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315 afleveringen, van nieuw naar oud
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Resveratrol Extended Life Only in Obese Mice, Not Healthy Ones | Joe Baur | 64
31 maart 2022 · 1 uur 25 min
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Nick talks to biochemist Joe Baur, PhD, whose lab at the University of Pennsylvania studies the molecular mechanisms of aging and metabolism. They discuss: aging as a passive vs. regulated process; mechanisms of aging (DNA mutations, oxidative stress, etc.); NAD and its role in normal physiology; the biology of sirtuins; rapamycin as an immunosuppressant & modulator of aging; the effects of diet & caloric restriction on aging; the potential slowing and reversing aging, and more.
*Not medical advice.
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A Young Mouse's Microbiome Reversed Some Signs of Brain Aging in Old Mice | John Cryan | 63
23 maart 2022 · 1 uur 29 min
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Nick talks to Dr. John Cryan, a Professor of Anatomy & Neuroscience at University College-Cork in Ireland whose lab studies the microbiota-gut-brain axis in health & disease.
They touch on a range of topics related to how our gut microbiome affects the brain and body, including: how the microbiome affects aging and immunity; how it affects social behavior, including potential links to autism; how antibiotics and the general hyper-cleanliness of the modern world impacts the microbiome; how it affects neuropsychiatric conditions like depression; how diet influences brain inflammation; towards the end John also shared an interesting example of a food he consumes for gut health.
To learn more about the microbiome, check out this content.
*Not medical advice.
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On a Low Dose of MDMA, Asocial Octopuses Turned Playful and Social | Gul Dolen | 62
16 maart 2022 · 1 uur 53 min
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Nick talks to Dr. Gül Dölen, a professor of neuroscience at Johns Hopkins University. Her lab studies the circuit and synaptic mechanisms of social cognition in health and disease.
Nick and Dr. Dölen discussed her research on critical periods for social reward learning in rodents, the role of oxytocin in social behavior and learning, and how MDMA ("ecstasy") promotes prosocial behavior in animals as diverse as humans, rodents, and octopuses. They also talked about how drugs like MDMA and psychedelics influence "metaplasticity," enabling environmental factors to trigger plasticity (physical changes in the brain) in a context-specific manner. Dr. Dölen also described how her research relates to developing treatments for autism, as well as her thoughts on whether the subjective effects of psychedelics and other drugs are necessary for some of their therapeutic effects.
*Not medical advice.
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Wuhan Numbers Showed Over a 1,000-Fold COVID Death-Risk Gap by Age | Martin Kulldorff | 61
7 maart 2022 · 1 uur 37 min
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Martin Kulldorff, PhD is an epidemiologist & biostatistician who has been studying infectious diseases for over two decades. He was a professor at Harvard Medical School for many years, a member of the FDA’s Drug Safety & Risk Management Advisory Committee, and a former consultant for the Centers for Disease Control. In 2020, Dr. Kulldorff co-authored the Great Barrington Declaration, a document criticizing the use of society-wide lockdowns for COVID-19 and advocating for a strategy of focused protection for high-risk people.
Nick and Dr. Kulldorff discussed a variety of topics related to the COVID pandemic, including the nature of how the SARS-CoV-2 virus spreads compared to other pathogens, how our public health strategy was implemented & his thoughts on how we could have handled the pandemic better, vaccine-induced immunity vs. natural immunity, vaccine efficacy, how and why various countries differed in their approach to COVID, and the health of our scientific & public health institutions in the US.
*Not medical advice.
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Is Everything Made of Consciousness? | Bernardo Kastrup | 60
2 maart 2022 · 2 uur 38 min
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Nick talks to computer scientist and philosopher Bernardo Kastrup about various topics related to consciousness and the nature of reality. They discuss: psychological dissociation; the scientific study of 'neural correlates of consciousness'; the nature of perception and the influence of language on the mind; why the 'Hard Problem' of consciousness is so difficult; Bernardo's philosophy of analytic idealism; Jungian psychology & psychological archetypes; psychedelic experiences with psilocybin, 5-MeO-DMT, and how these could model the phenomenology of organic death.
More content about consciousness.
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Epilepsy Patients Taking CBD Tested COVID-Positive About Half as Often | Marsha Rosner | 59
23 februari 2022 · 1 uur 26 min
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Nick Jikomes talks to cancer biologist Dr. Marsha Rosner, who is a Professor of Cancer Research at the University of Chicago. Her lab focuses largely on understanding the biochemical signaling mechanisms that lead to the generation of tumor cells, as well as how and why cancer cells metastasize, which is when they travel from one part of the body to another.
