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203 afleveringen, van nieuw naar oud
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Diversity, Equity, and Inclusion in Hematology
28 juni 2024 · 6 min
Join us for a stimulating conversation with our guest Dr. Eleni Gavriilaki, from G. Papanicolaou Hospital and Aristotle University of Thessaloniki in Greece, as she shares her insights on one of her passions: diversity, equity, and inclusion (DEI) in hematology. Together with our host Dr. Sarah de Vlieger, they discuss the current challenges of DEI in the field and how organizations like EHA are addressing these issues. Lees meer
They examine the importance of representation across gender, age groups and geographical location and how this impacts both clinical and research practices. Dr. Gavriilaki highlights ongoing initiatives to promote DEI, such as inclusive speaker selection, recruiting hematologists from diversity groups to leading roles, creating equitable grant opportunities. She further emphasizes the need for conscious efforts to provide opportunities to hematologists from underrepresented countries.
This conversation concludes with a call to action for hematologists who feel underrepresented to seize the current momentum and make their voices heard.
If you feel inspired to learn more about EHA’s DEI Initiatives, please feel free to check out the EHA Taskforce on Diversity, Equity, and Inclusion or reach out to membership@ehaweb.org.
Host: Sarah de Vlieger, EHA Head of Education
Guest: Dr. Eleni Gavriilaki
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Trends in CAR T-cell Therapy
21 juni 2024 · 14 min
Join us for a captivating interview with our guest Professor Carl June, Director of the Centre for Cellular Immunotherapies at the University of Pennsylvania, USA, as he discusses the current directions in CAR T-cell therapy. Lees meer
Together with our host Dr. Sarah de Vlieger, they examine the latest results on both pediatric and adult patients with over ten years of follow up. They cover ongoing trials aimed at drastically reducing the vein-to-vein time for autologous CAR T-cells, as well as trends toward academic manufacturing and the full automation of production processes.
Finally, Prof. June provides insight into USA FDA’s warning about secondary malignancies in CAR T-cell-treated patients issued in November 2023.
Host: Sarah de Vlieger, EHA Head of Education
Guest: Prof Carl June
This is the first of a series of podcasts recorded at the 6th European CAR T-cell meeting in Valencia in February 2024, more podcasts will be available in the future. Stay tuned!
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Interested in more content related to CART? We've got you covered. Check out free CART program on EHA Campus.
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Precision Medicine in Chronic Lymphocytic Leukemia (CLL)
24 mei 2024 · 22 min
Join us for a discussion with Prof Paolo Ghia, MD, PhD, from Università Vita Salute San Raffaele, Milan (Italy), as he explores how precision medicine is transforming CLL treatment. Lees meer
In this episode, discover how precision medicine is used daily in CLL to decide the best management and treatment for patients. Listen to Prof Ghia explain how CLL management is moving from traditional chemotherapy to targeted therapies based on specific genetic markers, like immunoglobulin mutational status or P53 aberrations, which help guide treatment decisions.
Explore the array of targeted therapies available for CLL, including BTK inhibitors and BCL-2 inhibitors, and understand how they target critical pathways in CLL pathogenesis. Gain insights from Prof Ghia on the complexities of selecting the right therapy for each patient based on genetic profile, disease risk, and individual preferences.
Through the discussion, recognise the challenges in CLL management, such as relapse scenarios and emerging therapies, and learn the research strategies being explored for potential cures in CLL
This is a series of podcasts covering precision medicine across several disorders, more podcasts will be available in the future. Stay tuned!
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Lucia de Franceschi
This is the eighth episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
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Interested in more content related to CLL? We've got you covered. Check out podcasts, clinical cases, courses, and more on EHA Campus.
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Precision Medicine in Rare Hematological Diseases: Pyruvate Kinase Activators
1 mei 2024 · 16 min
Join us on this podcast episode featuring Prof Lucia de Franceschi (Department of Medicine, University of Verona, Italy) as she discusses the latest advances on the use of Pyruvate kinase activators in the treatment of rare hematological diseases. Lees meer
Learn about the crucial role of Pyruvate kinase (PK) in erythrocyte metabolism and how pyruvate kinase activators are emerging as a new therapeutic option for chronic hemolytic anemias that had previously no other treatment than transfusion or iron chelation.
Discover how two oral pyruvate kinase activators, Mitapivat and Etavopivat, can help improve ineffective erythropoiesis and survival of red cells and therefore are being tested as a new therapeutic scenario for non-transfusion dependent thalassemia patients and sickle cell disease patients.
Discover how PK activators are able to reprogram red cells to a more normal metabolite context, which can have a beneficial effect in a wide range of rare diseases all characterized by an abnormal metabolite profile, which represents the ideal breakthrough in the management of rare diseases, as one drug has the ability to treat multiple disorders.
This is a series of podcasts covering precision medicine across several disorders, more podcasts will be available in the future. Stay tuned!
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Lucia de Franceschi
This is the seventh episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
Learn More
Matte, Alessandro, Enrica Federti, and Lucia De Franceschi. 2023. ‘Erythrocyte Pyruvate Kinase Activation in Red Cell Disorders’. Current Opinion in Hematology 30 (3): 93. https://doi.org/10.1097/MOH.0000000000000758.
Interested in more content related to Thalassemia? We've got you covered. Check out podcasts, clinical cases, courses, and more on EHA Campus.
