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315 afleveringen, van nieuw naar oud
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Vaping Lung Injuries Were Tied to Vitamin E Acetate Used to Dilute THC | Echo Rufer | 113
2 mei 2023 · 1 uur 14 min
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Nick talks to board-certified toxicologist Dr. Echo Rufer. The conversation starts with a brief overview of what the science of toxicology is all about & a little bit about alcohol toxicity. They then discuss: differences between vaping and smoking; what toxins are produced through the combustion of plant material, especially tobacco & marijuana; cannabinoids like THC & CBD, as well as cannabis terpenes; relationship between dose, method of consumption & toxicity of chemical compounds; causes of the vaping-associated pulmonary injury (VAPI) associated with the vitamin E acetate that was found in some illicit market cannabis vape products; best ways to minimize toxin exposure for people who inhale plant-based consumer products such as tobacco or nicotine products or marijuana.
*Not medical.
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Dementia May Begin When Neurons Run Short of Oxygen, His Model Says | Nathan Price | 112
13 april 2023 · 1 uur 26 min
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Nick talks to Dr. Nathan Price, who is a professor at the Institute of Systems Biology and Chief Science Officer of Thorne HealthTech. They discuss topics related to his new book, "The Age of Scientific Wellness: Why the Future of Medicine is Personalized, Data-Rich, and in Your Hands."
Listen to Nick's previous discussion with Dr. Nathan Price.
*Not medical advice.
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Your Accent Was Set in Infancy, When Your Brain Merged Unused Sounds | Dan Brady | 111
5 april 2023 · 45 min
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Nick talks to Daniel Brady, PhD a neuroscientist who studied sensory systems in the developing brain. Dr. Brady is also the co-founder and CEO of Orita.ai, a startup using machine learning & AI to solve data problems for direct-to-consumer brands. They discuss: critical periods of learning, childhood brain development, neuroplasticity, synesthesia, language acquisition, Orita.ai, machine learning & AI, customer segmentation, data science, and more.
*Not medical advice.
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Isolation Nearly Halted New Neuron Growth in Mice. Novelty Restarted It | Rusty Gage | 110
20 maart 2023 · 1 uur 21 min
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Nick talks to Dr. Rusty Gage, a neurobiologist at the Salk Institute whose lab studies how genes & environment interact to influence brain development, including the process of adult neurogenesis. They discuss: what neurogenesis is and how it works; lifestyle factors that influence neurogenesis, such as exercise, intermittent fasting, etc.; molecular pathways involved in neurogenesis; depression & PTSD; memory formation and the function of newly born adult neurons; and more.
*Not medical advice.
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Inflated THC Labels Are a Bigger Problem Than Pesticides on the Shelf | Nick Mosley | 109
17 maart 2023 · 49 min
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Nick talks with Nick Mosley, who is CEO of a cannabis testing lab called Confidence Analytics, which conducts analytical testing for legal cannabis products in Washington & California. They discuss: how analytical testing for cannabis products works; THC, CBD, and cannabinoid content; terpenes; pesticides, heavy metals, and microbial contaminants; the phenomenon of THC inflation & lab shopping in the legal marijuana industry; how consumers can discern whether cannabis products are safe & consistent.
*Not medical advice.
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Mind & Matter Podcast | Nick Jikomes, PhD | Neuroscience, Psychedelics, Psychology, Psychology, Molecular Biology, Genetics, Evolution, Metabolism, Nutrition, Biotech
14 maart 2023 · 2 min
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What is Mind & Matter?
Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers about alive today about how your body & mind react to what they’re fed.
The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.
Learning philosophy
At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.
As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.
I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or pushing my own viewpoint.
My beliefs:
Taking ownership of your health starts with taking ownership of your information diet.
All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.
Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information.
Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:
“Γνῶθι σεαυτόν” (Know thyself)
“Μηδὲν ἄγαν” (Nothing in excess)
“…
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Voles Without Oxytocin Receptors Still Formed Strong Pair Bonds | Devanand Manoli | 108
8 maart 2023 · 1 uur 52 min
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Nick talks to psychiatrist & neuroscientist Devanand Manoli, MD, PhD, whose lab at UCSF studies the neural basis of social behavior & attachment in prairie voles. As a psychiatrist, he also treats patients with childhood psychosis. They discuss: the neural basis of pair bonding, monogamy, and parental & sexual behavior; oxytocin, vasopressin, testosterone & estrogen; evolution of behavior; menopause & multigenerational parental care; childhood psychosis; and more.
