysiology of 3D cardiac spheroids.
Photo Reference: Courtesy of Dr. Alysson MuotriSubscribe to our newsletter!
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The Stem Cell Podcast Does ISSCR – Part 1
27 augustus 2019 · 1 uur 20 min
Intro:
Back in June 2019, we attended the International Society for Stem Cell Research's (ISSCR) annual conference in Los Angeles, California! Here is the first of three special episodes featuring interviews with some of the top researchers in the stem cell field, as well as with up-and-coming junior trainees who talked to Daylon about their research and experience at the conference.
Junior Trainees:
We asked Junior Trainees the following question:
WHAT IS THE MOST EXCITING RESEARCH THAT YOU'VE SEEN AT ISSCR?
Dr. Amritha Jaishankar; Associate Director, Maryland Stem Cell Research Fund
Aaron Sandoval; Undergraduate Student, University of Florida
Ana Rita Leitoguinho; Graduate Student, Murdoch Children's Research Institute
Alejandro Torres; Graduate Student, University of California, Los Angeles
Oriana Genolet; Graduate Student, Max Planck Institute
Ojeni Touma; Intern, California Institute for Regenerative Medicine
Vivian Lu; Graduate Student, University of California, Los Angeles
Senior Researchers:
Dr. Senta Georgia, PhD; Principal Investigator, Children's Hospital Los Angeles
Dr. Georgia is investigating how pancreatic beta cells differentiate during organogenesis, how they increase their cell numbers during normal growth and in response to metabolic stress, and how they can be regenerated as a cellular therapy for diabetic patients.
Dr. Tenneille Ludwig, PhD; Director, WiCell Stem Cell Bank
Dr. Ludwig's expertise is in optimizing human pluripotent cell culture conditions, focusing on media development and biobanking. She created the first defined, feeder-free culture system for human embryonic stem cells.
Dr. Kim Jensen, PhD; Associate Professor, Danish Stem Cell Centre
Dr. Jensen seeks to identify and characterize the regulatory mechanisms that control cell fate during development, homeostasis and diseases such as cancer. He focuses on the epithelia of the gastrointestinal tract.
Sir John Gurdon, PhD, DSc, FRS; Distinguished Group Leader, University of Cambridg… Lees meer -
Episode 149: “From Academia to Industry” Featuring Dr. Steve Szilvassy
20 augustus 2019 · 1 uur 31 min
Guest:
Dr. Steve Szilvassy is the Senior Director, Head of Hematopoietic Products at STEMCELL Technologies. He has over 25 years of experience in the fields of hematology and oncology, having held a variety of research positions, including research scientist and project team leader, in both academia and industry.
Featured Products and Resources: Lees meerLive Webinar: Optimized Workflows for High-Efficiency Genome Editing in Stem and Primary Cell Types
Jobs at STEMCELL TechnologiesResources and Links
Blastocyst-Like Structures from Mouse Stem Cells - Researchers have generated 3D blastocyst-like structures from mouse PSCs that could be implanted into the uterus and grow before resorption.
Making Old Brain Stem Cells Young - Investigators have found that increasing brain stiffness during aging leads to the dysfunction of oligodendrocyte progenitor cells, but showed that the effects can be reversed.
Stem Cell Combination Repairs Damaged Hearts - Heart muscle cells and epicardial cells derived from human ESCs were co-transplanted into rats with damaged hearts, generating grafts that had greater cell growth and that lived longer.
Using CAR-T against HIV - Scientists have developed duoCAR-T cells that target multiple sites on the HIV envelope, and that were able to kill HIV cells while resisting infection themselves.
Photo Reference: Courtesy of Dr. Stephen SzilvassySubscribe to our newsletter!
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Ep. 148: “Stem Cell Ethics” Featuring Dr. Ubaka Ogbogu
6 augustus 2019 · 1 uur 38 min
Guest:
Dr. Ubaka Ogbogu is an Associate Professor at the University of Alberta cross-appointed to the Faculties of Law and Pharmacy & Pharmaceutical Sciences. He is interested in the ethical, legal and societal implications of novel and emerging biomedical research and health care technologies.
Featured Products and Resources: Lees meerJobs at STEMCELL Technologies
Mesenchymal Stromal Cell Updates and DebatesResources and Links
Major 'Don't Eat Me' Signal Found in Cancer Cells - Researchers have identified a protein whose signaling enables cancer cells to evade detection by the immune system, making it a promising target for cancer immunotherapy.
Smooth Muscle Cells Change Identity to Protect against Atherosclerosis - Investigators have found that smooth muscle cells modulate their phenotype during atherosclerosis to protect the arterial walls.
Tracking Stem Cells in Skin - Scientists tracked stem cell division in the sebacious gland to understand the development and maintenance of the skin, and the effects of mutations on stem cell behavior.
Reversing Sickle Cell Disease with CRISPR- CRISPR was used to edit HSCs in nonhuman primates to reverse the clinical symptoms of certain blood disorders.
Modeling Monogenic Diabetes - The authors modeled monogenic diabetes using human ESCs to identify the role of the transcription factor that is mutated in the most common form of the disease.
Photo Reference: Courtesy of Dr. Ubaka OgboguSubscribe to our newsletter!
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Ep. 147: “Targeted Repair in Blood Stem and Progenitor Cells” Featuring Dr. Jennifer Adair
23 juli 2019 · 1 uur 23 min
Guest:
Dr. Jennifer Adair is an Assistant Member in the Clinical Research Division at Fred Hutchinson Cancer Research Center. Her lab uses a combination of cell biology, molecular biology, chemistry, engineering, nanomedicine and bioinformatics to develop new gene therapy treatments for many different diseases, including cancer. Her goal is to develop safe, cost-effective and clinically relevant applications for gene therapy that can be implemented worldwide.
Featured Products and Resources: Lees meerScience in Seattle
StemSpan SFEM IIResources and Links
Possible Drug Target for Heart Condition Identified - Researchers have found that a genetic mutation linked to dilated cardiomyopathy activates a signaling pathway that is normally turned off in healthy adult hearts.
Fibrosis Target Identified - Investigators have identified a protease that is activated by TGFβ that contributes to fibrosis development.
Improved Kidney Organoids - Scientists have developed a protocol for generating vascularized and functional human PSC-derived 3D kidney organoids, and used them to model disease.
New Tool for Immune Monitoring using Mass Cytometry - A mass cytometry workflow has been developed for identifying major immune cell lineages to improve biomarker discovery in immunotherapy trials.
Delayed Neurodevelopment in Zika-Exposed Children - In this prospective cohort study, the authors found that one third of children up to age three who were exposed to Zika in-utero had below-average neurological development.
Photo Reference: Courtesy of Dr. Jennifer AdairSubscribe to our newsletter!
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Ep. 146: “CRISPR-Based Modeling of Congenital Heart Disease in Patient iPSCs” Featuring Dr. Arun Sharma
9 juli 2019 · 1 uur 18 min
Guest:
Dr. Arun Sharma is a Senior Research Fellow in the Svendsen lab at Cedars-Sinai. His research focuses on the applications of iPSCs for studying cardiovascular biology, modeling diseases in a dish with genome editing technologies, and developing high-throughput platforms for screening drug toxicity and efficacy.
Featured Products and Resources: Lees meerSTEMdiff™ Cardiomyocyte
Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their ExcitabilityResources and Links
Regeneration Potential of Neonatal Mouse Heart - Researchers have shown that the regeneration capacity of the neonatal mouse heart is limited, suggesting that the processes of embryonic heart development and postnatal heart generation are distinct.
Guiding Human Development in a Dish- Scientists have developed a method for exposing human ESCs to gradients of key signaling molecules to mimic the early stages of embryonic development.
Immune Cells Invade Aging Brains - Investigators have found that T cells invade the brain of aged mice and inhibit the proliferation of neural stem cells.
Ethical Development of Stem-Cell Based Interventions - The authors address key ethical and policy challenges confronting the clinical translation of stem cell-based interventions.
Dopamine Replacement Trial for Parkinson's Disease - A clinical trial is underway to assess the efficacy of transplanting PSC-derived dopamine-producing cells in Parkinson's disease patients.
