Alle afleveringen
203 afleveringen, van nieuw naar oud
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AML Management in the Old and Unfit (with Prof Hartmut Döhner)
8 augustus 2025 · 18 min
Join us for this insightful interview with prof. Hartmut Döhner from University Hospital Ulm in Germany who tells about most recent developments in the management of older and unfit patients with AML. Lees meer
Prof. Döhner discusses all key aspects of the management including assessing patient fitness, genetic risk classification, and the choice of treatment, among which also the emerging therapies.
Tune in, to hear about the most relevant recommendations for the clinical decision making while treating older unfit patients with AML.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Hartmut Döhner, University Hospital Ulm, Germany
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Managing Young Fit AML patients with Prof Konstanze Döhner
31 juli 2025 · 13 min
Join EHA President prof. Konstanze Döhner from University Hospital Ulm in Germany who discusses the most recent developments in the management of young and fit patients with AML. Tune in to hear about the diagnostic workup, risk stratification, treatment and the evolving role of measurable residual disease (MRD) measurements in clinical decision making in this group of patients. Prof. Döhner also shares her thoughts on the future of the treatment landscape for AML. Lees meer
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Konstanze Döhner
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GoCART Coalition (with Prof Christian Chabannon)
25 juli 2025 · 30 min
Listen as Prof. Christian Chabannon from Aix Marseille Université in France who tells about GoCART Coalition in this new podcast episode. The main goal of this coalition, which unites expertise from many fields, is to promote access to novel cellular therapies, such as CAR T-cells. Prof. Chabannon explain how GoCART is working on reaching this goal by generating new clinical insights, improving standards of care, providing education and building policy. Tune in to learn more about the impact of this coalition on healthcare today and in the future. Lees meer
Stay tuned for future episodes!
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof. Christian Chabannon
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Empowering Healthcare through Patient Advocacy (with Jan Geissler)
18 juli 2025 · 26 min
Jan Geissler from Germany tells about his work as a patient advocate in the field of hematological malignancies. As a cancer survivor, patient advocate and patient engagement expert, Jan has been working tirelessly for many years in organizations such as European Patients Academy (EUPATI), Patvocates and many others. Listen to Jan’s passionate call for a collaborative spirit to achieve the best outcomes for patients. Tune in to hear his views on patient advocacy and the impact it has on patient care. Lees meer
Stay tuned for future episodes!
Guest: Jan Geissler, Patient Advocate, Germany
Host: Isabel Olivera-Martinez, PhD, Medical Writer
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Off-the-shelf CAR T-cells from iPSCs (with Prof Maria Themeli)
12 juli 2025 · 28 min
Prof. Maria Themeli tells about most recent developments in the field of “off-the-shelf” CAR T-cells. As the clinical success of advanced cellular therapies is growing, so is the need for broader access to these treatments. Listen as Prof. Themeli summarize the state-of-the-art technology that aims to generate “off-the-shelf” CAR T-cells from sources such as induced pluripotent stem cells (iPSCs) and how this approach may offer a feasible strategy to improve clinical outcomes and reduce the costs of advanced cellular therapies in the future. Lees meer
Stay tuned for future episodes!
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Maria Themeli
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AIDPATH – AI automated CAR T-cell manufacturing (with Dr Carmen Sanges)
4 juli 2025 · 21 min
Join dr. Carmen Sanges from University Clinic Würzburg in Germany as she tells us about AIDPATH. This collaborative initiative is dedicated to improving access to advanced cellular therapies by employing artificial intelligence (AI) in the production process. Listen to dr. Sanges explain how AI technology is used to integrate patient-specific information and biomarkers to optimize CAR-T therapy. Tune in to hear about the current approaches and future directions of this cutting-edge technology. Lees meer
Stay tuned for future episodes!
Host: Isabel Olivera-Martinez, Medical Writer
Guest: Dr Carmen Sanges
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What did you think of this podcast? Share your opinions with us in this short feedback survey.
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Hematology Portraits: prof. Elizabeth Macintyre
20 juni 2025 · 25 min
Join us for this inspiring interview with prof. Elizabeth Macintyre from Université Paris Cité in France who tells us about her professional journey in hematology. Lees meer
Listen to prof. Macintyre discuss her views on the current state and future directions of advanced diagnostics in malignant hematology and their implications for healthcare management and the training of young specialists. Tune in to hear how Biomedical Alliance may impact future policies through “trans-European” approaches.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Elizabeth Macintyre
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Would you like to explore more eLearning or podcasts? Please visit the EHA Campus.
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Is low-risk MDS really low risk? (with Prof Uwe Platzbecker)
6 juni 2025 · 27 min
Join Professor Kirsten Gronbaek and Professor Uwe Platzbecker as they discuss the complexities behind the classification and prognostication of low-risk myelodysplastic syndromes (MDS). They dive into the historical context of MDS classification, the evolution of prognostic indexes such as IPSS and IPSSM, and the implications of recent molecular findings. Lees meer
This conversation highlights the challenges in defining "low-risk" MDS, the role of genetic mutations in prognosis, and the considerations for treatment strategies, including the potential for stem cell transplantation.
Host: Professor Kirsten Gronbaek, University of Copenhagen, Denmark
Guest: Professor Uwe Platzbecker, University Clinic of Leipzig
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MRD Monitoring in MDS Patients (with Prof Arjan van de Loosdrecht)
30 mei 2025 · 30 min
Join host Professor Kirsten Gronbaek and guest Professor Arjan van de Loosdrecht as they dive into the complexities of measurable residual disease (MRD) monitoring in myelodysplastic syndromes (MDS) and myeloid cancers. Professor van de Loosdrecht explains the transition from minimal to measurable residual disease, the significance of MRD in predicting disease outcomes, and the various techniques used for MRD detection. Lees meer
Listen as they explore the challenges and potential strategies for MRD monitoring in MDS, and the implications for treatment decisions. This episode is a must-listen for anyone interested in the latest advancements in hematology and the future of MRD monitoring in MDS.
Tune in to EHA Unplugged to gain valuable insights and stay updated with the latest research and clinical practices in hematology.
Host: Prof Kirsten Gronbaek
Guest: Prof Arjan van de Loosdrecht
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Would you like to explore more eLearning or podcasts? Please visit the EHA Campus.