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Your Brain Doesn't Perceive, Then Think, Then Act. It Runs Control Loops | Paul Cisek | 107
27 februari 2023 · 2 uur 4 min
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Nick talks to Dr. Paul Cisek, a neuroscientist at the University of Montreal who studies sensorimotor control & decision making in primates. They discuss: the evolution of the brain from the earliest nervous systems to humans; metabolism & state control; the evolution of behavior; sensation, perception, cognition, decision making & consciousness; language & representation; why neuroscience needs evolutionary thinking; and more.
*Not medical advice.
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Diets Under 15% Protein Made People Overeat | Stephen Simpson & David Raubenheimer | 106
20 februari 2023 · 1 uur 50 min
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Nick talks to Dr. Stephen Simpson & Dr. David Raubenheimer, both professors at the University of Sydney who have been research collaborators for many years. Their research focuses on understanding animal feeding behavior, especially how & why different animals use their sensory systems in order to consume foods so that their diets contain the right balance of nutrients. Understanding animals in the evolutionary & ecological contexts they evolved to survive in enables us to build a holistic picture of the general principles underlying feeding behavior. Topics discussed include: Macronutrients (protein, fats & carbohydrates) and micronutrients (sodium, calcium); the 'protein leverage hypothesis' & how this explains the modern obesity epidemic; how different diets can promote fat weight, longevity, or reproductive success; the optimal macronutrient composition for weight loss; the comparative biology of feeding behavior across animals like humans, gorillas, spiders, wolves, etc.
More content about diet & nutrition.
*Not medical advice.
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Obesity Surgery Works via Gut Hormones, Not a Smaller Stomach | Christoffer Clemmensen | 105
8 februari 2023 · 1 uur 22 min
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Nick talks to Dr. Christoffer Clemmensen, who runs the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders. They discuss: the causes of obesity; environmental and biological factors influencing predisposition to obesity; novel anti-obesity drugs; gut hormones & peptides regulating food intake; whether psychedelics like psilocybin may be useful for treating obesity and other metabolic disorders.
*Not medical advice.
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Sunlight Lowers Blood Pressure Through Nitric Oxide, Not Vitamin D | Richard Weller | 104
23 januari 2023 · 1 uur 41 min
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Nick talks to academic dermatologist Dr. Richard Weller about: skin health; benefits & risks of sunlight & UV radiation exposure; nitric oxide, blood pressure & cardiovascular health; vitamin D; sunscreen & tanning; the evolution of skin color & skin physiology; and more.
*Not medical advice.
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Gut Bacteria Boost the Dopamine Reward From Exercise in Mice | Christoph Thaiss | 103
17 januari 2023 · 1 uur 42 min
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Nick talks to biologist Dr. Christoph Thaiss, a professor at the University of Pennsylvania. His lab studies how the body detects & responds to environmental stimuli, with a focus on interactions between the gut microbiome, immune & nervous systems. They discuss: sensory systems of the body & basic principles of how they work; gut microbiome & the consequences of depleting it with antibiotics; endocannabinoids & exercise; how microbiome composition influences the brain & motivation to engage in exercise; prebiotics & probiotics; circadian rhythms & eating patterns.
*Not medical advice.
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Swap One Atom in LSD and You Get a Drug That Isn't Psychoactive | Ryan Gumpper | 102
12 januari 2023 · 1 uur 15 min
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Nick talks to biochemist & biophysicist Dr Ryan Gumpper, a postdoc in Dr. Bryan Roth's lab at the University of North Carolina. They discuss the biochemistry, molecular biology & biophysics of serotonin receptors, including the molecular details for what happens when serotonin and tryptamines psychedelics (e.g. LSD) bind to 5HT2A receptors in the brain. They also discuss how understand these details relates to the quest to discover novel psychedelic-derived compounds with therapeutic benefits, as well as the inspiration Ryan received from reading Alexander Shulgin's famous book, PIHKAL.
*Not medical advice.
