Alle afleveringen
203 afleveringen, van nieuw naar oud
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Spotlight Talks: Updates on the Classification of Hematolymphoid Neoplasms—Lymphoid Diseases
20 januari 2023 · 13 min
Spotlight Talks: Updates on the Classification of Hematolymphoid Neoplasms: Lymphoid Diseases Lees meer
In this podcast, Prof John Gribben, former President of EHA, discusses the new ICC lymphoid malignancies classification (Campo E, et al. Blood, 2022), highlighting the main novelties introduced for specific entities and explaining the new criteria guiding the diagnosis and prognosis of lymphoproliferative diseases.
Listen to this podcast to gain an overview of the most innovative findings in the field, while waiting for the updated WHO classification to be published in 2023.
Guest: Prof John Gribben
This podcast was recorded as a Spotlight Talks session during EHA2022. More podcasts from EHA2022 will be available in the future. Stay tuned!
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Papers Unplugged: Is CAR-T Economically Sustainable?
13 januari 2023 · 17 min
Is CAR-T economically sustainable? Lees meer
Join our guest Prof Martin Dreyling and host Dr Nathalie van Havre as they discuss the costs of CAR-T cell therapy for the treatment of blood disorders at an individual level and whether it is economically sustainable for health systems.
Listen along as they consider the financial challenges of patient selection for this costly life-saving therapy, based on Prof Dreyling’s experience with relapsed or refractory Diffuse Large B-cell Lymphoma (DLBCL) patients. Challenges touched upon include reimbursement policies, time lags and associated costs of personalized therapy, and choosing the indications to include.
Prof Dreyling further offers his insights into the overall financial burden for health systems based on his participation on a recent Budget Impact Analysis (BIA) carried out in DLBCL patients in Germany. Finally, our guests contemplate cancer immunotherapy perspectives for the coming years, including bispecific antibodies as a potentially cost-effective alternative in development.
The details of the BIA were recently described in the article Budget Impact Analysis of CAR T-cell Therapy for Adult Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma in Germany published in HemaSphere by Skalt D, Moertl B, von Bergwelt-Baildon M, Schmidt C, Schoel W, Bücklein V, Weiglein T, Dreyling M, and Berger K.
Host: Dr Nathalie van Havre; Guest: Prof Martin Dreyling
This is the fifth of a series of podcasts discussing recently published scientific articles. More podcasts will be available in the future. Stay tuned!
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Papers Unplugged: What Ever Happened to Plan S?
9 december 2022 · 8 min
What is Plan S and what has happened to it? Lees meer
Join our guest Dr Nuno Borges and host Dr Christian Scharenberg as they talk about the core principles, goals, and challenges of Plan S.
Listen along as Dr Borges discusses the controversies aroused by Plan S and the “publish or perish” paradigm faced by early career scientists. Dr Borges ends this podcast on a positive note where he believes that slowly, but surely, and thanks to social media, we are heading towards a future where scientific publications will be open access and freely available to everyone.
This discussion is based on the recently published article Change is Coming: Plan S From the Early Career Scientist Perspective in HemaSphere by Dr Nuno Borges.
Host: Dr Christian Scharenberg; Guest: Dr Nuno Borges
This is the fourth of a series of podcasts discussing recently published scientific articles. More podcasts will be available in the future. Stay tuned!
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Papers Unplugged: CHIP and Associated Risk in Elderly Patients
25 november 2022 · 8 min
What is clonal hematopoiesis of indeterminate potential (CHIP) and its associated risks in elderly patients? Lees meer
Join our guest Prof Kirsten Gronbaek and host Dr Christian Scharenberg as they discuss CHIP, its biological significance, frequency in the general population, and its association with epigenetic age.
Listen along as Prof Gronbaek dives deeper into the subject and explains the association and significance of CHIP with mutations and patient survival. Last but not least, Prof Gronbaek talks about the challenges and current landscape of trials and studies on treatment for CHIP.
This discussion is based on the recently published article Clonal Hematopoiesis and Epigenetic Age Acceleration in Elderly Danish Twins in HemaSphere.
Host: Dr Christian Scharenberg; Guest: Professor Kirsten Gronbaek
This is the third of a series of podcasts discussing recently published scientific articles. More podcasts will be available in the future. Stay tuned!
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Papers Unplugged: EHA and War in Ukraine
11 november 2022 · 13 min
What can a not-for-profit NGO do for patients in a time of war? Lees meer
Join our guests, Prof Konstanze Döhner, Prof Elizabeth Macintyre, and Dr Nathalie van Havre as they discuss what the European Hematology Association (EHA) has done in favor of Ukraine and the Ukrainian hematological community.