Nick and Dr. Rosner and discuss mainly a recent study she led about the antiviral effects of cannabidiol (CBD) against SARS-CoV-2, including: why a cancer lab was working with CBD to begin with; what the results of her study actually show in terms of CBD’s antiviral effects; whether other cannabinoids showed this effect. She also commented on some misconceptions that have been circulating regarding this work, and described some of the clinical trials her team is running to measure CBD’s potential as an anti-COVID drug.
*Not medical advice.
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In Most CBD Cannabis Lines, the THC Gene Is Deleted Entirely | Kevin McKernan | 58
15 februari 2022 · 1 uur 43 min
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Kevin McKernan is a renowned leader in DNA sequencing technology. He led a research team part of the original Human Genome Project and is the founder and Chief Science Officer of Medicinal Genomics, a life sciences company that distributes genetics-based platforms for quality and safety testing of legal cannabis.
Nick and Kevin discussed the Cannabis genome, the genome of Psilocybe cubensis (magic mushrooms); Polymerase Chain Reaction (PCR) technology, how it works, and how it's used for COVID-19 testing; cannabinoids such as cannabidiol (CBD) and recent research indicating their potential anti-SARS-CoV-2 effects; blockchain technology for genomics data; and mRNA vaccines and SARS-CoV-2.
*Not medical advice.
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She Says There Is No Sci-Hub Team. She Has Always Run It Alone | Alexandra Elbakyan | 57
10 februari 2022 · 38 min
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Nick talks to Alexandra Elbakyan, the founder of Sci-hub, a shadow library website that provides free access to millions of research papers and books, without regard to copyright, by bypassing publishers' paywalls in various ways. Sci-hub is used by millions of people around the world each month, granting them free and easy access to scientific research findings.
Nick spoke to Alexandra about how Sci-hub works, why she built it, and some of the legal challenges she has faced from large scientific publishing corporations. This conversation was conducted with a professional Russian-English translator, whose voice you will hear in the recording in place of Alexandra's.
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Probiotics After Antibiotics Can Delay Your Gut's Natural Recovery | Suzanne Devkota | 56
3 februari 2022 · 1 uur 14 min
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Nick talks to Dr. Suzanne Devkota, a microbiologist whose lab studies the gut microbiome in health and disease.
They discuss a variety of topics related to the gut microbiome: how it is influenced by diet; how antibiotics and probiotics affect it; different disease states and metabolic disorders, such as IBS and obesity; how gut microbes can affect the brain and behavior; the microbiome beyond the gut, including the skin; and more.
*Not medical advice.
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Rats on Junk Food Did Worse on Memory Tests Within Days | Amy Reichelt | 55
27 januari 2022 · 1 uur 36 min
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Nick talks to Dr. Amy Reichelt, a neuroscientist and expert on the effects of diet and nutrition on the brain. They discussed how the brain is wired to help us learn about food, how what we eat influences the function of circuits within the brain, how certain diets can actually cause damage to the brain and negatively impact learning, obesity, and other topics related to nutrition and feeding behavior in humans and animals. They also discuss the potential role that psychoactive drugs like psychedelics may have to play in treating food addiction.
*Not medical advice.
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Dinosaurs Grew Far Faster Than Any Other Reptile We Know Of | Paul Barrett | 54
20 januari 2022 · 1 uur 59 min
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Nick talks to Dr. Paul Barrett, a paleontologist at the Natural History Museum in London, UK. Paul has spent nearly 30 years as a paleontologist studying the evolution and biology of dinosaurs and other extinct reptiles. He has authored over 200 scientific papers, and his speciality is in non-avian dinosaurs.
Nick talked to Paul about all things dinosaurs, including what a dinosaur actually is; how and when dinosaurs first evolved, changed over time, and eventually went extinct; what we know about dinosaur behavior, morphology, and physiology; which dinosaurs had feathers and what colors they had; Tyrannosaurus rex and Velociraptor; the evolution of mammals; the movie Jurassic Park; and why understanding the life's past is important for understanding life in the present.
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A Study Found 28% THC Didn't Feel Stronger Than 22 to 25% | Reggie Gaudino | 53
13 januari 2022 · 1 uur 30 min
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Nick talks to Dr. Reggie Gaudino, a molecular geneticist and expert in the phytochemistry, biochemistry, genomics, and breeding of commercial Cannabis. He is the former Chief Science Officer of Steep Hill, one of the first cannabis testing labs in the US, and is currently VP of Research & Development at Frontrange Biosciences.
