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315 afleveringen, van nieuw naar oud
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Psychedelic Trials Can't Truly Be Blinded. Why That Matters | Boris Heifets | 163
22 juni 2024 · 1 uur 45 min
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About the guest: Boris Heifets, MD, PhD is an anesthesiologist and researcher at Stanford University. His lab studies non-ordinary states of consciousness and psychoactive drugs like MDMA, ketamine, and psychedelics.
Episode summary: Nick and Dr. Heifets discuss: anesthesia and how anesthetics work; placebo effects & expectations in clinical research; ketamine as an antidepressant, anesthetic, and recreational drug; the subjective effects of psychedelics and other drugs; MDMA and Lykos Therapeutics’ attempts to gain FDA approval for MDMA-assisted psychotherapy; opioids & placebo effects; and more.
Related episodes:
How Does Ketamine Work & Is It Addictive? | Christian Lüscher | #90
*This content is never meant to serve as medical advice.
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Addiction Rewires the Same Synapses That Learning Uses | Robert Malenka | 162
16 juni 2024 · 1 uur 35 min
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About the guest: Robert Malenka, MD, PhD is psychiatrist & neuroscientist. He has spent most of his career at Stanford University, where his lab studies synaptic plasticity, mechanisms of drug action in the brain, and the neural basis of behavior.
Episode summary: Nick and Dr. Malenka discuss: mechanisms of synaptic plasticity in the brain, such as LTP & LTD; addiction & the dopamine reward circuitry of the brain; psychoactive drugs ranging from stimulants (cocaine, nicotine, amphetamines) to opioids (fentanyl), psychedelics, MDMA, THC, and alcohol; and more.
Related episodes:
How Does Ketamine Work & Is It Addictive? | Christian Lüscher | #90
Neuroscience of Social Behavior, Pain, Empathy, Emotion, Brain Mechanisms of MDMA | Monique Smith | #159
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His Lab Paired GLP-1 With an NMDA Blocker in One Drug | Christoffer Clemmensen | 161
12 juni 2024 · 1 uur 33 min
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About the guest: Christoffer Clemmensen, PhD is scientist running the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders.
Episode summary: Nick and Dr. Clemmensen discuss: GLP-1 & gut hormones; obesity & metabolic disease; GLP-1 agonists and weight loss drugs (e.g. Ozempic); novel, dual-action weight loss drugs his lab has created; and more.
Previous discussion: Metabolism, Obesity & Psychedelics for Metabolic Disease | Christoffer Clemmensen | #105
*This content is never meant to serve as medical advice.
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For Hunter-Gatherers, Fat Often Matters More Than Meat | Eugene Morin | 160
1 juni 2024 · 1 uur 24 min
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About the guest: Eugene Morin, PhD is a Professor of Anthropology at the University of Trent who studies Paleolithic humans and animals.
Episode summary: Nick and Dr. Morin discuss evolution of Paleolithic humans; Neanderthal diet & cultural capacity; key human adaptations related to endurance and stamina; hunter gatherer hunting strategies; evolution of human digestion; and more.
*This content is never meant to serve as medical advice.
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Pain Spreads Between Mice After an Hour Together. So Does Relief | Monique Smith | 159
23 mei 2024 · 1 uur 27 min
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About the guest: Monique Smith, PhD is an assistant professor of neurobiology at the University of California-San Diego, where her lab studies the neuroscience of social behavior, pain, and emotion.
Episode summary: Nick and Dr. Smith discuss: the neurobiology of pain perception; social & empathy-like behavior in animals; emotion; brain mechanisms of MDMA; serotonin; and more.
*This content is never meant to serve as medical advice.
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Fasting's Seizure Control Led to the Ketogenic Diet in the 1920s | Dominic D'Agostino | 158
16 mei 2024 · 1 uur 42 min
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About the guest: Dominic D'Agostino, PhD is a researcher and professor at the University of South Florida, where his lab studies metabolism, human biology, and related subjects.
Episode summary: Nick and Dr. D'Agostino discuss: ketosis and the ketogenic diet; effects of ketosis on diabetes, insulin resistance & metabolic health; effects on brain & mental health; relationship with exercise performance; cholesterol, LDL, triglycerides & other biomarkers; cancer; and more.