Our guests talk about support programs EHA has implemented and the obstacles that came with that. Prof Macintyre furthers the discussion by expressing her views on the role of medical organizations such as EHA in a crisis.
This discussion is based on the recently published article How a Medical Association Can Make a Difference in a Crisis Situation in HemaSphere by Dr Nathalie van Havre.
This is the second of a series of podcasts discussing recently published scientific articles, more podcasts will be available in the future. Stay tuned!
Guests:
Prof Konstanze Döhner, University Hospital of Ulm, Germany;
Prof Elizabeth Macintyre, Hôpital Necker-Enfants Malades et Université Paris Cité, France;
Dr Nathalie van Havre, EHA Executive Office, The Netherlands
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Papers Unplugged: Precision Medicine and Hemoglobinopathies
28 oktober 2022 · 11 min
Join our guest Prof David Rees and host Dr Christian Scharenberg as they discuss how the concept of precision medicine can be applied to Sickle Cell Disease (SCD). Lees meer
Listen as Prof David Rees talks about prognostic markers and how they can (or can't) guide SCD disease management, current and new treatment options for SCD patients, and how the situation of precision medicine can differ between low- and high-income countries. Last but not least, Prof David Rees ends the podcast with his view of how SCD management will be in the near and far future.
This discussion is based on a recently published article, Precision Medicine and Sickle Cell Disease by Prof David Rees, in Hemasphere. This is the first of a series of podcasts discussing recently published articles. More podcasts in this series will be available in the future. Stay tuned!
Visit the EHA Campus for more content on Hemoglobinopathies and Sickle Cell Disease:
1. EHA Sickle cell disease program
2. EHA Unplugged Sickle Cell Disease podcast series (Available on all major podcast platforms and on the EHA Campus)
3. Gene Therapy in Hemoglobinopathies
Host: Dr Christian Scharenberg, Skaraborgs Hospital, Sweden; Guest: Professor David Rees, Kings College London, United Kingdom
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Naive CLL
10 juni 2022 · 13 min
How did CLL lose its role of "Cinderella" in hematology in the last decades, thanks to the introduction of entirely new classes of drugs, and came under the spotlight of clinical research in hematology? Lees meer
Prof Jennifer Woyach discusses the fundamentals of CLL genetics and treatment in this podcast, as well as the selection of patients for therapy, the different, and somewhat unpredictable, clinical course the disease can follow, together with the last evidence from CLL clinical trials.
Host: Prof Shaun McCann; Guest: Prof Jennifer Woyach
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Thrombosis - Bleeding in Cancer
3 juni 2022 · 17 min
The links between thrombosis and cancer have been known for a long time and are associated with the type of cancer (pancreatic and lung carcinomas, for example, are particularly prone to give this complication), its localization, and the anti-neoplastic treatment used to fight the cancer itself. Lees meer
Prof Jan Marie Connors, in this podcast, explains how a thrombotic episode may represent the first indication of a cancer diagnosis, and how guidelines should be critically used to manage these patients, taking into account the concurrent anti-cancer therapy and potential drug interactions.
Host: Prof Shaun McCann; Guest: Prof Jean Marie Connors
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The Microbiome in HCT
27 mei 2022 · 13 min
In this podcast, Prof Tessa Andermann, an expert in infectious diseases, provides an overview of the role of the microbiome in the homeostasis of the human body and how it has been implicated in the development of complications after allogeneic transplantations, including acute graft-versus-host-disease, infections, mortality, and disease relapse. Lees meer
Some of the relationships observed between changes in the microbiome and clinical outcome might in the next future be better characterized and exploited to drive therapeutic choices.
Host: Prof Shaun McCann; Guest: Prof Tessa Andermann
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Diagnosing Erythrocytosis
20 mei 2022 · 18 min
How do you make a diagnosis of erythrocytosis? Is full blood count enough or do you need more specific tests? How is the classification in primary and secondary erythrocytosis linked to EPO levels? Is idiopathic erythrocytosis really a vanishing entity? Lees meer
These are some of the questions Prof Mary-Frances McCullin answers in this podcast, giving listeners the key information necessary to understand erythrocytosis in clinical practice.