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Precision Medicine in Follicular Lymphoma
26 april 2024 · 20 min
Join us for this captivating interview with our guest Prof Stefano Luminari, MD, PhD, from the University of Modena and Reggio Emilia in Italy, as he explores what precision medicine means today for follicular lymphoma. Lees meer
Together with our host Dr. Isabel Olivera-Martinez, they discuss the current precision medicine approaches to the diagnosis and treatment of follicular lymphoma. They explore the molecular events underlying the disease, the latest targeted therapies, and the future of treatment for follicular lymphoma. Professor Luminari shares his insights on the most promising developments in the field, including T cell engagers, bispecific antibodies, and CAR-T therapies. He also discusses the importance of considering not only the efficacy of these treatments but also their impact on the quality of life and long-term outcomes for patients. This episode provides a comprehensive and enlightening discussion on the current state and future of follicular lymphoma treatment.
This is a series of podcasts covering precision medicine across several disorders, more podcasts will be available in the future. Stay tuned!
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Stefano Luminari
This is the sixth episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
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Interested in more content related to Precision Medicine? We've got you covered. Check out podcasts, clinical cases, courses, and more on EHA Campus.
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Precision Medicine in Multiple Myeloma
12 april 2024 · 17 min
Join us for a captivating discussion with Prof Pieter Sonneveld, MD, PhD, from Erasmus MC Cancer Institute in Rotterdam, the Netherlands, as he explores the evolution of precision medicine in multiple myeloma. Lees meer
Prof. Sonneveld outlines the improvements in multiple myeloma treatment over the past decade, describing the progressive addition of targeted therapies such as daratumumab and bispecific antibodies, BiTEs, and CAR-T cells to the therapeutic arsenal.
Discover how treatment selection now hinges on whether a one-off or continuous therapy is most suitable, acknowledging the challenges of limited availability in Europe due to cost considerations. Learn about the outstanding findings from the phase III PERSEUS trial, demonstrating the effectiveness of daratumumab combined with lenalidomide for newly diagnosed transplant-eligible patients and transforming their standard of care.
This interview unveils cutting-edge strategies that are reshaping myeloma prognosis and underscores the importance of early adoption of novel therapies for improved patient outcomes.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Peter Sonneveld
This is the fifth episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
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If you'd like to learn more about Multiple Myeloma, check out the comprehensive EHA - Multiple Myeloma Program on EHA Campus.
Interested in more content related to Precision Medicine? We've got you covered. Check out podcasts, clinical cases, courses, and more on EHA Campus.
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Precision Medicine in Myeloproliferative Neoplasms
5 april 2024 · 13 min
Welcome to this podcast episode featuring Prof Claire Harrison (Clinical Director at Guy’s and St Thomas’ NHS Foundation Trust) and Prof Jean-Jacques Kiladjian (Professor at Université Paris-Diderot and Hôpital Saint-Louis). Lees meer
Join them as they navigate the challenges and opportunities of precision medicine in MPNs, discover how advancements in molecular techniques are reshaping disease diagnosis, patient stratification and treatment tailoring.
Gain insights into the evolving landscape of targeted therapies for MPNs, including JAK inhibitors and emerging strategies for CALR mutation targeting.
Listen as our experts highlight the heterogeneity of clinical needs based on individual patients' molecular profiles and the promise of personalised treatment approaches bringing exciting prospects for improving patient outcomes in this dynamic field.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Claire Harrison and Prof Jean-Jacques Kiladjian
This is the fourth episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
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If you'd like to learn more about MPN, check out the EHA - Myeloproliferative Neoplasms Program on EHA Campus.
Interested in more content related to Precision Medicine? We've got you covered. Check out podcasts, clinical cases, courses, and more on EHA Campus.
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Precision Medicine and Clonal Hematopoiesis
29 maart 2024 · 24 min
Join us on this podcast episode featuring Prof Helen Papadaki (University of Crete, Greece) as she discusses the link between clonal hematopoiesis and the risk of developing MDS or AML. Lees meer
Prof. Papadaki begins by explaining the difference between CHIP (clonal hematopoiesis of indeterminate potential), CCUS (clonal cytopenia of undetermined significance) and ICUS (Idiopathic cytopenia of undetermined significance). She underlines the clinical relevance of the association of clonal hematopoiesis with cytopenias, as a clear indicator of an increased risk of developing hematological malignancies.
Learn how important it is to better characterize by NGS sequencing the specific mutations of the clones, given that the type of mutation, the number of mutations, and the combination of mutations are critical parameters in accurately predicting the risk of developing MDS or AML.
Furthermore, Prof Papadaki explains the importance of discriminating between acquired and germline mutations leading to clonal hematopoiesis and their relationship with age. Finally, she highlights the fact that clonal hematopoiesis is a risk factor for developing not only hematological malignancies but also cardiac diseases.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Helen Papadaki
This is the third episode in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
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Precision Medicine: Hepcidin Mimetics for Polycythemia Vera Treatment
15 maart 2024 · 18 min
Join us on this podcast episode featuring Prof Domenico Girelli, Professor of Internal Medicine and Director of the Internal Medicine Unit, University Hospital of Verona (Italy), as he discusses the latest advances on the use of Hepcidin mimetics in the treatment of Polycythemia Vera and iron metabolism diseases. Lees meer
Discover how Hepcidin analogues offer a precise method for managing the overproduction of red blood cells in Polycythemia Vera patients. Explore the potential of Rusfertide, an inhibitor of Hepcidin, in regulating iron availability for erythropoiesis, thereby addressing the characteristic and chronic erythrocytosis seen in Polycythemia Vera. Gain insights into how targeting the Hepcidin-Ferroportin axis is revolutionizing the treatment of various iron metabolism disorders.