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Ambien Has Woken Some Patients From Long Minimally Conscious States | Alex Proekt | 101
26 december 2022 · 1 uur 37 min
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Nick talks to anesthesiologist & neuroscientist Dr. Alex Proekt, who runs a lab at the University of Pennsylvania, about altered states of consciousness. They discuss: NREM & REM sleep, anesthesia & anesthetic drugs like propofol; coma & vegetative states; sleeping pills like Ambien; the relationship between consciousness & the underlying brain dynamics; how ketamine differs from other anesthetics & what it does to brain activity; AI & ChatGPT.
*Not medical advice.
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Twitter Quietly Limited His Reach Over His COVID Policy Views | Jay Bhattacharya | 100
19 december 2022 · 2 uur 1 min
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Nick talks to Jay Bhattacharya, MD, PhD, who is a professor of medicine & economics at Stanford University. They discuss various aspects of the COVID pandemic, such as: how infectious, transmissible, and deadly SARS-CoV-2 is; mRNA vaccines, how well they stop transmission vs. severe COVID, and whether they can induce negative side effects such as myocarditis; how well masks really work; Jay's inclusion in the "TwitterFiles" and the suppression of speech on social media; what he thinks of Elon Musk after meeting him; his thoughts on the future of public health governance in the US.
Related episodes:
M&M #61: Public Health, Pandemics, Epidemiology, SARS-CoV-2 & COVID Public Policy | Martin Kulldorff
*This content is never meant to serve as medical advice
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Rats Learned to Seek Water When Their Transplanted Human Neurons Fired | Sergiu Pasca | 99
16 december 2022 · 1 uur 12 min
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Nick talks to Dr. Sergiu Pasca, a developmental neuroscientist and professor at Stanford University. They discuss topics related to human brain development, the origins of neuropsychiatric disease like autism & schizophrenia, new technologies for studying brain development, stem cells, and recent experiments from Dr. Pasca'a lab utilizing brain "organoids," "assembloids," and human-animal transplantations.
*Not medical advice.
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Serotonin Got Tied to Mood by Antidepressants, Not by Discovery, He Says | Zach Mainen | 98
28 november 2022 · 2 uur 24 min
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Nick talks to computational neuroscientist Dr. Zach Mainen, a neuroscientist and director of the Champalimaud Neuroscience Programme at the Centre of the Unknown in Lisbon, Portugal. His lab studies the neuroscience of decision making, neuromodulation & behavior using both experimental and computational approaches.
They discuss: what kinds of things animal brains are actually computing, and to what extent we can think about brains like computers; the difference between neurotransmitters and neuromodulators in the brain, including some discussion of what specific neuromodulators like dopamine and serotonin do in the brain; and we also discussed some of the research his lab is starting to do on serotonergic psychedelics, including how he thinks about whether the subjective effects of psychedelics are likely to be important for the therapeutic and neuroplastic effects.
*Not medical advice.
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SARS-CoV-2's Cut-Site Map Looks the Most Engineered of 1,491, He Says | Alex Washburne | 97
21 november 2022 · 1 uur 45 min
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Nick talks to mathematical biologist Dr. Alex Washburne about the origins of the SARS-CoV-2 virus.
*Not medical advice.
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In Her LSD Microdosing Trial, the Placebo Group Improved Just as Much | Harriet de Wit | 96
15 november 2022 · 57 min
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Nick talks to experimental psychologist Dr. Harriet de Wit, a professor at the University of Chicago whose lab studies the behavioral effects of psychoactive drugs on humans. They discuss: the effects of MDMA on emotional perception and touch sensation; the effects of microdosing LSD; THC's impact on memory.
*Not medical advice.
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Life Holds Off Decay by Pairing Two Processes That Check Each Other | Terrence Deacon | 95
7 november 2022 · 2 uur 30 min
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Nick talks to biological anthropologist & neuroscientist Dr. Terrence Deacon, who is a professor of biological anthropologist at UC-Berkeley and a leading thinker on the evolution of language, consciousness and human cognition. They discuss: how end-directed systems, such as life, can emerge from non-life; how complexity evolves once life originates; the origins of sentience and a sense of self; the evolution of the nervous system and consciousness; information, value, and "aboutness" in the universe; and more.