Photo Reference: Courtesy of Dr. Arun SharmaSubscribe to our newsletter!
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Ep. 145: “Cardiac Organoids” Featuring Dr. James Hudson
25 juni 2019 · 1 uur 4 min
Guest:
Dr. James Hudson is Group Leader of the Organoid Research Laboratory at the QIMR Berghofer Medical Research Institute in Brisbane, Australia, whose research is focused on developing state-of-the-art bioengineering approaches for human 3D organoids to use for studying cardiac biology and discovering new heart disease therapeutics.
Featured Products and Resources: Lees meerSTEMdiff™ Cardiomyocyte
Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their ExcitabilityResources and Links
Stimulating Hair Growth - Investigators have demonstrated that quiescent hair follicles can be stimulated to grow by small molecules that activate autophagy.
Organoid Model of Fibrotic Lung Disease - Researchers used ESC-derived 3D organoids to model fibrotic lung disease, and identified a possible pathogenic mechanism.
Antibody Conditioning for HSC Transplants - A transplant of mismatched HSCs without immune suppression by chemotherapy or radiation was successful in mice by performing a conditioning treatment with six antibodies.
Improving Pancreatic Islet Transplantation - Researchers have identified a protein that improves revascularization of pancreatic islet grafts, and is a potential target for enhancing transplant outcomes in type 1 diabetes.
Reprogramming Scar Tissue into Heart Muscle - For the first time, scientists have developed a stable, reproducible, and minimilistic platform to reprogram human fibroblast cells into cardiomyocytes.
Photo Reference: Courtesy of Dr. James HudsonSubscribe to our newsletter!
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Ep 144: “Multiscale Map of Stem Cell State in Pancreatic Adenocarcinoma” Featuring Dr. Tannishtha Reya
11 juni 2019 · 1 uur 27 min
Guest:
Dr. Tannishtha Reya is a Professor of Pharmacology and Medicine at the University of California, San Diego. Her lab focuses on understanding the signaling pathways that regulate the choice between stem cell renewal and commitment, and define how the same signals are subverted in cancer.
Featured Products and Resources: Lees meerCancer Stem Cell News
Dunn Webinar: Understanding Pancreatic Development and Diabetes Using Patient-Specific iPS CellsResources and Links
HIV-Preventing Gene Mutation Linked to Earlier Death - A variant of the CCR5 gene that protects against HIV infection, and that was infamously edited in babies using CRISPR, has been associated with an earlier death.
Establishment of Expanded Potential Stem Cells - Investigators have generated pig and human expanded potential stem cells that have the features of the first cells in the developing embryo.
Single Cell Trajectories of Cardiopharyngeal Fates - Scientists have mapped the development of heart lineages and identified the mechanisms dictating cardiopharyngeal fate choices.
Improved Human Brain Organoids - Researchers have developed a new method of generating brain organoids with little developmental variability between the organoids.
Stromal Cells Influence Pancreatic Cell Tumors - The stromal microenvironment has been shown to affect gene expression and shape tumor growth and metastasis in pancreatic cancer.
Photo Reference: Courtesy of Dr. Tannishtha ReyaSubscribe to our newsletter!
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Ep 143: “Cell Fate Decisions at Single-Cell Resolution” Featuring Dr. Bertie Göttgens
28 mei 2019 · 1 uur 7 min
Guest:
Dr. Bertie Göttgens is a Professor of Molecular Hematology at the University of Cambridge. His lab studies how transcription factor networks control the function of hematopoietic stem cells, and how mutations that perturb such networks cause leukemia. In this episode, he talks about his research and his groundbreaking paper that mapped mouse gastrulation and early organogenesis.
Featured Products and Resources: Lees meermTeSR™ Plus
#StemCellfie ContestResources and Links
New Neurons Form in Old Age, Even in People with Alzheimer's - Researchers have shown that hippocampal neurons continue to form well into old age, as well as in individuals with mild cognitive impairments and Alzheimer's disease.
Blocking an Inflammatory Protein Reverses Brain Aging - Blocking an inflammatory protein in brain cells reversed the effects of brain aging in old mice, and prevented signs of brain aging in young mice infused with old blood.
New Mechanism Identified for Blood Stem Cell Development - Researchers have discovered a new role for the epidermal growth factor receptor in regulating hematopoietic stem cell development.
Mapping the Bone Marrow Microenvironment - Investigators created a map of the stem cell niche in mouse bone marrow, and identified how it is influenced during healthy homeostasis and in leukemia.
Non-Invasive Tool Tracks Efficacy of Transplanted Stem Cells - Exosomes isolated from blood are a potential non-invasive method for monitoring the activity of transplanted cardiac progenitor cells following a heart attack.Photo Reference: Courtesy of Dr. Bertie Göttgens
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Ep 142: “Beta-Cell Proliferation and Diabetes” Featuring Dr. Adrian Teo
14 mei 2019 · 1 uur 12 min
Guest:
Dr. Adrian Teo is a Principal Investigator at the Institute of Molecular and Cell Biology at the Agency for Science, Technology and Research (A*STAR) in Singapore. His research focuses on using stem cell technology to model human pancreatic development in vivo and to study the mechanisms that cause diabetes and underlie diabetic complications.
Featured Products and Resources: Lees meerPancreatic Cell News
Ray Dunn WebinarResources and Links
Advancing Cell Therapies for Diabetes - Researchers mapped stem cell-derived beta cell differentiation, and developed an improved process for purifying beta cells, which can be used to enhance cell therapies for diabetes.
Essential Role of YAP in Liver Regeneration - YAP signaling, which activates the transcription of certain genes, has been shown to be necessary for the survival and regeneration of liver epithelial cells upon injury.
Gene Therapy Repairs Heart Attack Damage in Pigs - Expression of a microRNA delivered by adeno-associated viral vectors stimulated cardiac repair in pig hearts following a heart attack.
How Low Oxygen Affects the Premature Brain - Using 3D brain-region-specific organoids, research have identified certain brain cells that are susceptible to harm from exposure to oxygen deprivation during early development.
Tumor-Initiating Cells Addicted to Methionine - Scientists have found that tumor-initiating cells are metabolically dependent on methionine, providing a potential therapeutic target.Photo Reference: Courtesy of Dr. Adrian Teo
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Ep 141: “iPSC-Derived Myogenic Progenitors” Featuring Dr. Rita Perlingeiro
30 april 2019 · 1 uur 11 min
Guest:
Dr. Rita Perlingeiro is the Lillehei Professor in Stem Cell and Regenerative Cardiovascular Medicine at the Lillehei Heart Institute. Her lab is interested in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells, and applying this information to generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential. Much of her work is focused on muscular dystrophies. Lees meerFeatured Products and Resources:
Muscle Cell News
MyoCult™Resources and Links
New CAR T-Cell Therapy Less Toxic - A Phase I clinical trial has shown that a redesigned CAR T-cell molecule was less toxic and produced fewer side effects in patients, making the treatment safer.
Using MSCs to Engineer an HSC Niche - Researchers have identified genes in mesenchymal stem cells that enhanced the production of niche factors that could maintain hematopoietic stem cells in culture.
Generating Ovarian Cancer Organoids - Investigators developed a protocol for generating and expanding ovarian cancer organoids, and demonstrated their potential applications.
Stress-Resistant Muscle Stem Cells - Scientists have identified a population of muscle stem cells that resist radiation and are able to expand under severe stress.
Muscle Stem Cells Protected from Environmental Stress - The expression of a transcription factor has been shown to protect muscle stem cells against environmental stress caused by a toxic pollutant.Photo Reference: Courtesy of Dr. Rita Perlingeiro
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Ep 140: “Blood Vessel Engineering” Featuring Dr. Josef Penninger
16 april 2019 · 1 uur 16 min
Beluister deze afleveringGuest:
Dr. Josef Penninger is the Director of the Life Sciences Institute at the University of British Columbia and a Canada 150 Chair in Functional Genetics. He was previously the Scientific and Founding Director of the Institute for Molecular Biotechnology of the Austrian Academy of Sciences. His research is focused on understanding the complex mechanisms of how diseases develop, particularly in cardiovascular, autoimmune and bone diseases, and cancers. Lees meerFeatured Products and Resources:
Science in the City - Vancouver
EC-Cult™Resources and Links
Shutting Down Glioblastoma at its Earliest Moments - By performing cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer, scientists have identified a molecular driver of glioblastoma.