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Hematology Portraits: prof. Martin Dreyling
23 mei 2025 · 24 min
In this episode, we sit down with prof. Martin Dreyling from the Ludwig-Maximilians-University in Munich who talks about his professional journey in hematology as a clinician and a researcher. Lees meer
Listen to prof. Dreyling as he recalls his contributions to the field of lymphoma, and in particular mantle cell lymphoma, that resulted in novel therapeutic approaches. The ongoing emphasis on the cross-border teamwork in clinical trials and the importance of European cooperation highlights the impact that these initiatives had on prof. Dreyling’s career.
Tune in to hear his thoughts about the future directions in lymphoma treatment and collaborative clinical research in general.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: prof. Martin Dreyling
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MDS Pathophysiology and the Role of Immune Dysfunction (with Dr Shahram Kordasti)
16 mei 2025 · 23 min
In this episode, prof. Kirsten Gronbaek and dr. Shahram Kordasti discuss the role of immune dysfunction in MDS. With the improving understanding of complex pathophysiology of MDS, the major role of the immune system in this process is becoming increasingly apparent. Lees meer
Listen to dr. Kordasti discuss the multifactorial interactions between the malignant clones and the inflammatory environment, manifesting in elements of autoimmunity and elements of autoinflammation in MDS. As the complexity of immunophenotypes observed in MDS is being unraveled, the need to include immunophenotypic factors in the prognostic scores is growing.
Tune in to hear dr. Kordasti’s and prof. Gronbaek’s thoughts on the future of prognostication, the more comprehensive approach for patient stratification designed to predict therapy responses and the future of immunotherapy in MDS.
Host: Prof Kirsten Gronbaek
Guest: Dr Shahram Kordasti
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Mapping Rare Anemia Patient Data: RADeep (with Dr. María del Mar Mañú Pereira)
10 mei 2025 · 30 min
In this interview, dr. Maria del Mar Mañu Pereira from Vall d’Hebron Research Institute in Spain talks about the Rare Anemia Disorders European Epidemiological Platform (RADeep). RADeep is an initiative of ERN-EuroBloodNet and functions as an umbrella for both new and already existing European patients' registries in rare anemia disorders. Lees meer
Listen to dr. Mañu Pereira talk about the history of RADeep from its early days until today and about its ambitious goals to advance research and promote best practices in care for RAD patients across Europe. You will hear about the milestones achieved, current research, and how RADeep registry and the ENROL (European Rare Blood Disorders Platform) initiative complement each other to achieve optimal health outcomes for RAD patients.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Dr. Maria del Mar Mañu Pereira
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Hematology Portraits: prof. Antonio Almeida
25 april 2025 · 19 min
Prof. Antonio Almeida from Hospital da Luz in Lisbon takes us through his professional journey in hematology as a clinician and educator, and his current role as the President of EHA. Listen to prof. Almeida recount his professional path that allowed him to experience various facets of hematological clinical practice in the UK and Portugal. Lees meer
Alongside his career as a hematologist, prof. Almeida cultivated a growing love for education, where he tries to employ student-centered techniques to enhance educational experiences.
Tune in to hear how prof. Almeida describes his journey to becoming the President of EHA and what he sees as today’s most significant challenges in hematology and what solutions he has in mind to address those.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof. Antonio Almeida
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Targeting the Immune System in MDS (featuring Prof Dominik Wolf)
18 april 2025 · 24 min
Join us for a conversation between prof. Kirsten Gronbaek and her guest prof. Dominik Wolf, as they discuss targeting the immune system in MDS management. In light of accumulating evidence that inflammatory signals play a role throughout disease evolution in MDS patients, prof. Wolf elucidates the current insights and possible future therapeutic options. Lees meer
He uses the example of targeting NLRP3/IL-1 axis in low-risk MDS to highlight the need of understanding the underlying cellular biology to translate that knowledge into clinical approaches. He also discusses the concept of possibly targeting both non-clonal and clonal compartments for better patient outcomes in the future.
Tune in, to hear about other future directions in treatment of MDS, such as recent developments in CAR T-cell approaches and about the central role that allo-transplantation is likely to keep in the treatment of high-risk MDS. You will also hear about the potential link between inflammation and fatigue, which is clinically highly relevant, but as yet an unsolved issue in MDS.
Host: prof. Kirsten Gronbaek
Guest: prof. Dominik Wolf
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Accelerating Clinical Trials with AI (with Dr Jan Moritz Middeke)
11 april 2025 · 17 min
Listen to Dr. Jan Moritz Middeke from University Hospital in Dresden as he discusses the future of clinical trials in hematology and the role artificial intelligence (AI) may play in that field. Dr. Middeke explains how synthetic data is generated and what are the potential benefits and limitations of its use in clinical trials. He also points out the open questions and hurdles that need to be addressed before AI-generated synthetic patients can be included in clinical trial design. Lees meer
Tune in to hear how Dr. Middeke envisages the role of AI in solving the challenges of clinical trials for rare malignant diseases and how it may accelerate data generation and access to novel therapies.
If you want to know more:
https://www.nature.com/articles/s41746-024-01076-x
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Dr. Jan Moritz Middeke
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What did you think of this podcast? Share your opinions with us in this short feedback survey.
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The Current Diagnostic Approach to MDS (with Dr Onima Chowdhury)
4 april 2025 · 36 min
In this episode, Dr. Onima Chowdhury, a hematologist from the University Hospital in Oxford, talks about the diagnostic workup of Myelodysplastic Syndromes (MDS). With a focus on both clinical practice and research, Dr. Chowdhury outlines the essential steps and tests required for diagnosing MDS, discusses the role of morphology, cytogenetics, and the significance of NGS panels in the diagnostic process. Lees meer
The conversation also touches on the potential of artificial intelligence in diagnostics, the prognostic value of genetic mutations, and the importance of considering germline disorders in MDS. This episode is a must-listen for healthcare professionals seeking to deepen their understanding of MDS diagnostics.
Host: Prof Kirsten Grønbæk
Guest: Dr Onima Chowdhury
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Hematology Portraits: Prof Brian Huntly
1 april 2025 · 30 min
Join us for this insightful interview with prof. Brian Huntly from the University of Cambridge who tells about his professional journey in hematology as a clinician, scientist and educator. Lees meer
Listen to prof. Huntly discuss his important contributions to the field of leukemia stem cell biology in the context of current understanding of cell biological hierarchies and leukemia development.
