Alle afleveringen
427 afleveringen, van nieuw naar oud
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Oct 10 2025 This Week in Cardiology
10 oktober 2025 · 26 min
GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and imaging before AF ablation are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Listener Feedback
HYPERION trial https://www.nejm.org/doi/10.1056/NEJMoa2508170
ZENITH trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415160
II GLP1 Use in HFrEF
Effects of GLP-1s in Patients With HFrEF https://doi.org/10.1016/j.jchf.2025.102573
FIGHT Study https://jamanetwork.com/journals/jama/fullarticle/2540402
FIGHT Study Post-hoc Analysis https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14862
Substudy of EXSCEL Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041659
III LA Posterior Wall Isolation Saga
Failure of PW Wall Isolation by PFA with Epicardial Mapping https://doi.org/10.1016/j.jacep.2025.08.017
IV Peridevice Leaks After LAAO
IMPRESSION LAAC Study https://doi.org/10.1016/j.jacep.2025.08.014
V Post Cardiac Surgery AF
Monitoring of New-Onset AF After CABG https://jamanetwork.com/journals/jama/fullarticle/2839710
PACES trial https://clinicaltrials.gov/study/NCT04045665
VI TEE vs ICE Before AF ablation
ICE vs TEE Study https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Oct 03 2025 This Week in Cardiology
3 oktober 2025 · 27 min
Two great stories of translation science leading to beneficial drugs in terrible diseases of the heart and the Sisyphean task of predicting the need for pacing after TAVI are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Sotatercept
HYPERION Trial https://www.nejm.org/doi/10.1056/NEJMoa2508170
ZENITH Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415160
Evidence report on treatment for PAH https://icer.org/news-insights/press-releases/icer-publishes-final-evidence-report-on-treatment-for-pulmonary-arterial-hypertension/
PAH Sotatercept Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2503944
II Acoramidis and ATTR Cardiomyopathy
ATTRIBUTE-CM Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2305434?logout=true
ATTRIBUTE-CM Analysis - Substudy https://www.jacc.org/doi/10.1016/j.jacc.2025.09.013
Tafamadis Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1805689
III Pacing After TAVI
Prophylactic pacemaker after TAVI https://www.jacc.org/doi/10.1016/j.jacep.2025.07.028
PROMOTE study https://doi.org/10.1016/j.hrthm.2024.12.019
Evaluation of ESC criteria on RBBB patients undergoing TAVI https://doi.org/10.1016/j.hrthm.2024.11.030
Editorial on Heart Rhythm journal papers https://www.heartrhythmjournal.com/article/S1547-5271(25)00114-6/abstract
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Sep 26 2025 This Week in Cardiology
26 september 2025 · 23 min
A bold trial in valvular heart disease, a CV prevention trial whose message is humility, VTE dogma challenged, more news on oral GLP-1 agonists, and a few public service announcements are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I DOUBLE-CHOICE: Minimalist Approach to TAVI May Be as Good as Standard of Care https://www.medscape.com/viewarticle/double-choice-minimalist-approach-tavi-may-be-good-standard-2025a1000pp7
Patient & Physician Perspectives on CV Risk https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.124.011837
II KP Vaccinate Trial
KP Vaccinate Trial https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500208
IAMI trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057042
Increasing Flu Vaccinations in Patients With Chronic Disease https://jamanetwork.com/journals/jama/fullarticle/2824956
MI FREEE Trial https://www.nejm.org/doi/full/10.1056/NEJMsa1107913
III Hi PRO Trial
Apixaban for Extended Treatment of VTE https://www.nejm.org/doi/full/10.1056/NEJMoa2509426
Recurrent VTE in Patients with Provoked VTE https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/226140
IV Oral GLP-1 Agonists
ATTAIN 1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511774
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Sep 19 2025 This Week in Cardiology
19 september 2025 · 34 min
More trials at ESC, including PARACHUTE HF, DAPA ACT HF-TIMI 68, AMALFI, and a super-interesting modeling study of when to start oral anticoagulants in AF, are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I PARACHUTE HF
First Evidence of Treatment Benefit in Chagas Heart Failure
https://www.medscape.com/viewarticle/first-evidence-treatment-benefit-chagas-heart-failure-2025a1000oem
PARACHUTE-HF https://www.jacc.org/doi/10.1016/j.jchf.2024.05.021
II SGLT2i Early Initiation — DAPA ACT HF-TIMI 68 Trial
Trial Data Support In-Hospital Initiation of SGLT2 Inhibitors for Heart Failure https://www.medscape.com/viewarticle/trial-data-support-hospital-initiation-sglt2-inhibitors-2025a1000o5q
DAPA ACT HF-TIMI 68
https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076575
III AMALFI Trial of AF Screening
Remote ECG Screening Ups Atrial Fibrillation Detection 'Modestly' https://www.medscape.com/viewarticle/remote-ecg-screening-ups-atrial-fibrillation-detection-2025a1000myx
AMALFI Trial https://jamanetwork.com/journals/jama/article-abstract/2838482
STROKESTOP Trial https://www.thelancet.com/article/S0140-6736(21)01637-8/fulltext
LOOP Trial 10.1016/S0140-6736(21)01698-6 External Link
IV Finding that Sweet Spot of Stroke Risk Threshold for Starting DOAC therapy
Stroke Risk Threshold for non-Vitamin K Antagonist OAC in AF https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.125.012090
Variations in Rates of Stroke Across Patients With AF https://www.ahajournals.org/doi/10.1161/circulationaha.116.024057
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Sep 12 2025 This Week in Cardiology
12 september 2025 · 31 min
More from ESC including: Valvular HD guidelines, a new drug class for HTN, myosin inhibition in HCM, vericiguat, and digoxin are the topic discussed by John Mandrola, MD. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I New European Valvular Heart Disease Guidelines
2025 ESC/EACTS Guidelines for the management of valvular heart disease https://doi.org/10.1093/eurheartj/ehaf194
Debate: Does Asymptomatic Aortic Stenosis Warrant Early Intervention? https://exp.medscape.com/debates/does-asymptomatic-aortic-stenosis-warrant-early-intervention/
Surgical Ablation of Atrial Fibrillation during Mitral-Valve Surgery https://www.nejm.org/doi/full/10.1056/NEJMoa1500528
Surgical ablation of atrial fibrillation: a systematic review and meta-analysis https://doi.org/10.1093/europace/eux336
II New Drug for Resistant HTN
Baxdrostat: A 'Game Changer' for Hypertension? https://www.medscape.com/viewarticle/baxdrostat-game-changer-hypertension-2025a1000mz7
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension https://www.nejm.org/doi/full/10.1056/NEJMoa2507109
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension https://www.nejm.org/doi/10.1056/NEJMoa2501440
III HCM News at ESC
New Trials Clarify Role of Myosin Inhibitors for Hypertrophic Cardiomyopathy https://www.medscape.com/viewarticle/new-trials-clarify-role-myosin-inhibitors-hypertrophic-2025a1000myv
MAPLE HCM https://www.nejm.org/doi/full/10.1056/NEJMoa2504654
SEQUOIA HCM https://www.nejm.org/doi/10.1056/NEJMoa2401424
ODYSSEY HCM https://www.nejm.org/doi/full/10.1056/NEJMoa2505927
IV Vericiguat at ESC
New Data Said to Support Vericiguat as Standard Therapy for Heart Failurehttps://www.medscape.com/viewarticle/new-data-said-support-vericiguat-standard-therapy-heart-2025a1000mz9
VICTOR https://doi.org/10.1016/S0140-6736(25)01665-4
VICTORIA https://www.nejm.org/doi/full/10.…
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Sep 05 2025 This Week in Cardiology
5 september 2025 · 38 min
The big beta-blocker story from ESC, dual pathway therapy with aspirin and OAC, stopping OAC after successful AF ablation, and DANCAVAS II trial are the topics John Mandrola, MD, discusses on this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
This Week in Cardiology Podcast – August 29 https://www.medscape.com/viewarticle/1002877
II The Big Beta-blocker Story from ESC
Beta-Blockers Post-MI: A Clear Clinical Message https://www.medscape.com/viewarticle/beta-blockers-post-mi-clear-clinical-message-2025a1000mz0
REBOOT https://www.nejm.org/doi/full/10.1056/NEJMoa2504735