Nick & Reggie discuss various topics related to the science of commercial Cannabis, including: it's botanical characteristics and history, the ecological reasons for why it produces psychoactive and other compounds, some of the major cannabinoids and terpenes found in Cannabis, and whether or not popular labelling systems in the legal cannabis industry (e.g. "Indica" vs. "Sativa") will tell you anything useful about the effects a product is likely to have.
*Not medical advice.
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Lab Rodents Show More Pain When a Woman Runs the Test Than a Man | David Roberson | 52
6 januari 2022 · 1 uur 43 min
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Nick Jikomes talks to Dr. David Roberson, a neuroscientist and co-founder of three ongoing biotech companies: Nocion Therapeutics, Blue Therapeutics, and Blackbox Bio. David is an expert in the neuroscience of pain and the conversation focuses mainly on pain: how does our brain sense and perceive pain? Why does pain sometimes become chronic, and last for a long-time? How do various classes of pain drugs work to relieve pain?
They discuss NSAIDs and opioids, including oxycodone, heroin, and fentanyl, as well as some interesting novel pain drugs currently in development.
A portion of the podcast has a visual component, where David shows some of the technology he has helped develop that allows for automated, high-throughput measurements of animal behavior to detect and measure pain. Towards the end, they also discuss how this tech could be used for the characterization of novel psychoactive drugs and psychedelics.
*Not medical advice.
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Past Dunbar's ~150 People, Organizations Turn Political, He Argues | Alexandros Marinos | 51
30 december 2021 · 1 uur 33 min
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Nick talks to Alexandros Marinos, PhD, founder & CEO of the edge computing technology startup, Balena. They discuss the internal organization of complex human systems.
Alex talked about how he thinks about the organizational structure of his own company and how organizational structures impact group dynamics, growth, conflicts of interest, and innovation. One interesting area Alex provided commentary and analysis on towards the end is how to make sense of the behavior of large institutional organizations, such as the Centers for Disease Control (CDC).
If you’re interested in complex systems like human organizations, how the internal structures of different organizations influence what they do and how they behave, and why human organizations can sometimes behave in deranged ways, this episode will be of interest to you.
*Not medical advice.
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These Vaccine Vials Get a Glass Layer ~1,000x Thinner Than a Hair | Christopher Weikart | 50
23 december 2021 · 58 min
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Nick Jikomes talks to materials scientist Dr. Chris Weikart, who is currently chief scientist at SiO2, an advanced materials science company that combines chemistry and engineering to create containers and surfaces for use by biotechnology, genomics, diagnostics, and consumer products companies.
They discuss how SiO2 created a new kind of vaccine vial, which combines both glass and plastic that are superior for storing and transporting biologics, such as vaccines. SiO2 is currently producing an enormous number of these vials for Moderna’s mRNA vaccines for COVID-19. Chris described how the vials are made, and what they’re made of, as well as what materials science is and how important it is to society. This conversation also gives you a sense of different parts of the COVID-19 vaccine supply chain and how they fit together.
*Not medical advice.
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The Twin Who Used More Cannabis Showed No Extra Psychosis Signs | Jonathan Schaefer | 49
16 december 2021 · 1 uur 27 min
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Nick talks to Dr. Jonathan Schaefer about the link between adolescent cannabis (marijuana) use and psychosis.
Jonathan has a PhD in clinical psychology and he is currently a research psychologist at the University of Minnesota Institute of Child Development. His research focuses largely on the relationship between people’s environments that influence their mental health. He has conducted a number of longitudinal studies using cohorts of identical and fraternal twins, which allow him to tease apart the role of genetic vs. environmental factors in different psychiatric outcomes.
The conversation focuses mainly on recent twin studies Dr. Schaefer has done looking at the relationship between adolescent cannabis (i.e. marijuana) use, and psychosis. They talk about what psychosis is and what factors are linked to it, historical work on the relationship between cannabis use and psychosis, and the results of Jonathan's recent twin studies & what they mean.
*Not medical advice.
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Injury to the Newborn Cerebellum Raises Autism Risk 30 to 40 Fold | Sam Wang | 48
9 december 2021 · 1 uur 18 min
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Nick Jikomes talks to Sam Wang, PhD professor of neuroscience at Princeton University. Dr. Wong’s lab investigates how brains learn from sensory experience, in adulthood and development, with relevance for autism. A lot of their work focuses on a part of the brain called the cerebellum.
They talk about the cerebellum and what we’re learning about its functions, as well as how it’s tied to autism, and what the causes and nature of autism actually are. This included both the genetic and environmental risk factors for autism, and how to think about treatment. Lastly, they talk about another side of his work, which is related to using data and science to help repair our democracy by combatting things like congressional gerrymandering.