Host: Prof Shaun McCann; Guest: Prof Mary-Frances McMullin
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Clinical Trials of the Future (Clinical Trial)
16 mei 2022 · 46 min
In the seventh and final episode of the Clinical Trial podcast series, you can hear Prof. Konstanze Döhner and Prof. Antonio Almeida exchanging ideas and thought-provoking opinions about how investigator-initiated clinical trials and new trial designs can provide patients early access to novel drugs. Lees meer
They discuss the importance of large collaborative groups, the complexity of current requirements that must be in place, and the impact that these challenges may have, along with the relevant issues that could be changed in order to enable more uncomplicated participation and conduction of clinical studies.
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. Konstanze Döhner; Prof. Antonio Almeida
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Would you like to explore more podcasts or check out the Clinical Trial Map? Please visit the EHA Campus.
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Cutaneous T Cell Lymphoma (CTCL) Episode 1: Presentation and Diagnosis
13 mei 2022 · 22 min
This series of two podcasts leads you on a journey through the main clinical and therapeutical aspects of Cutaneous T Cell Lymphomas (CTCLs), a heterogeneous group of lymphoid neoplasms characterized by primary cutaneous localization. Albeit rare, CTCLs have peculiar clinical characteristics, requiring a multidisciplinary approach and a strict collaboration between different specialists, allowing for a timely and precise diagnosis, critical for the good outcome of these patients. Lees meer
Join dermatologist Prof Maarten Vermeer (Dept. of Dermatology, Leiden University Medical Center) and hematologist Dr Erik Marijt (Head of the Central Laboratory of Clinical Hematology and the Interdivisional Flowcytometry Core Facility, Leiden University Medical Center) as they exchange their views and expertise on the diagnosis and management of patients with CTCLs.
In this first episode, listen to Prof Vermeer and Dr Marijt illustrating the dermatologic and hematologic approaches to the diagnosis and staging of CTCLs, including the different clinical presentation and prognosis of the most common types of CTCLs.
Hosts: Prof Maarten Vermeer; Dr Erik Marijt
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Cutaneous T Cell Lymphoma (CTCL) Episode 2: Treatment
13 mei 2022 · 26 min
This series of two podcasts leads you on a journey through the main clinical and therapeutical aspects of Cutaneous T Cell Lymphomas (CTCLs), a heterogeneous group of lymphoid neoplasms characterized by primary cutaneous localization. Albeit rare, CTCLs have peculiar clinical characteristics, requiring a multidisciplinary approach and a strict collaboration between different specialists, allowing for a timely and precise diagnosis, critical for the good outcome of these patients. Lees meer
Join dermatologist Prof Maarten Vermeer (Dept. of Dermatology, Leiden University Medical Center) and hematologist Dr Erik Marijt (Head of the Central Laboratory of Clinical Hematology and the Interdivisional Flowcytometry Core Facility, Leiden University Medical Center) as they exchange their views and expertise on the diagnosis and management of patients with CTCLs.
In this second episode, listen to Prof Vermeer and Dr Marijt discussing how CTCL patients with localized and diffuse disease can be effectively treated, and how new targeted agents and allogeneic transplantation can be integrated into the management algorithm.
Hosts: Prof Maarten Vermeer; Dr Erik Marijt
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Circulating Tumor DNA
8 april 2022 · 16 min
Dr David Kurtz discusses in this podcast the most recent technical developments and practical applications of circulating tumor DNA and liquid biopsies, an active area of research in the last 25 years, which is now gaining more importance and translational application in the clinic. In tumors like B-cell non-Hodgkin lymphomas, for example, somatic mutations can now be tracked and diagnosed using these techniques. Other fields of active investigations include CLL and solid tumors, as well as disease monitoring and early diagnosis on relapses. Lees meer
Host: Shaun McCann; Guest: Dr. David Kurtz
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Treating CML in Developing Countries
1 april 2022 · 14 min
The whole world of CML changed in the early 2000s with the introduction of imatinib and TKIs, however, the situation in developing countries can be significantly different from Europe and USA, as discussed by Prof Hemant Malhotra in this podcast. Lees meer
Short-backs may encompass the molecular diagnosis and monitoring of the disease (not everywhere available) as well as the cost of drugs and medical expense coverage. On the other hand, the relative affordability of generic TKIs may cause skipping of expensive diagnostic procedures before starting treatment, whereas their current prolonged life expectancy is making the number of CML patients increasingly high. A complex picture that is worth listening to in order to better understand medicine across different regions in the world.
