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315 afleveringen, van nieuw naar oud
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Cannabis Use Has Jumped Over 400% Among People 55 and Older | Ziva Cooper | 15
26 maart 2021 · 1 uur 30 min
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Dr. Ziva Cooper, Director of the UCLA Cannabis Research Initiative, discusses the latest medical cannabis research. She goes into everything from the potential interactive of effects of cannabinoids and terpenes, to the efficacy of cannabidiol (CBD), to sex- and age-dependent differences in how cannabinoids affect the body.
*Not medical advice.
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He Engineers Yeast to Brew Cannabinoids Without the Plant | Jeff Ubersax | 14
20 maart 2021 · 1 uur 20 min
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Nick Jikomes talks to Jeff Ubersax, PhD, CEO of the biotechnology company Demetrix (who supported this episode). Jeff discussed the science behind how Demetrix is engineering baker's yeast to produce cannabinoids at an industrial scale, with a focus on making rare cannabinoids other than THC and CBD.
Jeff also discussed how he transitioned from academic science to running his own company, and offered advice for academic scientists in training who might be thinking about moving into biotechnology.
Episode Support: This episode was supported by Demetrix, a biotechnology company using cutting edge fermentation technology to produce rare cannabinoids that are safe, legal, and effective for health and wellness.
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Monk Parakeets Appear to Know the Whole Group's Pecking Order | Elizabeth Hobson | 13
12 maart 2021 · 1 uur 33 min
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Nick talks to Elizabeth Hobson, PhD, whose lab studies the evolution of decision-making, social cognition, social networks, and dominance hierarchies using a combination of naturalistic field observations of animal behavior combined with computational modeling and network analysis.
They discuss social behavior in animals, including when and why members of a group display aggression, how animal dominance hierarchies form and change, and how changes in the environment can cause sudden “tipping points” where group behavior suddenly changes. We also discussed whether human societies may be near tipping points today, and how changes due to COVID have impacted remote learning.
*Not medical advice.
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Double an Animal's Size and Each Cell Needs Only 75% as Much Energy | Geoffrey West | 12
5 maart 2021 · 1 uur 56 min
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Nick talks to theoretical physicist Dr. Geoffrey West about the universal scaling laws that describe how organisms, companies, and cities grow and die. Dr. West is the Shannan Distinguished Professor and former President of the Santa Fe Institute, as well as author of, "Scale: The Universal Laws of Life, Growth, and Death in Organisms, Cities, and Companies."
*Not medical advice
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The Pain-Free Woman Had the Highest Anandamide He Ever Measured | Matthew Hill | 11
27 februari 2021 · 1 uur 46 min
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Nick talks to Dr. Matthew Hill about the role of the endocannabinoid system in regulating stress and emotional behavior. They also discuss how plant cannabinoids from Cannabis, such as THC and CBD, impact the endocannabinoid system.
*Not medical advice.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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A Gene Inherited From Neanderthals Cuts COVID Risk by About 30% | John Hawks | 10
19 februari 2021 · 2 uur 26 min
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Nick talks to paleoanthropologist John Hawks about the story of human evolution.
Listen to a more recent conversation with John Hawks.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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Whole-Plant CBD Controlled Seizures at 1/5 the Dose of Pure CBD | Ethan Russo | 9
15 februari 2021 · 1 uur 33 min
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Nick talks to neurologist and plant medicine expert Dr. Ethan Russo about medical cannabis and related topics, such as cannabinoids (e.g. THC, CBD, CBG, THCV), terpenes (myrcene, limonene, beta-caryophyllene), endocannabinoid biology, and Ethan's thoughts on the legal cannabis industry, including whether the terms "Indica" and "Sativa" are meaningful.
*Not medical advice.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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Block the 5-HT2A Receptor and a Classic Psychedelic Stops Working | Katrin Preller | 8
6 februari 2021 · 1 uur 12 min
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Nick talks to neuropsychologist Katrin Preller, PhD about psychedelics like LSD and psilocybin, empathogens like MDMA, and stimulants like cocaine. Katrin explains how each type of drug affects the brain differently and what that means for their impact on empathy, social cognition, and their addictive potential.
*Not medical advice.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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Ibogaine Is Real Psychotherapy: The Most Logical Night of His Life | Hamilton Morris | 6
1 februari 2021 · 2 uur 6 min
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Hamilton Morris discussing his documentary series on psychoactive drugs, their science, cultural impacts, and misconceptions.
Topics Discussed:
Origins of Hamilton's Pharmacopeia: Started as a column and web series to provide honest, science-based discussions on drugs, countering 1990s media stigma.
