Alle afleveringen
427 afleveringen, van nieuw naar oud
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Oct 30 2026 This Week in Cardiology
30 oktober 2026 · 33 min
The ASPIRED syncope RCT, two studies in coronary artery calcium scoring, and the LEAP-Block trial of CSP vs RV pacing are the topics John Mandrola, MD, discusses in this week’s podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Syncope
ASPIRED Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605812
REMOSYNCED Trial https://clinicaltrials.gov/study/NCT05066347
II TWO CAC Studies
Atherosclerosis in Young Adults and Risk of Mortality Over 30 Years https://jamanetwork.com/journals/jamacardiology/fullarticle/2855732
Predictive Utility of CAC Score Added to PREVENT Score https://jamanetwork.com/journals/jama/fullarticle/2853347
III Conduction System Pacing vs Standard RV Pacing for AV block
LEAP-Block Trial https://jamanetwork.com/journals/jama/fullarticle/2855975
Meta-analysis: CSP vs RV Pacing in Preserved or Mildly Reduced EF https://doi.org/10.1016/j.cjca.2026.04.009
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Oct 23, 2026 This Week in Cardiology Podcast
23 oktober 2026 · 33 min
Listener feedback on the nonobstructive HCM trials, AI-enhanced visits, timing of non-culprit PCI in STEMI, new tricuspid valve intervention, and EP at a crossroads are the topics John Mandrola, MD, discusses in this week’s podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Koelemen meta-analysis https://www.medrxiv.org/content/10.64898/2026.09.08.26362195v1.full.pdf
Improving SCD Risk Stratification in HCM https://pmc.ncbi.nlm.nih.gov/articles/PMC11026183/
II More on Nonobstructive HCM
Communication on Post-Hoc Analysis of ODYSSEY (mavacamten)
Mavacamten in Nonobstructive HCM 10.1016/j.jacc.2025.12.092
III Complete vs Staged PCI in STEMI With Multivessel Disease
Immediate vs Staged CR in Multivessel Disease and STEMI: Meta-Analysis https://doi.org/10.1016/j.jcin.2026.07.033
Timing of Nonculprit PCI for STEMI and Multivessel Disease: Editorial https://doi.org/10.1016/j.jcin.2026.08.009
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
FLOWER MI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2104650
FRAME AMI Trial https://doi.org/10.1093/eurheartj/ehac763
iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918
COCUA Trial https://doi.org/10.1016/j.ahj.2023.01.020
MULTISTARS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307823
OPTION STEMI Trial 10.1016/S0140-6736(25)01529-6 External Link
CULPRIT SHOCK Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1710261
BioVasc Trial Substudy https://eurointervention.pcronline.com/article/immediate-versus-staged-complete-revascularisation-in-patients-presenting-with-stemi-and-multivessel-disease
Main BioVasc Trial 10.1016/S0140-6736(23)00351-3 External Link
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
IV A Call to Action for Electrophysiologists
Twenty Years at the Crossroads 10.1016/j.jacep.2026.09.023
EP at a Crossroads - J…
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Oct 16, 2026 This Week in Cardiology Podcast
16 oktober 2026 · 34 min
Some promising studies in amyloidosis, aficamten in nonobstructive HCM, costs of the microaxial flow pump in cardiogenic shock, and more on the VESALIUS trial of evolocumab are the topics John Mandrola, MD, discusses in this week’s podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Light Chain Amyloidosis – A Potentially Helpful Drug
Anselamimab Does Not Reduce Light-Chain Amyloidosis Deaths
https://www.medscape.com/viewarticle/anselamimab-does-not-reduce-light-chain-amyloidosis-deaths-2026a1000z79
II Aficamten in Nonobstructive HCM: The ACACIA trial
III Microaxial Flow Pump Cost Analysis of Danger Shock
IV More on Evolocumab at ESC: Vesalius Trial Substudies
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
https://www.medscape.com/viewarticle/1003092
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Oct 09 2026 This Week in Cardiology
9 oktober 2026 · 29 min
Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
POET II Response-Tailored or Standard-Duration ABX for Infectious Endocarditis
POET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312
POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887
II PVI-SHAM-AF trial Back in the News
GAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337
PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link
Why Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External Link
The Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External Link
III ICDs in HCM
I CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597
ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687
IV Agenda Laundering
How Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Oct 02 2026 This Week in Cardiology
2 oktober 2026 · 32 min
Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7
Identifying LV Posterior Wall Delay in RBBB Using Lead V8 https://doi.org/10.1016/j.jacep.2026.03.009
Using Lead V8 as a Tool to Improve Patient Selection in CRT https://doi.org/10.1093/europace/euaf194
II POET II Response-Tailored or Standard-Duration Antibiotics for Endocarditis
POET I https://www.nejm.org/doi/10.1056/NEJMoa1808312
POET II https://www.nejm.org/doi/full/10.1056/NEJMoa2607887
III Obesity and AF – A Neat Study from the Team in Prague
LA Remodeling and Functional Maladaptations in Obesity https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014509
IV Reducing CAC: The DANCODE Trial
DANCODE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.082363
V Two Big RCTs of New GLP-1 Drugs
TRIUMPH-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604169
SYNCHRONIZE-2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607219
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
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Sep 25 2026 This Week in Cardiology
25 september 2026 · 34 min
Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback LBBP ICD Lead
LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/
TRIC-I-HF trial
TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030
II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial
PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012
III Targeting CS leads in CRT devices – DANISH-CRT Trial
DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7
IV Exercise for AF, Especially When There Is LA Disease
Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999
V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX
REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017
ROTAS Trial https://heart.bmj.com/content/110/20/1223
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
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Sep 18 2026 This Week in Cardiology
18 september 2026 · 32 min
Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Correction on PROFID Trial
II Listener Feedback
III Fifth Universal Definition of MI
Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101
Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967
IV New ESC HF Guidelines
ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100
Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20
Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/
V AIR STEMI Trial
AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373
CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051
PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
VI GLP-1 News – A SELECT Trial Secondary Analysis
Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Sep 11 2026 This Week in Cardiology
11 september 2026 · 29 min
A second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola, MD Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Lp(a) Disappointment
HORIZON https://clinicaltrials.gov/study/NCT04023552
Press Release https://www.novartis.com/news/media-releases/novartis-announces-lpahorizon-phase-iii-topline-results-pelacarsen-patients-elevated-lpa-and-established-cardiovascular-disease-cvd
Rationale paper https://doi.org/10.1016/j.ahj.2025.03.019
II FDA Clears AI-ECG for Acute MI Detection
Accuracy of cath lab activation decisions for STEMI-equivalent and mimic ECGs: Physicians vs. AI (Queen of Hearts by PMcardio) 10.1016/j.ajem.2025.07.061
AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry https://www.jacc.org/doi/10.1016/j.jcin.2025.10.018
Queen of Hearts™ AI ECG App https://www.powerfulmedical.com/pmcardio-stemi/
III TARGET CTCA Trial
Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain https://www.nejm.org/doi/10.1056/NEJMoa2608903
IV CorCal trial
Press release https://www.escardio.org/news/press/press-releases/new-data-presented-on-the-use-of-coronary-artery-calcium-for-cardiovascular-risk-assessment/
CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics https://doi.org/10.1016/j.ahj.2026.107473
V AMUNDSEN Trial
LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial InfarctionThe AMUNDSEN Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2853274
VI TRIC-I-HF trial
Tricuspid Repair Cuts Death, HF Hospitalization in Severe TR https://www.medscape.com/vie…
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Sep 04 2026 This Week in Cardiology
4 september 2026 · 41 min
ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I SINGLE-AF Trial
To Anticoagulate or Not in Intermediate-Risk AF: The SINGLE-AF Trial https://www.medscape.com/viewarticle/anticoagulate-or-not-intermediate-risk-af-single-af-trial-2026a1000uko
SINGLE-AF https://www.nejm.org/doi/10.1056/NEJMoa2607978
II Scar as an ICD risk stratifier
Is Scar on CMR an Indication for ICD? CMR Guide Leaves Doubts
https://www.medscape.com/viewarticle/scar-cmr-indication-icd-cmr-guide-leaves-doubts-2026a1000ukq
CMTR GUIDE Trial https://jamanetwork.com/journals/jama/fullarticle/2853395
MADIT II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa013474
III Single vs Dual Therapy in ATTR-CM
HELIOS-B Trial Sub-analysis https://www.sciencedirect.com/science/article/pii/S0735109726072086
HELIOS-B Sub-analysis Editorial https://www.sciencedirect.com/science/article/pii/S0735109726073766#bib8
HELIOS-B main trial https://www.nejm.org/doi/10.1056/NEJMoa2409134
CARDIO-TTRansform Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608510
IV A Stunning Result of another Sham-controlled AF ablation trial
Does AF Ablation Work? That's in Question After PVI-SHAM-AF https://www.medscape.com/viewarticle/does-af-ablation-work-s-question-after-sham-pvi-af-2026a1000uli
PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link
SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283
PFA-Sham Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484
V Should Older Adults Take Statins: The STAREE trial.