Tune in for a comprehensive discussion on these groundbreaking advancements in hematology research.
Host: Isabel Olivera-Martinez, PhD
Guest: Prof Domenico Girelli
This is the second in a series of podcasts covering precision medicine across various disorders; more podcasts will be available in the future. Stay tuned!
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To go further: Kremyanskaya M et al. Rusfertide, a Hepcidin Mimetic, for Control of Erythrocytosis in Polycythemia Vera. N Engl J Med. 2024 Feb 22;390(8):723-735. doi: 10.1056/NEJMoa2308809. PMID: 38381675.
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Precision Medicine in Inherited Bone Marrow Failure Syndromes
16 februari 2024 · 11 min
Welcome to another season of EHA Unplugged. In our first episode of 2024, listen to Prof Carlo Dufour, Chairperson of the Paediatric Hemato-Oncology department of G. Gaslini Children’s Hospital in Genova (Italy), as he discusses how classical IBMFs (such as Fanconi Anemia, Diamond-Blackfan Anemia, Shwachman-Diamond Syndrome, and the telomere disorders) are now being joined by a large number of other diseases included in this category, thanks to the increasing precision of diagnostic genetic tools. Lees meer
Prof Dufour explains further how crucial precise genetic-based diagnosis is in discriminating between true acquired and constitutional bone marrow failure disorders in order to properly determine the best line of treatment for these rare diseases and to establish a monitoring plan to prevent the occurrence of secondary malignancies.
Tune in to find out how IBMFS patients may benefit from precision medicine and a therapy tailored to their genetic constitution.
This is a series of podcasts covering precision medicine across various disorders, more podcasts will be available in the future. Stay tuned!
Guest: Prof Carlo Dufour, G. Gaslini Children’s Hospital in Genova (Italy)
Host: Isabel Olivera-Martinez, PhD, European Hematology Association (EHA)
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To go further: Miano M, Grossi A, Dell'Orso G, et al. Genetic screening of children with marrow failure. The role of primary Immunodeficiencies. Am J Hematol. 2021; 96(9): 1077–1086. https://doi.org/10.1002/ajh.26242
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The Whats in Scientific Publishing
1 december 2023 · 21 min
In this episode, join HemaSphere's editor-in-chief, Prof Jan Cools, as he guides you through article publishing. Acquire valuable insights, tips, and new perspectives on often-overlooked considerations. Prof Cools sheds light on the pivotal role of reviewers in the publishing process and provides his insights into the evolving impact of AI on publishing. Lees meer
Guest: Prof Jan Cools, KU Leuven. Belgium. Editor-in-Chief of HemaSphere
Host: Dr Wilson Lim, European Hematology Association (EHA)
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The New Classification of Hemochromatosis: Why and How
17 november 2023 · 17 min
Welcome to EHA Unplugged! In this episode, join host Dr Wilson Lim as he delves into the world of hemochromatosis with esteemed Prof Domenico Girrelli from the University of Verona. Lees meer
Prof Girrelli provides valuable insights into the new classification of hemochromatosis, shedding light on its genetic determinants, clinical manifestations, and recent advancements in its diagnosis and treatment. Discover the complexities of iron metabolism and the impact of this classification on patient management.
Tune in to stay informed about the latest developments in hemochromatosis classification.
Guest: Prof Domenico Girrelli, University of Verona, Italy
Host: Dr Wilson Lim, European Hematology Association (EHA)
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Diversity, equity, and inclusion: Why this is important?
10 november 2023 · 9 min
In this episode Prof Tarec El-Galaly gives an overview of diversity, equity, and inclusion (DEI). He explains what is DEI in hematology and the work EHA taskforce DEI taskforce is doing for patients benefit. Listen to this great initiative and perhaps it can benefit your practice. Lees meer
Guest: Prof Tarec El-Galaly, Aalborg University Hospital, Denmark
Host: Dr Wilson Lim, European Hematology Association (EHA)
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Unraveling Autoimmune Neutropenia: From Childhood to Adulthood
3 november 2023 · 21 min
Join us for this update on Autoimmune Neutropenia (AIN), a rare blood disorder that presents and develops differently in children and adults. Lees meer
Experts Dr Francesca Fioredda and Prof Helen Papadaki along with our host Dr. Isabel Olivera discuss the diagnostic challenges associated with AIN and the need for a broader definition, based on the latest insights from the different mechanisms underlying AIN’s pathogenesis.
Learn how to adapt the treatment of AIN to the specific form of neutropenia, the patient’s age, evolving needs, and underlying disease. Our experts also emphasize the importance of carefully monitoring AIN patients and of maintaining accurate patient registries.
Read this review article on AIN at HemaSphere or follow the AIN course on the EHA Campus to learn more about AIN.