Prof. Huntly also touches on the concepts of early interception and tumor-specific and tumor-nonspecific areas to personalized medicine. Tune in to hear how prof. Huntly combines his work in the fields of science and clinical medicine and what his recommendations are for younger colleagues, who are in the early stages of their careers.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Brian Huntly
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Mental Health in CLL
21 maart 2025 · 25 min
In this podcast, Prof Dame Lesley Fallowfield and Prof Clemens Wendtner discuss patient mental health and communication in the context of Chronic Lymphocytic Leukemia (CLL) treatment. They explore the psychological impact of CLL and leukemia in general, the importance of patient communication, and the need for integrated mental health support. Lees meer
The conversation highlights the challenges of explaining complex medical concepts to patients and the role of resilience in both patients and physicians. They also address the challenges of managing patient anxiety and depression, the role of trust in the doctor-patient relationship, the importance of empathy, and the need for integrated psychological support services.
Guests:
Prof Dame Lesley Fallowfield
Prof Clemens Wendtner
Note: This podcast is based on content provided by BeiGene. It has been reviewed by EHA, which found it unbiased and aligned with EHA educational standards, as well as edited by EHA to create an effective educational experience.
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Patient Perspectives on Gene Therapy for Sickle Cell Disease and B-Thalassemia
14 maart 2025 · 28 min
Join us for an insightful interview with patient advocates Miriam Santos Freire (sickle cell disease) and Loris Brunetta (beta-thalassemia major). Benefit from their experiences as they discuss with our host Isabel Olivera-Martinez the promises and challenges of gene therapy for these conditions. Lees meer
Listen to their experiences of living with these genetic conditions while they highlight the disparities in treatment access between wealthy and low-income countries. Both view gene therapy as a breakthrough that has the potential to cure these diseases, but express caution regarding its current limitations and complications. Tune in for their valuable insights and recommendations for advancing SCD and thalassemia management.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guests:
Miriam Santos Freire, Patient representative for EuroBloodNet
Patient Advocacy & Communication for Sickle Cell (Portugal & UK) at European Sickle Cell Federation (ESCF)
European Hematology Association (EHA)
ERN-EuroBloodNet
Associação Portuguesa de Pais de Doentes com Hemoglobinopatias (APPDH) – also a Board Member
Loris Brunetta
Board Member of Thalassaemia International Federation (TIF),
Vice-chair of EHA Patients’ Advocacy Committee (PAC),
Member of the Patients and Consumer Working Party (PCWP) at EMA,
EMA expert on ESEC,
Former member of Committee for Orphan Medicinal Products (COMP) at EMA,
ePAG at EuroBloodNet,
Coordinator of the Italian Associations Advocacy Council (IAAC)
President of Associazione Ligure Thalassemici (Italy).
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Hematology Portraits: Prof Kostas Stamatopoulos
28 februari 2025 · 24 min
Join us for an interview with Prof Kostas Stamatopoulos, as he shares his personal journey as both a medical doctor and a researcher in hematology and understand how these two activities have always been profoundly linked in his drive to deliver impactful solutions for patients - even though years may pass between a discovery and a change for patients in clinical practice. Lees meer
Prof Stamatopoulos describes here his work into stereotypy of B-cell receptor (BCR) immunoglobulin and how this phenomenon explains the existence of the same or highly similar subsets of BCR clones in unrelated patients with CLL. Our guest explains further how this knowledge is leading to the classification of CLL patients into subsets with specific pathologies and might help personalize the treatment.
Next to translational research, Prof Stamatopoulos is focusing on patient empowerment. In this podcast, he will explain how he strives to create a more participatory healthcare model, and how he aims to transform education and training for young clinicians and researchers.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Kostas Stamatopoulos
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Management of High-risk MDS: Seeking Clarity for Classification and Treatment
14 februari 2025 · 34 min
This podcast episode is derived from the MDS Algorithm on EHA Campus. Check out the MDS Algorithm, which is an expert based tool for healthcare providers, ensuring a structured and evidence-based approach to managing myelodysplastic syndromes. Lees meer
In this episode, our host Prof Kirsten Grønbæk from University of Copenhagen, discusses the management of high-risk MDS with Prof Katharina Götze from Technical University of Munich and Prof Valeria Santini from University of Florence. The experts delve into the two classification systems for MDS, defined by the International Consensus Classification (ICC) and World Health Organization (WHO) in 2022.
They discuss the impact of the similarities and discrepancies between these systems on clinical practice and the patients’ understanding of their disease. The speakers further talk about hypomethylating agents (HMA) as the backbone of current treatments for high-risk MDS. They exchange their views on the considerations for choosing the patients who are most likely to benefit from these treatments, while avoiding myelotoxicity. The experts also discuss selecting the right patients for other (emerging) treatments, such as venetoclax and magrolimab, while stressing that data from phase III trials is yet to become available for some of these agents.
The role of allogeneic transplantation as the only curative option for patients with high-risk MDS is also emphasized, with the experts highlighting the role of Molecular International Prognostic Scoring System (IPSS-M) in selecting the eligible patients. In the closing remarks, the importance and challenges of monitoring the molecular evolution of the disease are stressed, as this technology allows to tailor the available treatments to each individual patient.
Host: Prof Kirsten Grønbæk
Guests: Prof Katharina Götze & Prof Valeria Santini
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Hematopoietic Stem Cells in Health, Aging and Malignancy: Focus on Metabolism (EHA2024)
7 februari 2025 · 8 min
In this episode on recent insights about metabolism of the hematopoietic stem cells (HSCs), Dr Krzysztof Szade from Jagellonian University in Krakow, Poland, discusses HSPc in health, aging and malignancy. This podcast recaps the findings that aim to elucidate the metabolic requirements of HSCs at different stages of aging. Lees meer
Listen to Dr Szade summarize the data on how heme oxygenase-1 (HO-1) influences glycolytic metabolic stemness of HSCs, impacting on their self-renewal and differentiation. Follow his explanations of the hierarchical relationship between myeloid-biased and balanced HSCs and other observations shedding more light on the mechanisms of HSC aging. As the understanding of the metabolic requirements of HSCs during aging can point to new therapies for hematological disorders, tune in for this latest update.
Guest: Dr Krzysztof Szade
This episode is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. This podcast containing accompanying slide content is available as a video on Spotify, YouTube, and EHA Campus. More lectures will be available in the future. Stay tuned!