STAREE Strengthens Case for Over-the-Counter Statins https://www.medscape.com/viewarticle/staree-strengthens-case-over-counter-statins-2026a1000vr…
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Aug 28 2026 This Week in Cardiology
28 augustus 2026 · 26 min
Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback on Mechanical Compression Devices for OHCA
Mechanical CPR Device Use and Cardiac Arrest Survival
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
PARAMEDIC trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
CIRC trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037
Cochrane Review – Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
II PFA and Stroke
Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092
AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/
EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008
III A New ICD Lead
LEADR LBBAP Trial https://doi.org/10.1016/j.hrthm.2026.08.030
IV ESC Preview
Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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August 21 2026 This Week in Cardiology
21 augustus 2026 · 33 min
Mechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Mechanical Compression Devices for OHCA
· Mechanical CPR Device Use Cardiac Arrest Survival
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
· PARAMEDIC Trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
· CIRC Trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
· LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037
· Cochrane Review of Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
II ACC AF Performance Measures
· 2026 AHA/ACC Clinical Performance for Patients With AF https://www.jacc.org/doi/10.1016/j.jacc.2026.05.032#sec-3
III Two Critical Appraisals of the recent LAAC trials
· Reappraising CHAMPION-AF 10.1016/j.hrthm.2026.07.048 External Link
· CHAMPION and CLOSURE: Reconciling Contrast Results https://doi.org/10.1093/eurheartj/ehag608
ESC Early Preview
· CMR Guide trial https://pmc.ncbi.nlm.nih.gov/articles/PMC6931571/
· SINGLE AF Trial 10.1016/j.hroo.2025.12.008 External Link
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Aug 14 2026 This Week in Cardiology
14 augustus 2026 · 29 min
Listener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I ZEUS Fails
Rethinking Inflammation and ASCVD: Four Lessons From the ZEUS Trial
https://www.medscape.com/viewarticle/rethinking-inflammation-and-ascvd-four-lessons-zeus-trial-2026a1000rlm
ZEUS Trial https://doi.org/10.1001/jamacardio.2025.4491
II Statins and the Elderly
SAGA/SITE trial 10.1016/j.lanhl.2026.100884 External Link
III GLP-1 and CV Risk
SURMOUNT-1 Trial https://www.nejm.org/doi/10.1056/NEJMoa2206038
SURMOUNT-1 Post Hoc Analysis https://www.jacc.org/doi/10.1016/j.jacc.2026.04.044
Reframing GLP-1s as Cardiometabolic Health Drugs: Editorial https://www.jacc.org/doi/10.1016/j.jacc.2026.06.039
IV Radiation Exposure to the Uterus in the EP Lab
Occupational Radiation Safety in EP During Pregnancy https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.080556
Survey: Working in Cath Lab During Pregnancy https://www.surveymonkey.com/share/d5c1edf7-6d99-49d4-a9fa-e9168f63ab55
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Jul 31 2026 This Week in Cardiology
31 juli 2026 · 32 min
Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588
II Another Failure of Posterior Wall Isolation
CORNERSTONE-AF Trial https://doi.org/10.1093/eurheartj/ehag486
CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186
PVIOTAL IDE Trial 10.1016/j.hrthm.2025.08.018 External Link
III First Line AF ablation – One new study and a discovery about a second one
Catheter Ablation vs AAD for First-line Treatment of AF 10.1016/j.hrthm.2025.07.061 External Link
EAST-AFNET 4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2019422
Cardiology Trials Substack https://cardiologytrials.substack.com/p/summary-and-discussion-of-east-afnet
IV Left Atrial Appendage Closure Meta-analysis
Long-Term Efficacy and Safety of LAAC vs OAC -- Meta-analysis https://academic.oup.com/europace/article/28/7/euag159/8739567
V Prevention of AKI after Cardiac Surgery: MERCURI-2
MERCURI-2 Study https://jamanetwork.com/journals/jama/fullarticle/2852324
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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July 24 2026 This Week in Cardiology
24 juli 2026 · 26 min
The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Enlicitide Approved
First Oral PCSK9 Inhibitor Welcomed for Potential Primary Care Impact https://www.medscape.com/viewarticle/first-oral-pcsk9-inhibitor-welcomed-potential-primary-care-2026a1000own
Dr Gregory Katz Substack https://gregorykatz.substack.com/p/are-we-sure-mercks-new-cholesterol
CORALreef Lipids Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
CORALreef HeFH Trial https://jamanetwork.com/journals/jama/fullarticle/2841258
CORALreef Outcomes Trial https://clinicaltrials.gov/study/NCT06008756
II MRI Scans in Non-conditional CIEDs
Specialized Nurse Practitioners Safely Manage MRI in Patients With Cardiac Implantable Devices https://www.medscape.com/viewarticle/specialized-nurse-practitioners-safely-manage-mri-patients-2026a1000ozt
Nurse Practitioner-Led CIED Monitoring During MRI 10.1016/j.hroo.2026.04.031 External Link
MRI in Nonconditional Pacemakers and ICDs https://academic.oup.com/europace/article/22/2/288/5717383
Heart Rhythm Society Consensus Document 10.1016/j.hrthm.2017.04.025 External Link
III PFA-SHAM trial
PFA-SHAM Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484
SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283
IV Orthopedic Injuries in Cardiology
What Will It Take to Make Fluoroscopy Labs Safer?
https://www.medscape.com/viewarticle/what-will-it-take-make-fluoroscopy-labs-safer-2026a1000ox6
Expert Consensus Statement on Enhanced Radiation Protection https://www.jacc.org/doi/10.1016/j.jcin.2026.06.011
'Shed the Lead' and the Injuries. Should Cath Labs Go Lead-Free? https://www…
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Jul 17 2026 This Week in Cardiology Podcast
17 juli 2026 · 34 min
DAPT back in the news, a practice-changing trial in VTE therapy, new knowledge in sudden cardiac death, heart failure definitions updated, and a dumb decision by NICE in the UK are the topics discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Antiplatelet Therapy After Stenting
DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588
HOST-EXAM Trial at 2 years https://pubmed.ncbi.nlm.nih.gov/34010616/
HOST-EXAM Trial at 10 years 10.1016/S0140-6736(26)00422-8 External Link
Nick Kurzen on X https://x.com/ncurzen/status/2077676739463922151
II Aspirin Proves Its Mettle After Hip and Knee Replacement
EPCAT III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2603649
CRISTAL Trial https://jamanetwork.com/journals/jama/fullarticle/2795528
III New (and old) Knowledge in Sudden Cardiac Death
Sudden Cardiac Death and its Relation to Cardiac Disease at Autopsy https://doi.org/10.1016/j.jacc.2026.01.029
Sudden Cardiac Death Due to MI With Obstructive and Nonobstructive Coronary Arteries https://doi.org/10.1016/j.jacc.2026.01.030
Frequency of Sudden Cardiac Death and Profiles of Risk https://www.ajconline.org/article/S0002-9149(97)00477-3/fulltext
IV Heart Failure Diagnosis
AHA/ACC/ESC/WHF Expert Consensus Document http://jacc.org/doi/10.1016/j.jacc.2026.05.036
V NICE Makes a Dumb Decision
NICE Recommends New Nonsteroidal MRA for Heart Failure
https://www.medscape.com/viewarticle/nice-recommends-new-nonsteroidal-mra-heart-failure-2026a1000nzv
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Jul 10 2026 This Week in Cardiology
10 juli 2026 · 32 min
Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets after cardiac arrest are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
Oct 10, 2025 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1002990
ICE vs TEE in Atrial Fibrillation Ablation https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370
II FFR Without the Wire – Angiography-Derived FFR to Guide PCI
ALL-RISE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600949
FAST III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601841
FAVOR III Trial 10.1016/S0140-6736(24)02175-5 External Link
FAME 2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1205361
Venk Murthy on X https://x.com/venkmurthy/status/2074849421452329456?s=20
III More Bad News for Ticagrelor
Jul 11, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1002704
Prasugel, Ticagrelor, or Clopidogrel After PCI https://jamanetwork.com/journals/jamacardiology/fullarticle/2849614
IV The Polypill in Heart Failure
POLY-HF trial https://www.nature.com/articles/s41591-026-04504-5
V Oxygen Targets After Cardiac Arrest
LOGICAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513814
ICU-ROX Trial https://link.springer.com/article/10.1007/s00134-020-06196-y
Secondary Analysis of the PILOT Trial https://journal.chestnet.org/article/S0012-3692(25)00553-7/fulltext
Oxygen Targets in Comatose Survivors of Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa2208686
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Jun 26 2026 This Week in Cardiology
26 juni 2026 · 34 min
Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137
II Statins and Frailty
Statin Initiation Tied to Lower Frailty Risk in Older Adults https://www.medscape.com/viewarticle/statin-initiation-tied-lower-frailty-risk-older-adults-2026a1000lec
Statins and Survival Free of Incident Frailty https://doi.org/10.1093/eurheartj/ehag451
III LA Posterior Wall Isolation Fails Again
CORNERSTONE Trial https://doi.org/10.1093/eurheartj/ehag486
CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186
IV Does the Display of Test Results Improve Clinical Decisions?