Host:
Dr. Isabel Olivera
European Hematology Association
Guests:
Dr Francesca Fioredda
Istituito Giannina Gaslini, Italy
Prof Helen Papadaki
University of Crete School of Medicine, Greece
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Navigating the World of Hematology Research: from Mentorship to Work-Life Balance
27 oktober 2023 · 40 min
Join us in this enlightening podcast as three experienced researchers, Dr Anastasia Conti, Prof Konstanze Döhner, and Dr Simona Valletta, delve into the dynamic world of scientific research. This discussion moderated by Prof Kirsten Grønbæk offers valuable insights into the pivotal aspects of successful careers in research for hematologists. Lees meer
The conversation dives deeply into topics relevant to aspiring and established researchers, such as the crucial role of mentorship, and the importance of female mentors in the field, as they may offer valuable guidance to women in science. Choosing the right research lab, the need for a work-life balance, and how to balance clinical work with research endeavors for clinician-scientists are other valuable insights shared by the panel.
The podcast concludes with a focus on fostering a supportive work environment for researchers. They emphasize flexibility, strong communication, and the importance of respecting boundaries to maintain a positive and productive lab atmosphere.
Tune in to gain a wealth of knowledge for navigating in the world of scientific research in hematology.
Host:
Prof Kirsten Grønbæk
Rigshospitalet and BRIC, Denmark
Guests:
Dr Anastasia Conti
San Raffaele Telethon Institute for Gene Therapy, Italy
Prof Konstanze Döhner
University Hospital of Ulm, Ulm, Germany
Dr Simona Valletta
University of Manchester, United Kingdom
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Myelodysplastic Syndrome (MDS) with Prof Kirsten Grønbæk
20 oktober 2023 · 19 min
Join Prof Kirsten Grønbæk and Prof Konstanze Döhner as they talk about the current landscape in MDS. Prof Grønbæk shares her interest and passion in the disease, the challenges in diagnosis and treatment, and what is on the horizon in research and management of MDS. Lees meer
Guest: Prof Kirsten Grønbæk, Rigshospitalet and BRIC, Copenhagen, Denmark
Host: Prof Konstanze Döhner, University Hospital of Ulm, Germany
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Immune cell therapies and targeted therapies in AML
13 oktober 2023 · 11 min
In this podcast, expert Prof Paresh Vyas and host Dr Enrica Orsini delve into the latest developments in the treatment of Acute Myeloid Leukemia (AML). They discuss new drug targets, new therapies in clinics and the impact of the new treatment on aging patients Moreover, they address existing challenges and provide a glimpse into what the future holds for AML treatment. Lees meer
Guest: Prof Paresh Vyas, University of Oxford, United Kingdom
Host: Dr Enrica Orsini, EHA
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Patient Communication and Self Care
9 oktober 2023 · 35 min
Join us for this insightful podcast where our experts Prof Kirsten Grønbæk, Dr Mirjam Belderbos, Dr Umut Yilmaz, and Prof Konstanze Döhner discuss their experiences, challenges, and strategies for thriving in their demanding and rewarding careers as hematologists. They share valuable insight from effective communication with patients and caregivers to coping with the emotional aspects of their work. Discover how they strike a balance between personal well-being and professional responsibilities. Lees meer
Host:
Prof Kirsten Grønbæk,
Rigshospitalet and BRIC, Copenhagen, Denmark
Guests:
Dr Umut Yilmaz
İstanbul University-Cerrahpaşa, Istanbul, Turkey
Prof Konstanze Döhner
University Hospital of Ulm, Ulm, Germany
Dr Mirjam Belderbos
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
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If you'd like to continue learning about patient communication, check out the course The Divided Brain: Emotion vs. Logic in Patient Communication on EHA Campus.
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Building prognostic models using big data with Prof Kimmo Porkka
29 september 2023 · 11 min
Guest Prof Kimmo Porkka together with host Dr Enrica Orsini talk about using big data to build prognostic models. Based on Prof Porkka’s experience on working with big data, he uses the Harmony Alliance as an example and gives an overview of data collection, the importance of data security and the importance to have the participation of a large network of hospitals or academic centers, and recognising the challenges behind that. Lees meer
Guest: Prof Kimmo Porka. University of Helsinki, Finland
Host: Dr Enrica Orsini, EHA.
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Myeloma - Prof Jorge Sierra
22 september 2023 · 24 min
Prof Jorge Sierra provides an overview of myeloma, delving into its clinical aspects and sharing his personal passion for the disease. Lees meer
Together with host Prof. Konstanze Döhner, they explore myeloma's treatment challenges and advancements. Prof. Sierra also offers valuable advice on initiating myeloma research, making this an engaging podcast for students, trainees, and young hematologists alike.
Guest: Prof Jorge Sierra
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Host: Prof Konstanze Döhner
University Hospital of Ulm, Ulm, Germany
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Lymphoma - Dr Umut Yilmaz
15 september 2023 · 14 min
In this episode, we talk to Dr. Umut Yilmaz from İstanbul University-Cerrahpaşa. Umut shares his interest in lymphoma, its diversity, and the challenges in his work. He also offers unique advice for inspiring starting hematologists and calls for more people to join the exciting field of lymphoma research and treatment. Lees meer
Guest: Dr Umut Yilmaz
İstanbul University-Cerrahpaşa, Istanbul, Turkey
Host: Prof Kirsten Grønbæk
Rigshospitalet and BRIC, Copenhagen, Denmark
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How to Get Started in Hematology Research - Dr Anastasia Conti, Assoc Prof Maria Paola Martelli and Dr Simona Valletta
8 september 2023 · 44 min
Our guests Dr Anastasia Conti, Assoc Prof Maria Paola Martelli and Dr Simona Valletta give an overview on starting research in hematology. They go through their experience, give advice and talk about the challenges they face. Lees meer
The podcast starts with the basics of how to get started in hematology research, starting how to come up with research ideas and how to develop these ideas into projects. Our guests continue with their view on PhD programmes, where they give advice to those who want to start a PhD or a research focused career. Anastasia, Maria and Simona recollects how rewarding their PhD experience was and emphasizes the importance of motivation, resilience and persistence in research. A PhD shapes you Simona says. Last but not least, they delve into the topic of research funding and their experiences in writing grants.