BETAMI-DANBLOCK https://www.nejm.org/doi/abs/10.1056/NEJMoa2505985
REDUCE AMI https://www.nejm.org/doi/10.1056/NEJMoa2401479
CAPITAL RCT https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199347
Post Hoc Analysis From REBOOT Trial https://eurointervention.pcronline.com/article/effect-of-beta-blocker-withholding-or-withdrawal-after-myocardial-infarction-without-reduced-ejection-fraction-on-ischaemic-events-a-post-hoc-analysis-from-the-reboot-trial
Beta-Blockers After MI With Mildly Reduced Ejection Fraction https://doi.org/10.1016/S0140-6736(25)01592-2
CAPRICORN 10.1016/S0140-6736(00)04560-8 External Link
BHAT https://jamanetwork.com/journals/jama/fullarticle/370103
ISIS 1 https://pubmed.ncbi.nlm.nih.gov/2873379/
III Aspirin and OAC Combination Clearly Dangerous
Aspirin Plus Oral Anticoagulants Raises Mortality, Bleeding https://www.medscape.com/viewarticle/aspirin-plus-oral-anticoagulants-raises-mortality-bleeding-2025a1000nam
AQUATIC https://www.nejm.org/doi/full/10.1056/NEJMoa2507532
AFIRE https://www.nejm.org/doi/full/10.1056/NEJMoa1904143
EPIC CAD https://www.nejm.org/doi/10.1056/NEJMoa2407362
OAC-ALONE https://pubmed.ncbi.nlm.nih.gov/30586700/
IV Stop or Continue OAC after Successful AF Ablation
ALONE-AF https://jamanetwork.com/jo…
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Aug 29 2025 This Week in Cardiology
29 augustus 2025 · 34 min
CAC 0 takes a gut punch, ICD therapies cannot be surrogates for benefit, and two important trials from ESC are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I CAC 0
LDL-C and CVD Risk With CAC Score 0 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf497/8228645
II ICD Therapies
Contemporary ICD Benefit https://www.jacc.org/doi/10.1016/j.jacep.2025.06.028
PROFID Trial https://profid-project.eu/profid-ehra-trial/
MADIT-RIT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1211107
Declining Risk of Sudden Death in HF https://www.nejm.org/doi/full/10.1056/NEJMoa1609758
III Digit-HF
DIGIT-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415471
Digoxin–Mortality: Comparison in the DIG trial https://academic.oup.com/eurheartj/article/40/40/3336/5520008
IV POTCAST
POTCAST trial https://www.nejm.org/doi/full/10.1056/NEJMoa2509542
ESC Preview
IV HTN Guidelines
New Blood Pressure Guidelines: 4 Things I Like and 2 Concerns https://www.medscape.com/viewarticle/new-blood-pressure-guidelines-4-thing-i-and-2-concerns-2025a1000m1x
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Aug 22 2025 This Week in Cardiology
22 augustus 2025 · 26 min
John Mandrola discusses conduction system pacing vs standard pacing, withdrawing HF meds when AF is corrected and patient selection in LAAO. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Conduction System Pacing
CSPACE trial https://doi.org/10.1016/j.jacc.2025.06.043
BLOCK HF trial https://www.nejm.org/doi/full/10.1056/NEJMoa1210356
BioPace trial https://doi.org/10.1093/europace/euaf029
II Withdrawing Meds After AF Corrected
WITHDRAW AF https://doi.org/10.1093/eurheartj/ehaf563
TRED HF https://pubmed.ncbi.nlm.nih.gov/30429050/
III Patient Selection in Left Atrial Appendage Occlusion
Long-Term Outcomes Following LAAO in Medicare Beneficiaries: Outcomes From the National Cardiovascular Data Registry https://www.ahajournals.org/doi/10.1161/JAHA.124.039780
ESC Preview
IV HTN Guidelines
New Blood Pressure Guidelines: 4 Things I Like and 2 Concerns https://www.medscape.com/viewarticle/new-blood-pressure-guidelines-4-thing-i-and-2-concerns-2025a1000m1x
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Aug 15 2025 This Week in Cardiology
15 augustus 2025 · 23 min
Big new hypertension guidelines, ultraprocessed foods, coronary sinus reduction and evidence-based medicine, and more news on pulsed field ablation for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I HTN Guidelines
BP Meds Should Begin Promptly, New ACC/AHA Guidelines Say
https://www.medscape.com/viewarticle/bp-meds-should-begin-promptly-new-acc-aha-guidelines-say-2025a1000lms
Guideline for Management of High Blood Pressure https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356
BPROAD trial https://www.nejm.org/doi/full/10.1056/NEJMoa2412006
Trial Score Framework https://pmc.ncbi.nlm.nih.gov/articles/PMC6459598/
II UltraProcessed Foods
AHA statement on Ultraprocessed Foods and Cardiometabolic Health
https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001365
III Refractory Angina and the Coronary Sinus Reducer – A Lesson in EBM
Coronary Sinus Reducer Shows Promise, With Caveats https://www.medscape.com/viewarticle/coronary-sinus-reducer-shows-promise-caveats-2025a1000l76
Coronary Sinus Reducer — Meta-analysis https://www.jacc.org/doi/10.1016/j.jcin.2025.06.012
COSIRA II Trial https://clinicaltrials.gov/study/NCT05102019
IV Pulsed Field Ablation Still Looking Strong
Management of OACs After PFA 10.1016/j.hrthm.2025.03.1952 External Link
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Aug 08 2025 This Week in Cardiology
8 augustus 2025 · 32 min
Listener feedback on SURPASS CVOT, AF ablation and the limits of meta-analyses, a Watchman alert from FDA, and oral anticoagulation choices in elderly patients are discussed by John Mandola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I SURPASS CVOT
This Week in Cardiology Podcast, August 1 https://www.medscape.com/viewarticle/1002781
Mounjaro Appears More Heart Protective Than Trulicity in Trial Of Eli Lilly Diabetes Drugs
https://www.medscape.com/s/viewarticle/mounjaro-proves-more-heart-protective-than-trulicity-trial-2025a1000kct
II Catheter and Surgical AF ablation
Catheter and Surgical Ablation for AF: Meta-Analysis https://www.acpjournals.org/doi/10.7326/ANNALS-25-00253
III Watchman Air Embolism Alerts
Looming Pay Cut to LAAO Triggers Objection From Card Groups
https://www.medscape.com/viewarticle/looming-pay-cut-laao-triggers-objection-card-groups-2025a1000l0j
FDA Alert https://www.fda.gov/medical-devices/medical-device-recalls/early-alert-watchman-access-system-issue-boston-scientific
IV Switching Oral Anticoagulants in Frail Older Adults Patients
FRAIL AF Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.066485
COMBINE AF Substudy https://doi.org/10.1016/j.jacc.2025.05.060
The Most Important Study From ESC: FRAIL-AF https://www.medscape.com/viewarticle/996063
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Aug 01 2025 This Week in Cardiology
1 augustus 2025 · 30 min
Exercise and CV outcomes, aldosterone modulation, AI for ECG reading, GLP-1 comparisons, end-of-life decisions, and another well-meaning policy that caused harm in veterans are discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Exercise and CV outcomes
II Aldosterone Modulation in Cardio-Kidney Disease
Aldosterone and Aldosterone Modulation https://doi.org/10.1016/j.jacc.2025.06.012
Randomized Aldactone Evaluation Study https://www.nejm.org/doi/full/10.1056/NEJM199909023411001
III AI vs MD ECG-Reading for Cath Lab Activation
Accuracy of Cath Lab Activation Decisions https://doi.org/10.1016/j.ajem.2025.07.061
IV Tirzepatide vs Dulaglutide - SURPASS CVOT Study
Eli Lilly Press Release https://investor.lilly.com/news-releases/news-release-details/lillys-mounjaro-tirzepatide-gipglp-1-dual-agonist-demonstrated
REWIND Study 10.1016/S0140-6736(19)31149-3 External Link
V End-of-Life Decisions
Doctors' Own End-of-Life Choices Defy Common Medical Practice
https://www.medscape.com/viewarticle/doctors-own-end-life-choices-defy-common-medical-practice-2025a1000k01
Physicians' Preferences for Their Own End of Life https://jme.bmj.com/content/early/2025/06/05/jme-2024-110192
How US Doctors Die: A Cohort Study https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.14112
VI Well-Meaning Policies That Make Sense
The Mission Act and Cardiovascular Procedures https://jamanetwork.com/journals/jama/fullarticle/2837067
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July 25 2025 This Week in Cardiology
25 juli 2025 · 31 min
The VENTOUX study of endurance athletes, the 10,000 step myth was not busted, rate vs rhythm control for AF, and GLP1 drugs and observational studies are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Endurance Athletes and Arrhythmia (again)
VENTOUX trial
https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.125.018470
II Daily Step Count and Health — no myths were busted.