For more information about a past or upcoming EHA Congress, visit https://ehaweb.org/congress/
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Innovative Trial Design (EHA2024)
31 januari 2025 · 18 min
This podcast episode highlights the need to use innovative clinical trial designs in the era of increasingly personalized medicine in hematology. Listen to Dr Jurjen Versluis from Erasmus Medical Center in Rotterdam, the Netherlands, discuss his research on this topic. Lees meer
As the amount of novel targeted drugs is increasing, and treatments lead to increasingly better survival outcomes, we need to think about new, adaptive designs that will result in impactful trials in shorter time. Follow Dr Versluis as he explains the different designs and methods that can be used to estimate whether trial will be efficacious or futile before its completion.
The combination of clinical trials with data from existing real-world registries, such as HARMONY or Dutch Cancer Society datasets, may also be an alternative to standard designs. By using examples of trials run by HOVON, the Dutch Hemato-oncology Foundation, Dr Versluis provides additional depth to the discussion.
Guest: Dr Jurjen Versluis
This episode is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. This podcast containing accompanying slide content is available as a video on Spotify, YouTube, and EHA Campus. More lectures will be available in the future. Stay tuned!
For more information about a past or upcoming EHA Congress, visit https://ehaweb.org/congress/
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Hereditary Hematological Malignancies (HHMs): A New Era of Discovery in MDS and AML (EHA2024)
24 januari 2025 · 23 min
As knowledge about hereditary hematological malignancies (HHMs) increases, so do the options for better management of these diseases. Please join us in this podcast to hear Dr Kiran Tawana from Addenbrooke’s Hospital in Cambridge, UK, share her insights on this topic. HHMs are syndromes where two or more cases of cytopenia and hematological malignancy (typically MDS/AML) occur within the same family. Lees meer
Dr Tawana discusses the discovery of HHMs and provides advice on how to recognize them in clinical practice, which can be hampered by low penetrance and significant differences in disease latency.
Listen to the stories of families affected by HHMs and how the molecular insights gathered from disease evolution in these case studies provide base for improved management of patients in the future. Tune in to hear the recommendations of dr. Tawana on how to optimize testing in clinical pathways and improve outcomes for people with HHMs.
Guest: Dr Kiran Tawana
This episode is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. This podcast containing accompanying slide content is available as a video on Spotify, YouTube, and EHA Campus. More lectures will be available in the future. Stay tuned!
For more information about a past or upcoming EHA Congress, visit https://ehaweb.org/congress/
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Hairy Cell Leukemia (HCL): Treatment of Relapsed Disease (EHA2024)
20 januari 2025 · 18 min
In this podcast, Prof Thorsten Zenz from University Hospital in Zurich, Switzerland, discusses the current approaches to treatment of relapsed hairy cell leukemia (HCL). Based on his personal journey as a hematologist interested in precision oncology, prof. Zenz summarizes the years of accumulating data and clinical experience to explain the treatment approach he often uses for his patients. Lees meer
Thanks to the clear molecular target (V600E mutation of BRAF), treatment of classical hairy cell leukemia with BRAF inhibitors, such as vemurafenib, is an example of precision oncology that can result in deep responses. As combination of this treatment with anti-CD20 antibody leads to durable complete responses in most patients, Prof Zenz often uses this regime in his patients with refractory or relapsed hairy cell leukemia.
However, as different countries have access to different treatment options, Prof Zenz also discusses the role, sequencing and combinations of other drugs, such as to purine analogs (i.e. cladribine), MEK inhibitors, BTK-inhibitors, Bcl-2 inhibitors (i.e. venetoclax) or recombinant CD22-targeting immunotoxin (i.e. moxetumomab). In light of emerging (although still limited) data on these drugs and questions about their optimal sequencing, guidelines are being developed by Hairy Cell Leukemia Foundation (HCLF) and EHA that aim to help the clinicians with making choices for their patients.
This podcast is further enriched by insights from prof. Enrico Tiacci from University and Hospital of Perugia in Italy, who discovered that V600E mutation of BRAF is the key genetic lesion underlying hairy cell leukemia. Prof Tiacci shares his views on the treatment options and their sequencing, based on the clinical trials he conducted and his clinical experience.
Guest: Prof Thorsten Zenz
This episode is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. This podcast containing accompanying slide content is available as a video on Spotify…
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Iron Metabolism in Myelodysplastic Syndrome (MDS)
10 januari 2025 · 33 min
In this episode of EHA Unplugged, Prof Kirsten Grønbæk and our guests Prof Yelena Ginzburg and Prof Amit Verma discuss iron metabolism and its role in erythropoiesis in MDS. Lees meer
The experts share their views on the management of iron overload in the transfusion-dependent patients with MDS, as they acknowledge that it poses a real challenge in their clinical practice. Starting from the criteria used to select patients for iron chelation and then discussing its beneficial effects and limitations, the podcast guests formulate clear thoughts on the role of this therapy in both low- and high-risk MDS. They then clarify recent scientific insights into the putative mechanisms that may link iron overload with the ineffective erythropoiesis.
Please tune in to hear about the data from a mouse model pointing to the role of iron transport in erythroblast function and differentiation (please also see the Reference). You will also hear what direction the future research into the mechanism of the communication between ineffective erythropoiesis and iron metabolism may take.
This podcast is brought to you by EHA and the BioIron Society.
Host: Prof Kirsten Grønbæk
University of Copenhagen, Denmark
Guests:
Prof Yelena Ginzburg
Icahn School of Medicine at Mount Sinai, NY, USA
Prof Amit Verma
Albert Einstein College of Medicine, NY, USA
Reference: An W, et al. Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice. Elife. 2023 Dec 28:12:e83103. doi: 10.7554/eLife.83103
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First-line Treatment of Primary Central Nervous System Lymphoma (PCNSL) (EHA2024)
27 december 2024 · 18 min
In this podcast, Dr Elisabeth Schorb from University Medical Center in Freiburg, Germany, discusses the first-line treatment of primary central nervous system lymphoma (PCNSL), which has seen tremendous advances in the last years. PCNSL is a rare condition, and because of its location prompt diagnosis and timely treatment are of the essence. Lees meer
As for other hematological diseases, treatment of PCNSL today is based on two pillars: induction treatment and consolidation treatment. Listen to Dr Schrob describe her clinical experience and contributions to the international clinical trials that have shifted PCNSL prognosis from a disease with short life-expectancy if left untreated to a curable disease. And get inspired by Dr Schorb’s appeal to “stay tuned, stay in touch because your investigator-initiated ideas can make all the difference”.