The Bone Marrow Microenvironment at Single-Cell Resolution - Researchers have mapped the transcriptional landscape of mouse bone marrow cell populations, both at homeostasis and under conditions of stress-induced hematopoiesis.
Exploring the Mouse Gut Endoderm at Single Cell Resolution - Investigators have shown that throughout embryogenesis endoderm cells acquire a transcriptional identity that reflects their future fate and spatial positioning.
Specification of Positional Identity in the Forebain - Scientists have grown topographically organized human forebrain organoids using engineered signaling centers.
The Developmental Origin and Lifespan of Osteoclasts - Researchers have identified the developmental origin of osteoclasts and a mechanism that controls their maintenance in bones after birth.Photo Reference: Courtesy of Dr. Josef Penninger
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Ep 139: “In Vitro Models of Schizophrenia” Featuring Dr. Kristen Brennand
2 april 2019 · 1 uur 5 min
Beluister deze afleveringGuest:
Dr. Kristen Brennand is an Associate Professor of Genetics and Genomics, Neuroscience, and Psychiatry at the Icahn School of Medicine at Mount Sinai in New York. A major focus of her work is in developing in vitro models for schizophrenia in order to identify novel insights into the molecular and cellular phenotypes of mental illness. Her lab has established a new mechanism using iPSC-based models to systematically test the impact of causal variants in human cells. Lees meerFeatured Resource:
Subscribe to Neural Cell News
Dr. Kristen Brennand Webinar: Using hiPSCs to Study Genetic Variants Linked to SchizophreniaResources and Links
Testicular Graft Produces Sperm and Live Offspring - Primates that had prepubertal testicular tissue removed, frozen, and grafted back later in life were able to produce sperm and offspring.
Using Cardiac Organoids for Drug Screening - Cardiac organoids were used to identify pro-regenerative drugs without detrimental side effects on cardiac function.
A Common Embryonic Origin of Neural Progenitors - Investigators have found that in mice, a single population of neural progenitors contributes to lifelong neurogenesis in the hippocampus.
New Brain Cells Made throughout Life - Scientists have shown that humans can make new brain cells into their nineties, but this production progressively declines in individuals with Alzheimer's disease.
Using Phenotypes to Identify Schizophrenia Genes - Researchers have developed a phenotypic atlas of schizophrenia-associated genes, and identified 30 genes for further study.Photo Reference: Courtesy of Dr. Kristen Brennand
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Ep. 138: “Cell-Based Therapies in Late-Stage Clinical Trial” Featuring Dr. Robert Mays
19 maart 2019 · 1 uur 14 min
Beluister deze afleveringGuest:
Dr. Robert Mays is the Co-founder and Vice President of Regenerative Medicine and Head of Neuroscience Programs at Athersys Inc. He focuses on Athersys' proprietary stem cell product, MultiStem®, and its applications in regenerative medicine and drug discovery, with a specific focus on injuries and diseases affecting the central nervous system.
Featured Resource: Lees meerApply to become a co-host on the Stem Cell Podcast!
CytokinesResources and Links
New Drug Developed to Treat Heart Attack Damage - Using iPSC-derived cardiomyocytes, scientists have developed a new drug that minimizes cardiomyocyte death following a heart attack.
Enhancing iPSC Immune Compatibility - Researchers used CRISPR to make immunocompatible donor iPSCs that could increase iPSC-based regenerative medicine applications.
Kidney Organoids Created from Urine - Researchers have generated kidney tubular epithelial organoids from both kidney tissue and urine cells, which can be used for personalized disease modeling.
Modeling Developmental Disorder with Brain Organoids - Cerebral organoids were used to model the developmental disorder neuronal heterotopia, providing insight into the mechanisms causing impaired neuronal migration.
Cancer-Specific Inhibitor Identified - Researchers have identified a cancer-specific inhibitor that targets the metabolic needs of cancer cells.Photo Reference: Courtesy of Dr. Robert Mays
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Ep. 137: “Hematopoiesis and Cardiovascular Disease” Featuring Dr. Andrew Murphy
5 maart 2019 · 57 min
Beluister deze afleveringGuest:
Dr. Andrew Murphy is an Associate Professor at the Baker Heart and Diabetes Institute and Monash University in Melbourne, Australia. He seeks to understand the processes by which hematopoietic stem cells and the bone marrow niche become affected in disease, specifically in the context of cardiovascular and metabolic disease.
Featured Resource: Lees meerApply to become a co-host on the Stem Cell Podcast!
Hematopoiesis HubResources and Links
Quiescence Increases the Resistance and Function of Old Neural Stem Cells - Increased quiescence makes aged neural stem cells resistant to regeneration. But, if activation is enforced, both young and old NSCs show similar proliferation and differentiation capacity.
A Gliogenic Switch for Human Astrocytes - Researchers have developed a new method to rapidly differentiate astrocytes from PSC-derived neural stem cells using a protein switch.
Generating Thalamic Organoids - Researchers have created thalamic organoids and fused them together with an organoid of the frontal cortex to study brain development and disease.
CRISPR Therapy for Hutchinson-Gilford Progeria Syndrome (Article 1)(Article 2) - Two separate research groups have used CRISPR to suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome.
CRISPR Makes iPSCs Invisible to the Immune System - Using CRISPR, scientists have created iPSCs that evade the immune system and prevent transplant rejection, poising them as a "universal" donor stem cell.Photo Reference: Courtesy of Dr. Andrew Murphy
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Ep. 136: “HSC Trafficking” Featuring Dr. Paul Frenette
19 februari 2019 · 1 uur 18 min
Beluister deze afleveringGuest:
Dr. Paul Frenette is the Chair and Director of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at the Albert Einstein College of Medicine. Dr. Frenette's research focuses on the molecular and cellular constitutents of the stem cell niche, mechanisms of sickle cell vaso-occlusion, the role of the nervous system in cancer, and understanding how hematopoietic stem cells and mature blood cells traffic in vivo.
Featured Resource:
STEMvision™
Resources and Links
An Improved Approach for Generating Kidney Organoids - Researchers have developed a new in vitro method for generating vascularized, mature kidney organoids by exposing them to fluidic shear stress.
Functional Insulin-Producing Cells Grown in Lab - For the first time, mature insulin-producing cells have been developed from stem cells.
Reprogramming Pancreatic Cells to Treat Diabetes - Scientists have reprogrammed pancreatic α-cells into insulin-producing pancreatic β-cells that were able to reverse diabetes in mice.
A Bioengineered Factory for T Cells - Researchers have developed an injectable bone marrow-like scaffold that enhances T cell development following a bone marrow transplant.
Sleep Protects against Heart Disease - By subjecting mice to chronic sleep fragmentation, researchers have discovered a neuro-immune axis that links sleep to hematopoiesis and atherosclerosis. Lees meerPhoto Reference: Courtesy of Dr. Paul Frenette
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Ep. 135: “3D Bioprinting and Tissue Engineering” Featuring Dr. Stephanie Willerth
5 februari 2019 · 51 min
Beluister deze afleveringGuest:
Dr. Stephanie Willerth is an Associate Professor and Canada Research Chair at the University of Victoria. Her research focuses on using engineering-based approaches to stem cell biology. Her team develops bioactive scaffolds for directing stem cell differentiation, and investigates the expression of transcription factors that regulates this process. The goal of her group's research is to develop engineered tissues that can be transplanted in the human nervous system to treat diseases like Parkinson's or repair damaged spinal cord tissue.
Featured Resources: Lees meerSTEMdiff™ Neural System for hPSC-Based Neurological Modeling
Science in VancouverResources and Links
A Druggable Target for Alzheimer's Disease - Researchers have identified a cholesterol product regulating Tau proteostasis, which could serve as a drug target for Alzheimer’s disease.
New Biomarker and Drug Target for ALS - Using an iPSC model of human motor neurons, researchers discovered that the STMN2 gene may be a potential biomarker and therapeutic target for ALS.