Lancet Public Health: https://doi.org/10.1016/S2468-2667(25)00164-1
III Rate vs Rhythm Control of AF
Medscape: Everyone Deserves a Shot at the American Dream: Sinus Rhythm
https://www.medscape.com/viewarticle/everyone-deserves-shot-american-dream-sinus-rhythm-2025a1000jle
This Week in Cardiology, July 11, 2025 https://www.medscape.com/viewarticle/1002704
AFFIRM trial https://www.nejm.org/doi/full/10.1056/NEJMoa021328
AFFIRM substudy https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/486560
IV GLP-1 Drugs and Observational Studies
Neurodegeneration and Stroke After Semaglutide and Tirzepatide
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836412
SUSTAIN-6 https://www.nejm.org/doi/full/10.1056/NEJMoa1607141
SELECT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
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Jul 18 2025 This Week in Cardiology
18 juli 2025 · 32 min
Finerenone, what not to consider when choosing treatment of AS, brain health after atrial fibrillation ablation, early rhythm control for AF, and Watchman reimbursement cuts are discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Finerenone FDA Widens Indication of Finerenone for Heart Failure Patients
https://www.medscape.com/viewarticle/fda-widens-indication-finerenone-heart-failure-patients-2025a1000ive
FDA finerenone approval https://bayer2019tf.q4web.com/news/news-details/2025/U-S--FDA-Approves-KERENDIA-finerenone-to-Treat-Patients-With-Heart-Failure-With-Left-Ventricular-Ejection-Fraction-40-Following-Priority-Review/default.aspx
FINEARTS-HF trial https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
II Choosing TAVI or Surgical AVR
Carbon Emission when treating AS
EHJ study https://doi.org/10.1093/eurheartj/ehaf379
III Brain Lesions and Visual Migraine After Left-Sided Ablations Post-Ablation Visual Auras a Sign of Transient Brain Injury?https://www.medscape.com/viewarticle/post-ablation-visual-auras-sign-transient-brain-injury-2025a1000iro
TRAVERSE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.071352
TRAVERSE Migraine Substudy https://doi.org/10.1016/j.hrthm.2025.06.035
IV Early Rhythm Control for AF
EHJ Rapid Communication https://doi.org/10.1093/eurheartj/ehaf397
EAST-AFNET 4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2019422
V Watchman Cuts
CMS Reduces LAAO Value in Proposed Fee Schedule https://www.acc.org/Latest-in-Cardiology/Articles/2025/07/15/20/08/CMS-Reduces-LAAO-Value-in-Proposed-2026
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Jul 11 2025 This Week in Cardiology
11 juli 2025 · 26 min
Approval of first-generation devices, the ticagrelor controversy, ICD longevity, the PRAGUE-25 trial (one of the most important trials of the year), and some thoughts on the end of EP as a profession are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I More Ticagrelor Controversy
BMJ Investigation Finds More Concerns in Ticagrelor Trials https://www.medscape.com/viewarticle/investigation-bmj-raises-more-concerns-about-ticagrelor-2025a1000gh3
Ticagrelor PLATO study https://www.bmj.com/content/389/bmj.r1201
Ticagrelor vs Clopidogrel https://www.nejm.org/doi/full/10.1056/NEJMoa0904327
Review of the Ticagrelor Trials Evidence Base https://www.ahajournals.org/doi/10.1161/JAHA.123.031606
The Plato Trial: Do you believe in magic? https://doi.org/10.1093/eurheartj/ehp545
ONSET/OFFSET Antiplatelet Effects https://www.ahajournals.org/doi/10.1161/circulationaha.109.912550
RESPOND Study https://www.ahajournals.org/doi/10.1161/circulationaha.109.919456
II ICD Battery Longevity
Variability in ICD Battery Longevity https://doi.org/10.1016/j.hrthm.2025.05.031
PRAGUE-25 Trial of AF Ablation vs LFM
PRAGUE-25 Trial https://www.jacc.org/doi/10.1016/j.jacc.2025.04.042
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Jun 27 2025 This Week in Cardiology
27 juni 2025 · 29 min
FDA approves triple-drug polypill, a change of opinion, a deep dive into invasive pulmonary embolism therapies, heart disease trends, and diabetes care is on fire are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I FDA News in HTN
FDA announcement https://george-medicines.com/george-medicines-announces-fda-approval-of-widaplik-telmisartan-amlodipine-and-indapamide-a-new-single-pill-combination-treatment-for-hypertension-in-adults-including-initial-treatment/
Lancet Study https://doi.org/10.1016/S0140-6736(24)01744-6
JACC study vs placebo https://www.jacc.org/doi/abs/10.1016/j.jacc.2024.08.025
JAMA Cardiology Meta-analysis https://jamanetwork.com/journals/jamacardiology/fullarticle/2804313
II Invasive PE Therapy
EHJ-Open review: https://academic.oup.com/ehjopen/article/5/3/oeaf071/8156689
PEITHO Trial https://www.nejm.org/doi/10.1056/NEJMoa1302097
REAL PE Observational Study https://pmc.ncbi.nlm.nih.gov/articles/PMC11308131/
III Heart Disease Trends
King et al https://www.ahajournals.org/doi/10.1161/JAHA.124.038644
IV Diabetes Coverage
Medscape Link https://www.medscape.com/viewcollection/37830
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Jun 20 2025 This Week in Cardiology
20 juni 2025 · 33 min
A big, deep dive into CTA and fractional flow reserve CT, and a sobering report on the new EVOQUE valve are discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback and Correction
CRAAFT HF https://clinicaltrials.gov/study/NCT06505798
II Imaging and Behavior Change
SCOT HEART 1 https://www.nejm.org/doi/full/10.1056/NEJMoa1805971
Five Reasons I Don't Believe an Imaging Test Improves Outcomes https://www.medscape.com/viewarticle/901204
SCOT HEART 2 https://www.jacc.org/doi/10.1016/j.jcmg.2024.05.016
III. More on Imaging and CT FFR Symptoms Don't Always Indicate the Severity of Coronary Artery Disease https://www.medscape.com/viewarticle/symptoms-dont-always-indicate-severity-coronary-artery-2025a1000ge6
ADVANCE Registry Protocol https://www.journalofcardiovascularct.com/article/S1934-5925(16)30288-X/abstract
Research Letter JACC CV Imaging https://doi.org/10.1016/j.jcmg.2025.05.002
ADVANCE Registry Paper 2018 https://doi.org/10.1093/eurheartj/ehy530
Cook et al JAMA Card https://jamanetwork.com/journals/jamacardiology/fullarticle/2629072
Low diagnostic yield Patel paper NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa0907272
Venk Murthy thread https://x.com/venkmurthy/status/1033379922679660544
IV EVOQUE Real World Data
JACC has published a sobering research letter on the Transcatheter Tricuspid Valve Replacement called EVOQUE valve.
Lupu et al JACC IV https://doi.org/10.1016/j.jcin.2025.03.019
TRISCEND II https://www.nejm.org/doi/full/10.1056/NEJMoa2401918
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Jun 13 2025 This Week in Cardiology
13 juni 2025 · 27 min
Listener feedback on cardiac sarcoidosis, SA node ablation, surgical AF ablation, chronic kidney disease protection, and recruiting for clinical trials are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
EHJ paper Mathijssen et al https://doi.org/10.1093/eurheartj/ehaf338
Nordenswan et al https://www.ahajournals.org/doi/full/10.1161/CIRCEP.117.006145#tab-contributors
II IST
HR Case Reports https://doi.org/10.1016/j.hrcr.2025.05.017
Lakkireddy et al https://doi.org/10.1016/j.hrthm.2021.07.010
III Survival After Surgical AF ablation during CABG
McClure et al https://doi.org/10.1093/europace/eux336
Schaffer et al https://doi.org/10.1016/j.athoracsur.2025.03.044
IV Finerenone with Empagliflozin in CKD and DM
The Confidence Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2410659
V Recruiting for Important Trials and the Stature of EP as a Profession
Two UK Cardiology Trials Struggle to Recruit Patients
https://www.medscape.com/viewarticle/two-uk-cardiology-trials-struggle-recruit-patients-2025a1000ffs
CRAFT HF https://clinicaltrials.gov/study/NCT06505798
BRITISH https://doi.org/10.1016/j.ahj.2023.09.008
PROFID https://profid-project.eu/profid-ehra-trial/