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Rats With 99% of Their Dopamine Gone Still Liked Sweet Tastes | Kent Berridge | 94
31 oktober 2022 · 1 uur 33 min
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Nick talks to neuroscientist Dr. Kent Berridge, a professor of psychology & neuroscience at the University of Michigan. They discuss: the neurobiology of the brain processes rewards and generates pleasure & motivation; the difference between "liking" and "wanting"; hunger and whether food addiction is similar to drug addiction; emotion and consciousness; and more.
*This content is never meant to serve as medical advice.
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In His Study, CBD Blunted the Memory Hit From THC | Amir Englund | 93
24 oktober 2022 · 1 uur 31 min
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Nick talks to Dr. Amir Englund, a psychopharmacologist at the Institute of Psychiatry, Psychology & Neuroscience at King's College, London. Dr. Englund's research focuses on the effects of cannabis, medical marijuana and specific cannabinoids (e.g. THC, CBD, THCV) on human cognitive function. They discuss topics including: what is the addiction liability of marijuana? What are the acute & chronic cognitive effects of THC, including how it impacts memory & executive function; how the effects of THC can be modulated by cannabinoids like CBD & THCV; the relationship between marijuana & THC and psychosis (e.g. schizophrenia); and more.
*Not medical advice
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Cutting Branched-Chain Amino Acids Extended Male Mouse Lifespan ~30% | Dudley Lamming | 92
18 oktober 2022 · 1 uur 7 min
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Nick talks to molecular physiologist Dr. Dudley Lamming, a professor of medicine at the University of Wisconsin-Madison whose lab studies how the body responds to the nutrient and calorie content of food. We discuss: how the protein and amino acid composition of food impacts metabolic health & aging; branched chain amino acids & disease; sex differences between males & females in how diet affects health; fasting, calorie restriction & fasting; and more.
*Not medical advice.
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People Outside Africa Carry Roughly 1.5 to 2.5% Neanderthal DNA | Razib Khan | 91
11 oktober 2022 · 1 uur 45 min
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Nick talks to genetics researcher & writer Razib Khan. Razib did graduate work in genetics at the University of California-Davis and recently founded a genomics data startup. He also runs a Substack, "Unsupervised Learning," where he writes a lot of fascinating articles on the subjects of human evolutionary & population genetics, personal genomics, and more. Nick and Razib discussed: how the story of human evolution has changed over the past two decades; genomics technology & ancient DNA; Neanderthals, Denisovans & ancient humans; personal genomics (e.g. 23AndMe, Ancestry.com); Razib's experience as a writer on Substack.
*Not medical advice.
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Cocaine Rewired Reward Synapses in Mice. Ketamine Didn't | Christian Lüscher | 90
5 oktober 2022 · 46 min
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Nick talks to Christian Lüscher, MD, PhD, a neuroscientist at the University of Geneva whose lab studies the cellular mechanisms that underlie drug reinforcement, dependence and addiction. Dr. Lüscher talks about the nature of addictive drugs in the brain, how ketamine works, and the latest research from his lab look at how ketamine's unique effects within the brain's reward circuitry enable it to be psychoactive & reinforcing, but have a very low addiction liability (in rodents). He also discusses what this research may mean for the use of ketamine as a therapeutic treatment for depression in humans.
*Not medical advice.
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Castrated Male Mice Regained the Ability to Fight When Given Estrogen | David Anderson | 89
28 september 2022 · 1 uur 53 min
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Nick talks to neuroscientist Dr. David Anderson, a professor at Caltech whose lab studies the neurobiological basis of animal behavior and emotion. They discuss: technologies for understanding cause-and-effect in the brain; neurobiological basis of animal behavior, including aggression/fighting, mating, feeding, and social behavior; how hormones such as estrogen regulate behavior; emotions, feelings, and consciousness; and David's new book, "The Nature of the Beast."
*Not medical advice.
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Antidepressants Beat Placebo by About 2 Points on a 52-Point Scale | Joanna Moncrieff | 88
21 september 2022 · 1 uur 26 min
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Nick talks to psychiatrist Dr. Joanna Moncrieff about depression. What causes it? How do SSRIs work? How well do antidepressants work? What are the risks & benefits of long-term antidepressant use? What is the evidence that depression is caused by a chemical imbalance (too little serotonin) in the brain? How is social media & technology influencing mental health?