*This content is never meant to serve as medical advice.
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He Taught Medical Students Things He Now Says Were Wrong | Robert Lufkin | 157
9 mei 2024 · 1 uur 45 min
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About the guest: Robert Lufkin, MD is a radiologist and professor at UCLA. His new book is called, "Lies I Taught in Medical School."
Episode summary: Nick and Dr. Lufkin talk about: the history of medicine in the United States; diet & lifestyle vs. pharmaceuticals in acute vs. chronic disease; diabetes, metabolic syndrome & insulin resistance; health institutions like the American Diabetes Association & American Heart Association, including their financial influences; carbohydrates, fats, dietary cholesterol, ketosis, and related topics in metabolism; bloodwork & choosing the right doctor; and more.
*This content is never meant to serve as medical advice.
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Resilience Is Built From Skills You Can Practice | Stephen Sideroff | 156
4 mei 2024 · 1 uur 40 min
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About the guest: Stephen Sideroff, PhD is a clinical psychologist and Associate Professor of Psychiatry and Behavioral Sciences at UCLA. His new book is, "The 9 Pillars of Resilience."
Episode summary: Nick and Dr. Sideroff discuss: childhood & developmental psychology; clinical & Gestalt psychology; stress & resilience; pharmaceuticals, talk therapy, and plant medicines; emotions & psychopathology; and more.
*This content is never meant to serve as medical advice.
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Dialing Down Mitochondria in Neurons Made Worms Live Longer | Andrew Dillin | 155
29 april 2024 · 1 uur 40 min
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About the guest: Andrew Dillin, PhD is Professoer of Molecular & Cell Biology at UC-Berkeley and Howard Hughes Medical Institute investigator. His lab studies mechanisms of aging, mitochondrial biology, and related subjects.
Episode summary: Nick and Dr. Dillin discuss: cell biology; mitochondria & the endoplasmic reticulum; aging & autophagy; mitochondrial biology in neurons; diet, exercise, and oxygen effects on mitochondrial health; and more.
*This content is never meant to serve as medical advice.
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Light Skin Evolved After Humans Had Already Left Africa | Eske Willerslev | 154
24 april 2024 · 1 uur 52 min
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About the guest: Eske Willerslev, PhD is an evolutionary biologist and Professor of evolution at both the University of Copenhagen and University of Cambridge.
Episode summary: Nick and Dr. Willerslev discuss: human evolution out of Africa; the origins of modern Europeans; hunter gatherers, early farmers, and pastoralists; genetics of human disease risk; evolution of diet & metabolism; evolution of light skin color; and more.
*This content is never meant to serve as medical advice.
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She Treats Bipolar Disorder and Schizophrenia With Diet | Georgia Ede | 153
20 april 2024 · 1 uur 51 min
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About the guest: Georgia Ede, MD is a psychiatrist and author of, "Change Your Diet, Change Your Mind: A Powerful Plan to Improve Mood, Overcome Anxiety, And Protect Memory for a Lifetime of Optimal Mental Health."
Episode summary: Nick and Dr. Ede discuss: glucose vs. ketones for brain energy; metabolic health & insulin resistance; animal vs. plant-based foods; nutrients, anti-nutrients & plant toxins; ketogenic, carnivore & plant-based diets; carbohydrates & processed foods; treating bipolar disorder, schizophrenia & psychiatric illness with diet; and more.
*This content is never meant to serve as medical advice.
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Two Buds From One Plant Don't Share One Chemical Profile | Ryan Vandrey | 152
12 april 2024 · 1 uur 31 min
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About the guest: Ryan Vandrey, PhD is a Professor of Psychiatry & Behavioral Sciences at Johns Hopkins University, where his lab studies the behavioral pharmacology of cannabis (marijuana), nicotine/tobacco, and other substances.
Episode summary: Nick and Dr. Vandrey discuss: marijuana; cannabinoids like THC; terpenes like limonene, myrcene, and pinene; the entourage effect; anxiety and other side effects of cannabis consumption; and more.
*This content is never meant to serve as medical advice.
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Resveratrol Never Lived Up to the Red Wine Longevity Story | Matt Kaeberlein | 151
7 april 2024 · 2 uur 29 min
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About the guest: Matt Kaeberlein, PhD is a Professor of at the University of Washington and CEO of OptiSpan. His research focuses on the biology of aging and longevity.