Guest: Dr Elisabeth Schorb
This episode is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. This podcast containing accompanying slide content is available as a video on Spotify, YouTube, and EHA Campus. More lectures will be available in the future. Stay tuned!
For more information about a past or upcoming EHA Congress, visit https://ehaweb.org/congress/
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Optimizing Global Care for Women with von Willebrand Disease (VWD) (EHA2024)
21 december 2024 · 22 min
With the increasing scrutiny of healthcare pathways for women, this podcast provides a timely plea by Dr Michelle Lavin from St. James’s Hospital in Dublin, Ireland, to optimize global care for women with von Willebrand disease (VWD). Lees meer
In this podcast, Dr Lavin gives a passionate appeal for more international collaboration and increased awareness to improve care for women and girls suffering from bleeding disorders. As challenges facing women with these disorders are multiple, including diagnostic inequalities and suboptimal treatments, the solutions are also multi-factorial. Listen to dr. Lavin give her recommendations to provide the best possible care, based on the findings from the Annual Global Survey of the World Federation of Hemophilia, World Bleeding Disorder Registry and other data.
In Dr Lavin’s own words: “there's momentum behind Women's Health”, so tune in to participate.
Guest: Dr Michelle Lavin
This episode is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. This podcast containing accompanying slide content is available as a video on Spotify, YouTube, and EHA Campus. More lectures will be available in the future. Stay tuned!
For more information about a past or upcoming EHA Congress, visit https://ehaweb.org/congress/
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Iron and Infections: Back to the Future (EHA2024)
13 december 2024 · 18 min
In this lecture from EHA2024, Prof Domenico Girelli from University of Verona, Italy, discusses the complex relationship between iron metabolism and infection. Lees meer
As an essential element for physiology of all living organisms, iron is involved in many vital processes, including our immune responses to infections. Since the pathogens themselves also depend on iron to survive, the resulting host/pathogen “battle” for iron is one of the key determinants of outcomes of most infectious diseases.
Interestingly, this dependence of pathogens on iron may offer a much-needed solution for multidrug resistance (MDR) of microbes, which poses a significant and growing challenge for the global healthcare. Tune in, to hear about the novel “metallo-antibiotics” and other clinical developments based on accumulating data about role of iron in infections.
Guest: Prof Domenico Girelli
This episode is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. This podcast containing accompanying slide content is available as a video on Spotify, YouTube, and EHA Campus. More lectures will be available in the future. Stay tuned!
For more information about a past or upcoming EHA Congress, visit https://ehaweb.org/congress/
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Long-term Outcomes in the Chemo-free era for Acute Promyelocytic Leukemia (EHA2024)
6 december 2024 · 19 min
Join us for an insightful lecture by Prof Maria Teresa Voso from University of Rome Tor Vergata in Italy, as she discusses the advances in the treatment of a rare subtype of AML, the acute promyelocytic leukemia (APL). As the PML::RARA rearrangement, resulting in a fusion protein that disrupts retinoic acid signaling and PML function, is the hallmark driver of APL, it is used as target for APL treatment. Lees meer
Listen to Prof Voso as she talks about the scientific developments leading to significant improvements in clinical outcomes for patients with APL and the role of ATRA / ATO therapy, which combines all-trans retinoic acid (ATRA) and arsenic trioxide (ATO).
Prof Voso highlights contributions of the late prof. Francesco Lo Coco, the significance of the EU-wide HARMONY registry and other collaborative efforts in establishing the optimal treatment regimens for APL. This podcast also provides insights into remaining open issues in the clinical management of APL, including high-risk APL for which the results of the much-anticipated APOLLO trial may provide some answers.
This is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. The podcasts in this series are better consumed in video form because of the accompanying slide content. More lectures will be available in the future. Stay tuned!
For more information about a past or upcoming EHA Congress, visit https://ehaweb.org/congress/
Guest: Prof Maria Teresa Voso
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Thrombotic thrombocytopenic purpura (TTP): Is plasmapheresis history?
29 november 2024 · 17 min
Join us for this engaging debate on the future of acquired TTP (aTTP) treatment chaired by Dr. Eleni Gavriilaki from Aristotle University of Thessaloniki in Greece. This discussion features Prof. Marie Scully from University College London Hospital in UK and Prof. Paul Coppo from Saint-Antoine Hospital in Paris, France. The debate centers on whether therapeutic plasma exchange (PEX) combined with immunosuppression, long considered the standard treatment for acute aTTP episodes, has become obsolete with the advent of new therapies. Lees meer
First Prof. Scully argues that plasmapheresis is indeed a thing of the past, citing its complexity and inherent safety concerns. Prof Scully predicts that the best alternative option will incorporate the use of recombinant ADAMTS13, caplacizumab and immunosuppression primarily with steroids and anti-CD-20 therapy.
In contrast, Prof Coppo argues that a PEX-free strategy cannot be universally applied to all aTTP patients, regardless of clinical presentation and severity because there is insufficient data yet to support this approach, the availability of caplacizumab is not guaranteed.
Tune in for this debate to hear further our experts’ views on the impact of treatment costs on availability and clinical decision making.
Guests:
Dr Eleni Gavriilaki
Aristotle University of Thessaloniki, Greece
Prof Marie Scully
University College London, UCLH, London, UK
Prof Paul Coppo
Sorbonne University and Saint-Antoine Hospital, Paris, France
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The Role of Artificial Intelligence in Hematology (featuring Dr Gregor Hormann)
22 november 2024 · 16 min
Join us in this podcast episode to get a glimpse of what the future holds in the big field of innovation in hematology. With the help of our host, Dr Gregor Hormann (MLL Munich Leukemia Laboratory, Germany), you will be taken on a journey toward a future that is already here. Lees meer
Dr Hormann will discuss the many potentials of AI in hematology and oncology, including the automated integrated diagnostic tools, from morphology to chromosomal banding analysis in a few minutes, new classification algorithms, and innovative large language models (LLMs) assisting physicians in the diagnosis prediction.
The take-home message? "AI will not replace physicians. However, physicians who use AI will replace those who don't."