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Jun 06 2025 This Week in Cardiology
6 juni 2025 · 29 min
Listener feedback on cardiac sarcoidosis, out-of-hospital cardiac arrest, less is more when it comes to post-stent antiplatelets, lipoprotein(a), and atrial fibrillation in HFpEF are discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
Mathijssen https://doi.org/10.1093/eurheartj/ehaf338
Poyhonen https://doi.org/10.1161/CIRCEP.124.013239
II News in out of hospital cardiac arrest
AHA Press Release https://newsroom.heart.org/news/nfl-safety-justin-reid-expands-cpr-education-for-youth-through-summer-program
Chan et al https://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.124.011799
III Post-Stent Antiplatelet
4D ACS trial https://eurointervention.pcronline.com/article/one-month-dual-antiplatelet-therapy-followed-by-prasugrel-monotherapy-at-a-reduced-dose-the-4d-acs-randomised-trial
IV Lp(a) and the new PREVENT equation for Predicting cardiac events
Aug 02, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1001429
Bhatia et al https://jamanetwork.com/journals/jamacardiology/fullarticle/2835022
V AF in HFpEF
Saksena et al https://doi.org/10.1093/europace/euad095
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May 30 2025 This Week in Cardiology
30 mei 2025 · 31 min
Listener feedback, CRT vs CSP, important clues on the ECG, beta-blocker interruption after myocardial infarction, novel approaches to LDL-C lowering, and ICD decisions in cardiac sarcoidosis are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
II CRT vs CSP – CONSYST-CRT
• Trial JACC EP https://doi.org/10.1016/j.jacep.2025.03.024
III The Important QRS
• Kewcharoen et al https://www.ahajournals.org/doi/10.1161/CIRCEP.125.013809
IV ABYSS Trial of BB Interruption after MI Continues to be Mis-interpreted
• ABYSS Main https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
• ABYSS substudy https://doi.org/10.1093/eurheartj/ehaf170
• REDUCE AMI https://www.nejm.org/doi/full/10.1056/NEJMoa2401479
V Oral PCSK9i and the PURSUIT Trial
• Koren et al https://www.jacc.org/doi/10.1016/j.jacc.2025.03.499
• Editorial https://doi.org/10.1016/j.jacc.2025.03.518
• Is Lifelong LDL-C Lowering Within Reach? The heart-1 Gene-Editing Trial https://www.medscape.com/viewarticle/998162
• Heart-1 Gene Therapy Trial Pauses Enrollment https://www.medscape.com/viewarticle/998162
• EHJ coverage VERVE https://academic.oup.com/ehjcvp/article/10/2/87/7455877
VI Cardiac Sarcoidosis and Risk of VT
• EHJ paper Mathijssen et al https://doi.org/10.1093/eurheartj/ehaf338
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May 23 2025 This Week in Cardiology
23 mei 2025 · 22 min
Listener feedback on sports "disqualification," big digoxin news, Brugada syndrome, another positive finerenone study, and unblinded transcatheter trials are discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Listener Feedback
JACC EP Paper https://www.jacc.org/doi/10.1016/j.jacep.2025.03.013
II Digoxin News
DIGIT HF Baseline Characteristics paper https://doi.org/10.1002/ejhf.3679
DIGIT HF Rationale paper https://pmc.ncbi.nlm.nih.gov/articles/PMC6607489/
Dig trial https://www.nejm.org/doi/full/10.1056/NEJM199702203360801
DECISION trial https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.3428
Ziff et al BMJ meta-analysis https://www.bmj.com/content/351/bmj.h4451
III Brugada Syndrome
Gomes et al https://doi.org/10.1093/europace/euaf091
IV Another Finerenone Substudy Published
FINEARTS-HF trial substudy, Bhatt, A et al https://doi.org/10.1016/j.cardfail.2025.05.006
FINEARTS HF Main paper https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
TOPCAT https://www.nejm.org/doi/full/10.1056/NEJMoa1313731
TOPCAT regional variation Circ paper https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255
V Another Opinion on Unblinded Transcatheter Intervention Trials
Kaul https://eurointervention.pcronline.com/article/unblinded-trials-of-transcatheter-interventions-with-subjective-endpoints-what-are-the-implications
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May 16 2025 This Week in Cardiology
16 mei 2025 · 29 min
The BedMed trial of nighttime BP meds, SURMOUNT-5, Troponin URL, gene tests in patients with no disease, and guideline-directed medical therapy for HF are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Timing of BP Meds – The BedMed RCT
MAPEC https://doi.org/10.3109/07420528.2010.510230
Hygia https://doi.org/10.1093/eurheartj/ehz754
Turgeon et al https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.16501
TIME trial https://doi.org/10.1016/S0140-6736(22)01786-X
BedMed https://jamanetwork.com/journals/jama/fullarticle/2833860
Time Antihypertensives Taken Doesn't Matter: New Trials https://www.medscape.com/viewarticle/time-antihypertensives-taken-doesnt-matter-new-trials-2024a1000g3z
Timing of BP Dosing Doesn't Matter: BedMed and BedMed-Frail https://www.medscape.com/viewarticle/timing-blood-pressure-dosing-doesnt-matter-again-bedmed-and-2024a1000fz2
Timing of Blood Pressure Meds Doesn't Affect Outcomes: BedMed in Print https://www.medscape.com/viewarticle/timing-blood-pressure-meds-doesnt-affect-outcomes-bedmed-2025a1000cdm
II Tirzepatide vs Semaglutide
SURMOUNT 5 https://www.nejm.org/doi/full/10.1056/NEJMoa2416394
III Age-specific Troponins
Coyle and McEvoy https://doi.org/10.1093/eurheartj/ehaf308
Mandrola/Foy JAMA-IM https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967
IV Return to Play for Gene Positive Phenotype Negative athletes
Martinez et al https://doi.org/10.1016/j.jacep.2025.03.013
V Rapid Titration of GDMT in HF
STRONG HF: More Beats Less After Discharge for Heart Failure https://www.medscape.com/viewarticle/983698
JACC-HF Substudy https://doi.org/10.1016/j.jchf.2025.02.020
STRONG HF https://doi.org/10.1016/S0140-6736(22)02076-1
AVID https://www.nejm.org/doi/full/10.1056/NEJMoa013474
EAST https://www.nejm.org/doi/full/10.1056/NEJMoa013474
You ma…
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May 09 2025 This Week in Cardiology
9 mei 2025 · 32 min
The controversial KETO-CTA study, tough decisions in subclinical AF, and another potentially huge benefit for GLP-1 agonist drugs are discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I The KETO-CTA Study
JACC Advances Paper: https://www.jacc.org/doi/10.1016/j.jacadv.2025.101686
Meta-analysis https://doi.org/10.1016/j.ajcnut.2024.01.009
II Subclinical AF – Anticoagulate or Not?
Anticoagulation in Subclinical AF May Offer Little Benefit
https://www.medscape.com/viewarticle/anticoagulation-subclinical-af-may-offer-little-benefit-2025a1000b31
Treat AFib 'Diagnosed' by Smartwatch
https://www.medscape.com/viewarticle/treat-afib-diagnosed-smartwatch-2025a1000avp
JAMA NO paper https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833437
NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062
ARTESIA https://www.nejm.org/doi/full/10.1056/NEJMoa2310234
McIntyre meta-analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067512
Singer et al https://pmc.ncbi.nlm.nih.gov/articles/PMC2777526/
Stroke paper https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.123.045843
American Journal of Medicine paper https://pubmed.ncbi.nlm.nih.gov/38331136/
III GLP1a for Treatment of Fatty Liver Disease
ESSENCE trial https://www.nejm.org/doi/10.1056/NEJMoa2413258
Features
CABG Still Superior to Stents Despite FAME 3 Endpoint Swap
https://www.medscape.com/viewarticle/cabg-still-superior-stents-despite-fame-3-endpoint-swap-2025a1000ao5
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May 02, 2025 This Week in Cardiology
2 mei 2025 · 30 min
The FDA approval of TAVR for asymptomatic AS, digital health, subcutaneous vs transvenous ICD, and cryptogenic stroke in young adults are discussed by John Mandrola, MD. Lees meer
This podcast is intended for healthcare professionals only.