Episode summary: Nick and Dr. Kaeberlein discuss: the biology of aging; mTOR, FGF1, growth & metabolism; sirtuins, NAD & NMN; longevity drugs like metformin & rapamycin; facts & myths about longevity molecules like resveratrol & taurine; controversies in aging research related to prominent Harvard researcher David Sinclair; epigenetic clocks; healthspan & lifespan; and more.
*This content is never meant to serve as medical advice.
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Briefly Silencing the Retinas Restored Vision in Amblyopic Animals | Mark Bear | 150
3 april 2024 · 1 uur 16 min
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About the guest: Mark Bear, PhD is a Professor of Neuroscience at MIT, where his lab studies the visual system, neuroplasticity, and the pathophysiology of amblyopia and visual impairments.
Episode summary: Nick and Dr. Bear discuss: the visual system in the brain, from the retina to visual cortex; critical periods of brain development; mechanisms of neuroplasticity; metaplasticity; amblyopia and visual impairments; ketamine & psychedelics; and more.
*This content is never meant to serve as medical advice.
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He Sequenced Vaccine Vials and Found Pfizer's Plasmid DNA Inside | Kevin McKernan | 149
30 maart 2024 · 1 uur 51 min
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About the guest: Kevin McKernan is the Chief Science Officer at Medicinal genomics and has been working the the biotechnology sector and conducting genomics research going back to his involvement in the Human Genome Project.
Episode summary: Nick and Kevin discuss: basics of DNA and RNA biology; mRNA vaccines and how they work compared to traditional vaccines; the mRNA vaccine manufacturing process; DNA contamination in the Pfizer and Modern mRNA vaccines for COVID; the SARS-CoV-2 spike protein; vaccine side effects; ivermectin and hydroxychloroquine; and more.
*This content is never meant to serve as medical advice.
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A 100-Gram Protein Meal Beat 25 Grams for Muscle Protein Synthesis | Luc van Loon | 148
27 maart 2024 · 1 uur 23 min
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About the guest: Luc van Loon, PhD is a Professor of Physiology of Exercise and Nutrition and Head of the M3-research group at the Department of Human Biology at Maastricht University. His lab focuses on the skeletal muscle adaptive response to physical (in)activity, the impact of nutrition on metabolism, and related topics.
Episode summary: Nick and Dr. van Loon discuss: amino acid biology; branched chain amino acids like leucine; atypical amino acids like taurine; muscle growth & muscle biology; dietary protein and plant vs. animal protein sources; resistance training and anabolic growth; the limits of dietary protein on muscle growth; and more.
*This content is never meant to serve as medical advice.
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Naltrexone Altered Ketamine's Brain Effects in Male Rats Only | Tommaso Di Ianni | 147
22 maart 2024 · 1 uur 21 min
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About the guest: Tommaso Di Ianni, PhD is an Assistant Professor in the Departments of Psychiatry & Behavioral Sciences and Radiology & Biomedical Imaging at the University of California, San Francisco. His lab uses ultrasound technology and deep learning to study the brain.
Episode summary: Nick and Dr. Di Ianni discuss: the current state of scientific understanding of ketamine; S-ketamine vs. R-ketamine isomers; the antidepressant effects of ketamine; ketamine's known mechanisms of action; sex-dependent effects of ketamine action in the brain; involvement of the opioid system in ketamine's effects; addiction; and more.
*This content is never meant to serve as medical advice.
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Near-Infrared Sunlight Penetrates Skin and Skull, Reaching the Brain | Scott Zimmerman | 146
19 maart 2024 · 1 uur 17 min
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About the guest: Scott Zimmerman is an optical engineer and photobiology expert
Episode summary: Nick and Scott talk about: how light interacts with the body and affects our cells; melatonin as an antioxidant; how red & near-infrared light affect mitochondria; sunlight, fire light, and artificial light; incandescent light bulbs vs. LEDs; negative health effects of artificial light; sunscreen & makeup; red & near-infrared light therapy; the optical properties of the human body; and more.
*This content is never meant to serve as medical advice.