Interval Likelihood Ratios for Clinical Decsion-Making https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500249
Making Sense of Health Statistics https://journals.sagepub.com/doi/full/10.1111/j.1539-6053.2008.00033.x
V AI and the ECG and Saving Doctors
Case Report — AI-Enhanced Diagnostics https://www.nature.com/articles/s41591-026-04454-y
The New York Times article https://www.nytimes.com/2026/06/22/health/artificial-intelligence-heart-damage.html
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Jun 19 2026 This Week in Cardiology
19 juni 2026 · 37 min
Listener feedback, more long-term data on the TAVR/SAVR question, population prevalence of valvular heart disease in the US, and a CMS proposal to expand TAVR coverage are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
ICD Trends and Outcomes: 15-Year Analysis https://doi.org/10.1093/europace/euag110
MADIT-RIT https://www.nejm.org/doi/full/10.1056/NEJMoa1211107
II More Long Term Data on TAVR vs SAVR
PARTNER 2 Trial https://www.jacc.org/doi/10.1016/j.jacc.2026.03.169
10-Year Outcomes of SAPIEN 3 TAVR or SAVR in Intermediate-Risk Patients https://doi.org/10.1016/j.jacc.2026.03.170
TAVR at a Decade: Editorial https://doi.org/10.1016/j.jacc.2026.04.042
EVOLUT Trial https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5063
Updated 5-year Outcomes of TAVR vs SAVR in AS https://heart.bmj.com/content/early/2026/02/11/heartjnl-2025-327092
NOTION Trial https://doi.org/10.1093/eurheartj/ehae043
PARTNER 3 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2509766
NOTION 2 Trial https://academic.oup.com/eurheartj/article/45/37/3804/7673297
TAVR vs SAVR Editorial : https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehag407/8708044
III The PREVUE-VALVE Study
PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137
IV CMS has Proposed New Coverage for TAVR
CMS Proposal Document https://www.cms.gov/medicare-coverage-database/view/ncacal-decision-memo.aspx?proposed=Y&ncaId=321
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Jun 12 2026 This Week in Cardiology
12 juni 2026 · 30 min
Listener feedback, transcatheter tricuspid valve replacement, a new metabolic disease called CKM, the ARISE-FLUIDS Trial, the BIHCA trial, and temporal trends in ICD therapies are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I Listener Feedback
LOSE-AF Trial https://jamanetwork.com/journals/jama/fullarticle/2849335
ARREST-AF Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2840225
POP-AF Trial https://doi.org/10.1093/eurheartj/ehaf689
PRAGUE-25 Trial https://www.jacc.org/doi/10.1016/j.jacc.2025.04.042
II Transcatheter Tricuspid Valve Replacement
TRISCEND Cost Study https://doi.org/10.1016/j.shj.2026.101049
TRISCEND II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2401918
III More Disease Creation – the CKM Syndrome
ACC/AHA Release First-Ever Guideline for CKM Syndrome https://www.medscape.com/viewarticle/acc-aha-release-first-ever-guideline-ckm-syndrome-2026a1000jbs
CKM Guideline in Circulation https://www.ahajournals.org/doi/10.1161/CIR.0000000000001447
IV Two Trials That Teach Important EBM Lessons
ARISE-FLUIDS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2516225
Dr Josh Farkas Post on X https://x.com/PulmCrit/status/2065064796270022845?s=20
V Bicarbonate for Inpatient Cardiac Arrest –The BIHCA trial
BIHCA Trial https://jamanetwork.com/journals/jama/fullarticle/2850405
VI The Decline of VT in Heart Failure
Trends and Outcomes in ICD Recipients: 15-Year Analysis https://doi.org/10.1093/europace/euag110
Declining Risk of Sudden Death in HF https://www.nejm.org/doi/full/10.1056/NEJMoa1609758
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Jun 05 2026 This Week in Cardiology
5 juni 2026 · 32 min
Chemical cardioversion in the ED, HF monitoring, weight loss in AF, and surgical LAA excision are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Chemical Cardioversion of AF in the ED: The FLECA-ED Trial
FLECA-ED Rationale paper https://pmc.ncbi.nlm.nih.gov/articles/PMC10299428/
FLECA-ED ESC Slides https://esc365.escardio.org/presentation/321209
Review on Flecainide Use Despite CAST https://doi.org/10.1016/j.hrthm.2025.08.034
RACE 7 ACWAS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1900353
II Heart Failure Monitoring – The ALLEVIATE-HF Trial
ALLEVIATE-HF Trial https://doi.org/10.1016/j.jacc.2026.03.075
CHAMPION Trial https://doi.org/10.1016/S0140-6736(11)60101-3
GUIDE HF Trial https://doi.org/10.1016/S0140-6736(21)01754-2
ALLEVIATE-HF Editorial: Alerts Are Not Treatment https://doi.org/10.1016/j.jacc.2026.04.014
Steve Stiles Medscape report on CHAMPION https://www.medscape.com/viewarticle/755189
III A Negative Weight Loss Study in AF
LOSE-AF Trial https://jamanetwork.com/journals/jama/fullarticle/2849335
IV Surgical LAA Excision
OPINION Trial https://doi.org/10.1093/eurheartj/ehaf674
LAAOS 3 trial https://www.nejm.org/doi/full/10.1056/NEJMoa2101897
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May 29 2026 This Week in Cardiology
29 mei 2026 · 29 min
A life-long treatment for high LDL, a VESALIUS subanalysis, tirzepatide beats semaglutide again, arrhythmia burden in cardiac amyloidosis, and a lipid guideline rebuttal are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
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I Permanent Lipid Lowering therapy
Verve 102 Therapy for FH https://www.nejm.org/doi/full/10.1056/NEJMoa2601283
II Vesalius Substudy on PCSK9i Use in Patients With Previous PCI
VESALIUS Subgroup Analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080616
VESALIUS Study - NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
III Tirzepatide looking to be best again
SURPASS-EARLY Trial https://www.acpjournals.org/doi/10.7326/ANNALS-25-05602
SURMOUNT-5 Trial https://www.nejm.org/doi/abs/10.1056/NEJMoa2416394
IV Arrhythmias in Cardiac Amyloidosis
Loop Recorders Reveal Arrhythmias in Cardiac Amyloidosis https://www.medscape.com/viewarticle/loop-recorders-reveal-arrhythmias-cardiac-amyloidosis-2026a1000gq9
EXCALIBUR Study https://www.jacc.org/doi/10.1016/j.jacc.2026.04.030
V Lipid Guidelines
· In Defense of the 2026 Dyslipidemia Guideline https://www.medscape.com/viewarticle/defense-2026-dyslipidemia-guideline-2026a1000hd0
Lipid Guidelines: Four Major Concerns https://www.medscape.com/viewarticle/lipid-guidelines-four-major-concerns-2026a1000fim
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May 22 2026 This Week in Cardiology
22 mei 2026 · 32 min
Three more digoxin trials, yet another GLP-1 drug on the horizon, vagal nerve stimulation, trial inside baseball, and more on lipid guidelines are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I More About Low-dose Digoxin in HF — The DECISION Trial(s)
DECISION Trial https://www.nature.com/articles/s41591-026-04406-6
Digitalis Glycosides in HF — JAMA Meta-Analysis https://jamanetwork.com/journals/jama/fullarticle/2848972
DIGIT-HF Trial https://www.nejm.org/doi/10.1056/NEJMoa2415471
RADIANCE Trial (1993) https://www.nejm.org/doi/full/10.1056/NEJM199307013290101
DECISION Withdrawal Study https://doi.org/10.1093/eurheartj/ehag385
Digoxin Discontinuation vs Continuation in Chronic HF https://doi.org/10.1016/j.amjcard.2007.02.099
II Yet another GLP-1 Drug Announced this Week
Lillly News Release on Retatrutide https://investor.lilly.com/news-releases/news-release-details/lillys-triple-agonist-retatrutide-delivered-powerful-weight-loss
III A Big Story in HF Science – Vagal Nerve Stimulation in HFrEF
ANTHEM HFrEF trial https://doi.org/10.1016/j.jacc.2026.03.040
Editorials
An Unfinished ANTHEM https://doi.org/10.1016/j.jacc.2026.04.033
When Trials Stop Prematurely https://doi.org/10.1016/j.jacc.2026.03.039
IV Lipid Guideline News
Lipid Guidelines: Four Major Concerns
https://www.medscape.com/viewarticle/lipid-guidelines-four-major-concerns-2026a1000fim
Editorial: Time to Move Beyond the Statin Nocebo Effect https://www.jacc.org/doi/10.1016/j.jacc.2026.04.002
Correspondence: SAMSON N-of-1 Trial of Statin, Placebo, or No Treatment https://www.nejm.org/doi/full/10.1056/NEJMc2031173
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May 15, 2026 This Week in Cardiology
15 mei 2026 · 31 min
Another positive digoxin trial, another classic coronary physiology study from Imperial College London (ORBITA-FIRE), news in hypertrophic cardiomyopathy, and TAVR done in the wrong patients are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Digoxin in Rheumatic Heart Disease