Guests:
Dr Anatasia Conti
San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
Assoc Prof Maria Paola Martelli
University of Perugia, Perugia, Italy
Dr Simona Valletta
University of Manchester, Manchester, United Kingdom
Host: Prof Kirsten Grønbæk
Rigshospitalet and BRIC, Copenhagen, Denmark
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Pediatric Hematology - Dr Mirjam Belderbos
1 september 2023 · 17 min
Listen as guest Dr Mirjam Belderbos talk to our host Prof Kirsten Grønbæk about her own experience in pediatric hematology, how she interacts with her patients and their family, the challenges in the field and how it differs from adult hematology. She also indulge us in the fun annual custom her pediatric unit does and how rewarding her role is to her. She ends by giving some advice to trainees and medical students who are interested in the field of pediatric hematology. Lees meer
Guest: Dr Mirjam Belderbos. Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Host: Prof Kirsten Grønbæk. Rigshospitalet and BRIC, Copenhagen, Denmark
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Iron metabolism: physiology and pathology
25 augustus 2023 · 14 min
This week, we have guest Prof Laura Silvestri from Vita-Salute San Raffaele University who gives an amazing overview of iron regulation from the perspective of the protein hepcidin. Lees meer
Prof Silvestri illustrates the mechanism behind hepcidin regulation and how is transcription effected by proinflammatory cytokines in certain hematological disorders.
Host: Dr Enrica Orsini; Guest: Prof Laura Silvestri
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Pathogenesis and Management of Acute Chest Syndrome (ACS) in SCD
11 augustus 2023 · 12 min
In this episode, Prof David Rees gives an overview of acute chest syndrome (ACS) in SCD. Lees meer
Prof Rees and host Dr Enrica Orsini talk about epidemiology, the clinical picture, patient management, and the importance of recognizing this disease.
Host: Dr Enrica Orsini; Guest: Prof David Rees
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EHA Unplugged: MDS Classification and Risk Assessment
4 augustus 2023 · 16 min
In this episode, Prof Maria Teressa Voso talks about MDS classification and risk assessment. She explains the different risk scores, the importance of molecular genetics in classification, risk stratification and management in MDS patients. Lees meer
Guest: Prof Maria Teressa Voso ; Host: Dr Enrica Orsini
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New Treatment of Iron Metabolism Defects: A Focus on Anemia of Inflammation
28 juli 2023 · 21 min
Listen as our guest Prof. Martina Muckenthaler and host Dr. Isabel Olivera Martinez give an overview on anemia of inflammation. They discuss the pathogenesis of the disease and the current treatment landscape in particular with HIF-PH inhibitors, and hepcidin as a target in certain disease entities. Lees meer
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Guest: Prof. Martina Muckenthaler ; Host: Dr. Isabel Olivera Martinez
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Latest Innovations and Future Perspectives in CAR-T Therapy
21 juli 2023 · 14 min
Listen as Dr. Maria Themeli and Dr. Ciprian Tomuleasa provide an overview of the latest developments and novel ideas in CAR-T therapy. Lees meer
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
What did you think of this podcast? Share your opinions with us in a short feedback survey.
Guests: Dr. Maria Themeli and Dr. Ciprian Tomuleasa
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Current CAR-T Treatment for Lymphomas Focusing on DLBCL
14 juli 2023 · 14 min
Listen as Dr. Anna Sureda explains the available CAR-T treatments for lymphomas, focusing on DLBCL (diffuse large B cell lymphoma) and the challenges of CAR-T therapy in the current treatment landscape. She also considers the possibility of using CAR-T cells in 2nd line treatment (or earlier) and in combination with other drugs. Lees meer
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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Guest: Dr Anna Sureda
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Clinical Management of CAR-T Therapy in Myeloma
7 juli 2023 · 7 min
In this episode Dr Wilson Lim interviews our guest Prof. Carlos Fernández de Larrea on CAR-T toxicities and how to control or avoid adverse reactions to CAR-T therapies in patients with myeloma. Lees meer
Guest: Prof. Carlos Fernández de Larrea ; Host: Dr Wilson Lim
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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Challenges in receiving CAR-T treatment: Patient's perspective
30 juni 2023 · 6 min
Listen as Dr. Anna Sureda discusses CAR-T therapy from a patients perspective and the steps that physicians can take to help patients overcome the challenges that comes with CAR-T treatment. Lees meer
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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Guest: Dr Anna Sureda ; Host: Dr Wilson Lim
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Ph+ acute lymphoblastic lymphoma and the immune system in hematological neoplasms.