*Not medical advice
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A Beef Stew Spiked His Blood Sugar Twice as Much as Ice Cream | Nathan Price | 47
2 december 2021 · 1 uur 43 min
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Nick Jikomes talks to Dr. Nathan Price, who has a Ph.D. in bioengineering and has been faculty at the University of Washington and the Institute of Systems Biology. He was also CEO of a health intelligence startup called Onegevity, which recently merged with Thorne HealthTech, where he is the Chief Science Officer.
Nathan and Nick discussed various topics in personalized medicine, digital phenotyping, and systems biology, including metabolism and blood sugar monitoring, the microbiome and diet, aging and longevity, and more. They discussed the basic biology of these things as well as different emerging technologies related to health monitoring.
*Not medical advice.
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Depression Shrivels Neurons, and Psychedelics Regrow Them | David Olson | 46
24 november 2021 · 1 uur 7 min
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Nick Jikomes talks to medicinal chemist Dr. David Olson whose lab at the University of California-Davis studies a class of compounds called ‘psychoplastogens,’ which are small molecules capable of promoting neural plasticity. His lab is on the cutting edge when it comes to understanding the mechanisms by which psychedelics and other psychoactive drugs work in the brain. They touch on: latest research from his lab, new tools they're developing and using to understand these drugs, whether it’s likely that we'll be able to produce non-hallucinogenic drug variants of classic psychedelics, and microdosing.
*Not medical advice.
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In 2012, Six Miners Fell Sick in a Bat Cave and Three of Them Died | Alina Chan | 45
16 november 2021 · 1 uur 27 min
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Nick Jikomes talks to genetic engineer Dr. Alina Chan about the origins of the SARS-CoV-2 virus responsible for the COVID-19 pandemic. They discuss Alina's new book, "Viral: The Search For the Origin of COVID-19," which she co-wrote with Matt Ridley. The book thoroughly documents the events & people relevant to COVID's origins. They discuss everything from the original SARS-1 epidemic in China, wildlife spillover vs. accidental lab leak hypotheses; pangolins, bats, and other animals; SARS-CoV-2 genome; institutions and people like Francis Collins, the NIH, WHO, and EcoHealth Alliance.
*Not medical advice.
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A Brain 'Complexity' Score Reveals Awareness in Unresponsive Patients | Anil Seth | 44
11 november 2021 · 1 uur 34 min
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Nick talks with Dr. Anil Seth, a neuroscientist and professor of cognitive & computational neuroscience at the University of Sussex. The conversation is all about the neuroscience of consciousness, which is the subject of his Dr. Seth's book, “Being You: A New Science of Consciousness.“
They touch on everything from what consciousness actually is, whether or not neuroscientists can measure different levels of consciousness in the brain, what characterizes psychedelic experiences and non-ordinary states of consciousness in terms of the brain, and the nature of perception. In particular, they discuss ideas related to the notion that our conscious perceptions are a kind of inference, or guess, our brain’s are making about the world, as well as the idea that all of our conscious perceptions are "controlled hallucinations."
They also discuss: exteroception (perceiving things outside the body, like objects); interoception (perceiving things within the body); and emotion. Lastly, Nick gets Anil’s take on whether consciousness is an evolutionary adaptation and psychedelics.
*Not medical advice.
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Dreams May Exist to Keep Your Brain From Overfitting Reality | Erik Hoel | 43
4 november 2021 · 1 uur 27 min
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Nick talks to neuroscientist and writer Dr. Erik Hoel. Erik is a professor of biology at Tufts University. He received his PhD in neuroscience from the University of Wisconsin, where he studied under the sleep and consciousness researcher, Giulio Tononi. He did postdoctoral work at Columbia University, where he used information theory and other analytical tools to explore the biological basis of consciousness. He has come up with the so-called Overfitted Brain Hypothesis of dreaming, which explains the potential adaptive function of dreams by drawing analogies to techniques used to train Deep Neural Networks in the world of machine learning.
Erik and Nick discuss the biology and phenomenology of dreams and sleep generally, including some of the various theories for why we sleep. They also discuss Deep Learning (on a very basic level) and Erik described the Overfitted Brain Hypothesis of dreaming. They also discuss fiction and the arts, including Erik’s new novel and the potential evolutionary reasons for why humans create and consume fiction, as well as some technology-driven developments that are reshaping how we create and consume written work online.
*Not medical advice.
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CBD Can Cancel Out THC's Anxiety and Psychosis Effects | Steven Laviolette | 42
27 oktober 2021 · 1 uur 21 min
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Nick Jikomes talks to Dr. Steven Laviolette, a neuroscientist at the University of Western Ontario. They discuss how different types of drugs impact emotion, cognition, brain development and the development of psychiatric conditions (e.g. addition, schizophrenia); drug interactions (THC + CBD, THC + L-Theanine, CBD + Omega-3 Fatty Acids), how drugs can affect brain development when consumed during adolescence, or by pregnant women; how cannabinoids interact with opioids in different ways.