Learn more about topics in psychiatry.
*This content is never meant to serve as medical advice.
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Homelessness Nonprofits Develop an Interest in Surviving, He Says | Leighton Woodhouse | 87
15 september 2022 · 1 uur 52 min
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Nick talks to journalist & documentary filmmaker Leighton Woodhouse. They discuss: homelessness & drug addiction; religion & ideology; sociology & social psychology; the social function of laws and norms; economic vs. cultural capital & the "overproduction of elites"; institutional science; civilizational decline & the future of American society.
*Not medical advice.
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Chimpanzees Reunite Each Night With a Drumming and Chorusing Ritual | Michael Winkelman | 86
31 augustus 2022 · 1 uur 34 min
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Nick talks to anthropologist Dr. Michael Winkelman, who was a professor at Arizona State University for many years, where he studied topics related to shamanism as practiced by early hunter gatherer societies, and other topics related to human cultural evolution. He is now retired and conducts independent research from Brazil, where he now lives. They discuss: what shamanism is & the core features of shamanic ritual practices across historical hunter gatherer cultures; how the various ritual practices associated with shamanism were used by forager societies (e.g. symbolism, group dance and drumming) & the use of psychedelics; evolution of shamanism & religion from prehistoric times to the present; role religion and spiritual practices have played in human evolution; how human culture is akin to virtual reality & how human ritual practices help sculpt the narratives that form within human cultures that regulate human behavior; future of religion & spirituality in the modern age & whether the use of psychedelics as entheogenic substances might have a role to play in that.
*Not medical advice
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Cut Magic Mushrooms Turn Blue as Psilocin Links Into Chains | Dirk Hoffmeister | 85
25 augustus 2022 · 1 uur 33 min
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Nick talks to pharmaceutical microbiologist Dr. Dirk Hoffmeister, who is professor at the Hans Knöll Institute in Germany. Professor Hoffmeister has a background in botany and mycology, the study of fungi. His lab studies various aspects of fungal biochemistry & molecular biology, including the biochemistry and molecular genetics of psilocybin production in magic mushrooms.
We spoke about various topics in mycology, mostly related to Psilocybe mushrooms. This included: how psilocybin is synthesized from the amino acid tryptophan; the ecological reasons for why some mushrooms produce psilocybin; why magic mushrooms turn a vibrant blue color when they are physically damaged; the production of monoamine oxidase inhibitors (MAOIs) by certain species; the ecology of Psilocybe mushrooms; other areas of mycology that his lab studies.
*Not medical advice.
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Hurricanes Aren't Getting More Frequent. The Debate Is Over Intensity | Judith Curry | 84
18 augustus 2022 · 1 uur 48 min
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Nick talks to climatologist Dr. Judith Curry, the former chair of the School of Earth and Atmospheric Sciences at the Georgia Institute of Technology. Her research interests have included hurricanes, atmospheric modeling, air-sea interactions, and a variety of other areas in climate science. She runs Climate, Etc., an online blog focused on climate science. She is also writing a new book called, “Climate Uncertainty & Risk,” which she described towards the end of the podcast. They discuss: how Earth’s climate has changed over time and how climate scientists measure this; what computer models are used for in climate science and what their strengths & weaknesses are; tropical storms and severe weather events; CO2, methane, and other greenhouse gasses; different forms of energy, such as oil, natural gas, solar, wind, and nuclear; how she thinks about the tradeoffs between different energy sources in terms of their abundance, environmental impact, costs, and other factors; the politicization of climate science and why certain branches of science are especially prone to it.
*Not medical advice.
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Free Samples, Not TV Ads, Are Pharma's Biggest Marketing Spend, He Says | David Cohen | 83
11 augustus 2022 · 1 uur 21 min
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Nick talks to Dr. David Cohen, a professor at the UCLA Luskin School of Public Affairs. His research looks at psychoactive drugs (prescribed, licit, and illicit) and their desirable and undesirable effects as socio-cultural phenomena “constructed” through language, policy, attitudes, and social interactions. They discuss: prescription psychiatric drugs, including SSRIs, benzodiazepines and stimulants (e.g. Adderall); the history of how some of the most widely prescribed psychiatric drugs came to be so popular; how pharmaceutical companies go about marketing these drugs and the conditions they aim to treat to both physicians and the public; the quality of the evidence supporting their use; what we are learning about the potential for dependency, long-term health effects, and actual level of benefit that comes from chronic psychiatric drug use; why many psychiatric drugs are increasingly prescribed in combination; and more.