23 juni 2023 · 24 min
Listen as Emeritus Prof Robin Foà brings you on the journey of Ph+ ALL management together with our host Dr Enrica Orsini. With a long career in ALL, Prof Foà runs through the history of Ph+ ALL, his experience in patient management, and then brings you up to date on the current picture in patient management. Lees meer
Tune in as Prof Foà describes the breakthrough in treatment with TKI inhibitors and the introduction of the immunotherapeutic drug blinatumomab in Ph+ ALL.
Guest: Emeritus Prof. Robin Foà
Host: Dr. Enrica Orsini
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CAR-T Treatment in Myeloma: State of the Art
2 juni 2023 · 7 min
Join us for another episode of EHA Unplugged. We have Prof. Herman Einsele here talking about the current landscapes of CAR-T therapy in myeloma, results achievable today, and the future perspectives for these patients. Lees meer
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
What did you think of this podcast? Share your opinions with us in a short feedback survey.
Guest: Prof Herman Einsele
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Reasons for Failure and Relapse and Mechanisms of Resistance in CAR-T
26 mei 2023 · 14 min
Join us here at EHA Unplugged with another episode on CAR-T updates. Listen as our guest Prof. Chiara Bonini and host Dr. Wilson Lim discuss the reasons for CAR-T therapy failure and relapse after treatment. Lees meer
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
What did you think of this podcast? Share your opinions with us in a short feedback survey.
If you liked this podcast and would like to explore related content, you can check out our CAR-T program on the EHA Campus.
Guest: Prof. Chiara Bonini ; Host: Dr. Wilson Lim
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Economic Aspects of CAR-T: Challenges and Solutions
18 mei 2023 · 19 min
Listen as Prof. Christian Chabannon provides an overview of the challenges and obstacles raised by the economic aspects of CAR-T treatment. He examines different solutions and proposes a way forward to address these issues. Lees meer
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
What did you think of this podcast? Share your opinions with us in a short feedback survey.
If you liked this podcast and would like to explore related content, you can check out our CAR-T program on the EHA Campus.
Guest: Prof. Christian Chabannon ; Host: Dr. Olivera Martinez
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Update on CAR-T Therapies in Acute and Chronic Leukemias
12 mei 2023 · 8 min
Listen as Prof. John Gribben provides an update on where we are with CAR-T in acute and chronic leukemias. Lees meer
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
What did you think of this podcast? Share your opinions with us in a short feedback survey.
Learn More
If you liked this podcast and would like to explore related content, you can check out our CAR-T program on the EHA Campus.
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Spotlight Talks: How I Treat Absolute Iron Deficiency in Inflammatory Disorders
28 april 2023 · 18 min
Prof Günter Weiss, from the University of Innsbruck, Germany, provides in this podcast a comprehensive pathogenetic and clinical overview of a relevant and frequent medical problem: Absolute Iron Deficiency, defined as the combination of anemia of chronic disease (ACD) and iron deficiency anemia (IDA) in people suffering from inflammatory disorders. Lees meer
The complex functional mechanisms and underlying diseases at work in these patients make the diagnostic work-up and treatment choices difficult and may require careful analysis. Prof Weiss’s clear explanation of the different issues associated with this condition provides a useful guide to clinicians in their daily practice.
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If you liked this podcast and would like to explore related content, you can check out our EHA Diagnosing And Treating Iron Deficiency Program on the EHA Campus.
EHA Social Learning
Explore our social media microlearning: https://ehaedu.org/SM_Learning
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Overview of the Current CAR-T Landscape
21 april 2023 · 10 min
Listen as Prof. Carl June provides an overview of the past and current landscape and challenges in CAR-T therapy, along with a summary of the innovations being introduced to lower the cost of CAR-T and improve CAR-T treatment and access. Lees meer
This podcast episode is part of our FREE course on CAR-T Updates on the EHA Campus. Prominent experts provide an overview of CAR-T treatment in different diseases, discussing clinical management, economic and regulatory aspects, and future developments.
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If you liked this podcast and would like to explore related content, you can check out our CAR-T program on the EHA Campus.
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Papers Unplugged: Precision Medicine and Myeloid Neoplasms
14 april 2023 · 15 min
In this podcast, Hartmut Döhner, Hematologist-Oncologist and Professor of Medicine in Germany, discusses with Dr. Nathalie van Havre the role of genomic characterization in the classification, prognosis and treatment of myeloid neoplasms. Lees meer
Discover the main methods of genomic testing, the kind of relevant information they can provide, and the essential techniques that should currently be available for hematology centers. The podcast also explores the significance of germline variants and the need for their investigation, and the challenges associated with the implementation of a comprehensive genomic assessment in routine clinical practice.
The podcast is based on the paper: "Genomic Profiling for Clinical Decision Making in Myeloid Neoplasms and Acute Leukemia", by Duncavage EJ, et al. Blood. 2022;140:2228-2247. (https://pubmed.ncbi.nlm.nih.gov/36130297/)
Host: Dr Nathalie van Havre; Guest: Prof Hartmut Döhner
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Debate: Gene Addition or Gene Editing for Hemoglobinopathies?
7 april 2023 · 41 min
In this podcast about gene therapy for hemoglobinopathies, our experts Dr. Evangelia Yanaki and Professor Franco Locatelli discuss the most effective approach for treating patients with these conditions, considering the safety concerns and potential complications associated, as well as the need for long-term monitoring of patients. Lees meer
In this debate recorded during the EHA22 Annual Congress, Dr. Yanaki advocates for gene addition therapy, while Professor Locatelli favors genome editing as a more precise approach. Despite their differing opinions, both speakers concur that additional research is necessary to fully comprehend the potential benefits and risks of both approaches.