Generation of Lung Organoids - Researchers have developed a protocol for differentiating hPSCs into human lung and bud tip progenitor organoids.
Scientists Grow Human Blood Vessels in a Dish - Scientists have grown functional human vascular organoids that can be used to model and study vascular diseases.
Organoid-Induced Differentiation of T Cells - Artificial thymic organoids were used to generate mature T cells from PSCs, providing a renewable source for treatment.Photo Reference: Courtesy of Dr. Stephanie Willerth
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Ep. 134: “The Power of Organoids” Featuring Dr. James Wells
22 januari 2019 · 58 min
Beluister deze afleveringGuest:
Dr. James Wells is the Director for Research in the Division of Endocrinology at Cincinnati Children's Hospital, as well as the Chief Scientific Officer at the Center for Stem Cell and Organoid Medicine (CuSTOM). His research focuses on understanding the embryonic development of the pancreas and gastrointestinal organs by identifying mechanisms involved in the embryonic development of endocrine cells. His translational projects include generating 3D human tissues from pluripotent stem cells to model diabetes and digestive disease.
Resources and Links
Creation of 3D Printed Implant for Spinal Cord Injuries - Researchers have succesfully 3D printed a two-millimeter spinal cord implant to repair spinal cord injuries in rats.
Researchers Generate Human Naive Induced Pluripotent Stem Cells - A combination of microfluidics and modified RNA have been used to directly reprogram somatic cells into naive, rather than primed, hiPSCs.
Cutting Off Melanoma's Escape Routes – Scientists have discovered stem cells which form blood vessels in tumors, and have identified how to switch the cells off, cutting off the blood supply.
Endoglin as a Target for Acute Leukemia - A glycoprotein on the cell surface, called endoglin, is a marker for cancer stem cells in acute myeloid leukemia and acute B-lymphoblastic leukemia.
Correcting the Genetic Mutation that Causes a Life-Threatening Autoimmune Syndrome - Researchers have developed a method for modifying blood stem cells to reverse the genetic mutation that causes IPEX syndrome.
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Ep. 133: “Regenerative and Malignant Stem Cells in the Lung” Featuring Dr. Carla Kim
8 januari 2019 · 59 min
Beluister deze afleveringGuest:
Dr. Carla Kim is a Professor in the Division of Hematology/Oncology and Pulmonary Respiratory Diseases at Children’s Hospital Boston, as well as in the Department of Genetics at Harvard Medical School and in the Harvard Stem Cell Institute. Her research involves characterizing the biology of stem cells in the normal lung and in lung cancer using a combination of mouse genetics, cell biology and genomics approaches. Her lab has also developed 3D lung organoid systems that makes it possible to derive specialized lung cells from lung stem cells and interrogate the crosstalk between specialized cell types in the healthy and diseased lung.
Resources and Links
Human Blood Cells Can Be Directly Reprogrammed into Neural Stem Cells - Researchers have established an approach for direct differentiation of somatic cells into expandable neural progenitor cells.
Stem Cell-Derived Neurons Stop Seizures and Improve Cognitive Function - Transplantation of hiPSC-derived neural cells into the hippocampus of rats who have experienced prolonged seizures can greatly reduce the frequency of spontaneous recurrent seizures.
How Sperm Stem Cells Maintain Their Number – Sperm stem cell numbers are achieved through competition for a limited supply of self-renewal-promoting fibroblast growth factors.
Researchers Discover Control Mechanism for Melanoma Skin Cancer - Tissue-resident memory T cells control the growth of melanomas in mice for the life of the animal, which likely equates to decades of protection in humans.
Age-Related Remodelling of Oesophageal Epithelia by Mutated Cancer Drivers - Researchers find that alcohol consumption and smoking substantially accelerate mutations in cancer driver genes with age.
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Ep. 132: “You Beta Watch Out” Featuring Dr. Jeffrey Millman
18 december 2018 · 1 uur 2 min
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Dr. Jeffrey Millman is an Assistant Professor of Medicine and Biomedical Engineering at the Washington University in St. Louis. His research focuses on the in vitro production and study of pancreatic insulin-producing β cells from human pluripotent stem cells for use in cellular replacement therapy and drug screening. He joins us to discuss his research.
Resources and Links
Efficient Scarless Genome Editing in Human Pluripotent Stem Cells - Researchers have established a new method for generating 'scarless' genetic changes in human pluripotent stem cells that do not
leave selection markers.
Platelets Grown from Stem Cells May be Alternative to Donated Platelets - Platelets generated from adipose-derived stromal stem cells could provide an alternative to donated platelets, which are in short supply and can cause infection in the recipient.
Tackling Treatment-Resistant Cancer – Researchers have found an epigenetic mechanism that cancer cells use to overcome drug treatment.
Honey Bee Protein Keeps Stem Cells Young - A mammalian analog of the active component of honeybee royal jelly acts as a fountain of youth for mouse embryonic stem cells by maintaining their pluripotency.
A Renewable Source of Beige Fat to Overcome Obesity - Reprogramming iPSCs to brown and beige adipose tissue, which burns glucose and improve metabolic function, could provide a new therapeutic strategy to address the health risks of obesity.
Photo Reference: Courtesy of Dr. Jeffrey Millman Lees meerSubscribe to our newsletter!
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Ep. 131: “Testicular Endos” Featuring Dr. Sandra Ryeom
6 december 2018 · 1 uur 10 min
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Dr. Sandra Ryeom is the Assistant Professor of Cancer Biology at the University of Pennsylvania's Perelman School of Medicine. Dr. Ryeom’s lab focuses on understanding the contribution of endothelial cells in different organs towards maintaining stem cell populations. She joins us to discuss her work and recent paper in Nature Communications.
Resources and Links
Zaps to Brain to Ease Depression - People’s moods quickly improved after scientists stimulated the orbitofrontal cortex in the brain, a finding that may ultimately usher in powerful ways to combat severe depression.
Gut Bacteria May Guard against Diabetes - The friendly gut bacterium Akkermansia muciniphila may help protect against Type II diabetes. Those bacteria are lost with aging, setting the stage for the disease.
Small Doses of Peanut Protein Can Help Allergies – A study finds that allergic children exposed to gradually increasing doses of peanut protein increased their tolerance to nuts, and lowered symptom severity.
Coffee or Tea Preference Is Written In DNA - Whether people drink tea or coffee may depend partly on which bitter chemicals they have a genetic sensitivity towards.
The First CRISPR Babies Are Born in China - A Chinese researcher claims that he helped make the world’s first genetically edited babies by using CRISPR technology.
Intestinal Allografts Contain Functional Hematopoietic Stem Cells – A surprising new study has found that the human intestine may provide up to 10 percent of blood cells in circulation from its own reservoir of hematopoietic stem cells.
Healthy Blood Stem Cell Have As Many DNA Mutations as Leukemic Cells - Researchers have found that the number of mutations in healthy and leukemic hematopoietic stem cells does not differ.
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Ep. 130: “Autism Genes” Featuring Dr. Karun Singh
20 november 2018 · 1 uur 6 min
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Dr. Karun Singh is a Principal Investigator, Associate Professor and the David Braley Chair in Human Stem Cell Research at McMaster University. The overall goal of Dr. Singh’s research program is to use stem cell-based models to study neurological disorders and devise new therapies for these conditions. His latest paper discusses an iPSC knockout resource for functional studies of autism-risk genes. Lees meerResources and Links
Microneedles for Eyes - A team of researchers developed a contact lens-like eyepatch that would leave tiny, dissolving microneedles in the eye to slowly deliver drugs over several days.
Making Mitochondria - Researchers engineered endosymbiosis between E. coli and Saccharomyces cerevisiae to model the endosymbiotic theory of mitochondrial evolution.
Obesity Linked to Tumor Growth - Obesity raises the risk of certain tumors and reduces immune activity, but might also amplify the effects of some cancer therapies.
People of the Andes Evolved Uniquely - A new study of ancient and modern DNA suggests that the Andean highland people of Peru adapted differently from lowland populations due to environmental and social pressures.