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Low Doses of Tributyltin Made Mice Fat, and Their Descendants Too | Bruce Blumberg | 145
14 maart 2024 · 1 uur 31 min
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About the Guest: Bruce Blumberg, PhD is a Professor of Cell & Developmental Biology at UC-Irvine. HIs lab studies epigenetics, gene x environment interactions, hormones & endocrine disruptors, obesogens & environmental toxins, and more.
Episode Summary: Nick and Dr. Blumberg discuss: Embryonic development; hormones and hormone receptors; estrogen & xenoestrogens; environmental toxins, obesogens, pesticides & contaminants; environmental causes of obesity; microplastics; how to avoid toxins in food & drinking water; and more.
*This content is never meant to serve as medical advice.
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An Omega-6 Fat That Rises During Fasting Dampened Inflammation | Clare Bryant | 144
10 maart 2024 · 1 uur 32 min
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About the Guest: Clare Bryant, DVM is a Professor of Innate Immunity at Cambridge University. Her lab studies the innate immune system, pathogen detection, inflammation, and chronic disease.
Episode Summary: Nick and Dr. Bryant discuss: mechanisms of inflammation; inflammasomes & fatty acids; infection & disease; innate vs. adaptive immunity; chronic inflammation; allergies & allergens; the evolution of the immune system; anti-inflammatory effects of fasting; and more.
*This content is never meant to serve as medical advice.
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Sugar and Fat Activate Separate Sets of Vagus Nerve Cells | Will de Lartigue | 143
5 maart 2024 · 1 uur 27 min
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Dr. Guillaume (Will) de Lartigue is a neuroscientist at the Monell Chemical Senses Center. His lab studies the neurobiology of eating, including how the vagus nerve senses internal stimuli in the gut. They discuss: gut-brain communication; the vagus nerve; gut hormones like leptin & GLP-1; weight loss drugs like Ozempic; glucose vs. fructose vs. non-caloric sweeteners; how the vagus nerve connects the gut to the dopamine reward system in the brain; the sensation of fats and sugars in the gut; food addiction & obesity; and more.
*Not medical advice.
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DMT Rose About Sixfold in Rat Brains After Cardiac Arrest | Nicolas Glynos | 142
29 februari 2024 · 1 uur 37 min
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Dr. Nicolas Glynos received his PhD in Molecular & Integrative Physiology from the University of Michigan, where he studied the psychedelic drug DMT in the mammalian brain. They discuss: the history of DMT research; the use of DMT in ayahuasca; whether DMT is found endogenously in animals; why plants produce DMT; pineal gland, DMT & melatonin; the latest research looking at the presence and effects of DMT in the brain; and more.
*Not medical advice.
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Domesticated Finches Sang More Variable Songs Than Wild Ones | Terrence Deacon | 141
24 februari 2024 · 2 uur 14 min
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About the Guest: Terrence Deacon, PhD is a Professor in the department of Anthropology at UC-Berkeley. He has written many papers and multiple books about the evolution of human language, origins of consciousness, and related topics.
Episode Summary: Nick and Dr. Deacon discuss various aspects of biological evolution, from natural vs. sexual selection to gene duplication and the consequences of domestication; the domestication of dogs and songbirds; human vs. non-human forms of vocal communication; ritual behavior & the origins symbolic cognition; artificial intelligence & large language models (LLMs); and more.
*This content is never meant to serve as medical advice.
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Cold, High Places Have Less Obesity. He Says Lifestyle Isn't Why | Robert Lustig | 140
17 februari 2024 · 2 uur
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About the guest: Robert Lustig, MD is a physician-researcher and expert of metabolic health. He is Professor emeritus of Pediatrics, Division of Endocrinology at the University of California, San Francisco (UCSF), specializing in neuroendocrinology with an emphasis on the regulation of energy balance by the central nervous system. His research and clinical practice has focused on childhood obesity and diabetes.
Episode summary: Nick and Dr. Lustig discuss the true causes of obesity and metabolic discussion; how the in utero environment during pregnancy leads to multigenerational effects on health; different forms of sugar like fructose vs. glucose; different dietary fats like omega-6 and omega-3 PUFAs, and saturated fat; oxidative stress & mitochondria biology; how temperature, altitude & oxygen affect obesity; processed foods and how industry influences public perception; body positivity & public education; insulin, diabetes & fatty liver disease; statins & cardiovascular health; and more.