*Not medical advice.
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Swallowed Cannabinoids Deliver Only About 10% to Your Bloodstream | Saoirse O'Sullivan | 41
21 oktober 2021 · 1 uur 23 min
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Nick Jikomes talks to Saoirse O'Sullivan, PhD, a physiologist specializing in the physiological effects of cannabinoids. Dr. O'Sullivan ran a lab at the University of Nottingham for many years before becoming a consultant and Vice President of Translational Research at Artello Biosciences.
They discuss some of the physiological effects of cannabinoids in the body, including endogenous cannabinoids our own bodies produce, and plant cannabinoids associated with the Cannabis plant (e.g. THC, CBD, THCV, and CBG). They cover: inflammation, brain injury, the blood-brain barrier, gut health, the cardiovascular system. Near the end, Saoirse also described why she eventually transitioned from academia to the private sector, and what motivated her decision to do so.
*Not medical advice.
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Most People Who Use an Addictive Drug Never Become Addicted | Christian Luscher | 40
14 oktober 2021 · 1 uur 8 min
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Christian Luscher, MD, PhD is a neuroscientist and neurologist who runs a research lab at the University of Geneva in Switzerland. Dr. Lusher's lab studies the mechanisms that underlie drug reinforcement and addiction in the brain and he is an expert in the neuroscience of drug addiction.
Christian talks to Nick about: what is addiction is and what some key parts of the brain and neurotransmitter systems are involved in drug addiction; differences in the addictive potential of different types of drugs, ranging from stimulants (e.g. cocaine, nicotine, caffeine) to cannabinoids (e.g. THC), opioids, and psychedelics; the difference between addiction vs. dependency, habitual vs. goal-directed behavior; latest research on how dopamine & serotonin systems in the brain are both involved in drug-seeking behavior.
*Not medical advice.
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SARS-CoV-2 Lacks the Telltale Signs of a Natural Origin, He Argues | Nicholas Wade | 39
30 september 2021 · 1 uur 13 min
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Nick Jikomes talks to writer and science journalist Nicholas Wade about the origins of the SARS-CoV-2 virus and the COVID-19 pandemic. Nicholas describes how this story has evolved since the start of the pandemic, and contrasts the the two main hypotheses for the origins of COVID: wildlife spillover vs. lab leak. He describes how viruses in the past (e.g. SARS1) emerged, peculiarities of the SARS2 genome, Peter Daszak & EcoHealth Alliance, Wuhan Institute of Virology, and various conflicts of interest that people have had. He describes how we don't have proof whether a wildlife spillover or a lab leak explains the origins of COVID-19, what definitive evidence would look like, and whether we are likely to resolve this mystery.
*Not medical advice.
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Homo Naledi Had a Tiny Brain Yet May Have Buried Its Dead | Lee Berger | 38
24 september 2021 · 1 uur 25 min
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Nick Jikomes talks to paleoanthropologist Dr. Lee Berger about human evolution. Dr. Berger is a professor of anthropology in South Africa, explorer-in-residence for National Geographic, and author of, "Becoming Human." Lee's team has mapped and explored caves all over South Africa, discovering a treasure trove of ancient human fossils. This includes the discovery of Homo naledi, an ancient human ancestor that had a much smaller brain than humans, but may have nonetheless appear to have had advanced cognitive abilities. Lee described the discovery of Homo naledi, human brain evolution, and why we are in a gold age of paleoanthropology.
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Before the Eyes Open, the Brain Rehearses Vision With Spontaneous Waves | Michael Crair | 37
17 september 2021 · 1 uur 17 min
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Nick talks to physicist and neuroscientist Dr. Michael Crair. Michael runs a lab at Yale University studying mechanisms of brain development. He discussed research related to neural plasticity, learning & memory, sensory maps, and critical periods of plasticity. Dr. Crair also described recent findings from his lab show that parts of the developing brain can simulate future sensory experiences, before animals ever open their eyes and see the external world.
*Not medical advice.
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Dating Apps Give 20% of Men 80% of Women's Interest | Heather Heying & Bret Weinstein | 36
9 september 2021 · 2 uur 49 min
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Applying evolutionary principles to navigate modern challenges like health, culture, and society. Not medical advice.
TOPICS DISCUSSED:
Human niche as niche-switching: Humans uniquely adapt by changing behaviors and environments, enabling survival across diverse conditions, unlike specialized animals.