Dig-RHD Trial https://jamanetwork.com/journals/jama/fullarticle/2848973
Safety and Efficacy of Digoxin: Meta-Analysis https://www.bmj.com/content/351/bmj.h4451.long
DIGIT-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415471
DIG Trial https://www.nejm.org/doi/full/10.1056/NEJM199702203360801
RADIANCE Trial https://www.nejm.org/doi/full/10.1056/NEJM199307013290101
II The Physiologic Threshold for Angina
ORBITA-FIRE Trial https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.125.078738
III Prediction in Hypertrophic Cardiomyopathy
Predictors of Long-Term Outcomes in HCM https://jamanetwork.com/journals/jama/fullarticle/2848800#250998713
IV TAVR Trends in Young Patients
Temporal Trends in AVR for Aortic Stenosis in Patients
Wall Street Journal article https://www.wsj.com/health/healthcare/heart-valve-tavr-surgery-aorta-1e0eda70
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May 08 2026 This Week in Cardiology
8 mei 2026 · 30 min
Listener feedback from the DanGer Shock investigators, complete vs staged revascularization, polygenic risk scores, and quality improvement failure in an RCT are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
DanGer Shock Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2312572
CHIP-BCIS 3 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2515704
II Immediate Complete vs Staged Revascularization in STEMI
Meta-analysis: Timing of Complete Revasc in Patients with STEMI and Multivessel Disease https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.126.016601
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775 FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918
III Polygenic Risk Scores for Prediction
Polygenic Risk Report in US-Based Hospitals for 8 CV Conditions https://www.jacc.org/doi/10.1016/j.jacc.2026.03.035
IV Practice Improvement Policies Undergo the Proper Test – Randomization
Quality Improvement on Hospitalizations and Health Outcomes for People with CHD https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.125.012904
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May 01 2026 This Week in Cardiology
1 mei 2026 · 29 min
Time to quadruple therapy, the disappointing AVANT GUARD trial, PFA risks, the TREAT-PVC trial, and NSTEMI care in the frail elderly are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Time to Quadruple Therapy in HFrEF
Time to Quadruple Therapy After Diagnosis of HFrEF https://jamanetwork.com/journals/jamacardiology/fullarticle/2846899
II AVANT GUARD
PFA Bests Meds as First-Line Treatment for Persistent AF in Randomized Trial https://www.medscape.com/viewarticle/pulsed-field-ablation-bests-meds-first-line-treatment-2026a1000dsm
Pulsed Field Ablation of AF Disappoints in Setup for Success: AVANT GUARD https://www.medscape.com/viewarticle/pulsed-field-ablation-af-disappoints-setup-success-avant-2026a1000ddt
AVANT GUARD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600929
Persistent AF: Meta-analysis of Invasive Strategies 10.1016/j.ijcard.2018.11.127 External Link
III Speaking of Scary News on PFA – The TIFFANY Study
Abstract - The TIFFANY Study https://www.heartrhythmjournal.com/article/S1547-5271(26)01747-9/fulltext
Delayed Myocardial Ischemia and Malignant Arrhythmias After PFA https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.077983
Alberto Alfie Comment https://x.com/ALFIEEP1/status/2050029151315189774?s=20
IV TREAT PVC Trial
TREAT-PVC Trial https://doi.org/10.1016/j.jacep.2026.01.011
TREAT-AF Study 2020 https://doi.org/10.1016/j.jacep.2019.11.008
V NSTEMI In Frail Older Patients
SENIOR-RITA Trial https://www.nejm.org/doi/10.1056/NEJMoa2407791
Subanalysis of Senior RITA Trial https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2847995
Timing of Invasive Strategy in Patients With Non-ST-Elevation Acute Coronary Syndrome -- Meta-analysis https://doi.org/10.1016/S0140-6736(17)31490-3
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Apr 24 2026 This Week in Cardiology
24 april 2026 · 33 min
PCSK9 inhibitors in high-risk diabetes without ASCVD, the CAAN-AF trial, conduction system pacing vs biventricular pacing, PFA and stroke, and therapeutic fashion infects expert consensus are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I VESALIUS-CV
VESALIUS-CV Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
JAMA Substudy https://jamanetwork.com/journals/jama/fullarticle/2847162
II How Best to Maximize CRT Benefit in Patients with AF
CAAN-AF Trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag206/8654625?searchresult=1
Role of AV Node Ablation: Meta-analysis of Observational Studies https://www.jacc.org/doi/10.1016/j.jacc.2011.10.891
III Stroke Rates in PFA vs Thermal Ablation
Comparative Safety of RF versus PFA for AF in a High-Volume US Medical Center https://esc365.escardio.org/Ehra-congress/sessions/18281
IV Five New CSP Studies Presented and Published
HeartSync-LBBP Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2845803
PhysioSync-HF Trial
https://jamanetwork.com/journals/jamacardiology/fullarticle/2845802
LEFT-BUNDLE-CRT Trial https://doi.org/10.1093/eurheartj/ehag225
Long-Term Follow-up of His-Alternative I Trial https://www.jacc.org/doi/10.1016/j.jacep.2026.02.016
LECART Trial https://esc365.escardio.org/Ehra-congress/sessions/17140
V New EP Training Document Published
Advanced Training Statement on Clinical Cardiac Electrophysiology https://www.jacc.org/doi/10.1016/j.jacc.2026.01.074
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Apr 17 2026 This Week in Cardiology
17 april 2026 · 28 min
SPIRIT-HF, another spironolactone trial in HFpEF; the ESSENCE imaging study of the drug olezarsen; the SirPAD trial in peripheral artery disease; and ultrasound-guided femoral venous access are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I ACC: SPIRIT-HF Trial
FINEARTS-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
TOPCAT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1313731
TOPCAT Americas Trial https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255
II A New Class of Lipid Lowering Drug Has a Dubious Debut At ACC
ESSENCE-TIMI 73b Imaging Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080012
ESSENCE-TIMI 73b Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2507227
IMPROVE IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1410489
III Drug-Coated Balloons Looked Quite Good in PAD interventions
Sirolimus-Coated Balloon Reduces Amputation Risk in Peripheral Artery Disease
https://www.medscape.com/viewarticle/sirolimus-coated-balloon-reduces-amputation-risk-peripheral-2026a1000a83
SirPAD trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600360
IV Another Vascular Story from the European Heart Rhythm Association
ULYSSES Trial https://doi.org/10.1093/eurheartj/ehag291
ULTRA-FAST Trial https://doi.org/10.1093/europace/eux175
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Apr 10 2026 This Week in Cardiology
10 april 2026 · 32 min
Three imaging-guided PCI trials (two with surprising results), LDL targets, an oral PCSK9 inhibitor, and another beta-blocker withdrawal trial are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I IVUS-Guided PCI
OPTIMAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600440
IVUS-CHIP Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601521
ILUMIEN IV Trial https://www.nejm.org/doi/10.1056/NEJMoa2305861
DKCRUSH VIII Trial https://doi.org/10.1016/j.jacc.2026.01.081
II Ez-PAVE Trial — Low vs Very Low LDL-targets
Does Ez-PAVE Support 'Lower Is Better' for LDL-C? https://www.medscape.com/viewarticle/does-ez-pave-support-lower-better-ldl-c-2026a1000akx
Ez-PAVE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600283
2026 ACC/AHA Lipid Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423
III CORALreef AddOn
CORALreef AddOn Trial https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.03.036
This Week in Caardiology 2-6-26 https://www.medscape.com/viewarticle/1003240
CORALreef Lipids Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
IV Another Post-MI Beta-blocker Withdrawal Study: SMART-DECISION
SMART-DECISION Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601005
ABYSS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
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Apr 03 2026 This Week in Cardiology
3 april 2026 · 44 min
John Mandrola offers an ACC recap of 5 big trials—Hi-PEITHO, PROTAVI, ORBITA-CTO, CHIPS-BCIS3 and CHAMPION AF Lees meer
This podcast is intended for healthcare professionals only.