The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells – Researchers found decreased proteasome activity in the satellite cells of mice lacking the crucial proteasomal component, Rpt3. Ablation of Rpt3 in satellite cells resulted in proliferation defects and apoptosis.
In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity – Researchers provided a protocol that enables the large-scale expansion of transplantable human hepatocytes, which could be further developed for modeling and treating human liver disease.
First Patient Receives Stem Cell Transplant in Parkinson's Trial - A research team at Kyoto University injected induced pluripotent stem cells, which have the potential to develop into any cell in the body, into the brain of a 50-year old male with Pa… -
Ep. 129: “The MSC Bucket” Featuring Dr. Pamela Robey
7 november 2018 · 1 uur 6 min
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Dr. Pamela Robey is a senior investigator at the National Institute of Dental and Craniofacial Research at the NIH. Dr. Robey’s work focuses on skeletal biology, and the characteristics and biological properties of bone marrow stromal cells, a subset of which are multipotent skeletal stem cells. In late September, Dr. Robey co-authored a commentary article in Nature discussing the ever famous, but dubious, mesenchymal stem cell. She comes on the show to talk about this and more. Lees meerResources and Links
Sunbathing Every Other Day for a Darker Tan and Less Damage - Exposure to the sun every other day, rather than daily, can improve a sunbather's dark tan while minimizing skin damage.
First Viable Freeze-Thawed Coral Larvae Reported - A technique called cryopreservation might help save some threatened coral reefs. The first coral larvae to survive being frozen and then thawed by scientists are a kind of a mushroom coral.
Mix of Gut Bacteria Allow Pathogens to Flourish - The bacterium Clostridioides difficile, that causes severe diarrhea, takes advantage when antibiotics or other factors disrupt the normal mix of microbes in the gut.
Changing Fruit Flies’ Gut Bacteria Makes Them Speed Walk - The authors suggest that microbes in the gut may affect how the brain controls movement.
Stem Cell Derived Neural Cells Are Going to Space - Research teams at the Summit for Stem Cell labs in La Jolla, California, and the New York Stem Cell Foundation Research Institute in New York, NY, will conduct the first long-term cell culture experiment in space focused on neurodegenerative diseases.
How Sleeping Mammary Stem Cells Are Awakened in Puberty - Scientists have discovered how the growth of milk-producing mammary glands is triggered during puberty.
Testicular Endothelial Cells Are a Critical Population in the Germline Stem Cell Niche - Identifying testicular endothelial cells as a niche population necessary for spermatogonial stem cell self-renewal may facilitate fertility pres… -
Ep. 128: “Targeting Pediatric Kidney Cancer” Featuring Dr. Benjamin Dekel
26 oktober 2018 · 1 uur 16 min
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Dr. Benjamin Dekel is a leading investigator in the field of human renal stem cell biology and regenerative medicine. He is the Head of the Pediatric Stem Cell Research Institute and the Director of the Division of Pediatric Nephrology at the Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Israel. Lees meerResources and Links
Gene Editing Creates Mice with Two Dads - Researchers gathered fathers’ stem cells, and used them to produce embryos that were implanted into surrogate mothers.
A New Microscope to Visualize Mammalian Development - A new microscope uses laser light to image growing mammal embryos. Scientists used the instrument to track a mouse embryo as it developed over two days.
Rising Temperatures and Drought Target Barley Crops Worldwide - Climate change impacts on barley crops could lead to less beer and skyrocketing prices.
Hundreds of Dietary Supplements Are Tainted with Potentially Harmful Drugs - Most of the nearly 800 dietary supplements flagged by the FDA as tainted with potentially harmful drugs from 2007 to 2016 were marketed to improve sex drive, help with weight loss or build muscle.
HOPX-Dependent Cardiomyocyte Maturation – Single-cell RNA-seq during cardiac hPSC differentiation reveals cellular heterogeneity.
CRISPR Screens to Identify Factors that Drive Neuronal Fate – Researchers activated the expression of all endogenous transcription factors and other regulators via a pooled CRISPRa screen in embryonic stem cells, revealing genes including epigenetic regulators such as Ezh2 that can induce neuronal fate.
A Biodegradable Device for Electrical Stimulation of Nerve Regrowth - Researchers have developed an implantable, biodegradable device that delivers regular pulses of electricity to damaged peripheral nerves in rats, helping the animals regrow nerves in their legs and recover their nerve function and muscle strength more quickly.
In Utero CRISPR Mediated Therapeutic Editing of Metabolic Genes - For the first time, scientist… -
Ep. 127: “Light Stem Cell Control” Featuring Dr. Tsvee Lapidot
9 oktober 2018 · 1 uur 11 min
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Dr. Tsvee Lapidot is a Professor at the Weizmann Institute of Science. His research investigates the regulation of normal and leukemic hematopoietic stem cells by the brain-bone-blood triad in transplanted mice. In this episode we talk to him about his research and his latest study in Cell Stem Cell looking at the influence of circadian rhythms on regulation of blood stem cells. Lees meerResources and Links
Nobel Congratulations - This year’s Nobel laureates discovered brakes that keep immune cells called T cells from attacking cancer. The laureates’ innovations remove those brakes, allowing the immune system to fight tumors.
Deadly Strain of Bird Flu Can Easily Infect Ducks - Some ducks in China’s Fujian province carry highly pathogenic strains of the H7N9 avian influenza virus.
Placing CRISPR Gene Editor into Bacteria Can Kill the Pathogen - A new approach to fighting antibiotic-resistance Staphylococcus aureus bacteria co-opts genes that normally make the bacteria more dangerous.
First Lab Test of Gene Drive Wiped Out Mosquito Population - The malaria-carrying mosquito Anopheles gambiae’s days might be numbered. Scientists have devised a gene drive that bottomed out the mosquito’s populations in lab tests.
Novel Method for Detecting Human Embryonic Stem Cells - A new method developed by researchers at Singapore University of Technology and Design can potentially ensure patient safety for future stem cell-based therapies by enhancing native stem cell bioelectric signals.
Erythro-Myeloid Progenitors Contribute Endothelial Cells to Blood Vessels - This new report shows that a complementary source of endothelial cells is recruited into pre-existing vasculature after differentiation from the earliest precursors of erythrocytes, megakaryocytes and macrophages - the erythro-myeloid progenitors that are born in the yolk sac.
Induction of Resistance to Chimeric Antigen Receptor T Cell Therapy - The progeny of a subclone of the parental leukemia generated during the cell m… -
Ep. 126: “Cancer Environment” Featuring Dr. Louis Vermeulen
25 september 2018 · 1 uur 5 min
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Dr. Louis Vermeulen is a Principal Investigator at the Center for Experimental Molecular Medicine at the Academic Medical Center in Amsterdam, and the New York Stem Cell Foundation, where he is focusing on the role of stem cells in colorectal cancer development and progression. He aims to develop improved preventative strategies and novel therapies for this disease by studying the effects of genetic mutations on the behavior of stem cells in the gut. Lees meerResources and Links
Recount of the Human Genome - A recount of human genes increases the number to at least 46,831. The new estimate is based on a broader definition a gene.
Bias in Studying the Genome - Despite the Human Genome Project having heralded the exploration of previously unknown human genes, the focus of genetic studies remains narrow.
Obesity Can Harm Learning and Memory - Obesity may prod immune cells to nibble parts of nerve cell connections called synapses, a mouse study suggests.
A New Antibiotic to Kill Superbugs - A new drug can wipe out strains of common bacteria that have resisted treatment to multiple other antibiotics, including Pseudomonas aeruginosa, which can cause urinary tract or respiratory infections.
Glial Cells Prevent Tau Pathology - By preventing the accumulation of senescent cells in the brain, scientists were able to diminish tau protein aggregation, neuronal death and memory loss.
Software for Personalized Leukemia Treatments - Early findings from a new study could help in the development of immune-based treatments personalized to people with acute myeloid leukemia who are undergoing stem cell transplantation.
Stem Cells to Save Rhino Species – A second rhino has become pregnant this year through artificial insemination at the San Diego Zoo Safari Park. Scientists reprogrammed cryopreserved rhino cells and matured them into germ cells to be used for the insemination.