Culture vs. consciousness: Culture encodes efficient, habitual behaviors passed down generations, while consciousness drives innovation in novel situations, creating a balance disrupted by modernity.
Omega Principle: Cultural traits serve genetic fitness, being flexible but subordinate to genes, explaining why behaviors like traditions persist if beneficial.
Mismatches in modern medicine & diet: Overuse of antibiotics harms microbiomes; processed foods and supplements often ignore evolutionary contexts, leading to health issues like deficiencies or imbalances.
Chesterton’s Fence: Before removing traditions or biological features (e.g., appendix as microbiome reservoir), understand their function to avoid unintended harms.
Childhood & education: Formal schooling is recent; pre-modern learning via observation and mixed-age groups fostered independence, unlike today’s systems that externalize motivation.
Religion’s adaptive role: Religions are evolved packages of metaphorically true behaviors that aid group success, not literal truths, but essential for cohesion.
Civilizational senescence: Societies accumulate innovations with early benefits but late costs (e.g., pollution), mirroring biological aging, requiring navigation to sustainable systems.
ABOUT THE GUEST: Bret Weinstein and Heather Heying are evolutionary biologists who studied under renowned figures like Robert Trivers and Richard Alexander; Weinstein holds a PhD in evolutionary biology from the University of Michigan, while Heying, with an anthropology background, conducted fieldwork on poison frogs in Madagascar. They co-authored “A Hunter-Gatherer’s Guide to the 21st Century.”
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One Brain Rhythm Can Detach Your Sense of Self From Your Body | Karl Deisseroth | 35
3 september 2021 · 1 uur 39 min
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Nick talks to Stanford psychiatrist and neuroscientist Dr. Karl Deisseroth. They discuss a range of topics about the brain, including autism, depression, bipolar disorder, dissociation, and more. They also talk about optogenetics, a technique Karl co-developed which uses light to control specific neurons in the brain, allowing neuroscientists to turn circuits in the brain on and off to reveal how the brain generates perception, emotion, and behavior. They also talk about Karl's new book, "Projections: A Story of Human Emotion."
*Not medical advice.
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At Yale, More Students Come From the Top 1% Than the Bottom 60% | Rob Henderson | 34
27 augustus 2021 · 1 uur 21 min
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Nick to talks to psychology student Rob Henderson about social status, social signaling, luxury beliefs, and related topics in social psychology and human behavior.
*Not medical advice.
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He Synthesized Much of the LSD Used in Modern Research Studies | David Nichols | 33
19 augustus 2021 · 1 uur
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Nick talks to medicinal chemist Dr. David Nichols, who has spent decades studying the chemistry and pharmacology of psychedelics. Dr. Nichols shared his knowledge of psychedelic tryptamines, including LSD and DMT, as well as phenethylamines, such as mescaline and MDMA. He also discussed his relationship with the late Dr. Alexander "Sasha" Shulgin and how his thoughts on companies trying to make non-hallucinogenic drugs derived from psychedelics.
*Not medical advice.
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The Alpha Variant Likely Evolved Inside One Chronically Infected Person | Sarah Otto | 32
11 augustus 2021 · 1 uur 8 min
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Nick talks with evolutionary biologist Dr. Sarah Otto about the evolutionary dynamics of SARS-CoV-2, the emergence of new variants, whether she thinks we will need shots every year (like with the flu), mRNA vaccines, and more.
*Not medical advice.
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The Brain Runs Reward and Punishment on Two Separate Systems | Aaron Gruber | 31
6 augustus 2021 · 1 uur 41 min
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Nick talks to neuroscientist Dr. Aaron Gruber about topics related to cognition and learning in the brain, including what we know about how the brain detects salience and assigns value, makes decisions, and constructs flexible models of the world, sometimes called ‘schemas.’ They also discuss how neuropsychiatric disorders like depression can influence the brain’s schemas, as well as how they can be impacted by psychoactive drugs, ranging from stimulants to psychedelics.
*Not medical advice.
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A Single Dose of Psilocybin Grew New Neural Connections Within Hours | Alex Kwan | 30
16 juli 2021 · 1 uur 18 min
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Nick talks to applied physicist and neuroscientist, Dr. Alex Kwan. His lab studies how neuropsychiatric drugs, such as psilocybin and ketamine, affect neural circuits in the brain’s of mice. They discuss how his lab actually conducts this research, what they have discovered so far, and look at some real data, images and movies of neurons in the brain, which you can see for yourself in the video version on YouTube.
*Not medical advice.