Host: Shaun McCann; Guest: Prof. Hemant Malhotra
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Less is More - Transfusion
25 maart 2022 · 15 min
Transfusion processes have changed significantly in recent years, at the same time changing the guidelines for blood cell replacement therapy. Listen to Prof. Michael Murphy in this podcast as he provides an overview of the most up-to-date topics in transfusion, including the relevant risk of over-transfusion, restricted transfusion practices, and also the issues of delayed transfusion and transfusion-related infections. Lees meer
"Don't give two when one will do," should remain the bottom line criterion in transfusion decisions in stable patients.
Host: Shaun McCann; Guest: Prof. Michael Murphy
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Chronic Myeloid Leukemia (Naomi)
4 maart 2022 · 7 min
This podcast follows a short discussion between two young hematologists on a clinical case review of a chronic myeloid leukemia patient called Naomi. In this discussion, the hematologists go through Naomi’s case while addressing the management of CML patients in complete molecular response and the requirements for discontinuation of tyrosine kinase treatment in CML patients. Lees meer
This podcast is rendered from QR Case 5 - Chronic Myeloid Leukemia (Naomi) on the EHA Campus.
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All Good Things Must Come to an End: How and When to End a Clinical Trial (Clinical Trial)
22 februari 2022 · 22 min
In the sixth episode of the Clinical Trial podcast series, Prof. Robert Hills discusses the different reasons that lead to the end of a trial – especially when it is earlier than planned. He also gives us a summary of what happens after the trial; the importance of some steps involving the data and their availability, and the writing of reports for the appropriate regulatory authorities. Lees meer
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. Robert Hills
What did you think of this podcast? Share your opinions with us in this short feedback survey.
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Would you like to explore more podcasts or check out the Clinical Trial Map? Please visit the EHA Campus.
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Iron Deficiency: Perioperative
18 februari 2022 · 28 min
In the fourth episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Prof Antonio Almeda discuss the diagnostic and therapeutic management of iron deficiency and anemia in the perioperative setting, a clinical situation where having inadequate iron stores carries significant clinical consequences on mortality and morbidity outcomes. They also address the conclusions of different studies that have investigated the impact of repleting patients with iron on the incidence of complications, mortality, or long-term health. They also disclose how they are monitoring their patients’ iron levels following surgery and why it is important. Lees meer
Host: Prof Gunnar Birgegård; Guest: Prof Antonio Almeda
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Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions in the EHA Diagnosing And Treating Iron Deficiency Program.
https://ehaedu.org/Campus
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Documentation and authorization: Safeguarding the Credibility of Clinical Trials (Clinical Trial)
15 februari 2022 · 20 min
In the fifth episode of the Clinical Trial podcast series, Prof. Robert Hills discusses the documentation of clinical trials and how it represents a safeguard for the credibility of the trial. He points out the importance of finding a good balance between too many documents and not enough of them. In addition, he highlights the multitude of different groups working on a clinical trial, which ultimately renders documentation an insurance to a smooth process. Lees meer
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. Robert Hills
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Provide Feedback
Would you like to explore more podcasts or check out the Clinical Trial Map? Please visit the EHA Campus.
https://ehaedu.org/Campus
Subscribe, share, and review this podcast to be able to address topics you enjoy and like to listen to.
Follow EHA on Instagram: https://www.instagram.com/EHA_Hematology/
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Ethical Issues Associated with Treating Hematological Malignancies in Older Adults (Aging Patient: Dispelling Myths)
11 februari 2022 · 38 min
In the fifth and final episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and guest experts Prof Raul Cordoba, Dr Ulrich Wedding, and Dr Dominique Bron discuss the ethical issues associated with treating hematological malignancies in older adults. They raise different points regarding treatment decisions made with (and not without) the patient and amongst other parameters, how much of an impact costs have in the choice of treatment. Lees meer
Dr Bron also reminds us of the 4 principles of healthcare (nonmaleficence, beneficence, autonomy, and justice) – and that age is not a criterion in deciding whether a patient should be treated or not. Finally, they address the impact of COVID-19 on the current clinical practice and whether it has exacerbated ethical issues.
Host: Gareth Tucker; Guest: Prof Raul Cordoba, Dr Ulrich Wedding, Prof Dominique Bron
In the second episode of the Aging Patient: Dispelling Myths podcast series, the importance of medical decision making based on a patient’s ‘fitness’ rather than their age will be stressed, and the impact of good diet and exercise in maintaining fitness and delaying sarcopenia highlighted.