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I FDA announces approval for TAVR in pts with asymptomatic AS
Edwards Press Release https://www.edwards.com/newsroom/news/2025-05-01-edwards-tavr-receives-fda-approval-for-patients-with-asymptomatic-severe-aortic-stenosis
Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis (EARLY TAVR) https://www.nejm.org/doi/full/10.1056/NEJMoa2405880
EARLY TAVR: A Positive Trial That Fails to Inform Clinical Decisions https://www.medscape.com/viewarticle/early-tavr-positive-trial-fails-inform-clinical-decisions-2024a1000kec
Asymptomatic Aortic Stenosis: 'Time to Act' or Not So Fast? https://www.medscape.com/viewarticle/asymptomatic-aortic-stenosis-time-act-or-not-so-fast-2025a10005o9
II PPG that Can Distinguish source of Tachycardia
Machine-learning guided differentiation between photoplethysmography waveforms of supraventricular and ventricular origin https://doi.org/10.1016/j.cmpb.2025.108798
III PRAETORIAN -XL trial
Device-related Complications in Transvenous Versus Subcutaneous Defibrillator Therapy During Long-term Follow-up: the PRAETORIAN-XL Trial https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.074576
Subcutaneous or Transvenous Defibrillator Therapy (PRAETORIAN trial) https://www.nejm.org/doi/full/10.1056/NEJMoa1915932
Subcutaneous or Transvenous Defibrillator Therapy Letter to Editor https://www.nejm.org/doi/full/10.1056/NEJMc2034917
The PRAETORIAN Trial: Guarded Approach to Subcutaneous ICD Best https://www.medscape.com/viewarticle/937156
IV Stroke in Young People
Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale https://www.ahajournals.org/doi/1…
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Apr 25 2025 This Week in Cardiology
25 april 2025 · 28 min
AI and ECGs, novel ways to treat hypertension, combined lipid-lowering therapy after myocardial infarction, PFA and silent stroke, a move toward accountability in AF ablation, and pacing issues in TTVR are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Help with ECGs in the ED
AI Shows Promise for Rapid NSTEMI Diagnosis
https://www.medscape.com/viewarticle/ai-shows-promise-rapid-nstemi-diagnosis-2025a10009pw
Buscher et al https://doi.org/10.1093/eurheartj/ehaf254
II A Novel way to Treat HTN
A Pacemaker to Control BP Gets FDA Breakthrough Designation
https://www.medscape.com/viewarticle/pacemaker-control-bp-gets-fda-breakthrough-designation-2025a10009t3
JAHA paper https://www.ahajournals.org/doi/10.1161/JAHA.120.020492
Backbeat https://clinicaltrials.gov/study/NCT06059638
III Type of PFA may matter for Silent Cerebral Lesions
Paper https://www.ahajournals.org/doi/10.1161/CIRCEP.125.013719
IV Accountability coming to US AF ablation
Heart Rhythm Society Releases a Document on Establishing Centers of Excellence for AF ablation -- Press Release https://www.hrsonline.org/news/new-white-paper-on-atrial-fibrillation-centers-of-excellence/
V Pacing in Patients with Undergoing Transcatheter Tricuspid Valve Replacement
Paper https://doi.org/10.1016/j.hrthm.2025.02.004
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Apr 18 2025 This Week in Cardiology
18 april 2025 · 24 min
The FAME 3 trial 5-year results, TAVR at 5 years, pacers after TAVR, and mavacamten not a wonder drug are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I FAME 3 at Five Years
Stents as Good as Surgery for Triple-Vessel Disease https://www.medscape.com/viewarticle/noninvasive-stents-good-surgery-triple-vessel-disease-2025a10007l4
Main trial NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2112299
Circulation 3-years https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065770
5-year results Lancet 10.1016/S0140-6736(25)00505-7 https://linkinghub.elsevier.com/retrieve/pii/S0140673625005057
II TAVR in Low-Risk Patients at 5 years
5-Year TAVR, Surgery Outcomes Similar in Low-Risk Patients
https://www.medscape.com/viewarticle/5-year-tavr-surgery-outcomes-similar-low-risk-patients-2025a10007zl
EVOLUT Low-Risk 5 years https://www.jacc.org/doi/10.1016/j.jacc.2025.03.004
EVOLUT Editorial – We're Halfway There https://www.jacc.org/doi/10.1016/j.jacc.2025.03.428
PARTNER 3 Low-Risk https://www.nejm.org/doi/full/10.1056/NEJMoa2307447
NOTION at 5 years https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.036606
III The Matter of Pacemakers After TAVI
JACC IV Study Badertscher https://www.jacc.org/doi/10.1016/j.jcin.2025.03.028
Assessing the quality of reporting of harms in randomized controlled trials published in high impact cardiovascular journals
IV Mavacamten Looks to Have Specific Indications
EXPLORER HCM 10.1016/S0140-6736(20)31792-X External Link
VALOR HCM https://jamanetwork.com/journals/jamacardiology/fullarticle/2809050
BMS Press Release https://news.bms.com/news/details/2025/Bristol-Myers-Squibb-Provides-Update-on-Phase-3-ODYSSEY-HCM-Trial/
FINAL THOUGHTS
PRAGUE 25 https://bmjopen.bmj.com/content/12/6/e056522
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April 11, 2025 This Week in Cardiology Podcast
11 april 2025 · 28 min
The TAP-IT, STRIDE, FreshUP, and SINGLE SHOT CHAMPION trials are discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic
I TAP IT
TAP IT trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.073521
II STRIDE
LANCET Ref 10.1016/S0140-6736(25)00509-4
SUMMIT HF https://www.nejm.org/doi/full/10.1056/NEJMoa2410027
III FRESH UP
No Need to Restrict Fluids in Stable Heart Failure
https://www.medscape.com/viewarticle/no-need-restrict-fluids-stable-heart-failure-2025a10008bu
Nature (Trial) https://www.nature.com/articles/s41591-025-03628-4
SODIUM HF https://pubmed.ncbi.nlm.nih.gov/35381194/
IV PFA for AF ablation
SINGLE SHOT CHAMPION https://www.nejm.org/doi/full/10.1056/NEJMoa2502280
ADVENT https://www.nejm.org/doi/full/10.1056/NEJMoa2307291
Foy et al https://pmc.ncbi.nlm.nih.gov/articles/PMC11852674/
MANIFEST REDO Study https://doi.org/10.1093/europace/euaf012
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Apr 04 2025 This Week in Cardiology
4 april 2025 · 27 min
Trials from the 2025 American College of Cardiology scientific sessions, including the WARRIOR, PROTECT TAVI, DAPATAVI, and SOUL are reviewed by John Mandrola, MD Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Thank you Comments
II WARRIOR Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD
Keep Fighting INOCA After Neutral WARRIOR Trial https://www.medscape.com/viewarticle/keep-fighting-inoca-after-neutral-warrior-trial-2025a10007uf
III Cerebral Embolic Protection in TAVI
PROTECT TAVI https://www.nejm.org/doi/full/10.1056/NEJMoa2415120
PROTECTED TAVR https://www.nejm.org/doi/full/10.1056/NEJMoa2204961
Instrumental Variables in Randomized Trials https://evidence.nejm.org/doi/10.1056/EVIDctw2400204
IV DAPATAVI
SGLT2 Inhibitors Progressing to New Standard After TAVI https://www.medscape.com/viewarticle/sglt2-inhibitors-progressing-new-standard-after-tavi-2025a100081y
Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation https://www.nejm.org/doi/full/10.1056/NEJMoa2500366
V SOUL Study of Oral Semaglutide and CV outcomes in Diabetes
Oral GLP-1 Receptor Agonist Reduces CV Risk https://www.medscape.com/viewarticle/oral-glp-1-receptor-antagonist-reduces-cv-risk-2025a10007kr
Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2501006
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Mar 28 2025 This Week in Cardiology
28 maart 2025 · 29 min
Stopping oral anticoagulation after AF ablation, the core problem with paradoxes like the smoker's paradox, chronic total occlusion PCI, and an ACC/EHRA preview are discussed by John Mandrola, MD, in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I Oral Anticoagulation after Successful AF Ablation
Iwawakie et al https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831851
OCEAN protocol paper https://doi.org/10.1016/j.ahj.2017.12.007
II Smoker's Paradox
Presch et al https://www.jacc.org/doi/10.1016/j.jcin.2024.12.028
Gupta et al https://doi.org/10.1161/JAHA.116.003370
III CTO PCI
Main sub-analysis paper Bangalore et al https://doi.org/10.1016/j.jacc.2025.01.029
DECISION CTO https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.031313
Main EURO CTO trial https://doi.org/10.1093/eurheartj/ehy220
3-year MACE of EURO CTO https://eurointervention.pcronline.com/article/three-year-outcomes-of-eurocto-a-randomized-multicentre-trial-comparing-revascularization-and-optimal-medical-therapy-for-chronic-total-coronary-occlusions
EXPLORE https://www.jacc.org/doi/abs/10.1016/j.jacc.2016.07.744
ISCHEMIA CTO https://www.clinicaltrials.gov/study/NCT03563417
IV ACC and EHRA Preview
Mandrola's 5 Trials to Look for at the 2025 American College of Cardiology Scientific Sessions https://www.medscape.com/viewarticle/mandrolas-5-trials-look-2025-american-college-cardiology-2025a10006zu
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Mar 21 2025 This Week in Cardiology
21 maart 2025 · 28 min
A large trial in cardiac pacing finally published, PVCs and cardiomyopathy, cannabis, CV risk and the danger of observational studies, and the tale of two disparate statin trials are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I BioPace Trial
Trial manuscript https://doi.org/10.1093/europace/euaf029
II Another Belief Challenged in EP this week—PVCs and CM '
UC Paper https://doi.org/10.1016/j.jacep.2025.01.004
JACC Review https://doi.org/10.1016/j.jacc.2024.03.416
Lee et al https://heart.bmj.com/content/105/18/1408
III Cannabis and CV Risk
Cannabis and MACE in JACC Advances: https://www.jacc.org/doi/10.1016/j.jacadv.2025.101698
Zeraatkar –Grilling the data https://doi.org/10.1016/j.jclinepi.2024.111278
PLOS-1 10.1371/journal.pone.0199705
IV Cardio-oncology
Jacc Onc Substdy https://www.jacc.org/doi/10.1016/j.jaccao.2024.11.008
Editorial https://www.jacc.org/doi/10.1016/j.jaccao.2025.01.006
STOP CA JAMA 2023 https://jamanetwork.com/journals/jama/fullarticle/2807988
PREVENT https://evidence.nejm.org/doi/10.1056/EVIDoa2200097
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Mar 14 2025 This Week in Cardiology
14 maart 2025 · 28 min
Listener feedback, resistant hypertension, K-binders for MRA use in heart failure, nutritional epidemiology, and a positive study for vitamin D are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I Listener Feedback
Califf editorial https://www.jacc.org/doi/10.1016/j.jaccas.2020.01.003
II Resistant HTN
Positive Topline Results for Lorundrostat in Hypertension
https://www.medscape.com/viewarticle/positive-topline-results-lorundrostat-hypertension-2025a100062e
III K-Binding
REALIZE K Trial https://doi.org/10.1016/j.jacc.2024.11.014
Packer Editorial https://doi.org/10.1016/j.jacc.2025.01.011
Diamond Trial EHJ https://doi.org/10.1093/eurheartj/ehac401
REALIZE K Commentary https://www.medscape.com/viewarticle/realize-k-new-potassium-binder-help-keep-spiro-board-2024a1000m2c
IV Butter vs Plant-based Oils and Mortality
JAMA-IM Study https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2831265
Is Red Meat Healthy? Multiverse Analysis Has Lessons Beyond Meat https://www.medscape.com/viewarticle/red-meat-healthy-multiverse-analysis-has-lessons-beyond-meat-2024a10008qv
Cookbook Review https://doi.org/10.3945/ajcn.112.047142
V Vitamin D
Impact Factor https://www.medscape.com/viewarticle/rare-win-vitamin-d-this-time-ms-2025a10005ul
D-Lay trial https://jamanetwork.com/journals/jama/fullarticle/2831270
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Mar 07 2025 This Week in Cardiology
7 maart 2025 · 32 min
Listener feedback on asymptomatic aortic stenosis (AS), transcatheter aortic valve replacement (TAVR) vs surgical aortic valve replacement (SAVR), coronary artery calcium (CAC), and revascularization for patients with ischemic LV dysfunction are discussed by John Mandrola, MD, in today's podcast. Lees meer
This podcast is intended for healthcare professionals only.