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I Catheter Based Fibrinolysis of Pulmonary Embolism –Hi PEITHO
Fibrinolysis Treatment Validated in Large Trial for Acute Intermediate-Risk PE https://www.medscape.com/viewarticle/fibrinolysis-treatment-validated-large-trial-acute-2026a10009im
Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism (HI PEITHO) https://www.nejm.org/doi/full/10.1056/NEJMoa2516567
National Early Warning Score (NEWS) https://www.england.nhs.uk/ourwork/clinical-policy/sepsis/nationalearlywarningscore/
II PRO-TAVI trial
Deferral of percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation (PRO-TAVI) 10.1016/S0140-6736(26)00308-9 External Link
PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation (Notion 3) https://www.nejm.org/doi/full/10.1056/NEJMoa2401513
III ORBITA CTO Sham vs PCI for Angina Relief
Tightly Blinded Trial Confirms PCI Reduces Angina in Obstructive Occlusion https://www.medscape.com/viewarticle/tightly-blinded-trial-confirms-pci-reduces-angina-2026a10009ob
A Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina - ORBITA-CTO https://www.jacc.org/doi/10.1016/j.jacc.2026.03.027
ORBITA 1 10.1016/S0140-6736(17)32714-9 External Link
ORBITA 2 https://www.nejm.org/doi/full/10.1056/NEJMoa2310610
DECISION CTO https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.031313
EuroCTO https://doi.org/10.1093/eurheartj/ehy220
IV CHIPS BCIS3 Impella Supported High-Risk PCI
Adoption Before Evidence: CHIP-BCIS3 Humbles Impella https://www.medscape.com/viewarticle/adoption-before-evidence-chip-bcis3-humbles-impella-2026a10009jh
Left Ventricular Unloading in High-Risk PCI (CHIP BCIS3)…
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Mar 27 2026 This Week in Cardiology
27 maart 2026 · 26 min
Early aortic valve replacement in aortic stenosis, left atrial appendage occlusion in JAMA Cardiology, and a big preview of the upcoming American College of Cardiology meeting are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I Early AVR
RECOVERY Trial at 10 Years https://www.nejm.org/doi/full/10.1056/NEJMoa2511920
II Major Bleeding with Amulet and Watchman in JAMA Cardiology
Amulet IDE Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2847047
5-year Results From Amulet IDE https://www.jacc.org/doi/10.1016/j.jacc.2024.10.101
III ACC Preview
Mandrola's Top 4 Trials from ACC 2026: Details Matter
https://www.medscape.com/viewarticle/mandrolas-top-4-trials-acc-2026-details-matter-2026a10008ti
CHIB-BCIS3 Trial https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.123.013367
Champion-AF Protocol https://doi.org/10.1016/j.ahj.2023.05.022
ORBITA-CTO Protocol Paper https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1172763/full
SPIRIT-HF Clinical Trials.gov https://clinicaltrials.gov/study/NCT04727073
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Mar 20 2026 This Week in Cardiology
20 maart 2026 · 35 min
Listener feedback, the huge CLOSURE-AF trial of LAAC vs best medical therapy, previews of CHAMPION AF, and the controversial ACC/AHA lipid treatment guidelines are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I Listener Feedback
COBRRA Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2510703
Closure AF published in NEJM
CLOSURE-AF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513310
CHAMPION AF Rationale - Watchman FLX vs DOACs in Patients With AF https://pubmed.ncbi.nlm.nih.gov/37279840/
LIPID Guidelines
ACC/AHA Joint Committee Guideline on Management of Dyslipidemia https://www.jacc.org/doi/10.1016/j.jacc.2025.11.016
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Mar 13 2026 This Week in Cardiology
13 maart 2026 · 32 min
Beta-blocker in non-obstructive hypertrophic cardiomyopathy, a head-to-head apixaban vs rivaroxaban RCT, diltiazem vs metoprolol combined with DOAC, and the accuracy of smart watches for AF are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I Listener Feedback
EMPATICC trial https://academic.oup.com/eurheartj/article/47/9/1034/8242490
II Beta-blocker in Non-obstructive HCM
BB vs Calcium Channel Blocker in Non-obstructive HCM https://doi.org/10.1016/j.jacc.2025.11.028
RCT of Metoprolol in Patients With Obstructive HCM https://doi.org/10.1016/j.jacc.2021.07.065
III Apixaban vs Rivaroxaban for Bleeding Risk
COBRRA Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2510703
AMPLIFY Trial (Apixaban) https://www.nejm.org/doi/10.1056/NEJMoa1302507
EINSTEIN Trial (Rivaroxaban) https://www.nejm.org/doi/full/10.1056/NEJMoa1007903
IV Diltiazem vs Metoprolol When Combined with DOAC
Risk for Bleeding in AF Patients Using Apixaban or Rivaroxaban With Diltiazem https://www.acpjournals.org/doi/10.7326/ANNALS-25-01408
V Actual Clinical Use of Smart Watches
CIRCA-DOSE Original Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.042622
Wearable Smartwatches for AF Detection After Ablation https://doi.org/10.1093/europace/euaf280
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Mar 06 2026 This Week in Cardiology
6 maart 2026 · 24 min
Listener feedback, urgent AF ablation, AF ablation as a stroke-reducing therapy, implantable loop recorder accuracy, and HF management in the setting of serious disease are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Urgent AF ablations
Urgent vs Elective AF Ablation in the US https://www.jacc.org/doi/10.1016/j.jacep.2025.12.030
II AF Ablation Is Not Likely a Good Therapy for Stroke Reduction
STABLED Trial https://jamanetwork.com/journals/jamaneurology/fullarticle/2845745
Catheter Ablation for AF Associated With Lower Incidence of Stroke https://doi.org/10.1093/eurheartj/ehw087
III Loop Recorders
ILR Accuracy - Multicenter, Multidevice Comparison https://doi.org/10.1016/j.jacep.2025.12.039
IV Heart Failure Therapy when there is Cancer
EMPATICC Trial https://doi.org/10.1093/eurheartj/ehaf705
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Feb 27 2026 This Week in Cardiology
27 februari 2026 · 29 min
A superb note on CPR and DNR orders, patients' vs doctors' preferences for statins, more on GLP-1s, another LAAC story, and some closing cautionary notes on PFA are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
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I Listener Feedback
Addressing Inadequate Documentation of Unilateral DNR https://jamanetwork.com/journals/jama/fullarticle/2829203
Video: Can We Talk About CPR? https://www.youtube.com/watch?v=yTCRfY3ETvI
Personal Reminiscences of CPR's Origin https://www.ajconline.org/article/S0002-9149(03)00977-9/pdf
II Public Preferences for Statin Therapy
Measuring Public Preferences for Statin Therapy https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2844660
III GLP-1 RA News
ACHIEVE Trial https://doi.org/10.1016/S0140-6736(26)00202-3
IV New Trial in GLP-1 for Patients with AF
Seminal-AF Trial https://clinicaltrials.gov/study/NCT06499857
V Relationship between Spontaneous Echo Contrast and LAAC Outcomes
OCEAN-LAAC Trial https://doi.org/10.1016/j.jacep.2025.09.028
News Release on Upcoming LAAOS-4 trial https://www.phri.ca/watchman/
Reading the "Smoke" -- Editorial on OCEAN-LAAC https://www.jacc.org/doi/10.1016/j.jacep.2025.10.029
VI Concluding Remarks on My Talk at Western AF
Delayed Myocardial Ischemia and Malignant Arrhythmias After PFA https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.077983
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Feb 20 2026 This Week in Cardiology
20 februari 2026 · 25 min
EVOLUT Low Risk data, a provocative meta-analysis, DNR orders, targeted hypothermia, good news in HFpEF evidence, and GLP-1s as AF drugs are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
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I EVOLUT Low Risk 6-year Results and a 5-year Meta-Analysis of TAVR vs SAVR
6-Year Outcomes of TAVR vs SAVR https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5063