*This content is never meant to serve as medical advice.
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After 12 to 14 Hours Without Food, Your Body Switches to Ketones | Mark Mattson | 139
14 februari 2024 · 1 uur 41 min
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About the Guest: Mark Mattson, PhD is a semi-retired neuroscientist at Johns Hopkins who ran a research lab at the NIH for many years. He wrote the book, "The Intermittent Fasting Revolution."
Episode Summary: Nick and Dr. Mattson discuss: intermittent fasting & diet; ketosis & metabolic switching; aging & neurodegenerative disease; exercise, stress, and neuroplasticity; and more.
*This content is never meant to serve as medical advice.
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New Body Forms Evolve by Rewiring Gene Switches, Not New Genes | Sean B. Carroll | 138
9 februari 2024 · 1 uur 53 min
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Sean B. Carroll, PhD is an evolutionary developmental biologist at the University of Maryland, who recently stepped down as VP of Education at the Howard Hughes Medical Institute. He is the author of many popular science books, such as "Endless Forms Most Beautiful." They discuss: developmental biology & genetics; evolutionary biology; genetics, genome size & genetic mutation; animal diversity; snake venom; human brain evolution; and more.
*Not medical advice.
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Some Psychedelics Fully Blocked Asthma Inflammation in Rats | David & Charles Nichols | 137
6 februari 2024 · 1 uur 38 min
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Dr. David Nichols is a retired chemist and father of Dr. Charles Nichols, a researcher studying psychedelics at Louisiana State University. They discussed: the history of psychedelics science from the 1970s to the present; DMT & 5-MeO-DMT; serotonin, inflammation, and psychedelics & anti-inflammatory drugs; psilocybin, ketamine, and other psychoactive drugs; and more
More M&M content about psychedelic science.
*Not medical advice.
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Omega-6 Rose From 1% to Nearly 12% of US Calories Since 1865, He Says | Chris Knobbe | 136
23 januari 2024 · 1 uur 34 min
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Dr. Chris Knobbe is a physician, diet & nutrition researchers, and author of, "The Ancestral Diet Revolution." He discusses: seed oils & their health consequences; different types of seed oils (soybean, corn, sunflower, etc.); omega-6 fats like linoleic acid; fatty acid metabolism and oxidation; obesity, diabetes & metabolic health; processed foods vs. whole foods; mitochondria & oxidative stress; and more.
*Not medical advice.
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Ancel Keys Was Brilliant, but Made Enormous Mistakes, He Argues | Orrin Devinsky | 135
10 januari 2024 · 1 uur 41 min
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Dr. Orrin Devinsky is a neurologist and Professor at the New York University School of Medicine. They discuss: dietary consumption trends in the US; processed vs. whole foods; vegetable oils & polyunsaturated fats; relationship between saturated fat, dietary cholesterol & heart disease; history of medicine in the US; obesity & diabetes; sugars, fructose, and metabolic health; ketogenic diet & ketosis; whether or not we can trust our public health institutions; and more.
*Not medical advice.
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Modern Diets Can Carry 20 Times More Omega-6 Than Omega-3 | Artemis Simopoulos | 134
3 januari 2024 · 1 uur 27 min
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Dr. Artemis Simopoulos is a physician and researcher specializing in endocrinology, nutrition, and metabolic health. They discuss: traditional hunter-gatherer diets vs. modern Western diets; dietary fats; omega-6 and omega-3 polyunsaturated fats; sucrose & sugar; chronic inflammatory diseases, obesity & diabetes; vegetable & seed oils vs. other cooking oils; processed foods; fish oil supplements; and more.
More content on the science of diet & metabolic health.
*Not medical advice.
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A Quarter of Breast Milk's Dry Weight Is Sugar Babies Can't Digest | Carolina Tropini | 133
20 december 2023 · 1 uur 37 min
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Dr. Carolina Tropini is an assistant professor of Microbiology & Immunology at the University of British Columbia, where her lab studies the microbiome in health & disease. Topics covered: infant & vaginal microbiome, breast milk nutrients & C-sections vs. natural births; oral microbiome & cavities; gut microbiome & irritable bowel disease (IBD); fiber, short-chain fatty acids & probiotics; how gut bacteria influence sex hormones (estrogen, testosterone) in the body; and more.