Host: Gareth Tucker; Guest: Prof Alessandra Tucci, Prof Sergio Storti
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Sponsor: A Role to Take Seriously (Clinical Trial)
8 februari 2022 · 17 min
In the fourth episode of the Clinical Trial podcasts, Dr. Eleftheria Hatzimichael gives us an overview of the sponsor's role and responsibilities in investigator-initiated clinical trials. The different meaning of "sponsor" and "funder", the importance for physicians to be involved in the design of clinical trials, the eight overarching responsibilities of the sponsor, are all key topics discussed in this podcast. Lees meer
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Dr. Eleftheria Hatzimichael
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Hematological Changes in Older Adults (Aging Patient: Dispelling Myths)
4 februari 2022 · 34 min
In the fourth episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and guest expert Prof Monica Engelhardt discuss how comprehensive geriatric assessment can guide treatment decisions and improve patient outcomes. Lees meer
Dr Engelhardt gives us an insight into her clinical practice and how elderly hematology patients are receptive - or not - to this testing. You will also learn what are the parameters to consider when treating elderly patients for hematologic malignancies, e.g., how frailty can influence the outcomes of the treatment. Finally, Dr Engelhardt addresses the current pandemic situation regarding these patients: are older patients more vulnerable to COVID-19 when they are already suffering from hematological malignancies and under treatment?
Host: Gareth Tucker; Guest: Prof Monika Engelhardt
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Patient Support: Relate and Create (Clinical Trial)
1 februari 2022 · 17 min
In the third episode of the Clinical Trial podcasts, Prof. Martin Dreyling from the University of Munich makes several points about standards of care in clinical studies, also mentioned as GCPs (Good Clinical Practices). He gives us a historical perspective on the establishment of these standards 20 years ago, and how they need an update through what he calls a ‘reality check’. Prof. Dreyling is part of the coalition Reducing Bureaucracy in Clinical Trials and explains what they are proposing to update and improve GCPs in 2021. Lees meer
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. Martin Dreyling
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Treatment of Hematological Malignancies in Older Adults (Aging Patient: Dispelling Myths)
28 januari 2022 · 32 min
In the third episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker and experts Prof Antonio Almeida, Prof Valentin Goede, and Dr Annamaria Brioli discuss the treatment of hematological malignancies in older adults, involving polypharmacy in most cases. They describe how patients commonly react to polypharmacy and how challenging it can be to have all the information about a patient’s full list of medication, and to keep them compliant. They also address the step of deprescribing, a critical point in the therapy of these patients. Lees meer
Host: Gareth Tucker; Guest: Prof Valentin Goede, Prof Antonio Almeida, Dr Annamaria Brioli
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The Paper Trail (CRO) (Clinical Trial)
25 januari 2022 · 18 min
In the second episode of the Clinical Trial podcasts, former EHA President Prof. John Gribben gives us an overview of the role(s) of CROs (Contract Research Organizations) in clinical investigation. He discusses how they can help, notably with the paper trails associated with clinical trials, and how they should be constructive partners in the process of clinical research. Lees meer
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Prof. John Gribben
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Patient Assessment In Older Adults (Aging Patient: Dispelling Myths)
21 januari 2022 · 31 min
In the second episode of the Aging Patient: Dispelling Myths podcast series, host Gareth Tucker discusses with experts Prof Alessandra Tucci and Prof Sergio Storti the definition and importance of patient assessment (including frailty, comorbidity, and polypharmacy), in older adults with hematological conditions and how it can be used to determine the overall ‘fitness’ of a patient. They also discuss the critical role of interactions between HCPs, patients, and their entourage in the assessment. Lees meer
You will listen to clinical examples showing how a complete geriatric assessment can help direct treatment for older patients with specific hematological malignancies and how a benefit can be obtained from more effective, novel treatments.
Host: Gareth Tucker; Guest: Prof Alessandra Tucci, Prof Sergio Storti
Additional information (in order of mention):
HCP: Healthcare Professional
CLL: Chronic Lymphocytic Leukemia
11q minus: deletion of a portion of the long arm (q) of chromosome 11
SF3B1 gene: Splicing Factor 3B1
POT1 gene: Protection of Telomeres 1
AML: Acute myeloid leukemia
IPSS: International Prognostic Scoring System
ADL: Activities of Daily Living
IADL: Instrumental Activities of Daily Living
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Multiple Myeloma in Underserved Populations (Episode 3)
20 januari 2022 · 23 min
In this podcast, the last of a series dedicated to Multiple Myeloma in underserved patient populations with, Prof Sonja Zweegman focuses on the challenges associated with MM treatment in older patients, namely the assessment of frailty and how to adapt treatment in this population. The podcast also addresses the specific characteristics of MM in the elderly, including the incidence of genetic mutations and the role of comorbidities. Lees meer
Speaker: Prof Sonja Zweegman; Host: Prof Pieter Sonneveld
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What matters in a trial design? (Clinical Trial)
18 januari 2022 · 18 min
In the first episode of the Clinical Trial podcasts, Amsterdam UMC researcher and author of “A Quick Guide on How to Conduct Medical Research” Dr. Marieke Ter Wee points out the importance of formulating a research question at the beginning of any clinical trial. What models are used to formulate the question and answer to it? She unravels the main parts of a research proposal that should be elaborated by the authors of clinical studies. Lees meer
In this series of Clinical Trial podcasts produced by EHA, experts unravel for you the many issues linked to the design and execution of a clinical study, complementing the information present in our Clinical Trial Map.