Learn More
If you liked this podcast and would like to explore related content, you can check out our EHA Gene Therapy Techniques Program on the EHA Campus.
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What's in Store for Lymphoid Malignancies?
31 maart 2023 · 18 min
In this episode, guest Prof Martin Dreyling and host Dr Nathalie van Havre discuss the latest developments in lymphoid malignancies and the research roadmap that has been put in place to guide future research. Lees meer
Professor Dreyling highlights the move away from traditional chemotherapy towards non-cytostatic approaches and discusses the long-term complications of traditional treatments and the need for precision therapy.
Host: Dr Nathalie van Havre; Guest: Prof Martin Dreyling
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Spotlight Talks: Postpartum Hemorrhage (PPH)
24 maart 2023 · 23 min
In this episode of EHA Unplugged, Prof Beverly Hunt discusses the global consequences of postpartum hemorrhage (PPH) and the unacceptable PPH-related mortality rate in developed countries. The discussion continues on the challenges faced in the identification of PPH and the primary causes of PPH. Prof Hunt further talks about the consequences of PPH on children and emphasizes the need for more research in PPH and campaigns to improve maternal health. Lees meer
Guest: Prof Beverly Hunt
This podcast was recorded as a Spotlight Talks session during EHA2022. More podcasts from EHA2022 will be available. Stay tuned.
Learn More
If you liked this podcast and would like to explore related content, you can check out our Women with Bleeding Disorder course on the EHA Campus. A multidisciplinary team of experts has developed this accredited micro e-learning program to increase awareness, knowledge, and understanding of bleeding disorders and their management among healthcare professionals who are the first to see women and girls with signs and symptoms of bleeding disorders.
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Papers Unplugged: The Perspectives of Doctors and Patients in the Treatment of CLL
17 maart 2023 · 9 min
Join Prof Paolo Ghia and our host Dr Enrica Orsini as they discuss the treatment of Chronic Lymphocytic Leukemia (CLL) from the perspectives of patients and doctors. Lees meer
In this episode, they discuss the factors that influence the decision of treatment choices from the perspectives of patients and doctors and how both parties have different perspectives on the subject. They further highlight the importance of understanding the differing priorities between these two groups and the need for shared decision-making in the treatment process.
The podcast is based on the paper: "What Are the Attributes Prioritized in the Choice of Therapy in Chronic Lymphocytic Leukemia? A Patient-physician Cross-matching Analysis of a Discrete Choice Experiment", by Laurenti L et al., published on HemaSphere in 2022.
Host: Dr Enrica Orsini; Guest: Prof Paolo Ghia
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To learn more about CLL and updated treatment recommendations, check out our comprehensive CLL Program on the EHA Campus.
Discover more of EHA's social media microlearning here.
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Papers Unplugged: Precision Medicine in AML
10 maart 2023 · 11 min
In this podcast, hear from Prof Hartmut Döhner, Hematologist-Oncologist and Professor of Medicine in Germany, as he discusses the growing roles of precise treatments based on the characteristics of the leukemic cells in acute myeloid leukemias. Discover the clinical developments of targeted treatments such as IDH1/2 inhibitors and venetoclax, and learn about the importance of combination treatment to improve results. Lees meer
The podcast also explores the use of epigenetic agents as part of standard care in older patients and how the proportion of patients treated with targeted agents is increasing. Tune in to find out how more AML patients may benefit from precision medicine and targeted therapy.
The podcast is based on the paper: "Towards precision medicine for AML", by Döhner H, et al. Nat Rev Clin Oncol. 2021;18:577-590. (https://pubmed.ncbi.nlm.nih.gov/34006997/)
Host: Dr Nathalie van Havre; Guest: Prof Hartmut Döhner
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To learn more about AML and updated classification and prognostic recommendations, check out QR Case 19 on AML on the EHA Campus.
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Debate: Should Low Risk PV-MF Patients be Treated?
3 maart 2023 · 39 min
Treatment of low-risk patients with polycythemia vera (PV) and myelofibrosis (MF) is still a matter of debate. Although traditionally these patients were managed exclusively with supportive treatment, more recent guidelines suggest the opportunity of identifying subgroups of patients eligible for cytoreduction. Lees meer
In this debate recorded during the EHA22 Annual Congress, experts Claire Harrison and Christen Lykkegaard Andersen support opposite statements on this topic, discussing the pros and cons of cytoreductive treatment in low-risk PV and MF patients, with the aid of representative clinical cases.
Learn More
If you liked this podcast and would like to explore related content, you can check out our Polycythemia Vera course on the EHA Campus.
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Would you like to explore more eLearning or podcasts? Please visit the EHA Campus.
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Health Technology Assessment (HTA)
1 maart 2023 · 20 min
Join our guest Dr Martin Kaiser and host Dr Nathalie van Havre, as they talk about Heath Technology Assessment (HTA) in hematology and in Europe’s public healthcare landscape. Lees meer
Our speakers discuss the relevance of HTA for hematologists and how it aims to standardize access to new health technologies for patients across Europe. Furthermore, they examine the challenges in generating solid evidence to support these assessments, particularly in the case of rare diseases, and whether HTAs are likely to cause new delays for new health technologies to reach the patients.