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I Aortic Valve Intervention for Asymptomatic AS
Asymptomatic Aortic Stenosis: "Time to Act" or Not So Fast?
https://www.medscape.com/viewarticle/asymptomatic-aortic-stenosis-time-act-or-not-so-fast-2025a10005o9
EARLY TAVR: A Positive Trial That Fails to Inform Clinical Decisions
https://www.medscape.com/viewarticle/early-tavr-positive-trial-fails-inform-clinical-decisions-2024a1000kec
Reddy et al: https://doi.org/10.1016/j.jacc.2024.12.031
Wallach editorial https://doi.org/10.1016/j.jacc.2025.01.020
Guerrero https://www.tctmd.com/slide/tavr-young-patients-current-treatment-patterns-us
II CAC - Coronary Artery Calcium
Coronary Artery Calcium Testing—Too Early, Too Late, Too Often https://jamanetwork.com/journals/jamacardiology/fullarticle/2830950
CAUGHT-CAD https://jamanetwork.com/journals/jama/fullarticle/2831115
III CABG, PCI or Meds for Ischemic LV Dysfunction
STICH https://www.nejm.org/doi/full/10.1056/NEJMoa1100356
STICHES https://www.nejm.org/doi/full/10.1056/NEJMoa1602001
REVIVED BCIS https://www.nejm.org/doi/full/10.1056/NEJMoa2206606
EHJ paper https://doi.org/10.1093/eurheartj/ehaf080
IV Preview
https://www.medscape.com/viewarticle/shed-lead-and-injuries-should-cath-labs-go-lead-free-2024a1000hnb
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Feb 28 2025 This Week in Cardiology
28 februari 2025 · 31 min
The treatment of asymptomatic aortic stenosis, the move to composite endpoints in trials, IFR vs FFR and high-frequency low tidal volume ventilation for AF ablation are the topics John Mandrola, MD, discusses in today's podcast. Lees meer
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I Aortic valve intervention for Asymptomatic AS
Lindman editorial https://jamanetwork.com/journals/jamacardiology/fullarticle/2829881
Trends https://pmc.ncbi.nlm.nih.gov/articles/PMC11308430/
Podcast EARLY TAVR Nov 8, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1001865
Faith Healing and Subtraction Anxiety https://www.ahajournals.org/doi/10.1161/circoutcomes.118.004665
Early TAVR trial https://www.nejm.org/doi/10.1056/NEJMoa2405880
EVOLVED https://jamanetwork.com/journals/jama/fullarticle/2825540
AVATAR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057639
II Trial Endpoints
Shepshelovich https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2830023
Brown meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560
III IFR vs FFR—a debate b/w RCTs and observational data
5-year DEFINE https://jamanetwork.com/journals/jamacardiology/fullarticle/2824470
5-year SwedeHeart IFR https://doi.org/10.1016/j.jacc.2021.12.030
Eftekhari meta-analysis https://doi.org/10.1093/eurheartj/ehad582
Gotberg SWEDEHEART Registry https://doi.org/10.1016/j.jcin.2024.12.003
Editorial of SWEDEHEART-Registry https://doi.org/10.1016/j.jcin.2024.12.014
IV High-frequency low-tidal-volume ventilation for AF ablation
Osorio et al https://doi.org/10.1016/j.hrthm.2024.07.094
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Feb 21 2025 This Week in Cardiology
21 februari 2025 · 29 min
Blanking period after AF ablation, periprocedural MI after PCI in non-STEMI, predicting AF after ischemic stroke, and the proper standards for mitral valve repair in primary mitral regurgitation are the topics John Mandrola, MD, discusses in today's podcast. Lees meer
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I AF blanking period
CIRCA DOSE Research letter https://www.ahajournals.org/doi/10.1161/CIRCEP.124.013232
Circa-Dose https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.042622
COMPARE CRYO https://doi.org/10.1016/j.jacep.2024.03.021
Mohanty et al 10.1016/j.hrthm.2024.08.011
Ruzieh, Foy, Mandrola Patients' Lives Don't Pause for Blanking Periods https://doi.org/10.1016/j.ahjo.2024.100497
II Periprocedural MI and Future events
Circulation paper https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.070729
III AI to detect AF related stroke
eClinical Medicine Paper https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(25)00050-1/fulltext
IV Mitral Valve Repair
JACC paper -- https://doi.org/10.1016/j.jacc.2024.10.108
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Feb 14 2025 This Week in Cardiology
14 februari 2025 · 27 min
Silent cerebral embolism after LAAC, AI in ECG rhythm analysis, anti-thrombotic strategies in patients with AF and CAD, and subclinical AF are the topics John Mandrola, MD, covers in today's podcast. Lees meer
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I. Silent Cerebral Embolism after LAAC
JAHA Case Series https://www.ahajournals.org/doi/10.1161/JAHA.124.037968
JACC https://doi.org/10.1016/j.jacc.2018.12.039
II. AI Transforming Rhythm Monitor Reading
Johnson and colleagues RCT https://www.nature.com/articles/s41591-025-03516-x
III. Anticoagulation Alone or OAC plus antiplatelets in patients with CAD and AF
Rashedi and colleagues Meta-analysis https://doi.org/10.1016/j.jacc.2024.12.030
AQUATIC https://clinicaltrials.gov/study/NCT04217447
IV. DOAC for Subclinical AF – A Subgroup Analysis of ARTESIA
Anticoagulation Uncertainty in Embolic Stroke of Undetermined Source https://www.medscape.com/viewarticle/anticoagulation-uncertainty-embolic-stroke-undetermined-2024a1000h5e
Lancet Neurology Subgroup Analysis of ARTESIA 10.1016/S1474-4422(24)00475-7
ARTESIA https://www.nejm.org/doi/full/10.1056/NEJMoa2310234
NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062
RE-SPECT ESUS https://www.nejm.org/doi/full/10.1056/NEJMoa1813959
NAVIGATE ESUS https://www.nejm.org/doi/full/10.1056/NEJMoa1802686
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Feb 07 2025 This Week in Cardiology
7 februari 2025 · 27 min
Sugar-sweetened beverages, the epidemiology of driving after an ICD, BP measurements, and massive EBM lesson in EVT for acute stroke are the topics John Mandrola, MD, discusses in today's podcast. Lees meer
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I. Sugar-Sweetened Beverages
Sugary Drinks Fuel Millions of Diabetes and CVD Cases https://www.medscape.com/viewarticle/sugary-drinks-fuel-millions-diabetes-and-cvd-cases-2025a10002wr
Nature Medicin;e Epidemiologic Study https://www.nature.com/articles/s41591-024-03345-4
JAMA-Network Open; Beverage Tax Observational Study https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829505
Lancet Regional Health; Beverage Tax Philadelphia EHR 10.1016/j.lana.2024.100906
II. Driving With an ICD
JACC Electrophysiology paper https://doi.org/10.1016/j.jacep.2024.12.002
Earlier HEART paper https://heart.bmj.com/content/110/24/1401
III. Blood Pressure Measurements and Simple RCTs
BP Readings in Noisy Market as Good as Quiet Office?