Host: Dr Wilson Lim
Guest: Dr Gregor Hormann
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From MDS to AML: Genetics of Progression (featuring Prof Lars Bullinger)
18 november 2024 · 21 min
Tune in to EHA Unplugged for an engaging chat with Professor Lars Bullinger from Charité University Medicine, Berlin. He'll break down the latest in myeloid disease classification, discussing how new genetic insights are transforming our understanding of MDS and AML. Lees meer
Discover the hurdles clinicians face, the promise of innovative treatments, and the future of preventive medicine, including the impact of clonal hematopoiesis and cutting-edge sequencing tech.
Host: Prof Kirsten Grønbæk
Guest: Professor Lars Bullinger
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Screening for Sickle Cell Disease (with Prof David Rees)
8 november 2024 · 18 min
Join us for an insightful episode featuring Prof David Rees from King’s College Hospital in London as he discusses screening practices for Sickle Cell disease (SCD). Hosted by Dr Sarah de Vlieger, this discussion explores both antenatal and neonatal screening practices for Sickle Cell disease. Lees meer
The conversation begins with an examination of antenatal screening challenges, comparing various techniques such as carrier screening, amniocentesis, chorionic villus sampling, and emerging non-invasive prenatal testing. Prof Rees and Dr de Vlieger then address the complex decisions arising from these test results and the disparities in screening access across different countries and cultures.
Moving to neonatal screening, Prof Rees emphasizes its crucial role in implementing early preventive measures. He advocates for the inclusion of Sickle Cell testing in general neonatal screening programs throughout Europe and aspires for screening to become more accessible in regions with higher disease prevalence.
Host: Sarah de Vlieger, EHA Head of Education
Guest: Prof David Rees
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The Environmental Impact on Hematology Practice (with Dr Stephen Hibbs)
1 november 2024 · 13 min
Join us for an engaging episode with Dr. Stephen Hibbs from Queen Mary University of London as he discusses the environmental impacts of hematology. Alongside our host Dr. Sarah de Vlieger, they explore how climate change is already affecting hematology, emphasizing that these effects are being felt now rather than in the future. Lees meer
The conversation highlights how climate change alters aspects of hematology practice, such as the risk of transfusion-transmitted infections due to evolving disease vectors. Dr. Hibbs describes also the surprising link between extreme heat during pregnancy and an increased risk of children developing ALL (acute lymphoblastic leukemia). He further discusses practice-changing initiatives, like using sevoflurane instead of desflurane as an anesthetic to reduce environmental impact, and explains his work on improving the logistics of blood transfusions to lessen their ecological footprint.
Finally, Dr. Hibbs encourages hematologists to focus on actionable steps to minimize their environmental impact, advocating for practical changes in clinical practices and increased awareness of the healthcare sector's contribution to global emissions.
Host: Dr Sarah de Vlieger
Guest: Dr Stephen Hibbs
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Synthetic Patients: The Future of Clinical Trials?
25 oktober 2024 · 15 min
Join us in this podcast episode, exploring with Prof Matteo Della Porta (Humanitas Research Hospital, Milano, Italy) the emerging role of "synthetic patients" in hematological clinical trials. Innovative generative artificial intelligence models allow today to create synthetic data set based on real patients, suitable to be used as control groups in clinical trials, helping in the identification of disease mechanisms and improving the prognostic risk prediction. Lees meer
Prof Della Porta will dig into the challenges and opportunities linked to these new technologies, from the overcoming of privacy barriers to the regulatory needs required with the advent of synthetic data in clinical trial settings, opening the door for novel models in clinical research.
Host: Dr Enrica Orsini
Guest: Prof Matteo Della Porta
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Innovative tools for Disease Monitoring in Multiple Myeloma
18 oktober 2024 · 18 min
Join us for an insightful interview with Prof Bruno Paiva from Clinical University of Navarra in Pamplona, Spain, as he and our host Dr. Isabel Olivera-Martinez, discuss the latest technical approaches to improving monitoring, risk stratification and differential diagnosis of patients with monoclonal gammopathies including MGUS (monoclonal gammopathy of unknown significance), smoldering myeloma and multiple myeloma. Lees meer
Prof Paiva begins by highlighting the importance of developing less invasive tools to assess MRD, given that multiple myeloma patients are living longer and need to be monitored multiple times.
He further describes the potential updates to the guidelines of the International Myeloma Working Group that may include the use of mass spectrometry, as a more sensitive method to quantify the M-component as well as the application of next-generation techniques - such as next-generation flow cytometry and next-generation sequencing- to monitor disease in peripheral blood, as a complement to bone marrow assessments.
Prof Paiva also discusses the two largest ongoing translational studies, which aim to elucidate the “unknown” and define the clinical significance of MGUS and smoldering myeloma for each individual patient.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Bruno Paiva
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Hematology Portraits: Prof Ivo Touw
11 oktober 2024 · 28 min
Join us for an interview with Prof Ivo Touw, who has received the prestigious EHA David Grimwade Award for his contributions to the field of hematology research. Prof Touw and his research group focus on molecular signaling in leukemia predisposition syndromes, such as severe congenital neutropenia (SCN). They have described the dysfunction of the membrane receptor for the growth factor G-CSF and its role in SCN and malignant transformation to acute myeloid leukemia. In this interview prof. Lees meer
Touw talks about his career path and choices that he has made along the way. He tells about his early fascination with the growth factors and how leukemia cells respond to them, which has driven his scientific career ever since. The simple questions such as “how can the growth factor in some cells only induce a proliferative response and in others both proliferation and differentiation?” or “why does one patient respond to G-SCF therapy and another does not?” triggered the discoveries of the complex underlying biological mechanisms.
If you want to hear about the stepwise discoveries of the roles of G-SCF mutants, RUNX gene and inflammatory stress and using novel technologies such as induced pluripotent stem (iPS) technology, CRISPR technology and computational biology, tune in to this episode with Prof Ivo Touw. He will also share his thoughts on the new avenues for thinking about therapy for SCN, such as repairing stem cells for autologous transplant or repurposing already available drugs.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Ivo Touw
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Preventing Venous Thromboembolism (VTE) in Pregnant Women
4 oktober 2024 · 16 min
Join us for an insightful interview with Professor Saskia Middeldorp from Radboud University Medical Center in Nijmegen, The Netherlands, as she and our host Dr. Isabel Olivera-Martinez, discuss the medical and ethical challenges of conducting randomized clinical trials to prevent venous thromboembolism (VTE) during pregnancy. Lees meer
VTE is a leading cause of maternal morbidity and mortality, and poses significant risks to pregnant women. Together, explore the relevance of prophylactic treatments like low molecular weight heparin, and the ethical and financial complexities of conducting trials in this population. Learn about the ALIFE2 trial results, that assessed whether LMWH heparin should be used in women with recurrent miscarriage and inherited thrombophilia; well as the latest research and guidelines aimed at improving care for pregnant women at risk of VTE.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Saskia Middeldorp
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If you liked this podcast and would like to explore related content, you can check out our clinical case about Thrombosis and Hemostasis on the EHA Campus.