*Not medical advice.
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Cells Remember Past Inflammation by Keeping Stress Genes Open | Shruti Naik | 82
4 augustus 2022 · 1 uur 7 min
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Nick talks to Dr. Shruti Naik, assistant professor of pathology & medicine at the NYU Langone. Her lab studies the interactions between immune cells, epithelial cells, and microbes in barrier tissues that interface with the environment (e.g. skin, lungs & gut). They discuss: inflammatory memory; how cells store memories of inflammation epigenetically; how skin cell regenerate and repair tissue damage; stem cell biology; cancer, and more.
*Not medical advice.
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Rats Deprived of Play Grew Up Hyper-Aggressive, but Only the Males | Margaret McCarthy | 81
28 juli 2022 · 1 uur 22 min
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Nick talks to neuroscientist Dr. Margaret McCarthy, whose lab at the University of Maryland studies the origins and mechanisms of sex differences in the brain, the endocannabinoid system, and neural basis of animal behavior. They discuss: the nature of sex differences observed in the mammalian brain, including differences in the susceptibility to various diseases and disorders of the brain; differences in juvenile play behavior in males vs. females, and how these can be altered by sex hormones and cannabinoids; sex differences in brain development that lead to sex differences in behavior; how the endocannabinoid system influences brain development and behavior; how cannabis use during pregnancy may influence brain development.
*This content is never meant to serve as medical advice.
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No Infected Animal Was Found in Wuhan's Market, Unlike With SARS in 2003 | Matt Ridley | 80
21 juli 2022 · 58 min
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Nick talks to science writer Matt Ridley, who most recently published the book, "Viral: The Search for the Origin of COVID-19" together with molecular biologist Dr. Alina Chan. They discussed what is known and still unknown about the origins of the SARS-CoV-2 virus, the latest developments in that mystery which have come to light in the past few months; the relationship between institutional science and politics; whether we are ever likely to know definitively the origins of this virus, and more.
*Not medical advice.
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His Startup Bets Shorter-Acting Psychedelics Are the Fastest to Clinics | Sam Banister | 79
14 juli 2022 · 1 uur 13 min
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Nick talks to medicinal chemist Sam Banister, who is co-founder and Chief Science Officer at Psylo, a biotech startup focused on developing next-generation psychedelic medicines. They discuss: the past, present, and future of psychedelic science; Sam's journey from academia to biotech startup co-founder; Alexander Shulgin; psychedelics like psilocybin, DMT, and others; and psychedelics & society.
*Not medical advice.
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If Your Identical Twin Has Schizophrenia, Your Own Risk Is About 50% | Kevin Mitchell | 78
7 juli 2022 · 1 uur 53 min
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Nick talks to neuroscientist & geneticist Dr. Kevin Mitchell about: 'Nature vs. Nurture,' the genetics of brain development, autism & schizophrenia, human brain and psychological variation, synesthesia, agency & free will, and more.
More neuroscience & genetics content here.
*Not medical advice.
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Some Smokers Lost All Craving for Cigarettes After a Stroke | Michael Fox | 77
30 juni 2022 · 58 min
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Nick talks to neurologist & neuroscientist Michael Fox, MD, PhD about his recent work mapping out an "addiction remission network" in the brain. They discuss addiction, brain networks involved in addiction, neurotechnologies like Deep Brain Stimulation and Transcranial Magnetic Stimulation, Parkinson's Disease, and more.
*Not medical advice.
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Fasted People Running on Ketones Felt Fine at Very Low Blood Sugar | Dominic D'Agostino | 76
23 juni 2022 · 1 uur 55 min
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Nick talks to physiologist and neuroscientist Dr. Dominic D'Agostino about human metabolism & nutrition; fats, carbohydrates, sugar, and protein; ketogenic diet, ketosis, BHB supplementation; inflammation and polyunsaturated fats; personal health and metabolism monitoring; and general questions related to the quality of the nutritional information we receive from our institutions.