EVOLUT Low Risk Trial at 2 years https://www.nejm.org/doi/full/10.1056/NEJMoa1816885
EVOLUT Low Risk Trial at 3 years https://www.jacc.org/doi/10.1016/j.jacc.2023.02.017
EVOLUT Low Risk Trial at 4 years https://www.jacc.org/doi/10.1016/j.jacc.2023.09.813
Nonproportional Hazards for Time-to-Event Outcomes in Clinical Trials https://www.jacc.org/doi/10.1016/j.jacc.2019.08.1034
TAVR vs SAVR 5-Year Outcomes - Systematic Review https://heart.bmj.com/content/early/2026/02/11/heartjnl-2025-327092
TAVR vs SAVR Updated Meta-Analysis of RCTs https://www.jacc.org/doi/10.1016/j.jacc.2024.12.031
UK TAVI Trial https://jamanetwork.com/journals/jama/fullarticle/2792251
Dr David Cohen on X https://x.com/djc795/status/2023556582030852172?s=46&t=zXMCUoVjSsdyemzWlzeBjA
II DNR in the Hospital
Inadequate Documentation of Unilateral DNR Orders https://jamanetwork.com/journals/jama/fullarticle/2829203
GeriPal Blog Unilateral DNR Orders https://geripal.org/unilateral-dnr-gina-piscitello-erin-demartino-will-parker/
III Yet another failure of Targeted Hypothermia
2-Year Follow-Up of TTM2 Trial https://jamanetwork.com/journals/jamaneurology/fullarticle/2845193
TTM2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2100591
IV Good news in HFpEF Evidence
ALT-FLOW II Trial https://doi.org/10.1093/ejhf/xuaf016
V GLP-1 as AF drugs
Semaglutide as Adjunctive Therapy in Obesity-Related PAF https://doi.org/10.1093/europace/euag018
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Feb 13 2026 This Week in Cardiology
13 februari 2026 · 30 min
Ticagrelor vs prasugrel, a new LAAC device, pulsed field ablation AF results, lifestyle intervention in AF, the term "provider" vs "doctor," and coffee are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I TUXEDO-2 Trial
TUXEDO-2 Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2844869
ISAR-REACT 5 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1908973
II VERITAS Study of Dual-Seal LAAO
VERITAS Study https://doi.org/10.1016/j.jacep.2026.01.021
III PFA vs RF over 4 years
Advent-LTO study https://www.nature.com/articles/s41591-026-04246-4
ADVENT Study https://www.nejm.org/doi/full/10.1056/NEJMoa2307291
SPHERE PER-AF Study https://www.nature.com/articles/s41591-024-03022-6 SINGLE SHOT CHAMPION Study https://www.nejm.org/doi/full/10.1056/NEJMoa2502280
BEAT PAROX-AF Trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf1115/8436829
IV What's in a Name — Use of the Term "Provider"
Physicians Are Not Providers: The Ethical Significance of Names https://www.acpjournals.org/doi/10.7326/ANNALS-25-03852
V Coffee and Dementia Risk
Coffee/Tea Intake and Dementia Risk https://jamanetwork.com/journals/jama/fullarticle/2844764
Mandrola Commentary: Enough With the Coffee Research and Other Distractions https://www.medscape.com/viewarticle/883709
VI Lifestyle interventions Post AF ablation
Improving Outcomes of AF by Lifestyle Interventions https://academic.oup.com/eurheartj/article/47/6/669/8243674
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Feb 06 2026 This Week in Cardiology
6 februari 2026 · 24 min
Problems with the PREVENT score, a breakthrough in lipid-lowering therapy, a surprising benefit in stroke care, and more thoughts on statins and preventive care of heart disease are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I PREVENT Score
PREVENT Equations in Young Adults https://doi.org/10.1016/j.jacc.2025.12.019
Hospital Readmission Reduction Program for HF
https://pmc.ncbi.nlm.nih.gov/articles/PMC7664458/
II A New Breakthrough in LDL-C Management With an Oral PCSK9 Inhibitor
https://www.medscape.com/viewarticle/time-overcome-pcsk9i-inertia-new-data-future-options-2025a1000wf8
CORALreef Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
CORALreef Outcomes Trial https://clinicaltrials.gov/study/NCT06008756
III A Win for the Factor XI Inhibitor Asundexian – OCEANIC Stroke Trial
https://www.medscape.com/viewarticle/first-clear-win-factor-xia-inhibitors-stroke-reduced-2026a10003t0
OCEANIC-STROKE Slide deck https://clinicaltrialresults.org/wp-content/uploads/2026/02/26-02-02_ISC_OCEANIC-STROKE-primary.pdf
OCEANIC-AF Study Stopped Early https://www.bayer.com/media/en-us/oceanic-af-study-stopped-early-due-to-lack-of-efficacy/
IV Statin Side Effects
Assessment of AEs Attributed to Statins -- Meta-analysis https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01578-8/fulltext
N-of-1 Trial to Assess AEs of Statins https://www.nejm.org/doi/full/10.1056/NEJMc2031173
When to Start a Statin Is a Decision About Preference -- Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.029808
V Heart Disease Statistics
CV Statistics in the US, 2026 https://www.jacc.org/doi/10.1016/j.jacc.2025.12.027
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Jan 30 2026 This Week in Cardiology
30 januari 2026 · 28 min
Listener feedback, huge news in the rapidly expanding world of PFA AF Ablation, obesity, and a beautiful trial studying an AI-enhanced diagnostic tool in the office are the topics discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I Listener Feedback
Risk-Based TEE Omission in PVI 10.1016/j.hrthm.2025.04.056 External Link
II PFA News
BEAT PAROX-AF trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf1115/8436829
Life-Threatening Delayed Myocardial Ischemia and Malignant Arrhythmias Occurring After PFA https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.125.077983
Heart Rhythm TV: Life-Threatening Delayed Myocardial Ischemia and Malignant Arrhythmias https://www.youtube.com/watch?v=M-npoLKmRa4
MAUDE Adverse Event report https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmaude/detail.cfm?mdrfoi__id=23733351&pc=QZI
III Obesity trends
US State-Level Obesity Trends 1990-2022 and Forecasted to 2035 https://jamanetwork.com/journals/jama/fullarticle/2844495
IV New Tools in the Office
TRICORDER Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02156-7/fulltext
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Jan 23 2026 This Week in Cardiology
23 januari 2026 · 30 min
Listener feedback, the value of procedural volume for TAVR and MTEER, ventricular arrhythmia in older athletes, and the Goldilocks time horizon for predicting and modifying CV risk are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
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I Procedural Volume and Outcomes for TAVI and M-TEER
Operator Procedural Volumes and Outcomes for TAVR and MTEER https://jamanetwork.com/journals/jamacardiology/fullarticle/2843740
II Ventricular Arrhythmia in Older Male Endurance Athletes
Myocardial Fibrosis May Raise Arrhythmia Risk in Older Male Endurance Athletes
https://www.medscape.com/viewarticle/myocardial-fibrosis-may-raise-arrhythmia-risk-older-male-2026a10001y0
Timing and Relationship of VA With Exercise Patterns in Older Male Endurance Athletes https://doi.org/10.1093/eurjpc/zwag021
III Predicting Cardiac Risk and Statin Use
30-Year ASCVD Risk Among US Adults Aged 30-59 https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.125.012348
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Jan 16, 2026 This Week in Cardiology
16 januari 2026 · 31 min
Some great listener feedback, one of the best studies of the year in atrial fibrillation and heart failure, imaging to exclude left atrial thrombus, and a truly amazing first cardiac procedure are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I Listener Feedback
On Fish Oil and AF
Links between omega-3 fatty acids and AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.058596
Omega-3 and risk of AF https://doi.org/10.1016/j.pcad.2024.11.003
DHA vs EPA in reducing vulnerability to AF https://www.ahajournals.org/doi/10.1161/CIRCEP.112.971515
II Withdrawal of HF Therapy AF rhythm control
The AF is Gone, the EF Is Up. Can You Stop the HF Meds?