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Gene Therapy for Hemophilia
17 september 2024 · 25 min
Join us for an insightful interview with Professor Frank Leebeek from Erasmus University in Rotterdam, The Netherlands, as he discusses together with our host, Dr. Isabel Olivera-Martinez, the potential of gene therapy to free hemophilia patients from the standard coagulation factor replacement therapy. Lees meer
Prof. Leebeek explains how gene therapy for hemophilia is carried out and differentiates the current possibilities for hemophilia A patients versus those with hemophilia B. He also highlights the advantages and challenges of this life-changing therapy, including its long-term effects, while addressing patient concerns related to safety and accessibility. Finally, he provides a glimpse into the future of gene therapy.
Host: Isabel Olivera-Martinez, PhD, Medical Writer
Guest: Prof Frank Leebeek
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If you liked this podcast and would like to explore related content, you can check out our EHA Gene Therapy Techniques Program on the EHA Campus.
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AI-driven Morphology in Hematology
6 september 2024 · 13 min
In this podcast episode, we will explore the application of artificial intelligence to morphological diagnosis in hematology. Listening to our host, Dr Mahesh Prahladan (University of Suffolk, UK) you will learn how innovative machine learning and deep learning models have led to the development of AI systems that have been applied in various areas of hematology, including digital pathology. Lees meer
As these systems have shown promise in improving diagnostic accuracy and efficiency, they also have a potential for enlarging accessibility to precise diagnostics, through remote digital morphology, and have potential applications in the prognostic stratification of patients.
According to Dr Prahladan, we are not ready to dispose of our microscopes yet, but automation may become a useful and time-saving tool in the hands of morphologists.
Host: Dr Enrica Orsini
Guest: Dr Mahesh Prahladan
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Regulatory Landscape for CAR T-cell Therapy
30 augustus 2024 · 11 min
Join us for an interview with Professor Julio Delgado from the Hospital Clinic de Barcelona (Spain), the first academic centre to achieve the authorisation to treat patients with a CAR T therapy developed 100% by academia. Lees meer
Prof Delgado discusses the complexities of obtaining regulatory approval for CAR T-cell therapy, under the EU regulation for advanced therapy medicinal products (ATMPs).
In this episode, Prof Delgado shares his own experience learning to navigate the EU regulatory expectations while working at the European Medicines Agency (EMA). He emphasizes the importance of scientists understanding these regulations and regulators understanding the specific position of academia in the approval pathway for ATMPs. Listen and take advantage of his valuable insights!
Host: Isabel Olivera-Martinez, Medical Writer
Guest: Prof Julio Delgado
This episode is part of a series recorded at the joint EHA-EBMT 6th European CAR T-cell meeting in Valencia in February 2024, more podcasts will be available in the future. Stay tuned!
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Interested in more content related to CART? We've got you covered. Check out free CART program on EHA Campus.
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Point-of-care CAR T-cell Manufacturing
23 augustus 2024 · 22 min
Join us for this podcast discussing the promises and challenges of academic and point-of-care CAR T-cell manufacturing with Dr Anna Sureda, president of EBMT (European Society for Blood and Marrow Transplantation). Lees meer
Dr Sureda provides her expert point of view on how CAR T-cells produced in academic centres may enhance patient access to CAR-T treatment, reducing costs and turnround times for production, and on the regulatory and quality issues linked to decentralized manufacturing of CAR T-cells.
Discover the current European landscape for academic CAR-T production, the evidence and experiences accumulated so far, and the potential role of scientific societies such as EBMT and EHA in shaping the future of CAR-T treatment.
Host: Enrica Orsini
Guest: Dr Anna Sureda
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Interested in more content related to CART? We've got you covered. Check out free CART program on EHA Campus.
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Processes in CAR T-cell Therapy
16 augustus 2024 · 28 min
Join us for an interview with Professor Julio Delgado from the Hospital Clinic de Barcelona (Spain) as he explains the intricate process of CAR T-cell therapy. In this episode, we cover the key steps involved in CAR T, such as patient identification, apheresis, manufacturing, cell infusion and managing post-infusion related toxicities. Lees meer
Prof Delgado offers expert insights on each component of this complex treatment and discusses possible improvements. He also highlights efforts to shorten vein-to-vein time and the importance of academic and non-profit manufacturing in reducing costs. This conversation offers a solid overview for clinicians and hematologists interested in advanced therapy medicinal products (ATMPs).
Host: Isabel Olivera-Martinez, Medical Writer
Guest: Prof Julio Delgado
This episode is part of a series recorded at the joint EHA-EBMT 6th European CAR T-cell meeting in Valencia in February 2024, more podcasts will be available in the future. Stay tuned!
Learn More
Interested in more content related to CART? We've got you covered. Check out free CART program on EHA Campus.
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CAR T-cell Therapy for Children with ALL
9 augustus 2024 · 19 min
Tune in to our podcast for an in-depth discussion on CAR T-cell therapy for acute lymphocytic leukemia (ALL) in children. In this episode, we feature Professor Concetta Quintarelli, a renowned expert in hematology from the Bambino Gesù Children Hospital in Rome. Lees meer
With host Isabel Olivera, they explore the advancements and challenges in treating ALL with CAR T-cells, the balance between treatment efficacy and safety, and the potential of combining CAR T-cells with other immunotherapies. The episode also delves into the complexities of the tumor microenvironment in ALL, antigen selection for targeted therapy, and the design of smarter CAR T-cells.
Professor Quintarelli discusses the future of CAR T-cell therapy, including the role of natural killer cells in ALL treatment and the importance of early intervention. Don't miss this insightful conversation on the latest developments in CAR T therapy for pediatric patients.