Next, the social and economic implications of HTA are discussed, in particular costs, limited resources, and equality in access to treatment. Dr Kaiser concludes this podcast by emphasizing the importance of HTA education and awareness in medical education.
Host: Dr Nathalie van Havre; Guest: Dr Martin Kaiser
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What did you think of this podcast? Share your opinions with us in this short feedback survey.
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Would you like to explore more eLearning or podcasts? Please visit the EHA Campus.
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Spotlight Talks: New Agents for the Treatment of Thalassemia
17 februari 2023 · 16 min
In this podcast, you will listen to Prof Antonis Kattamis summarizing the last developments in the treatment of patients with thalassemia. While the life expectancy of these patients has considerably improved in the last decades, quality of life and disease burden is still a relevant issue. Lees meer
However, new classes of drugs, with action of the pathophysiologic mechanisms of the disease, are entering the clinics—drugs able to improve globin chain imbalance or ineffective erythropoiesis, or decrease hemolysis. Prof Kattamis will discuss the efficacy of these treatments and of innovative gene therapy approaches, not neglecting economic evaluations on the sustainability of new treatments in thalassemia.
Guest: Prof Antonis Kattamis
This podcast was recorded as a Spotlight Talks session during EHA2022. More podcasts from EHA2022 will be available in the future. Stay tuned!
View this podcast on EHA Campus for key slides related to this episode.
Learn More
If you liked this podcast and would like to explore related content, you can check out our EHA Thalassemia Program on the EHA Campus.
For more social media microlearning from EHA, visit https://ehaedu.org/SM_Learning.
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Provide Feedback
Would you like to explore more eLearning or podcasts? Please visit the EHA Campus.
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Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
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Email us: education@ehaweb.org
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Papers Unplugged: What's New in the Treatment of CLL?
10 februari 2023 · 12 min
In this podcast, Prof Paolo Ghia discusses the current treatment landscape of Chronic Lymphocytic Leukemia (CLL), providing a guide for clinicians faced with an ever-growing number of therapeutic alternatives. Lees meer
Within targeted therapies, a special focus is dedicated to BTK inhibitors and their different characteristics, and to the long-term results of the ASCEND trial. The management of CLL is changing rapidly, and Prof Ghia's expertise can help hematologists to choose the right treatment for their patients, even in high-risk cases, such as the ones with TP53 mutation or del(17p).
The podcast is based on the paper: "Acalabrutinib Versus Investigator's Choice in Relapsed/Refractory Chronic Lymphocytic Leukemia: Final ASCEND Trial Results", by Ghia P et al., published on HemaSphere in 2022.
Host: Dr Enrica Orsini; Guest: Prof Paolo Ghia
Learn More
To learn more about CLL and updated treatment recommendations, check out our comprehensive CLL Program on the EHA Campus.
Discover more of EHA's social media microlearning here.
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Provide Feedback
Would you like to explore more eLearning or podcasts? Please visit the EHA Campus.
https://ehaedu.org/Campus
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
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Spotlight Talks: Updates on the Classification of Hematolymphoid Neoplasms—Myelodysplastic Syndromes
3 februari 2023 · 13 min
In this podcast, Prof Mario Cazzola illustrates the genesis of the new ICC classification of myeloid neoplasms, published in 2022 (Arber DA et al, Blood 2022), with a special focus on MDS, and the new nosological entities that have been defined in it. Lees meer
The new entities, namely SF3B1-mutant MDS, TP53 multi-hit MDS, and clonal cytopenia of undetermined significance (CCUS), underline the importance of gene sequencing for the diagnosis and risk stratification of myeloid neoplasms and MDS in particular.
Guest: Prof Mario Cazzola
This podcast was recorded as a Spotlight Talks session during EHA2022. More podcasts from EHA2022 will be available in the future. Stay tuned!
View this podcast on EHA Campus for key slides related to this episode.
Learn More
If you liked this podcast and would like to explore related content, you can check out our MDS Flashcards on the EHA Campus.
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Provide Feedback
Would you like to explore more eLearning or podcasts? Please visit the EHA Campus.
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Papers Unplugged: TIF Guidelines for the Management of Patients with Transfusion-Dependent Thalassemia (TDT)
27 januari 2023 · 17 min
What are the latest guidelines for the management of patients with Transfusion-Dependent Thalassemia (TDT)? Lees meer
In 2022, the fourth edition of the TIF (Thalassemia International Federation) guidelines for the management of patients with transfusion-dependent thalassemia (TDT) was published.
In this podcast, Prof Ali Taher discusses with our host, Dr Nathalie van Havre, the main news of this edition, including genetic work-up, chelation therapy, and prevention and management of complications.
Furthermore, Prof Taher illustrates the innovative gene therapy approaches and new drugs (such as luspatercept, the most recently approved drug for TDT) currently available for the treatment of these patients and how they can impact the management of TDT.
The podcast is based on the paper "2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia", by Farmakis D et al., published in HemaSphere in 2022 (HemaSphere. 2022;6:e732).
Host: Dr Nathalie van Havre; Guest: Prof Ali Taher
This is the sixth of a series of podcasts discussing recently published scientific articles. More podcasts will be available in the future. Stay tuned!
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What did you think of this podcast? Share your opinions with us in this short feedback survey.
Provide Feedback
Would you like to explore more eLearning or podcasts? Please visit the EHA Campus.
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