Learn more about the science of diet & metabolism.
*Not medical advice.
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Firewalkers' Heartbeats Synced With Family Watching, Not Tourists | Dimitris Xygalatas | 75
16 juni 2022 · 2 uur 16 min
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Nick talks to anthropologist Dr. Dimitris Xygalatas, who is an associate professor at the University of Connecticut. His research interests center around human ritual behavior and the interaction between cognition and culture. They discuss his new Book, "Ritual: How Seemingly Senseless Acts Make Life Worth Living." Topics covered: Rituals vs. habits; the psychological purpose of ritual; ritualism as an antidote to anxiety; religion and spiritual practices; culture & the birth of civilization; the physiological and psychoactive effects of ritual; Ayahuasca and psychoactive drugs; rituals in sports, gambling, and other human activities; the evolution of language & symbolic cognition; religion, community & Burning Man.
*Not medical advice.
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MDMA Can Make It Harder to Read Fear in Other People's Faces | Manoj Doss | 74
9 juni 2022 · 1 uur 58 min
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Nick talks to cognitive psychopharmacologist Dr. Manoj Doss about the effects of psychoactive drugs on memory, including sedatives, stimulants, psychedelics, cannabinoids, and MDMA. They also talk about recent research on the effects of psilocybin on the human brain.
*Not medical advice
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The Amygdala Detects Threats. The Feeling of Fear Comes Later, He Says | Joseph LeDoux | 73
2 juni 2022 · 1 uur 44 min
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Nick talks to neuroscientist Dr. Joseph LeDoux, who runs a research lab at New York University. His research focuses on the neurobiology of emotion, memory and behavior and he has written several popular science books including, "The Deep History of Ourselves." They discuss: brain evolution; what is behavior? what are emotion and cognition, and how are they intertwined; consciousness, language, and memory.
*Not medical advice.
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A 90%-Fat Ketogenic Diet Protected Mice From Colon Tumors | Maayan Levy | 72
26 mei 2022 · 1 uur 18 min
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Dr. Maayan Levy is an assistant professor of microbiology at the University of Pennsylvania, where her lab studies the communication between the microbiome and its host, with a focus on the gut microbiome and its relationship to diet, immune system function, and disease. We discuss: her recent study linking the ketogenic diet to lower risk of colon cancer; what the ketogenic diet is and what the metabolic state of ‘ketosis’ does in the body; molecules called ketone bodies, such as BHB, and the extent to which BHB supplementation can recapitulate some of the physiological effects of the ketogenic diet; how the microbiome influences the function and development of the immune system; and the hygiene hypothesis, the idea that modern human cultures may be too clean, or rely too heavily on antibiotics and other technology, and interfere with our microbiome in ways that may be detrimental to metabolic and immunological health.
*Not medical advice.
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Nobody Likes Pure THC, and Its Main Side Effect Is Paranoia | Andrew Chadeayne | 71
19 mei 2022 · 1 uur 31 min
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Nick talks to chemist & patent attorney Dr. Andrew Chadeayne, who is the CEO of the psychedelic startup CaaMTech. They discussed: the chemistry of magic mushrooms, including compounds beyond psilocybin, found in many species of psilocybin-containing mushrooms; the so-called entourage effect, the idea that multiple compounds found in plants and fungi might work together in a synergistic fashion to produce specific psychoactive or therapeutic effects; Cannabis and magic mushrooms; DMT, 5-MeO-DMT, and novel DMT analogues; how we went from academia, to patent law, to founding CaaMTech; the prospect of developing novel psychedelic drugs, non-hallucinogenic psychedelic drug analogues, and some of the details on how these various drugs differ in terms of their chemical structure.
Learn more about psychedelic science.
*Note medical advice.
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A Woman's Hair Lost Its Color as Stress Rose, Then Regained It | Martin Picard | 70
12 mei 2022 · 2 uur 12 min
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Nick talks to Dr. Martin Picard, a biologist at Columbia University whose lab studies mitochondrial psychobiology, linking together molecular processes within mitochondria with human experience. They discussed; what mitochondria are and where they came from; their role in energy & metabolism; the mitochondrial genome; the importance of mitochondria in stress & aging; how exercise, diet, and genetics influence mitochondria biology; hair graying and whether it's reversible; the mind-mitochondria connection.