It will help you answer interrogations such as:
• What is a CRO?
• How are clinical studies designed?
• Which role(s) should sponsors fulfil?
Experts will talk directly to you to give you an overview of several essential clinical research topics in a series of 6 podcasts.
Host: Dr. Marieke ter Wee
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Would you like to explore more podcasts or check out the Clinical Trial Map? Please visit the EHA Campus.
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Aging and Clonal Diseases (Aging Patient: Dispelling Myths)
14 januari 2022 · 20 min
In the Aging Patient: Dispelling Myths podcast series, Prof Raul Cordoba kicks off a series of podcasts that will offer you up-to-date information about hematology in older adults. Lees meer
For the first interview, he welcomes guest expert Dr Kristina Kirschner to discuss aging and clonal disease. You will learn how clonal hematopoiesis increases with advancing age and how the accumulation of some clonal mutations have been linked with hematological cancers.
Dr Kirschner answers questions - asked by patients - about the definition of aging by hematologists, or the relation of aging and susceptibility to clonal cancers. They also address the mechanisms of epigenetic mutations in aging hematopoietic stem cells and the impact of genes drivers of myeloid malignancies in the elderly population.
Host: Dr Raul Cordoba; Guest: Dr Kristina Kirschner
Additional information (in order of mention):
AML (disease): Acute Myeloid Leukemia
MDS (disease): Myelodysplastic Syndromes
DNMT3A gene (DNA Methyltransferase 3 Alpha)
TET2 gene (Tet Methylcytosine Dioxygenase 2)
ASXL1 gene (ASXL Transcriptional Regulator 1)
CHIP (disease): (Clonal Hematopoiesis of Indeterminate Potential)
PPM1D gene: Protein Phosphatase, Mg2+/Mn2+ Dependent 1D
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Iron Deficiency: Women
31 december 2021 · 40 min
In the third episode of the Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Dr Noemi Roy review the many important functions iron plays in the body, providing the background for the high prevalence of iron deficiency in women, particularly in their fertile life and during pregnancies. They address different strategies of treatment, including IV, oral treatment, and nutrition recommendations. Finally, they also highlight the importance of treating iron deficiency after childbirth when the mother comes back home. Lees meer
Host: Prof Gunnar Birgegård; Guest: Dr Noemi Roy
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Iron Deficiency: Chronic Kidney Disease
24 december 2021 · 30 min
In the second episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, host Prof Gunnar Birgegård and guest expert Prof Christopher Winearls highlight the high prevalence of iron deficiency anemia in patients with CKD, together with its association with poor long-term outcomes. They discuss the importance of monitoring iron on top of monitoring erythropoietin and treating the deficiency prior to the use of erythropoietin. Overall, Prof Winearls discloses how to evaluate ferritin and Hb levels in CKD patients and how to treat iron deficiency and monitor outcomes in this special population. Lees meer
Host: Prof Gunnar Birgegård; Guest: Prof Christopher Winearls
Additional information (in order of mention):
CKD (disease): Chronic Kidney Disease
HIF PH (treatment): Hypoxia-Inducible Factor Prolyl Hydroxylase enzyme inhibitors
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Iron Deficiency: Heart Failure
17 december 2021 · 32 min
In the first episode of the EHA Diagnosing And Treating Iron Deficiency podcast series, Prof Gunnar Birgegård and host expert Prof Antonio Almeida define what is iron deficiency and more precisely functional iron deficiency. They discuss the prevalence of anemia in cardiac failure patients and the relation between severity of the heart disease and incidence of iron deficiency. They also highlight the importance of monitoring potential renal symptoms for better treatment outcomes. Lees meer
Host: Prof Gunnar Birgegård; Guest: Prof Antonio Almeida
This episode was produced with the support of the World Heart Federation.