https://www.medscape.com/viewarticle/bp-readings-noisy-market-good-quiet-office-2025a10002z0
Annals of Internal Medicine Study https://www.acpjournals.org/doi/10.7326/ANNALS-24-00873
IV. A Big Shake-up in Interventional Stroke Care
Endovascular Therapy Fails to Show Benefit in Distal Occlusion Stroke https://www.medscape.com/viewarticle/endovascular-therapy-fails-show-benefit-distal-occlusion-2025a100035u
ESCAPE-MeVO https://www.nejm.org/doi/full/10.1056/NEJMoa2411668
DISTAL trial https://www.nejm.org/doi/full/10.1056/NEJMoa2408954
J. Mocco Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2500492
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Jan 31 2025 This Week in Cardiology
31 januari 2025 · 26 min
Another negative AF ablation trial, predicting AF after stroke, the value of RCTs, troponin testing in the ED and surgical aortic valve choice are the topics John Mandrola, MD, discusses this week. Lees meer
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I AF ablation
Coronary Sinus Isolation for High-Burden Atrial Fibrillation: A Randomized Clinical Trial https://doi.org/10.1016/j.jacep.2024.09.017
Approaches to Catheter Ablation for Persistent Atrial Fibrillation (STAR AFII) https://www.nejm.org/doi/full/10.1056/NEJMoa1408288
Effect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial https://doi.org/10.1001/jama.2020.16195
Hybrid Convergent Procedure for the Treatment of Persistent and Long-Standing Persistent Atrial Fibrillation: Results of CONVERGE Clinical Trial https://www.ahajournals.org/doi/10.1161/CIRCEP.120.009288
II Post-Stroke AF monitoring
Prediction of atrial fibrillation after a stroke event: a systematic review with meta-analysisMeta-analysis 10.1016/j.hrthm.2025.01.026
Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source https://www.nejm.org/doi/full/10.1056/NEJMoa1813959
Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source (Navigate ESUS https://www.nejm.org/doi/full/10.1056/NEJMoa1802686
Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy (ARCADIA) https://jamanetwork.com/journals/jama/fullarticle/2814933
III RCTs
Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-025-08724-x
Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction (TASTE) https://www.nejm.org/doi/full/10.1056/NEJMoa1405707
IV Troponin Testing in the ED
Cardia…
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Jan 24 2025 This Week in Cardiology
24 januari 2025 · 26 min
Familial hypercholesterolemia, cardiac arrest therapy, Factor XI inhibition, and tricuspid valve interventions are the topics John Mandroa, MD, discusses in this week's podcast. Lees meer
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I. Familial hypercholesterolemia
Danish Registry Study: https://doi.org/10.1093/eurheartj/ehae912
II. Cardiac Arrest
Vallentin and Colleagues RCT https://www.nejm.org/doi/full/10.1056/NEJMoa2407616
III. Factor XI
AZALEA https://www.nejm.org/doi/full/10.1056/NEJMoa2406674
OCEANIC https://www.nejm.org/doi/full/10.1056/NEJMoa2407105
VTE Study of Abelacimab 2021 https://www.nejm.org/doi/10.1056/NEJMoa2105872
IV. Tricuspid Valve Interventions
TRILUMINATE 1-year Study https://doi.org/10.1016/j.jacc.2024.10.086
Stone Editorial https://doi.org/10.1016/j.jacc.2024.11.045
TRISCEND Main Paper https://www.nejm.org/doi/full/10.1056/NEJMoa2401918
QOL Paper https://doi.org/10.1016/j.jacc.2024.10.067
PASTE Registry https://doi.org/10.1016/j.jacc.2024.10.068
AL-Lamee Editorial https://doi.org/10.1016/j.jacc.2024.10.085
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Jan 17 2025 This Week in Cardiology
17 januari 2025 · 32 min
Renal denervation, the obesity paradox, JACC and the FINEARTS trial of finerenone in HFpEF, a setback for a PFA system, and coffee are the topics Jon Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
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I. RDN
CMS https://www.cms.gov/medicare-coverage-database/view/ncacal-tracking-sheet.aspx?ncaid=318
Messerli https://doi.org/10.1016/j.jacc.2024.09.1244
Filippone https://doi.org/10.1016/j.amjmed.2023.05.010
II. Finerenone
FINEHEARTS -HF NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
FIDELIO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2025845
FIGARO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2110956
Why Have We Not Been Able to Demonstrate Reduced Mortality in Patients With HFmrEF/HFpEF? https://doi.org/10.1016/j.jacc.2024.08.033
Regional Variation TOPCAT https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255
Time from WHF Subanalysis https://doi.org/10.1016/j.jacc.2024.09.004
REDEFINE - https://clinicaltrials.gov/study/NCT06008197
Health status paper https://doi.org/10.1016/j.jacc.2024.09.023
Obesity subanalysis https://doi.org/10.1016/j.jacc.2024.10.111
Kidney outcomes https://www.sciencedirect.com/science/article/pii/S0735109724102525
Kidney outcomes 2 https://doi.org/10.1016/j.jacc.2024.11.020
Kaul editorial https://doi.org/10.1016/j.jacc.2024.11.024
III. PFA Setback
J&J Halts Varipulse Field Ablation for AFib
https://www.medscape.com/viewarticle/j-j-halts-varipulse-field-ablation-afib-2025a10000j8
IV. Coffee
Stop the Coffee Studies https://www.medscape.com/viewarticle/883709
Coffee drinking timing and mortality in US adults
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Jan 10 2025 This Week in Cardiology
10 januari 2025 · 30 min
Alcohol and cancer, GLP-1 trial representativeness, diagnosing CAD, changing stroke rates in patients with AF, blanking periods after AF ablation are the topics John Mandrola, MD, covers this week. Lees meer
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I. Surgeon General Causes Hoopla Regarding ETOH Warning
Dry January: Should Doctors Make It Year-Round?
https://www.medscape.com/viewarticle/dry-january-should-doctors-make-it-year-round-2025a100009t
Surgeon General Warning https://www.hhs.gov/about/news/2025/01/03/us-surgeon-general-issues-new-advisory-link-alcohol-cancer-risk.html
GBD 2016 Collaboration Lancet https://doi.org/10.1016/S0140-6736(18)31310-2
RCT Voskobonik and colleagues https://www.nejm.org/doi/full/10.1056/NEJMoa1817591
Marcus and colleagues; UCSF https://pubmed.ncbi.nlm.nih.gov/33516710/
Review of ETOH AF https://doi.org/10.1016/j.jacc.2016.08.074
II. GLP-1 Agonists for Obesity –Trial vs Real World
Generalizability of Trial Results https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2826335
HRS Document ICD http://dx.doi.org/10.1016/j.hrthm.2014.03.041
III. Stress Testing and CAD Severity
Reynolds and colleagues. Observational ISCHEMIA Sub-analysis https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.123.013743
Foy Meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243
ISCHEMIA https://www.nejm.org/doi/full/10.1056/NEJMoa1915922
IV. Changing Stroke Rates with AF
Teppo and colleagues. Finnish Study https://doi.org/10.1016/j.jacep.2024.10.029
Quinn and colleagues. https://www.ahajournals.org/doi/10.1161/circulationaha.116.024057
V. Patients' Lives Don't Pause for Blanking Periods
Ruzieh and colleagues. https://doi.org/10.1016/j.ahjo.2024.100497
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Dec 20 2024 This Week in Cardiology
20 december 2024 · 36 min
Listener feedback, multiple studies in AF ablation, Lees meer
a DANISH trial substudy of ICDs in NICM, and more data on eye complications of GLP-1 agonists are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. CCTA Feedback