*Not medical advice.
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In Mice, Dietary Fat Was the Only Macronutrient That Drove Fat Gain | John Speakman | 132
5 december 2023 · 1 uur 13 min
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Dr. John Speakman is a biologist whose research focuses on energy balance, energy expenditure, genetic and environmental drivers of obesity and the energetic contribution to aging. They discuss: the history of the obesity epidemic in the US vs. China; changes in patterns of physical activity, diet, and energy expenditure in humans over time; how saturated fats vs. PUFAs affect basal metabolism; the relative contributions of fats, carbs, and protein to fat & weight gain; and more.
*Not medical advice.
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A Low-Fat, High-Carb Diet Shifted 1 in 4 People to Riskier Small LDL | Ronald Krauss | 131
4 december 2023 · 1 uur 55 min
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Nick talks to Dr. Ronald Krauss, a physician and researcher at UCSF who studies the relationship between diet & cardiometabolic health. They discuss: saturated vs. unsaturated fats; carbohydrates & fat synthesis; "good" vs. "bad" cholesterol; official US dietary guidelines and how they're established; funding of research by the food industry; and more.
*Not medical advice.
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Multitasking Is Mostly an Illusion. Your Brain Just Switches Tasks | Tobias Egner | 130
5 november 2023 · 1 uur 13 min
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Dr. Tobias Egner is a Professor of Psychology & Neuroscience at Duke University, where his lab studies cognition, working memory, and cognitive control & flexibility. They discuss: what cognition is and how it's studied experimentally; working memory & attention; cognitive flexibility, cognitive control & multitasking; memory, perception, and predictive coding; and more.
*Not medical advice.
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Deep Voices Likely Evolved More to Intimidate Men Than to Attract Women | David Puts | 129
22 oktober 2023 · 1 uur 48 min
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Dr. David Puts is a biological anthropologist at the Penn State University. His research focuses on the evolution and development of human sexuality and sex differences. They discuss: the biological basis of sex; gametes, sex chromosomes & sex hormones; the development of sexual orientation; the evolution of sexual dimorphism & behavior in primates; monogamy & polygyny; and more.
*Not medical advice.
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Constipation and Poor Sleep Often Come Before Parkinson's Tremor | Moses Chao | 128
16 oktober 2023 · 1 uur 13 min
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Dr. Moses Chao is a professor at the New York University School of Medicine. His lab studies how the environment, neuronal activity, inflammation, injury and disease affect the nervous system. They discuss topics related to his new book, "Peripheral: How Your Nervous System Predicts and Protects Against Disease." Topics include: how the peripheral nervous system differs from the central nervous system; the enteric nervous system & gut health; pain sensation; exercise & neuroplasticity; neurodegenerative disease; and more.
*Not medical advice.
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Psilocybin Microdoses Every Other Day Changed Rat Brains and Behavior | Mikael Palner | 127
11 oktober 2023 · 59 min
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Mikael Palner, PhD is a neuroscientist at the University of Souther Denmark. His lab studies the neuronal circuits involved in obsessive compulsive disorder and anxiety . They investigate the effects of serotonergic psychedelic and non-psychedelic drugs that increase neuronal plasticity. They discuss: psychedelics & the brain; the neuroscience of stress, anxiety & compulsive behavior; microdosing psilocybin; and more.
More psychedelic science content.
*Not medical advice.
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A Species With a Third of Our Brain Size May Have Buried Its Dead | John Hawks | 126
28 augustus 2023 · 2 uur 4 min
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Dr. John Hawks is a paleoanthropologist and professor of anthropology at the University of Wisconsin-Madison. They discuss: the evolution of human behavior, diet, anatomy, and culture; Neanderthals, Denisovans, Homo erectus, and other species; the latest discoveries related to Homo naledi, which was the subject of the Netflix documentary, "Cave of Bones."
To learn more about evolution, check out these episodes.
*Not medical advice.
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The Brain's Immune Cells Help Control Anxiety and Compulsive Grooming | Mario Capecchi | 125
21 augustus 2023 · 1 uur 42 min
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Dr. Mario Capecchi is a professor of genetics at the University of Utah & Nobel laureate. He discussed: his latest work in neurobiology, looking at the role of microglia in anxiety & Obsessive Compulsive Disorder (OCD); his Nobel Prize-winning work in molecular genetics; molecular biology & genetics; his childhood experiences as an orphan in Italy during World War II; immigrating to the US; his education & scientific career; his exercise & diet; advice for aspiring scientists; and more.