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Ketamine Lifts Depression in Hours, While SSRIs Take Weeks | Lisa Monteggia | 29
9 juli 2021 · 1 uur 33 min
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Nick talks to neuroscientist Dr. Lisa Monteggia about research on psychiatric disorders of the brain. Lisa described how psychiatric disorders like depression manifest in the brain, how traditional anti-depressant drugs like SSRIs work in the brain, and her research on how the drug ketamine can have rapid depressant effects in treatment-resistant patients.
*Not medical advice.
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A Molecule's Complexity Alone Can Reveal Whether Life Made It | Lee Cronin | 28
25 juni 2021 · 1 uur 43 min
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Nick talks to chemist Dr. Lee Cronin about life: how it originated on Earth, how we might detect signs of alien life in the universe, whether it can be created in the lab, and related topics. Lee talked about his work on "assembly theory," which provides a framework for thinking about these questions and providing an unbiased way to detect signatures of life in the universe. They also discussed how some of these ideas might relate to evolution, selection, consciousness, and time.
*Not medical advice.
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Genome Sequencing Fell From $3 Billion to Under $1,000 | George Church | 27
18 juni 2021 · 1 uur 1 min
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Harvard-MIT geneticist George Church, PhD talks about advances in genome sequencing and editing technologies, interesting biotech startups using CRISPR genome editing to tackle human disease, and interesting areas in synthetic biology. Dr. Church also discussed how he has coped with both narcolepsy and dyslexia throughout his life, and became a successful scientist despite have these brain disorders.
*This content is never meant to serve as medical advice.
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After MDMA Therapy, 67% No Longer Qualified as Having PTSD | Berra Yazar-Klosinski | 26
11 juni 2021 · 1 uur 49 min
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Nick talks to Dr. Berra Yazar-Klosinski, the Chief Science Officer for the Multidisciplinary Association for Psychedelic Studies (MAPS). Berra talked about the results of MAPS' recent Phase III clinical trials for treating severe PTSD, how these studies are conducted, and what we know about the underlying biology of Post-Traumatic Stress Disorder (PTSD) and the drug MDMA.
*Not medical advice.
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On DMT, the Brain Slips Into Something Much Like Dreaming | Chris Timmermann | 25
4 juni 2021 · 1 uur 32 min
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Nick talks to neuroscientist & psychologist, Dr. Chris Timmermann, a scientist at the Centre for Psychedelic Research at Imperial College London. Chris led the first neuroimaging studies on the effects of the potent tryptamine psychedelic DMT on the brain. They discussed DMT and related psychedelics, including how DMT is normally consumed in both recreational and laboratory contexts, how people describe its effects, how it compares to psychedelics like psilocybin and LSD, and whether it is an endogenous compound present in our own bodies. Chris also described his research on how DMT affects patterns of brain activity, and what he hopes to learn from ongoing research, which includes extending the duration of DMT experiences from a few minutes up to 30 minutes per session.
*Not medical advice.
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About 70% of Your Immune Cells Live in Your Gut | Emeran Mayer | 24
28 mei 2021 · 1 uur 50 min
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Nick talks to gastroenterologist and neuroscientist, Dr. Emeran Mayer. Emeran is a distinguished professor at UCLA and an expert in gut health and the microbiome. His last book was titled, “The Mind-Gut Connection: How the Hidden Conversation Within Our Bodies Impacts Our Mood, Our Choices, and Our Health.” His latest book builds on this, and is titled, “The Gut-Immune Connection.”
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Six Years After a Psilocybin Trial, He Still Hasn't Had a Drink | Jon Kostakopoulos | 23
21 mei 2021 · 1 uur 20 min
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Nick talks to Jon Kostakopoulos, an early participant in an NYU study looking at psilocybin for the treatment of alcoholism. Jon went through psilocybin-assisted psychotherapy over the course of many weeks for this study, which included three separate days of psilocybin administration. He talked about his battle with alcoholism leading up to the study, how he was recruited to the study, and what his psilocybin experiences were like. He also shared what he has been doing since his psilocybin experiences, including founding Apollo Pact, a non-profit working to advance research into the therapeutic potential of psilocybin.
*Not medical advice.
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Mouse Behavior Breaks Into About 60 Reusable 'Syllables' | Alex Wiltschko | 22
14 mei 2021 · 1 uur 41 min
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Nick talks to neuroscientist and machine learning engineer, Alex Wiltschko, PhD. Alex is a senior scientist at Google Brain, where he leads the digital olfaction group, where are working to build machines with a sense of smell. Alex received a PhD in neurobiology from Harvard, where he developed sophisticated machine vision and machine learning techniques to study animal behavior. They discussed Alex's research, the neuroscience of olfactory perception and animal behavior, as well as Alex's thoughts on topics related to machine learning and artificial intelligence.