https://www.medscape.com/viewarticle/af-gone-ef-can-you-stop-hf-meds-2024a1000h6o
Effect of beta-blockers in patient with HF plus AF -- meta-analysis https://pubmed.ncbi.nlm.nih.gov/25193873/
TRED HF Trial 10.1016/S0140-6736(18)32484-X External Link
WITHDRAW-AF Trial https://academic.oup.com/eurheartj/article/47/2/250/8238240
III ICE or TEE Before AF Ablation
ICE vs TEE in Atrial Fibrillation Ablation https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370
IV The Vector Procedure
Percutaneous Aorto-Coronary Bypass Graft: the VECTOR procedure https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.125.016130
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Jan 09 2026 This Week in Cardiology
9 januari 2026 · 28 min
The limits of knowing coronary artery disease anatomy, fish oil and AF risk, a new drug for PSVT, and maybe I was wrong about a drug for AF conversion (the RAFF4 trial). These are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Prediction of CAD is hard — even if you have anatomy
CCTA in Prediction of First Coronary Events https://jamanetwork.com/journals/jama/fullarticle/2841255
II Fish Oil and AF (and as a bonus we learn again about analytic flexibility)
Are Fish Oils on the Hook for AF Risk?
https://www.medscape.com/viewarticle/995290
Omega-3 and Fish Oil Use With Risk of AF https://www.ahajournals.org/doi/full/10.1161/JAHA.125.043031
Effect of Long-Term Marine Omega-3 Fatty Acids on the Risk of AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654
RESPECT-EPA Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065520
Association Between Omega-3 Fatty Acids and AF: Meta Analysis https://link.springer.com/article/10.1007/s10557-021-07204-z
Fish Oil Supplements and Risk of AF https://academic.oup.com/eurjpc/article/29/14/1911/6679610
Editorial: Fish Oil Supplements and AF Risk https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057464
III A New Drug for PSVT
FDA Approval https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-drug-type-abnormally-fast-heart-rhythm
RAPID trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00776-6/fulltext
IV AF Conversion with Vernakalant
RAFF4 Trial https://www.bmj.com/content/391/bmj-2025-085632.long
Editorial: Rapid Cardioversion for Acute AF https://www.bmj.com/content/391/bmj.r2264
VI A Quick Note on HFpEF
Med Op-Ed: Avalanche Survival, HFpEF Skepticism, and More
https://www.medscape.com/viewarticle/med-op-ed-avalanche-survival-hfpef-skepticism-and-more-2026a1000012
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Dec 19 2025 This Week in Cardiology
19 december 2025 · 36 min
The MI paradox of risk scores, the CELEBRATE trial of a new subcutaneous glycoprotein IIb/IIIA inhibitor (with its funny endpoint), the SURPASS CVOT trial, and the bad story of andexanet alfa are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I What do risk scores mean for individuals? Or perhaps a better question: Is a first MI preventable?
Limitations of Screening in Predicting First MI https://www.jacc.org/doi/10.1016/j.jacadv.2025.102361
Sudden Death Due to Cardiac Arrhythmias https://www.nejm.org/doi/abs/10.1056/NEJMra000650
UMC Amsterdam group (EHJ) https://academic.oup.com/eurheartj/article/46/38/3762/8181058
II CELEBRATE Trial
CELEBRATE Trial https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268
III SURPASS CVOT Trial Published
Aug 01, 2025 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1002781
SURPASS-CVOT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2505928
REWIND Trial 10.1016/S0140-6736(19)31149-3 External Link
IV FDA Pulls Andexanet Alfa From the Market
ANNEXA 4 https://www.nejm.org/doi/10.1056/NEJMoa1814051
ANNEXA I https://www.nejm.org/doi/full/10.1056/NEJMoa2313040
Richard Buka Tweet https://x.com/richardbuka/status/2001045834050216327?s=20
V Mandrola's Top Cardiovascular Stories of 2025
https://www.medscape.com/viewarticle/mandrolas-top-10-cardiovascular-stories-2025-2025a1000yuh
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Dec 12 2025 This Week in Cardiology
12 december 2025 · 28 min
An elegant study in post-TAVI atrioventricular block, a PSA for my structural colleagues, revascularization in women, and a CTO PCI trial are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I AV Block After TAVR
Heart Blocks During vs After TAVR Show Distinct Patterns
https://www.medscape.com/viewarticle/heart-blocks-during-vs-after-tavr-show-distinct-patterns-2025a1000ypp
Mechanisms Underlying Alterations in Cardiac Conduction After TAVR https://jamanetwork.com/journals/jamacardiology/fullarticle/2842748
II Related PSA Announcement to My Structural Colleagues
III Revascularization Strategies in Women with Severe Chronic CAD
Women With Chronic Severe CAD Fare Better With CABG vs PCI
https://www.medscape.com/viewarticle/women-chronic-severe-cad-fare-better-cabg-vs-pci-2025a1000ygd
PCI vs CABG in Women With Chronic CAD https://doi.org/10.1093/eurheartj/ehaf806
PCI vs CABG - Meta-Analysis of 4 RCTs https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02334-5/abstract
CABG vs Drug-Eluting Stent Implantation for CAD - Meta-Analysis https://www.jacc.org/doi/10.1016/j.jcin.2016.10.008
RECHARGE trial https://therechargetrial.com/
IV A CTO PCI RCT – But don't get your hopes up
Early vs Late-Staged PCI After Subintimal Tracking and Re-entry for CTO https://doi.org/10.1016/j.jacc.2025.09.1598
DECISION CTO trial https://pubmed.ncbi.nlm.nih.gov/30813758/
National Inpatient Sample Database PCI CTO Associated With Higher Mortality https://pubmed.ncbi.nlm.nih.gov/37356643/
V Mandrola's Top 10 Stories
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Dec 05 2025 This Week in Cardiology
5 december 2025 · 30 min
Less is more after PCI, the TARGET-FIRST trial, a negative blood pressure trial that is actually positive, aspirin vs OAC for bleeding, AEDs, and Factor XI is not dead yet are the topics discussed by John Mandrola, MD, on this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Less is More: TARGET-FIRST
TARGET-FIRST Trial https://www.nejm.org/doi/10.1056/NEJMoa2508808
STOPDAPT-2 ACS Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2789701
II A Negative Trial That Is Actually Positive
The RETREAT-FRAIL Study https://www.nejm.org/doi/full/10.1056/NEJMoa2508157
III Major Bleeding With Aspirin vs Apixaban
Subanalysis of ARTESiA https://jamanetwork.com/journals/jamacardiology/fullarticle/2841075
ARTESiA Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2310234
AVERROES Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1007432
IV High Value Interventions – The AED
Experts Call for AED Placement on All Commercial Aircraft https://www.medscape.com/viewarticle/experts-call-aed-placement-all-commercial-aircraft-2025a1000xzf
In-Flight Sudden Cardiac Arrest and AED Use 10.1016/j.cjca.2025.10.010 External Link
V Factor XI Inhibitors – OCEANIC STROKE trial
Bayer Press Release on Asundexian https://www.bayer.com/en/us/news-stories/oceanic-stroke
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Nov 21 2025 This Week in Cardiology
21 november 2025 · 29 min
Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Complete Revascularization for Acute MI Meta-analysis https://doi.org/10.1016/S0140-6736(25)02170-1
II A Sea Change in the Treatment of Carotid Artery Disease — CREST-2 Published
ECST-2 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00107-3/fulltext
SPACE-2 https://pubmed.ncbi.nlm.nih.gov/36115360/
CREST-2 Trial www.nejm.org/doi/full/10.1056/NEJMoa2508800
CREST Protocol paper https://pmc.ncbi.nlm.nih.gov/articles/PMC5987521/
III Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt
PLATO trial https://www.nejm.org/doi/full/10.1056/NEJMoa0904327
Ticagrelor or prasugrel vs clopidogrel in PCI https://eurointervention.pcronline.com/article/ticagrelor-or-prasugrel-versus-clopidogrel-in-patients-undergoing-percutaneous-coronary-intervention-for-chronic-coronary-syndromes
ISAR-REACT 5 trial https://www.nejm.org/doi/full/10.1056/NEJMoa1908973
IV Another Coffee and AF study
Can Coffee Cut the Risk for Atrial Fibrillation?