*Not medical advice.
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The Best Anti-Aging Fixes Extend Mouse Lifespan Only 10 to 30% | Leonard Guarente | 69
5 mei 2022 · 1 uur 27 min
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Nick talks to biologist Dr. Leonard Guarente about the biology of aging, life extension, health supplements, and related topics. Dr. Guarente is a Professor of Biology at MIT, where his lab has studied the molecular and cellular mechanisms of aging for many years. He is also the co-founder and Chief Scientist of Elysium Health, which uses the science of aging to develop health supplements to combat age-related decline and technologies to help consumers understand their rate of aging.
Nick and Dr. Guarente discussed many topics related to aging, including: how and why aging occurs; whether humans can achieve immortality; NAD and the core metabolic processes of cells; resveratrol, pterostilbene, and other anti-aging molecules; epigenetics and technology that can be used to calculate biological age vs. chronological age.
*Not medical advice.
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High Incubation Heat Turns Genetically Male Bearded Dragons Female | Blanche Capel | 68
28 april 2022 · 1 uur 37 min
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Nick talks to cell & developmental biologist Dr. Blanche Capel. They discussed the nature of sexual reproduction and sexual dimorphism, including when these these things evolved, the evolutionary reasons for sexual reproduction, and the amazing diversity of mechanisms that determine the development of sexual traits across the animal kingdom; the contribution of genetic vs. environmental factors in sex determination, and how these vary across species; sex chromosomes, such as the X and Y chromosomes of humans and other mammals; sex hormones, such as testosterone and estrogen; as well as how gametes and gonads develop - these are the sex cells, such as sperm or egg, and the reproductive organs that produce them and the major sex hormones that shape sexual development; what we know, and don’t know, about the biology of puberty and sexual development after birth, as well as whether environmental factors, such as components of the diet an environmental contaminants, could be influencing sexual development.
*Not medical advice.
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Most People Exposed to Trauma Never Develop PTSD | Rachel Yehuda | 67
21 april 2022 · 1 uur 38 min
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Nick talks to neuroscientist & clinical researcher Dr. Rachel Yehuda, who is a professor of psychiatry & neuroscience at the Icahn School of Medicine at Mount Sinai, in New York. They discuss the biology and neuroscience of stress, PTSD (post-traumatic stress disorder), why people can be sensitive or resilient to stress, epigenetics, intergenerational trauma, and how MDMA and psychedelics are being explored for their ability to treat stress-related mental health conditions.
*Not medical advice
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People Are Easy to Fool Because They Want to Be, He Argues | Robert Greene | 66
14 april 2022 · 1 uur 33 min
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Nick speaks to writer Robert Greene, who is the author of several books exploring different, and sometimes dark, aspects of human psychology. The discussion focuses on the subject of his first book, "The 48 Laws of Power."
They discuss what power is and how it's used. Different psychological traits that people who successfully acquire power tend to have. Strategies that have been useful throughout history for acquiring more power, as well as those that lead to a loss of power. Robert talks the political scientist Niccolo Machiavelli, and how he is often misunderstood. He also gave his perspective on some influential people with power today, including Vladimir Putin, Angela Merkel, and Elon Musk.
More content on social psychology & behavior.
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Evolution Tuned Our Senses for Fitness, Not for Seeing the Truth | Donald Hoffman | 65
7 april 2022 · 2 uur 20 min
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Nick talks to cognitive scientist Dr. Donald Hoffman, who is professor emeritus of cognitive sciences at UC-Irvine and the author of many scientific papers and books, including "The Case Against Reality: Why Evolution Hid the Truth from Our Eyes.”
They discussed a variety of topics related to consciousness, the nature of perception, and evolution, including: how perception works; whether our conscious perceptions are accurate representations of underlying reality; the interface theory of perception, which likens our conscious perceptions to the digital icons displayed on your computer screen; language; psychedelic experiences; and the nature of reality itself, such as whether space and time are fundamental aspects of the universe, or artifacts of perception.
*Not medical advice.
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