*Not medical advice.
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Scientists Still Can't Agree on a Definition of Life, He Says | Carl Zimmer | 21
7 mei 2021 · 1 uur 27 min
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Nick talks to science writer and NYT columnist Carl Zimmer about his new book, "Life's Edge: The Search For What It Means To Be Alive." They discuss the scientific quest to understand life: what is it, how does it arise, and how might scientists identify it elsewhere in the universe? They also discuss Carl's approach to science writing, including where he draws inspiration and what his writing process looks like.
*Not medical advice.
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Only Humans Use True Symbols, and That Reshaped Our Brains | Terrence Deacon | 20
29 april 2021 · 2 uur 49 min
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Nick talks to biological anthropologist and cognitive scientist, Terrence Deacon. The conversation focuses on ideas from Terrence's book, "The Symbolic Species: The Co-Evolution of Language and the Brain." They spend nearly three hours talking about the origins of language. Topics include: what is language and how does it differ from animal communication? How do children acquire language so easily at a young age? What is symbolic cognition, how is it different from other forms of cognition, and how did this unlock our ability to evolve language?
See my other conversation with Terrence Deacon, "Purpose, Value, Evolution, Consciousness, Sentience, Life & Emergence of Mind From Matter"
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CBD Lowered Craving and Anxiety in People With Heroin Addiction | Yasmin Hurd | 19
23 april 2021 · 1 uur 17 min
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Nick talks to Dr. Yasmin Hurd, a neuroscientist studying medical cannabis, CBD, and opioid addiction. Dr. Hurd is investigating the ability of CBD to help treat withdrawal symptoms and prevent relapse in opioid-addicted individuals.
*Not medical advice.
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SARS-CoV-2 Was Well Adapted to Humans From the Very Start, She Says | Alina Chan | 18
16 april 2021 · 1 uur 29 min
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Nick talks to genetic engineer Alina Chan, PhD. She is working on engineering new forms of gene therapy using viral vectors to target diverse patient populations. In addition to her core scientific focus, Alina has recently investigated genomic data related to SARS-CoV-2, the virus responsible for the COVID19 pandemic.
They discuss the basics of virus biology, including what kind of virus SARS-CoV-2 is and how it infects human cells. They also talked about the published research on this virus that has come out in the past year, Alina's recent investigations into the origins of this virus and why it’s crucial for humanity to understand exactly how this virus originated, as well as new variants that have emerged, and where this virus might be going.
*This content is never meant to serve as medical advice.
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Top Journals Reject About 98% of the Papers Submitted | Michael Eisen | 17
9 april 2021 · 1 uur 57 min
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Nick talks to Dr. Michael Eisen, a biologist at UC-Berkeley and editor-in-chief for eLife, a non-profit open access science journal. Throughout his career, Dr. Eisen has been an advocate of open science, the free release of the results of scientific research, and has been critical of traditional forms of scientific publishing, which often place scientific results behind a paywall.
They discuss a variety of topics related to how academic science is conducted, including how it gets funded and what is involved in running a research lab. Much of the discussion centers on the business of scientific publishing, including what scientific journals are and their history, as well as the business models of for-profit journals and how they work. They also talk about open access journals and new ways that people are using technology to get around paywalls.
Scientific publishing is an industry that most people have little awareness of (including many scientists), and the size and profitability of large scientific publishing groups may surprise you.
*Not medical advice.
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Wake Someone During REM and About 80% Will Report a Dream | Bob Stickgold | 16
2 april 2021 · 1 uur 44 min
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Nick talks to Dr. Bob Stickgold, a cognitive neuroscientist and sleep expert. Dr. Stickgold is a professor of psychiatry at Harvard Medical School and has been studying sleep, dreams, and memory for over 25 years.
They discuss a variety of sleep topics, included sleep architecture and why there are different stages of sleep; the relationship between sleep stages and memory; how different drugs and disease states relate to sleep; how sleep differs as we develop and between species. Dr. Stickgold also shares various sleep-related health tips, including why it's important to get adequate sleep when you get vaccinated.
*Not medical advice.
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Chemical Analysis of Magic Mushrooms of the Pacific Northwest | Michael Beug | Bonus Episode
1 april 2021 · 28 min
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This bonus episode is a lecture given by mushroom expert Dr. Michael Beug (probably from the 1980s). Professor Beug describes the results of his work analyzing the chemical contents of various psilocybin-containing ("magic") mushrooms native to the Pacific Northwest. You'll learn some interesting observations about different Psilocybe mushrooms, including how psilocybin content varies across species, and which species tend to be the most potent.
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