*Not medical advice.
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The Estradiol in Birth Control Pills May Help Verbal Memory | Adriene Beltz | 124
15 augustus 2023 · 1 uur 29 min
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Dr. Adriene Beltz is an associated professor of psychology at the University of Michigan who studies the effects of sex hormones & hormonal contraception on human cognition and the brain. They discuss: sex hormones (androgens & estrogens); hormonal regulation of menstruation, puberty, and pregnancy; common forms of hormonal birth control & how they work; effects of sex hormones & hormonal birth control on cognition & the brain; and more.
*Not medical advice.
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Runner's High Likely Comes From Endocannabinoids, Not Endorphins | Matthew Hill | 123
10 augustus 2023 · 1 uur 30 min
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Nick talks to Dr. Matthew Hill, a neuroscientist at the University of Calgary whose lab studies how the endocannabinoid system and cannabis (marijuana) influence the brain & behavior. They discuss: endocannabinoid biology; endocannabinoid regulation of stress & anxiety; endocannabinoids & exercise; how marijuana & THC influence brain development; and more.
More content about cannabinoids & marijuana.
*Not medical advice
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Daily Taurine From Middle Age Extended Mouse Lifespan 10 to 12% | Vijay Yadav | 122
2 augustus 2023 · 1 uur 16 min
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Nick talks to molecular physiologist Dr. Vijay Yadav, an assistant professor at Columbia University whose lab studies the molecular & cell biology of aging, nutrition, and longevity. They discuss: the cell biology of aging; how nutrients affect aging & disease; the atypical amino acid taurine & its effects on aging; taurine clinical trials & supplementation; diet, nutrition & anti-aging effects; and more.
*Not medical advice.
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Five Psychedelics Reopened a Social Learning Window in Adult Mice | Gül Dölen | 121
19 juli 2023 · 1 uur 43 min
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Nick talks to Gül Dölen, MD, PhD, a neuroscientist at Johns Hopkins University whose lab studies social behavior, synaptic plasticity, psychedelics & evolution. They discuss: What drugs like LSD, psilocybin, ketamine, MDMA, and ibogaine have in common in terms of their molecular effects in the brain; why Dr. Gül Dölen believes all of these drugs can be described as "psychedelics"; the relationship between psychedelics and neuroplasticity vs. metaplasticity; how addictive drugs are similar to and different from psychedelics; social reward learning in rodents & critical periods of plasticity; the subjective effects of psychedelics; novel psychedelic drug development; human social behavior, mental health, and psychiatry; and more.
Check out my previous discussion with Gül Dölen.
*Not medical advice
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Therapy and SSRIs Work About Equally, Each Helping 30 to 50% of People | Alan Davis | 120
11 juli 2023 · 1 uur 7 min
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Nick talks to Dr. Alan Davis, a clinical psychologist and Director of the Center for Psychedelic Drug Research & Education at Ohio State University. They discuss: the effectiveness of mainstream forms of psychotherapy and antidepressant medications (SSRIs) for depression; psychedelic medicine & psilocybin-assisted psychotherapy; the relevance of the subjective effects of psychedelics for their therapeutic effects; FDA approval for MDMA- and psilocybin-assisted psychotherapy in the coming years; and more.
*Not medical advice.
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A Receptor 'Lid' Traps LSD for Hours, Helping Explain Its Long Trips | Bryan Roth | 119
6 juli 2023 · 1 uur 17 min
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Nick talks to Bryan Roth, MD, PhD, a Professor of Pharmacology at the University of North Carolina. Dr. Roth has been studying the molecular mechanisms of psychedelics since the 1980s. They discuss: serotonin 2A receptors in the mammalian brain; psychedelics & neuroplasticity; classic psychedelics (e.g. LSD, psilocybin, DMT) compared to drugs like ketamine & MDMA; TrkB receptors & BDNF; engineering novel drugs & psychiatric treatment methods; latest findings in psychedelic science.
*Not medical advice.