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HSCT in Multiple Myeloma
10 december 2021 · 24 min
In episode 9 of "EHA Unplugged", Prof. Shaun McCann describes the importance of general medical management in multiple myeloma (MM) patients and the application of the principles of treatment in different subpopulations of patients. He also explains how to diagnose MM and assess the response to treatment. Lees meer
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Multiple Myeloma in Underserved Populations (Episode 2)
7 december 2021 · 29 min
This podcast, the second of a series dedicated to Multiple Myeloma in underserved populations, addresses clinical challenges in MM, with a focus on high-risk disease and cytogenetics. Prof Weisel describes the established genetic prognostic markers in MM, and the new abnormalities that are becoming important, besides the role and impact of Minimal Residual Disease (MRD) on risk status and classification of MM patients. Lees meer
Speaker: Prof Katja Weisel; Host: Prof Pieter Sonneveld
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Chronic Lymphocytic Leukemia (CLL)
3 december 2021 · 27 min
In episode 8 of "EHA Unplugged", Prof. Shaun McCann details the diagnostic and prognostic criteria of CLL and the correct diagnostic work-up. He also describes the increasing array of treatments available for CLL patients and outlines the role of allogeneic transplantation in this disease. Lees meer
What did you think of this podcast? Share your opinions with us in this short feedback survey.
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Chronic Myeloid Leukemia (CML)
26 november 2021 · 28 min
In episode 7 of "EHA Unplugged", Prof. Shaun McCann describes the clinical and genetic features of chronic myeloid leukemia (CML), discusses the best therapeutic options, and characterizes the changes that occur in the natural history of the disease after the introduction of tyrosine-kinase inhibitors (TKIs). Lees meer
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SCD: What Physicians Can Learn From Patients And Carriers (Episode 3)
16 november 2021 · 32 min
This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. Lees meer
In this closing discussion, Dr Jo Howard and Professor Léon Tshilolo reflect on what they have learned from their conversations with people affected by sickle cell disease and sickle cell trait, and discuss the present and future of sickle cell disease treatment across the world.
SCD: What Physicians Can Learn From Patients And Carriers is a three-episode podcast series with the first one created to mark Black History Month 2021. It is a collaboration between EHA and Obsidian Healthcare Group, a global provider of medical education.
Interview with: Dr Jo Howard and Professor Léon Tshilolo Host: Mandi Watty-Miller
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Multiple Myeloma in Underserved Populations (Episode 1)
15 november 2021 · 33 min
In this podcast, the first of a series dedicated to Multiple Myeloma in underserved patient populations, Prof Terpos illustrates the impact of renal disease on MM outcomes and how it should best be managed. Follow the podcast to learn about assessment and monitoring of renal function in MM patients, the available treatment options for this population, and the role and outcomes of kidney transplantation. Lees meer
Speaker: Prof Evangelos Terpos; Host: Prof Pieter Sonneveld
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SCD: What Physicians Can Learn From Patients And Carriers (Episode 2)
10 november 2021 · 44 min
This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. Lees meer
In the second episode, a mother and daughter affected by sickle cell are joined by hematologist Professor Léon Tshilolo for an interview with Mandi Watty-Miller, an individual with sickle cell trait. They discuss the experience of raising a child with sickle cell disease, navigating the world of online misinformation about the condition, and how to improve communication and trust between doctors and patients.
SCD: What Physicians Can Learn From Patients And Carriers is a three-episode podcast series with the first one created to mark Black History Month 2021. It is a collaboration between EHA and Obsidian Healthcare Group, a global provider of medical education.