Gene Therapy via Skin to Protect from Cocaine Over Dose - A new study shows that epidermal stem cells, modifie… -
Ep. 125: “Mutation Burden” Featuring Dr. Kelly Frazer
11 september 2018 · 1 uur 11 min
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Dr. Kelly Frazer is the Director of the UC San Diego Institute for Genomic Medicine and Founding Chief of the Division of Genome Information Sciences in the Department of Pediatrics at UC San Diego. Dr. Frazer has spent the past 25 years studying various aspects of functional and structural human genomics. In this episode she talks to us about her recent paper looking at the mutational burden of human induced pluripotent stem cells. Lees meerResources and Links
New Found Skull Tunnels – Using a micro-CT scan, scientists found that the mouse skull is full of microscopic channels that connect the bone to the brain’s outer membrane. Similar channels were found in human skulls.
Microglia Part of Sex-Linked Brain Disorders – Scientists found that male microglia might be less protected against environmental insults and quicker to activate the cellular suicide program.
Genes to Help Plants Produce Morphine-Like Molecules - The newly deciphered genome of the opium poppy is helping scientists figure out how the plant evolved the ability to make morphine and other similar painkilling molecules.
CRISPR to Help Dog Muscular Dystrophy - Scientists have used CRISPR/Cas9 to repair a genetic mutation in beagle puppies that causes muscular dystrophy.
New Cell Fate Determinant Identified in Neural Stem Cells - Lisa Flanagan, PhD, and her research team examined several pathways that add sugars to cells and found one that differed between cells that make neurons and cells that make astrocytes.
A New Family Tree of Blood Production Provides Info on Stem Cells - A new study shows that humans have ten times more hematopoietic stem cells than previously thought.
Blood Brain Barrier Chip System - Wyss Institute researchers have created organ chips that mimic the brain and the blood-brain barrier and, by linking them together, have discovered how our blood vessels and neurons influence each other.
Using Stem Cell Factors in Wounds Could Help Heal Skin Ulcers - Scientists have developed a tec… -
Ep. 124: “Mutations and Palpitations” Featuring Dr. Joseph Wu
28 augustus 2018 · 1 uur 10 min
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Dr. Joseph C. Wu, MD, PhD is Director of the Stanford Cardiovascular Institute and Simon H. Stertzer Endowed Professor in Department of Medicine (Cardiology) and Department of Radiology at the Stanford School of Medicine. Dr. Wu is a pioneer in using iPS cells in personalized medicine and we talk to him about his work and the state of the field in respect to novel stem cell therapies for cardiovascular disease. Lees meerResources and Links
First FDA Approved RNAi Therapy - The FDA has approved Alnylam Pharmaceuticals’ Onpattro (patisiran) infusion, a first-of-its-kind RNA-based therapy for treating peripheral nerve disease (polyneuropathy) caused by hereditary transthyretin-mediated amyloidosis in adult patients.
Cancer Drug to Help Liver Overcome Painkiller Overdose - In mice given a toxic dose of acetaminophen, an anticancer medication kept liver cells alive.
Zika Virus Harms Nearly 1 in 7 Babies Exposed to The Virus in the Womb - A CDC study of births in U.S. territories tallies birth defects and later health problems.
Scientists Tracked the Speed of Cell Suicide - The study shows that the process of cells' self-inflicted death, called apoptosis, functions in trigger waves that travel at speeds of 30 micrometers per minute.
Why Salamanders Regenerate and Lizards Do Not - By transplanting neural stem cells between species, researchers have discovered that the lizard's native stem cells are the primary factor hampering tail regeneration.
Stem Cell Transplants to Treat Cystic Fibrosis - Researchers believe their breakthrough in stem cell transplantation therapy, developed in mice, could eventually provide a cure for cystic fibrosis.
iPS Cells for Platelet Transplant Therapy - A team at Japan's Kyoto University hopes to conduct the first clinical study of an intractable blood disease using induced pluripotent stem (iPS) cells.
Stem Cells Restore Some Vision in Blind Mice - The procedure is the first of its kind and researchers hope that it will lead to treatments for… -
Ep. 123: “Shot to the Heart” Featuring Dr. Charles Murry
14 augustus 2018 · 1 uur 5 min
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Dr. Charles Murry is the Woods Professor of Pathology, Bioengineering and Medicine/Cardiology at the University of Washington. He also serves as Director of the UW’s Heart Regeneration Program, with the goal of achieving stem cell-based heart regeneration in patients. He has recently published a paper that used stem cell derived heart cells to treat heart damage in monkeys.
Featured Resource: CloneR™ Defined Supplement for Single-Cell Cloning of Human ES and iPS Cells Lees meerResources and Links
Leeches And Drug Resistance - Medicinal leeches contain bacteria in their guts that can be transferred to humans. In some cases, it only takes a small exposure to antibiotics for those bacteria to become drug resistant.
Soccer Headers Affect Women More - A head-to-head comparison finds that heading a soccer ball may damage white matter in women’s brains more than men’s.
A New Ebola Species Identified - A new species of Ebola virus was found in two bat species in Sierra Leone, the Angolan free-tailed bat and the little free-tailed bat and experts fear it could spread to humans.
CRISPR Conversation - The researcher behind the world’s largest effort to edit human embryos with CRISPR is vowing to continue his efforts to develop what he calls “IVF gene therapy".
Generation of Human Spinal Cord Neural Stem Cells - Scientists report the derivation of spinal cord neural stem cells from human pluripotent stem cells.
Japan Launches First Clinical Trial Using Stem Cells for Parkinson’s - A much-anticipated induced pluripotent stem cell trial for Parkinson’s Disease reportedly will soon launch led by Professor Jun Takahashi.
Stem Cell Formation in Plants - A Purdue University study has uncovered mechanisms that led to stem cell formation and maintenance in plants.
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Ep. 122: “Cord Blood Cells” Featuring Dr. David Knapp and Colin Hammond
31 juli 2018 · 1 uur 8 min
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Dr. David Knapp is a Post-Doctoral Fellow at the University of Oxford. Colin Hammond is a graduate student in Dr. Connie Eaves' lab at the BC Cancer Agency. Dr. David Knapp and Colin Hammond talk about their recent publication in Nature Cell Biology regarding stem cell populations in cord blood cells.
Featured Resource: Webinar: Re-Creating Disease with Kidney Organoids and CRISPR Lees meerResources and Links
Anti-CRISP Protein Production - Phages produce Anti-CRISPR proteins (Acr-proteins) that battle the bacterial defense system.
Evidence of Oldest Life On Land - Scientists found evidence of terrestrial microbial life that they estimate is about 3.22 billion years old.
Hybrid Embryos of Endangered White Rhinos - Scientists are using artificial reproductive technology to inject a northern white rhino sperm cell into a southern white rhino egg, creating one of the first rhino embryos in a lab.
The Most Complete Look at a Fruit Fly’s Brain Cells - Using high-speed electron microscopy, scientists took 21 million nanoscale-resolution images of the brain of Drosophila melanogaster to capture every one of the 100,000 nerve cells that it contains.
Mutational Burden' of Human Induced Pluripotent Stem Cells – Researchers have scrutinized the whole genome sequences of 18 induced pluripotent stem cell lines derived from skin cells that they had reprogrammed to identify and characterize somatic mutations.
Creating Artificial Embryos - An international team of scientists have revealed that they used cells from mice to develop an embryo-like structure without the act of fertilization.
Bioreactor-Based Method to Generate Kidney Organoids - New treatments for kidney diseases and inherited kidney disorders could result from new research that is revolutionizing the way human kidney tissue is grown from stem cells.
Functional Dissection of The Enhancer Repertoire - Scientists combined chromatin immunoprecipitation with a massively parallel reporter assay (ChIP-STARR-seq) to identify … -
Ep. 121: “Science Communication” Featuring Samantha Yammine
17 juli 2018 · 1 uur 11 min
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Samantha is an enthusiastic Science Communicator completing her PhD at the University of Toronto. Her doctoral research focuses on brain development and stem cell biology, under the supervision of renowned scientist Dr. Derek van der Kooy. We talk with Sam about her research and also about how she embraces science communication, using it to tell her science story!