Host: Dr Isabel Olivera
Guest: Prof Concetta Quintarelli
This episode is part of a series recorded at the joint EHA-EBMT 6th European CAR T-cell meeting in Valencia in February 2024, more podcasts will be available in the future. Stay tuned!
Learn More
Interested in more content related to CART? We've got you covered. Check out free CART program on EHA Campus.
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CAR T-cell Therapy in AML: State of the Art
2 augustus 2024 · 15 min
Tune in to our podcast for an in-depth discussion on immunotherapeutic strategies for Acute Myeloid Leukemia (AML). In this episode, we feature Dr Sarah Tettamanti, a senior scientist at the Fondazione Tettamanti Research Centre in Italy, who shares her expertise on CAR T-cell therapy for AML. Lees meer
With host Dr Sarah de Vlieger, they examine the progress and challenges in treating AML with CAR T-cells, the balance between treatment efficacy and safety, and the potential of combining CAR T-cells with other immunotherapies.
The episode also covers the complexities of the tumor microenvironment in AML, antigen selection for targeted therapy, and the design of smarter CAR T-cells. Sarah discusses the future of CAR T-cell therapy, including fourth-generation CAR T-cells and the role of natural killer cells in AML treatment.
Host: Dr Sarah de Vlieger
Guest: Dr Sarah Tettamanti
This episode is part of a series recorded at the joint EHA-EBMT 6th European CAR T-cell meeting in Valencia in February 2024, more podcasts will be available in the future. Stay tuned!
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Interested in more content related to CART? We've got you covered. Check out free CART program on EHA Campus.
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Ethical Considerations in CAR T-cell Therapy
26 juli 2024 · 22 min
Welcome to a thought-provoking episode of our podcast series, where we dive into the ethical and practical challenges of CAR T-cell therapy with Professor Marie José Kersten from Amsterdam University Medical Centers. Lees meer
In this episode, our host Dr Isabel Olivera engages in a deep dive with Professor Kersten on the intricacies of patient access to CAR T-cell therapy, the ethical considerations in patient selection, and the financial implications of this groundbreaking treatment.
Discover the rigorous process of patient eligibility assessment in the Netherlands, the national CAR-T tumorboard's role, and the ongoing efforts to make CAR T-cell therapy more accessible across different regions. Join us as we explore the potential of clinical trials in advancing treatment options, the quest for cost-effective manufacturing methods, and the critical importance of ethical decision-making in healthcare.
This conversation also offers valuable advice for hematologists and sheds light on the importance of multidisciplinary discussions in improving patient outcomes. Don't miss this insightful discussion that navigates the complexities of modern medicine and the future of lymphoma treatment.
Host: Dr Isabel Olivera Martinez
Guest: Prof Marie José Kersten
This is part of a series recorded at the joint EHA-EBMT 6th European CAR T-cell meeting in Valencia in February 2024, more podcasts will be available in the future. Stay tuned!
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Interested in more content related to CART? We've got you covered. Check out free CART program on EHA Campus.
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CAR T-cell Therapy - A Patient's Perspective
19 juli 2024 · 12 min
Join us for a conversation with Jonathan Clark, a patient advocate who has been in remission for over five years after receiving CAR T-cell therapy for Mantle Cell Lymphoma. Lees meer
Jonathan shares his journey from relapse to recovery, detailing the challenges and triumphs of this cutting-edge treatment from a patient’s perspective. With host Dr. Sarah de Vlieger, they discuss his motivation for sharing his story and the profound physical and psychological impacts of long-term remission.
Jonathan also talks about managing long-term side effects like immunodeficiencies and how apparently small changes can significantly improve quality of life. He emphasizes the importance of understanding the patient's perspective, advocating for quality of life improvements, and the need for personalized care that goes beyond medical statistics. Jonathan highlights the global disparities in accessing advanced treatments like CAR T-cell therapy and concludes with a call to prioritize quality of life in treatment decisions.
Host: Dr Sarah de Vlieger
Guest: Jonathan Clark
This episode is part of a series recorded at the joint EHA-EBMT 6th European CAR T-cell meeting in Valencia in February 2024.
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Interested in more content related to CART? We've got you covered. Check out free CART program on EHA Campus.
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Developments in CAR T-cell Therapy
12 juli 2024 · 18 min
Join us for a captivating interview with our guest Professor Michael Hudecek from the Universitätsklinikum Würzburg in Germany as he offers his insights on the latest advancements in CAR T-cell therapy and gene-engineered immune cell therapies. Lees meer
Together with our host Dr. Isabel Olivera Martinez, they discuss the mounting real-world data on CAR T-cell treatments and how AI is helping analyze this data to design new strategies and extend CAR-T to new indications.
Discover the strides being made to predict and manage treatment-related toxicities and to make CAR T-cell therapy more accessible and affordable, including potential off-the-shelf treatments and automated manufacturing techniques.
Learn about the role of gene editing and the challenges of creating universally compatible immune cell products. Finally, gain insights from the 2024 CAR T-cell meeting, where groundbreaking clinical updates and new applications of CAR-T to autoimmune and cardiovascular diseases were showcased.
Host: Dr Isabel Olivera Martinez
Guest: Prof Michael Hudecek
This is part of a series recorded at the joint EHA-EBMT 6th European CAR T-cell meeting in Valencia in February 2024, more podcasts will be available in the future. Stay tuned!
Learn More
Interested in more content related to CART? We've got you covered. Check out free CART program on EHA Campus.
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Precision Medicine in Myelodysplastic Syndromes (MDS)
5 juli 2024 · 18 min
Join us on this podcast episode featuring Prof. Maria Teresa Voso (Tor Vergata University of Rome, Italy) as she offers her insights on the latest advancements in precision medicine for diagnosing and treating myelodysplastic syndromes (MDS). Lees meer
In this interview with our EHA host, Dr. Isabel Olivera Martinez, Prof. Voso begins by explaining how the use of NGS myeloid panels in identifying individual myeloid mutations enhances the diagnostic accuracy of MDS. Our guest then discusses the novelties in the 2022 WHO and ICC MDS classifications and the significance of germline predisposition. Furthermore, she explores the emerging targeted therapies for MDS, including lenalidomide, luspatercept, and imetelstat.
This episode offers a comprehensive overview of the evolving landscape of MDS diagnosis and management, highlighting the importance of personalized approaches in improving patient outcomes.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Maria Teresa Voso
This is the ninth episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
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