Interview with: Prof Léon Tshilolo Host: Mandi Watty-Miller
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BCR-ABL1-like ALL
9 november 2021 · 14 min
In this podcast, Dr. Rijneveld discusses BCR-ABL1-like acute lymphoblastic leukemia (ALL), a specific subgroup of ALL characterized by an expression profile similar to Ph+ ALL, albeit lacking the BCR-ABL1 rearrangement, and by sensitivity to TKIs. She highlights how TKIs were game-changing for the prognostic of these patients, although their cost and associated toxicities (usually low but fatiguing in the long-term), may still be issues in the clinical practice. Lees meer
Interview with: Anita Rijneveld. Host: Shaun McCann
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ALL Hope For The Future
5 november 2021 · 14 min
Listen to this expert interview to discover characteristics and outcomes of acute lymphoblastic leukemia (ALL) in adults and children. Dr Advani guides us in the biology and genetics of the disease in these two categories of patients, dedicating a special focus to Philadelphia-like ALL and to the clinical and prognostic role of measurable residual disease (MRD). Finally, as CAR-T therapies are becoming available to adult ALL patients, challenges and promises of this approach are discussed in the concluding part of the podcast. Lees meer
Interview with: Anjali Advani. Host: Shaun McCann
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Iron Homeostasis in Host Defense and Inflammation
29 oktober 2021 · 7 min
In this podcast, Dr Nemeth reminds us that iron is not only necessary for hematopoiesis and red cell production. A complex relationship exists between iron levels and susceptibility to infections, which involves the different sensibility of microbes to iron as well as the association between iron deficiency and poor response to immunization, as you will discover in this clear overview on the role of iron in host defence. Lees meer
Interview with: Elizabeta Nemeth. Host: Ayan Panjan
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SCD: What Physicians Can Learn From Patients And Carriers (Episode 1)
28 oktober 2021 · 45 min
This podcast series brings together people affected by SCD and specialist hematologists to shed light on this widely misunderstood condition, bringing the guidelines to life and helping healthcare professionals improve their practice by understanding the patient experience. Lees meer
In this first episode, consultant hematologist Dr Jo Howard has a conversation with two individuals affected by sickle cell disease (SCD) and sickle cell trait (SCT). They discuss the impact that the condition has on their personal and family lives, common misconceptions about the SCD experience, areas where treatment frequently falls short, and how to raise awareness further.
SCD: What Physicians Can Learn From Patients And Carriers is a three-episode podcast series with the first one created to mark Black History Month 2021. It is a collaboration between EHA and Obsidian Healthcare Group, a global provider of medical education.
Host: Dr Jo Howard
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Impact of Social Stigma on Coping with SCD
22 oktober 2021 · 16 min
Listen to this podcast to hear a psychologist’s point of view on sickle cell disease (SCD), and how to address the psychological as well as the hematological needs of SCD patients. The importance of specific psychological support services for SCD patients, the concept of social stigmatization as a true complication of the disease, and its consequences for physicians dealing with these patients are discussed in this podcast. Lees meer
Interview with: Kofi Anie. Host: Ayan Panjan
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Interventions in Adolescent SCD
15 oktober 2021 · 16 min
This podcast focuses on the social aspects of SCD, in particular on the challenges confronting adolescents with SCD and their treating physicians. Prof. Hankins speaks about the delicate transition from pediatric to adult care, the use of technology in improving the care of these patients, and the issues associated with access to new treatments. Lees meer
Interview with: Jane Hankins. Host: Shaun McCann
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Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions. The module associated with this podcast will be released on Oct 22.
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Sickle Cell Disease in Pregnancy
8 oktober 2021 · 14 min
In this podcast, Dr Smith-Whitley illustrates the many different aspects and possible pregnancy complications for mother and fetus in women with SCD. Practical aspects dealt within the clinical practice, such as the management of pain in the pregnant woman, use of transfusions and HU, and reproductive education for SCD patients, are also discussed in the podcast. Lees meer
Interview with: Kim Smith-Whitley. Host: Shaun McCann
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Would you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions. The module associated with this podcast will be released on Oct 22.
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HSCT in Paroxysmal Nocturnal Hemoglobinuria
1 oktober 2021 · 20 min
In episode 6 of "EHA Unplugged", Prof. Shaun McCann discusses Paroxysmal Nocturnal Hemoglobinuria. You will hear him describe the etiology and the clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH), apply the correct diagnostic work-up if the disease is suspected, and discuss the principles of treatment in these patients, including monoclonal antibodies and HCT. Lees meer
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Provide FeedbackWould you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions.
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HSCT in Severe Aplastic Anemia
24 september 2021 · 25 min
In episode 5 of "EHA Unplugged", Prof. Shaun McCann discusses HSCT in Severe Aplastic Anemia. You will hear him detail the diagnostic criteria of severe aplastic anemia (SAA) and the current therapeutic approaches for this disease. He will also characterize the results of HCT, the best conditioning options and different source of hemopoietic cells for SAA patients. Lees meer
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Provide FeedbackWould you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions.
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Engraftment and Chimerism following HSCT
17 september 2021 · 12 min
In episode 4 of "EHA Unplugged", Prof. Shaun McCann discusses the phenomenon of engraftment and chimerism following hemopoietic cell transplantation (HCT) and the main techniques used to determine the origin of the cells in the recipient. Lees meer
What did you think of this podcast? Share your opinions with us in this short feedback survey.
Provide FeedbackWould you like to receive EBAH CME credit points for listening to this podcast? Please visit the EHA Campus and finalize the quiz questions.
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