Drug education and media bias: Traditional scare tactics fail; honest information fosters better relationships with substances, as seen in parallels with abstinence education.
Methamphetamine misconceptions: Often stigmatized due to class differences, not pharmacology; similar to amphetamine, with FDA-approved uses for ADHD and obesity.
Xenon gas as an anesthetic: A noble gas inducing euphoria via NMDA antagonism; harvested from air, it's expensive but potentially ideal for medical use.
Ketamine and dissociatives: NMDA antagonists like ketamine offer rapid antidepressant effects; experiences are dose-dependent, from alcohol-like to visionary out-of-body states.
Ibogaine in Bwiti rituals: Used for addiction treatment in Gabon; induces logical self-reflection, challenging Western views on psychedelics and spirituality.
Drug regulation ideals: Advocate for freedom with quality controls, like food regulations; decriminalization alone lacks purity safeguards.
Future projects: Shifting to chemistry research on psychedelics; highlights challenges in documentary production and value of synthesis education.
*Not medical advice
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Salvia's Molecule Is the Most Potent Natural Psychedelic Known | Peter Addy | 7
30 januari 2021 · 1 uur 36 min
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Nick talks to Peter Addy, PhD about the atypical, dissociative psychedelic, salvia. Peter is a psychotherapist and spent several years at the Yale, studying human experiences with atypical psychedelics such as Salvia divinorum.
Nick and Peter talked about salvia, including how it works and how it differs from other psychedelics, as well as dissociative and dysphoric effects, and how his research has informed his psychotherapy practice.
*Not medical advice.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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Cannabis Dependency Hits About 9% of Regular Users, Like Caffeine | Jon Page | 5
16 januari 2021 · 2 uur 43 min
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Jonathan Page, PhD is a botanist and entrepreneur with deep expertise in Cannabis. Nick and Jon talked about all things Cannabis science including the botany and natural history of Cannabis, the chemistry and biology of Cannabis and its psychoactive effects, and whether or not different types of Cannabis can cause different effects. Jon also shared amazing stories about transitioning from scientific research to starting, building, and selling a cannabis company, and his thoughts on what’s next for the cannabis industry.
*Not medical advice.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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About a Third of All Prescribed Drugs Act on One Receptor Family | Bryan Roth | 4
9 januari 2021 · 1 uur 49 min
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Bryan Roth, MD, PhD discusses his career studying how psychedelics and other psychoactive drugs affect the brain, the massive $27 million research effort he is leading to understand psychedelics and develop novel drugs for psychiatric disease, and the practice of zen meditation.
*Not medical advice.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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Chance, Not Just Selection, Shapes Who You Are, He Argues | Sean B. Carroll | 3
1 januari 2021 · 1 uur 37 min
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Sean B. Carroll, PhD is an award-winning biologist, author, and filmmaker. Nick and Sean discuss everything from Sean's unique career trajectory and writing process, to dinosaurs and snake venom, to COVID19, the evolution of viruses, and why comedians and scientists are kindred spirits.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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A Psychedelic Was 100x Stronger Than a Steroid Against Inflammation | Charles Nichols | 2
25 december 2020 · 1 uur 53 min
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Dr. Nichols is a professor of pharmacology at Louisiana State University. He has been studying the molecular, genetic, and behavioral effects of psychedelics for nearly 25 years and is considered one of the world’s top experts on the biological effects of psychedelics in the brain and body.
Nick spoke to Charles for almost two hours, covering a wide range of topics related to how psychedelics work. They discuss everything from how psychedelics impact the serotonin system in the brain, the similarities and differences between drugs like psilocybin and ketamine, how microdosing specific psychedelics can lead to potent anti-inflammatory effects, and much more.
*Not medical advice.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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An Ancient Greek Shrine in Spain Tested Positive for Ergotized Beer | Brian Muraresku | 1
14 december 2020 · 1 uur 30 min
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Brian is the author of the New York Times-bestselling book, "The Immortality Key: The Secret History of the Religion With No Name." Brian is fluent in Ancient Greek, Latin, and Sanskrit, and spent over a decade putting together an incredible story about the intentional use of psychoactive plants in the ancient world, including scientific evidence for the ritual use of spiked beers and wines.
Nick and Brian cover topics related to his book, including the use of psilocybin mushrooms in the present to treat end of life anxiety, how “Mystery Schools” in the ancient Greco-Roman world, such as Eleusis, may have utilized psychedelic beverages, the evidence for the potential widespread use of psychoactive plants in ritual settings in ancient times, and how this may have influenced early Christianity, and how psychedelic drugs may induce brain states similar to those produced in near-death experiences.
*This content is never meant to serve as medical advice.
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Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
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