Featured Resource: STEMdiff™ Cerebral Organoid Kit Lees meerResources and Links
Most Americans Believe Funding Science Pays Off - A new survey shows that government funding of basic science enjoys widespread support among U.S. adults, but most people have no idea how much or how little government money goes to scientific research.
Gene Edited Monkeys Offer Hope for Heart Disease Patients - Researchers have used gene-editing tools in adult monkeys to lower animals’ blood cholesterol levels, suggesting a treatment for heart disease.
Gene Drive Passes First Test in Mammals - A controversial technology capable of altering the genomes of entire species has been applied to mammals for the first time.
Nerve Cells That Help Control Hunger Identified - Scientists found that somatostatin neurons in the tuberal nucleus, which is known to exhibit pathological or cytological changes in human neurodegenerative diseases, plays a crucial role in regulating feeding in mice.
Stem Cells Repair Muscle After Heart Attack in Monkeys - According to a new study, injecting stem-cell-derived cardiac cells after a heart attack may help repair damaged tissue.
New iPSC Reprogramming Method - Scientists succeeded in converting human skin cells into pluripotent stem cells by activating the cell’s own genes.
Muscle Stem Cells Derived from Teratomas - Researchers have developed a process to regenerate skeletal muscle cells in mice with muscular dystrophy.
Human iPSC-Derived Natural Killer Cells - In a new study, researchers report that similarly modified natural killer (NK) cells derived from human induced pluripotent stem cells (iPSCs) a… -
Special Episode: “Peer Review of STEMCELL Technologies”
11 juli 2018 · 1 uur 25 min
Beluister deze afleveringIntro:
In early 2018, STEMCELL Technologies put out a call for scientists to visit their Vancouver facilities and peer review them against their company motto of “Scientists Helping Scientists”. Out of over 300 applicants, three postdoctoral fellows were selected to form the peer review team; they visited STEMCELL in April 2018 and conducted their review over three days.
In this special episode of the Stem Cell Podcast, conducted at the end of the peer review initiative, Daylon and Kiki sat down with the peer reviewers to discuss their research interests, current issues and concerns in life science research and education, and their motivations for wanting to be involved in the peer review. Our hosts also asked the reviewers to deliver their final verdict on whether STEMCELL is truly a company of Scientists Helping Scientists and provide recommendations on how STEMCELL can improve in the future. Listen to find out the results!
About the Peer Reviewers
Dr. Amy Stone, PhD; Senior Fellow, University of Washington, United States
Dr. Stone is investigating how humans defend against RNA viruses. Specifically, she is trying to understand how macrophages sense RNA virus infections, what changes in polarization and function occur in those macrophages, and the downstream effects on the adaptive immune system. Dr. Stone wanted to be part of this peer-review to contribute towards resolving the reproducibility crisis currently plaguing bioscience and to answer the question of “Can I rely on STEMCELL’s products to generate reproducible, accurate, trustworthy data?”
Dr. Craig Ayre, PhD; Postdoctoral Fellow, Atlantic Cancer Research Institute, Canada
Dr. Ayre is studying the basic biology of extracellular vesicles and investigating their diagnostic and therapeutic potential in different cancers. Dr. Ayre was interested in joining the peer review as a way to bridge the gap between the perceptions surrounding academic- vs. industry-led science, stating that industrial science needs t… Lees meer -
Ep. 120: “Mending Injured Spines” Featuring Dr. Joseph Ciacci
3 juli 2018 · 1 uur 3 min
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Dr. Joseph Ciacci, MD, is a board-certified neurosurgeon with extensive experience in neuro-oncology of the spine and brain. Dr. Ciacci’s primary interests include tumors of the spine and brain, complex spinal reconstruction, and stereotactic radiosurgery, a form of radiation therapy that focuses high-power energy on a small area of the body. In this episode we talk to him about the results of his Phase I clinical trial transplanting stem cells into spinal cord injury patients.
Featured Resource: Neural Stem Cells Wallchart Lees meerResources and Links
Link between Alzheimer’s and Herpes Virus - Researchers suggest that two types of human herpes virus may play a role in Alzheimer's disease.
Stopping Pandemics Like Zika Virus - A group of scientists launched a remarkable new project which aims to spot the next pandemic virus. The international initiative is known as the Global Virome Project (GVP) and it aims to pinpoint the causes of fatal new diseases before they start to make people ill.
Drinking Coffee Protects Your Heart - Studies have shown that people who drink four cups of coffee a day have a lower risk of dying of a heart attack. A new study in mice may show one reason for that; caffeine in coffee gives cells energy to fight off damage.
Dog’s Carry a Variety of Flu Viruses - Some dogs in southern China carry flu viruses originally transmitted from pigs. The viruses probably spread most easily where animals are crowded, such as shelters, farms and markets.
New Characteristics of the Cancer Stem Cell Phenotype - Using systems-level approaches, scientists developed a replication stress response defect gene signature that predicted risk of cancer development from hyperplastic lesions.
ICAM-1 Role in Blood Stem Cells - Recent advances in imaging and genetic manipulation of mouse models have allowed the identification of distinct vascular niches that have been shown to orchestrate the balance between quiescence, proliferation and regeneration of the bone marrow.
W… -
Ep. 119: “Kidney Organoids” Featuring Dr. Benjamin Freedman
19 juni 2018 · 1 uur 11 min
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Dr. Benjamin Freedman is an Assistant Professor of Medicine at the University of Washington School of Medicine, Division of Nephrology. Dr. Freedman is currently performing biomedical research using human pluripotent stem cells to model kidney disease pathophysiology and develop new therapies. In this episode we talk about his work studying kidney disease and his latest paper in Cell Stem Cell using robots to create kidney organoids. Lees meerFeatured Resource: Wallchart: Growing Organoids from Stem Cells
Resources and Links
CRISPR-Cas9 Genome Editing Induces a p53-Mediated DNA Damage Response - Scientists report that genome editing by CRISPR-Cas9 induces a p53-mediated DNA damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, leading to a selection against cells with a functional p53 pathway.
New Studies on Ocean Bacteria - A large-scale study of the Earth's surface ocean indicates the microbes responsible for fixing nitrogen there -- previously thought to be almost exclusively photosynthetic cyanobacteria -- include an abundant and widely distributed suite of non-photosynthetic bacterial populations.
New Centriole Identified in Human Sperm - Researchers identified a new structure in human sperm that functions in the zygote and may provide new avenues for addressing male infertility and insights into early embryo developmental defects.
Life on Mars - After more than four decades of searching for organic molecules on the surface of Mars, scientists have conclusively found them in mudstones on the lower slopes of Mount Sharp.
New Treatment for Metastatic Breast Cancer - Researchers developed a high-throughput method to identify mutations present in a cancer that are recognized by the immune system.
Tackling CRS and Neurotoxicity Associated with CAR T Cell Therapy - Recently developed animal models allow mechanistic dissection and prevention of toxicity without loss of therapeutic benefit.
Single-Cell Analysis Identifies a CD33+… -
Ep. 118: “Synthetic Embryos” Featuring Dr. Nicolas Rivron
5 juni 2018 · 1 uur 10 min
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Dr. Nicolas Rivron leads the Laboratory for Synthetic Embryology at the MERLN Institute for technology-driven regenerative medicine and at the Hubrecht Institute for Developmental Biology and Stem Cell Research. His laboratory created the blastoid system, the first model of early, pre-implantation embryos made in a dish from stem cells.
Featured Resource: STEMdiff™ Trilineage Differentiation Kit - Functional Assay Kit to Assess Pluripotency by Directed Differentiation of Human ES and iPS Cells to All Three Germ Layers Lees meerResources and Links
Update on Deadly Nipah Virus - As the rare virus claims more lives in the Indian state of Kerala, concerns have been raised about the potential of Nipah to become a global health emergency.
Genetics of Flower Smells - An analysis of rose genes, including of those in the heirloom rose 'Old Blush', identifies overlooked ways the plants make some of their sweet-smelling compounds.