https://www.medscape.com/viewarticle/can-coffee-cut-risk-atrial-fibrillation-2025a1000w11
A Coffee a Day to Keep the AFib Away? The DECAF Trial Discussed https://www.medscape.com/viewarticle/coffee-day-keep-afib-away-decaf-trial-discussed-2025a1000v5z
DECAF trial https://jamanetwork.com/journals/jama/fullarticle/2841253
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Nov 14 2025 This Week in Cardiology
14 november 2025 · 37 min
Listener feedback on the PISCES trial, AHA news (including a big PCSK9i trial), beta-blockers post MI, LAAC, and post-AF ablation OAC use are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Why I Believe Fish Oil's Big CV Benefit in Dialysis Patients https://www.medscape.com/viewarticle/why-i-believe-fish-oils-big-cv-benefit-dialysis-patients-2025a1000uzg
PISCES trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513032
II PCSK9 Inhibitor News
In Global Trial, PCSK9 Inhibitor Provides Major Protection Against First CV Event https://www.medscape.com/viewarticle/global-trial-pcsk9-inhibitor-provides-major-protection-2025a1000uzp
VESALIUS-CV trial https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
ODYSSEY trial https://www.nejm.org/doi/full/10.1056/NEJMoa1801174
FOURIER https://www.nejm.org/doi/full/10.1056/NEJMoa1615664
Anish Koka Tweet on LDL-lowering https://x.com/anish_koka/status/1987280506937909326?s=20
III Beta-Blockers After MI and John Cleland
Beta-Blockers after MI with normal EF https://www.nejm.org/doi/full/10.1056/NEJMoa2512686
REBOOT-CNIC trial https://www.nejm.org/doi/full/10.1056/NEJMoa2504735
REDUCE AMI trial https://academic.oup.com/ehjcvp/article/9/2/192/6895544?login=false
ABYSS trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
CAPITAL RCT trial https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199347
Beta-Blockers after MI with mildly reduced EF https://pubmed.ncbi.nlm.nih.gov/40897190/
John Cleland Clinical Outlook https://www.nature.com/articles/s41569-025-01228-w
IV Left Atrial Appendage Closure – The CLOSURE-AF trial
Percutaneous LAAC in AF Falls Short Again in CLOSURE-AF https://www.medscape.com/viewarticle/percutaneous-left-atrial-appendage-closure-af-falls-short-2025a1000uzu
Prague-17 Trial https://www.jacc.org/doi/10.1…
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Nov 07, 2025 This Week in Cardiology
7 november 2025 · 32 min
Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Meta-analysis of MI as a surrogate https://pubmed.ncbi.nlm.nih.gov/34694318/
Compare Acute Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1701067
DANAMI-3–PRIMULTI 10.1016/S0140-6736(15)60648-1 External Link
CULPRIT-SHOCK https://www.nejm.org/doi/full/10.1056/NEJMoa1710261
II Huge Cardiac News for Patients with ESRD PISCES article EMBARGOED Till 1130 AM EST
PISCES Trial www.nejm.org/doi/full/10.1056/NEJMoa2513032
REDUCE-IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1812792
STRENGTH Trial https://jamanetwork.com/journals/jama/fullarticle/2773120
FISH trial https://jamanetwork.com/journals/jama/fullarticle/1150094
III Obesity Agents
White House announces deal with Lilly and Novo on GLP-1 drugs https://www.reuters.com/business/healthcare-pharmaceuticals/novo-lilly-shares-rise-trump-obesity-drug-deal-nears-2025-11-06/
Amylin Agonists
Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial
https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf
Eloralintide Phase 2 Study https://doi.org/10.1016/S0140-6736(25)02155-5
GLP-1 Comparisons
SURMOUNT-5 Trial https://www.nejm.org/doi/10.1056/NEJMoa2416394
Tirzepatide vs Semaglutide in 10-year CVD Risk Reduction https://doi.org/10.1093/ehjopen/oeaf117
IV A Problematic Trial in Stroke Care
LAMP trial https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2840370
V AHA Preview
AHA 2025: Mandrola's Four Trials to Look For https://www.medscape.com/viewarticle/aha-2025-mandrolas-four-trials-look-2025a1000u80
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Oct 31 2025 This Week in Cardiology
31 oktober 2025 · 31 min
Four pillars of cardiology today, stable coronary artery disease, severe aortic stenosis, the evaluation of chest pain, and best therapies for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Stable CAD Complete vs culprit-only revascularization at time of STEMI
iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918
PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
PCI Revascularization Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051
CULPRIT SHOCK Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1710261
How a Meta-Analysis Can Mislead https://www.sensible-med.com/p/how-a-meta-analysis-can-misleadthe
II SEVERE Aortic Senosis
7-Year PARTNER 3 Results – TAVI vs SAVR
7-year results PARTNER 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2509766
PARTNER 3 at 1 year https://www.nejm.org/doi/10.1056/NEJMoa1814052
PARTNER 3 at 5 years https://www.nejm.org/doi/10.1056/NEJMoa2307447
III Functional vs Anatomic Assessment in Suspected CAD
10-year follow-up of PROMISE trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2838118
PROMISE Trial https://www.nejm.org/doi/10.1056/NEJMoa1415516
CCTA vs Functional Stress Test – Meta-Analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243
IV ARREST AF
ARREST AF trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2840225
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Oct 24 2025 This Week in Cardiology
24 oktober 2025 · 30 min
The PREVENT score in hypertension, GLP-1 mechanism of action in cardiovascular disease, CAD type and statin benefit, and the problem with hospitalization endpoints in HF trials are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Is the PREVENT Calculator Best for Determining CVD Risk? Insights From a Post Hoc Analysis of SPRINT Trial
https://www.medscape.com/viewarticle/prevent-calculator-best-determining-cvd-risk-insights-post-2025a1000svo
PREVENT Calculator https://doi.org/10.1016/j.jacc.2025.07.037
SPRINT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1511939
II GLP-1 Mechanism of Action in CV Disease
Analysis of SELECT Trial 10.1016/S0140-6736(25)01375-3 External Link
SELECT trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
III Statins and CAD Phenotype on CTA and Outcomes
Interactions Between Statin Use, CAD Phenotypes on CTA https://www.jacc.org/doi/10.1016/j.jcmg.2025.05.018
Statin Use for Primary Prevention of CVD https://jamanetwork.com/journals/jama/fullarticle/2795522
IV HHF Endpoints in Heart Failure Trials
The Problem with Hospitalization Endpoints in HF Trials https://onlinelibrary.wiley.com/doi/10.1002/ejhf.70070
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Oct 17 2025 This Week in Cardiology
17 oktober 2025 · 32 min
Another knock against the antiplatelet/anticoagulant combo, polypills in HF, the physical exam of the future, and the problem of underpowered trials that even Bayesian analyses cannot rescue are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Trends Study https://www.heartrhythmjournal.com/article/S1547-5271(11)00496-6/fulltext
II Another knock against the Antiplatelet/Anticoagulation combination
"Antiplatelet Plus Oral Anticoagulant Lowers Stroke, Raises Bleeding Risk" https://www.medscape.com/viewarticle/antiplatelet-plus-oral-anticoagulant-lowers-stroke-raises-2025a1000re0
ATIS-NVAF Trial https://jamanetwork.com/journals/jamaneurology/fullarticle/2839511
AQUATIC trial https://www.nejm.org/doi/abs/10.1056/NEJMoa2507532
III Polypill for HFrEF
A Multilevel Polypill for Patients With HFrEF https://www.jacc.org/doi/10.1016/j.jacadv.2025.102195
IV The Physical Exam of the Future
Point-of-Care Ultrasound https://doi.org/10.1016/j.jchf.2025.102707
V More on Underpowered Trials – GA vs Moderate Sedation in IV stroke
SEGA Trial https://jamanetwork.com/journals/jamaneurology/fullarticle/2839838
Bayesian Analyses of CV Trials https://doi.org/10.1016/j.cjca.2021.03.014
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