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Psychedelics Heal Through the Trip Itself, Not Just the Molecule | Dennis McKenna | 118
29 juni 2023 · 1 uur 29 min
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Nick talks to ethnopharmacologist Dr. Dennis McKenna, who is the brother of psychonaut Terence McKenna and author of the book, "The Brotherhood of the Screaming Abyss." They discuss: the lives and psychedelic adventures of Dennis & Terence McKenna; experiences with psilocybin mushrooms & DMT; Carl Jung & psychology; the medical relevance of subjective psychedelic experiences; drugs, culture & society; and more.
*Not medical advice
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Anxiety and Depression Definitions Overlap About 80% in the DSM | Daniel Karlin | 117
10 juni 2023 · 1 uur 37 min
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Nick talks to Daniel Karlin, MD, a board-certified physician in psychiatry, addiction medicine & clinical informatics who is the Chief Medical Officer at MindMed. They discuss: psychiatry; incentives in scientific & medical research; healthcare & mental health; psychedelics; LSD for anxiety; MDMA for autism; ibogaine derivatives for addiction; patient access & care; and more.
*This content is never meant to serve as medical advice.
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About 80% of Store-Bought Avocado Oils Tested Were Oxidized or Impure | Selina Wang | 116
2 juni 2023 · 1 uur 24 min
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Most store-bought “extra virgin” olive and avocado oils fail basic purity or freshness tests.
TOPICS DISCUSSED:
Oxidation Chemistry: Triacylglycerols break down into tasteless peroxides then into aldehydes that produce rancid odors; concentration and matrix determine whether the same compounds smell pleasant or foul.
Extra-virgin vs. Refined: Mechanical crushing and centrifugation yield EVOO with intact phenolics and pigments; refining removes defects, color, and antioxidants from low-grade fruit.
Purity Testing: Fatty-acid and sterol profiles distinguish true olive or avocado oil from canola, soybean, or other adulterants.
2010 Olive-Oil survey: ~68% of imported samples failed USDA quality standards, largely from oxidation rather than outright substitution.
Avocado-Oil Findings: ~80% of retail samples were oxidized or impure; some were 100% soybean oil labeled “extra-virgin avocado.”
Packaging Effects: Clear plastic permits light and oxygen; dark glass, tin, or bag-in-box better preserves freshness once opened.
Sensory Standards: Olive oil is one of few foods with mandatory trained-panel evaluation of defects such as fusty or rancid notes.
ABOUT THE GUEST: Selina Wang, PhD is a food scientist and chemist at the University of California, Davis. Her lab develops analytical methods for assessing quality, purity, and authenticity of edible oils and other California crops.
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Protein Given During Sleep Still Built Muscle in Older Adults | Luc van Loon | 115
25 mei 2023 · 43 min
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Nick talks to Dr. Luc van Loon, Professor of Exercise Physiology & Nutrition at Maastricht University, about topics in exercise science, health & nutrition. They discuss: macronutrients & energy; protein quality & digestibility; endurance & resistance training; plant vs. animal protein; muscle conditioning & muscle fibers; sleep & aging; muscle physiology & metabolism; and more.
To learn more about diet & metabolism, check out this content.
*Not medical advice.
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Smell Is a Good Freshness Test for Cannabis. Key Compounds Fade Fast | Iain Oswald | 114
8 mei 2023 · 54 min
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Nick talks to Dr. Iain Oswald, who has a PhD in chemistry from the University of Texas-Dallas and is principal scientist Abstrax Tech, a cannabis research and product development company. He is an expert in using cutting edge analytical chemistry techniques to study plant chemistry and has done a lot of work to decipher the chemistry of commercial cannabis, including lesser-known compounds found in the essential oils of marijuana plants and how these relate the sensory qualities of marijuana.
They discuss: the aroma of cannabis & the chemical compounds that dictate different aspects of its aroma; consumer preferences when it comes to marijuana aroma; terpenes, which are volatile compounds abundant in the plant world; his research on volatile sulfur compounds, which are found in nature in things like garlic and the aerosols produced by skunks, and how lesser-known cannabis compounds in this chemical family relate to some of the pungent, gassy/skunky odors commonly associated with marijuana; his journey from academia into the private sector, and what’s on the horizon for cannabis research.
More content about cannabinoids & marijuana
*Not medical advice.
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