Chicxulub Asteroid Impact Caused the Planet to Warm Up for 100,000 Years - The asteroid that hit Earth about 66 million years ago, wiping out most of the planet’s life, also spewed carbon dioxide into the air and warmed up the planet by about 5 degrees Celsius.
Microbes May Influence Multiple Sclerosis - Scientists found a link between molecules released by commensal bacteria and the degree of inflammation in a mouse model of multiple sclerosis.
‘Reprogrammed’ Stem Cells Approved to Mend Human Hearts for the First Time - The latest clinical use of induced pluripotent stem cells excites researchers, but some fear the therapy will be rushed to market.
Hybrid-Human Chicken Embryos - A new technique reveals the earliest stages of human development without the need for human embryos.
Embryonic Mammary Gland Stem Cells Identified - Researchers define for the first time the mechanisms responsible for mammary gland development.
Cerebrospinal Fluid Flow Regulates Neural Stem Cell Division - The authors found that ion channels play a key role in mediating forc… -
Ep. 117: “Biology and Beer” Featuring Peter Lengyel
22 mei 2018 · 1 uur 7 min
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Peter Lengyel is the co-founder and “Beer Commander” of Kings County Beer Collective in Brooklyn, NY. Pete managed big name laboratories at Rockefeller University, UCSF and Regeneron Pharmaceuticals but after spending a huge amount of his time brewing beer first as a hobbyist, he made the leap to brewing full time. Pete started his first professional brewing enterprise in Bushwick Brooklyn a couple years back as a collaboration with two other brewers, which they called the King County Brewer’s Collective, and they have taken the craft brew scene by storm with high praise in local and national critical circles. Lees meerResources and Links
Artificial Intelligence Using Wiring Similar to Human Brain - An AI that mentally maps its environment, much like mammals do, could help solve a mystery about the navigational nerve cells in our brains.
Telomerase at High Resolution – The authors present the cryo-electron microscopy structure of the substrate-bound human telomerase holoenzyme at subnanometre resolution, showing two flexibly RNA-tethered lobes: the catalytic core with telomerase reverse transcriptase and conserved motifs of telomerase RNA, and an H/ACA ribonucleoprotein.
First Small Pox Treatment Close to FDA Approval - Fears that the disease could be used as a biological weapon have risen in light of anthrax attacks and other terrorist acts of this century.
Turtles That Change Sex in Warm Temperature - Scientists have identified a gene in the red-eared slider turtle, that makes embryonic turtles turn male or female depending on nest temperature.
Stem Cells and Organoids to Understand Neanderthal Brains -A team of geneticists from the Max Planck Institute in Germany genetically altered human stem cells by combining them with Neanderthal DNA. The team hoped to grow miniature brains from these engineered human stem cells.
Fasting Boosts Stem Cells’ Regenerative Capacity - Intestinal stem cells from mice that fasted for 24 hours, produced much more substantial intestin… -
Ep. 116: “Functional Endothelium” Featuring Dr. Valeria Orlova
8 mei 2018 · 1 uur 5 min
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Dr. Valeria Orlova is the Principal Investigator at the Leiden University Medical Center. Dr. Orlova’s lab uses stem cells to study the blood vessels and vasculature. She joins us to talk about her work and latest findings.
Featured Resource: STEMdiff™ Trilineage Differentiation Kit - Functional Assay Kit to Assess Pluripotency by Directed Differentiation of Human ES and iPS Cells to All Three Germ Layers Lees meerResources and Links
Plastic That Can Be Recycled Again and Again - The development of chemically recyclable polymers offers a solution to the end-of-use issue of polymeric materials and provides a closed-loop approach toward a circular materials economy.
Genetically Modified Plant as Malaria Drug - Derived from sweet wormwood plants, the antimalarial compound artemisinin usually composes 0.1 to 1 percent of the dry weight of the leaves. New research more than triples a plant’s yield of artemisinin, to 3.2 percent.
Hospital Surfaces that Kill Superbugs - A newly developed coating uses overhead light to trigger bacteria-killing molecules and could be used in hospitals to help stop the spread of some infections.
A Bird’s Internal Compass - During the long range migrations of European robins, production of the protein Cry4 increases and that may facilitate the birds’ sense of Earth’s magnetic field.
Inducible GDNF Expression in Transplanted Neural Cells - Glial cell line-derived neurotrophic factor (GDNF) has provided benefits to Parkinsonian patients and is being used in a clinical trial for amyotrophic lateral sclerosis.
Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression – A recent study found that differentiated glioblastoma cells (DGCs) accelerated GSC tumor growth. DGCs preferentially expressed brain-derived neurotrophic factor (BDNF), whereas GSCs expressed the BDNF receptor NTRK2.
Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses - Res… -
Ep. 115: “Motor Neurons” Featuring Evangelos Kiskinis
24 april 2018 · 1 uur 2 min
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Evangelos Kiskinis, PhD is an Assistant Professor in Neurology at Northwestern University. His lab focuses on addressing fundamental aspects of the biology of human neurons in the context of physiological conditions and in the context of diseases such as ALS.
Featured Resource: Madeline Lancaster on Brain Organoids: Modeling Human Brain Development in a Dish Webinar
Resources and Links
How Norovirus Invades - While investigating the cell tropism for murine norovirus, scientists discovered that a rare cell type, tuft cells, carrying the CD300lf receptor were the virus’s specific target.
Viruses that Clean Up Bacteria- Viruses can be engineered to carry magnetic nanoparticles and modified DNA, transforming them into nanobots that detect bacteria in water or food.
Cancers Should Be Treated by Type Not Location - Cancer should not be treated based on where it is first found in the body, but depending on the type of tumor, scientists have said.
California Ordered to Add Cancer Warning to Coffee, but the Science Doesn't Hold Up - Storm clouds are brewing in California’s coffee cups. Companies across the state will have to add a cancer-warning label to coffee, a judge ruled, because the drink contains a chemical called acrylamide.
Thrombopoietin is Required for Bone Marrow Stem Cell Maintenance- Investigators found that hematopoietic stem cells (HSCs) were markedly reduced in hepatocyte-specific thrombopoietin-deficient mice. These results indicate that systemic factors, in addition to the local niche, are a critical extrinsic component for HSC maintenance.
Researchers Optimize Lung Stem Cell Engineering Process- The Center for Regenerative Medicine’s pioneering research using induced pluripotent stem cells, which self-renew indefinitely as undifferentiated cells that become specific adult cell types, has helped create an inexhaustible source of disease- or patient-specific stem cells.
An In Vivo Model of Functional and Vascularized Human Brain Organoids- Scientist… Lees meer -
Ep. 114: “Stem Cell Pioneer” Featuring Dr. Janet Rossant
10 april 2018 · 1 uur 5 min
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Dr. Janet Rossant is a Senior Scientist in the Developmental & Stem Cell Biology Program at The Hospital for Sick Children and is a Professor in both the Department of Molecular Genetics and the Department of Obstetrics and Gynaecology at the University of Toronto. Her research interests center on understanding the genetic control of normal and abnormal development in the early mouse embryo using both cellular and genetic manipulation techniques. Her interests in the early embryo have led to the discovery of a novel placental stem cell type, the trophoblast stem cell. Rossant is also the Director of the newly formed Ontario Institute for Regenerative Medicine.
Featured Resource: STEMdiff™ Definitive Endoderm Kit: Defined Animal Component-Free Medium for the Differentiation of Human ES and iPS Cells to Definitive Endoderm Lees meerResources and Links
Cancer Vaccine Eliminates Tumors in Mice- Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine.
Tiny Stomach Found in Lung Tumors- Findings demonstrate that elements of pathologic tumor plasticity mirror the normal developmental history of organs in that cancer cells acquire cell fates associated with developmentally related neighboring organs.
Is the Interstitium a New Organ?- A study confirms that the spaces between cells are fluid-filled, rather than tightly packed with connective tissue, but pathologists say the implications of the findings remain to be seen.
Brain Organoids and Blood Vessels- Unpredictable variations and deficiencies have hampered the usefulness of organoids in research, but new techniques for creating mini-brains may change that.
RPE Cell Transplantation to Treat Macular Degeneration - Scientists demonstrated the feasibility and safety of human embryonic stem cell-derived retinal pigment …