Foy meta-analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243
DANCAVAS https://www.nejm.org/doi/full/10.1056/NEJMoa2208681
II. Listener Feedback on my negative take of the OPTION Trial.
Option trial https://www.nejm.org/doi/pdf/10.1056/NEJMoa2408308
My Preview https://www.medscape.com/viewarticle/mandrola-previews-option-trial-most-worrisome-study-aha-2024-2024a1000kmz
4 Reasons to Question Percutaneous Left Atrial Appendage Closure After AF Ablation
https://www.medscape.com/viewarticle/4-reasons-question-percutaneous-left-atrial-appendage-2024a1000l0u
III. AF Ablation
PVI Add-Ons Provide Better Control of Persistent AF
https://www.medscape.com/viewarticle/pvi-add-ons-provide-better-control-persistent-af-2024a1000lcm
VENUS https://jamanetwork.com/journals/jama/fullarticle/2772281
PROMPT AF https://jamanetwork.com/journals/jama/fullarticle/2826710
STAR AF 2 https://www.nejm.org/doi/full/10.1056/NEJMoa1408288
CRRF-PeAF https://pmc.ncbi.nlm.nih.gov/articles/PMC9241129/
CAVAC trial https://doi.org/10.1161/CIRCEP.124.012917
CRRF-PeAF from multiple centers in Japan (not published)
IV. DANISH Trial Substudy
Danish Trial Substudy https://www.ahajournals.org/doi/epdf/10.1161/CIRCULATIONAHA.124.071777
Danish Main https://www.nejm.org/doi/full/10.1056/NEJMoa1608029
MADIT-2 EF Substudy https://doi.org/10.1016/S0002-9149(01)01729-5
SCD-HeFT subgroup https://www.nejm.org/doi/full/10.1056/NEJMoa043399
Appraisal of ICD to Prevent SCD https://doi.org/10.1016/j.jacc.2008.05.058
V. Eye disease and GLP-1 Agonists
Jul 26, 2024 This Week in Cardiology Podcast
https:…
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Dec 13 2024 This Week in Cardiology
13 december 2024 · 29 min
US doc's pay, the ticagrelor controversy and new RCTs, clopidogrel beats ASA, holding antiplatelets for non-cardiac surgery, and Prof Cleland and ASA dogma are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. US Healthcare
Mandrola's Top 10 Stories in 2024 https://www.medscape.com/viewarticle/mandrolas-top-10-stories-2024-2024a1000mxe?_gl=1*dcvmkh*_gcl_au*MTgzOTY2ODQ0Ni4xNzI5MjU4NjUz
CMS Proposal
II. Ticagrelor Controversy
New Investigation Casts Doubt on Landmark Ticagrelor Trial
https://www.medscape.com/viewarticle/new-investigation-casts-doubt-landmark-ticagrelor-trial-2024a1000n1d
Doshi Review https://www.bmj.com/content/387/bmj.q2550
PLATO https://www.nejm.org/doi/full/10.1056/NEJMoa0904327
ISAR REACT 5 https://www.nejm.org/doi/full/10.1056/NEJMoa1908973
Bates Review https://www.ahajournals.org/doi/epub/10.1161/JAHA.123.031606
Victor Serebuany and Dan Atar Editorial https://doi.org/10.1093/eurheartj/ehp545
III. New Ticagrelor vs Clopdiogrel trial
Preprint: https://www.medrxiv.org/content/10.1101/2024.11.06.24316875v1.full-text
IV. Clopidogrel Better Than ASA Even in HBR
Substudy Long-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity
HOST-EXAM 10.1016/S0140-6736(21)01063-1
HOST-EXAM-Extended https://doi.org/10.1161/CIRCULATIONAHA.122.062770
V. ASA During Non-Cardiac Surgery
ASSURE DES https://doi.org/10.1016/j.jacc.2024.08.024
VII. Professor Cleland on ASA for Secondary Prevention
Cleland Editorial https//jamanetwork.com/journals/jamacardiology/article-abstract/2827201
ASA Meta-analysis 10.1016/S0140-6736(09)60503-1
AMIS https://jamanetwork.com/journals/jama/fullarticle/368745
SAPAT 10.1016/0140-6736(92)92619-Q
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Dec 06 2024 This Week in Cardiology
6 december 2024 · 28 min
Tirzepatide vs semaglutide in obesity; GLP1a use is complicated; HF outcomes; the misuse of meta-analyses in HF; and a breakthrough in HF care are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. SURMOUNT 5
Clinicaltrials.gov https://clinicaltrials.gov/study/NCT05822830
Press Release
II. Access to GLP-1 Agonist Drugs
CMS statement https://www.cms.gov/newsroom/press-releases/biden-harris-administration-announces-medicare-advantage-and-medicare-part-d-prescription-drug
III. SUMMIT TRIAL commentary
Has Tirzepatide Scaled the HFpEF/Obesity SUMMIT?
https://www.medscape.com/viewarticle/has-tirzepatide-scaled-hfpef-obesity-summit-2024a1000m2h
IV. Blank Spot in HF Evidence – All cause hospitalizations
Sayed and colleagues What Is Success in HF Trials? https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2827168
EMPEROR-Preserved https://www.nejm.org/doi/full/10.1056/NEJMoa2107038
Mayo Observational Study 10.1016/j.mayocp.2016.11.009
DIG Trial https://jamanetwork.com/journals/jama/fullarticle/195990
V. Misuse of Meta-analysis by HF Community
Lu and colleagues PARAGON/PARADIGM Meta-analysis https://jamanetwork.com/journals/jamacardiology/fullarticle/2823259
Desai 2004 https://jamanetwork.com/journals/jama/fullarticle/199995
PARADIGM HF https://www.nejm.org/doi/full/10.1056/NEJMoa1409077
PARAGON HF https://www.nejm.org/doi/full/10.1056/NEJMoa1908655
VI Integration of Palliative Care Into HF Care
Chuzi and colleagues Palliative Care in HF 10.1016/j.cardfail.2024.10.435
Kotecha and colleagues Beta-blocker Metaanalysis 10.1016/S0140-6736(14)61373-8
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Nov 22 2024 This Week in Cardiology
22 november 2024 · 32 min
An AHA review: the OPTION, SUMMIT, VANISH 2, SARAH, and CLEAR trials are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. OPTION Trial
For AF, LAA Rivals Anticoagulants After Ablation
https://www.medscape.com/viewarticle/af-laa-rivals-anticoagulants-after-ablation-2024a1000l7n
4 Reasons to Question Percutaneous Left Atrial Appendage Closure After AF Ablation
https://www.medscape.com/viewarticle/4-reasons-question-percutaneous-left-atrial-appendage-2024a1000l0u
OPTION in NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2408308
II. SUMMIT Trial
Tirzepatide Reduces Heart Failure Events in HFpEF With Obesity
https://www.medscape.com/viewarticle/tirzepatide-reduces-heart-failure-events-hfpef-obesity-2024a1000kx5
SUMMIT in NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2410027
III. VANISH Trial
New Trial Result Pushes Past Antiarrhythmic Therapy After MI
https://www.medscape.com/viewarticle/new-trial-result-pushes-past-antiarrhythmic-therapy-after-mi-2024a1000l08
VANISH 2 https://www.nejm.org/doi/full/10.1056/NEJMoa2409501
VANISH 1 https://www.nejm.org/doi/full/10.1056/NEJMoa1513614
IV. Cardioprotection
Common Heart Failure Drugs Ease Heart Damage During Chemo https://www.medscape.com/viewarticle/common-heart-failure-drugs-ease-heart-damage-during-chemo-2024a1000l14
Strain Imaging Review Article https://www.jacc.org/doi/10.1016/j.jcmg.2024.07.011
V. CLEAR trial
Spironolactone Shows Mixed Results in Acute MI
https://www.medscape.com/viewarticle/spironolactone-shows-mixed-results-acute-mi-2024a1000l41
Routine Colchicine or MRA Post-MI: No CLEAR Benefit
https://www.medscape.com/viewarticle/routine-colchicine-or-mra-post-mi-no-clear-benefit-2024a1000la2
CLEAR-Spironolactone https://www.nejm.org/doi/full/10.1056/NEJMoa2405923
CLEAR-Colchicine https://www.nejm.org/doi/full/10.1056/NEJMoa2405…
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Nov 15 2024 This Week in Cardiology
15 november 2024 · 28 min
Tirzepatide, AF screening, and an AHA preview, including VT ablation, LAAC at the time of AF ablation, BP targets, and GLP1 agonists in HF are the topics John Mandrola, MD, covers in today's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Tirzepatide
SURMOUNT 1 – Three-year results https://www.nejm.org/doi/full/10.1056/NEJMoa2410819
II. AF Screening
GUARD AF https://www.jacc.org/doi/10.1016/j.jacc.2024.08.019
LOOP 10.1016/S0140-6736(21)01698-6
STROKE STOP 10.1016/S0140-6736(21)01637-8
III. LAAC with AF ablation
Mandrola Previews the OPTION Trial, the Most Worrisome Study at AHA 2024
https://www.medscape.com/viewarticle/mandrola-previews-option-trial-most-worrisome-study-aha-2024-2024a1000kmz
The OPTION Trial Rationale https://doi.org/10.1016/j.ahj.2022.05.003
IV. Blood Pressure Targets
BPROAD https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.13411
ACCORD - https://www.nejm.org/doi/full/10.1056/NEJMoa1001286
V. GLP1a for HFpEF
SUMMIT at Clinicaltrials.gov https://clinicaltrials.gov/study/NCT04847557
VI. VT Ablation
VANISH2 Rationale https://doi.org/10.1016/j.ahj.2024.04.009
VANISH 1 https://www.nejm.org/doi/full/10.1056/NEJMoa1513614
VII. Spironolactone Results of CLEAR-SYNERGY
Nov 08, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1001865
'No Hint of Benefit' in Large Colchicine Trial
https://www.medscape.com/viewarticle/no-hint-benefit-large-colchicine-trial-2024a1000ko4
CLEAR SYNERGY Rationale https://pubmed.ncbi.nlm.nih.gov/38936755/
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Nov 08 2024 This Week in Cardiology
8 november 2024 · 32 min
The EARLY TAVR trial, colchicine after MI, and the TRISCEND II trial of tricuspid valve replacement are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Early TAVR
EARLY TAVR https://www.acc.org/latest-in-cardiology/clinical-trials/2024/10/24/14/42/early-tavr
Rationale https://doi.org/10.1016/j.ahj.2023.11.019
AVATAR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057639
RECOVERY https://www.nejm.org/doi/full/10.1056/NEJMoa1912846
FAME 2 https://www.nejm.org/doi/full/10.1056/NEJMoa1205361
Rajkumar; Faith Healing in Unblinded Trials https://pubmed.ncbi.nlm.nih.gov/29530888/
PARTNER 3 trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307447
EARLY TAVR: A Positive Trial That Fails to Inform Clinical Decisions https://www.medscape.com/viewarticle/early-tavr-positive-trial-fails-inform-clinical-decisions-2024a1000kec
II. Colchicine
Meta-analysis https://doi.org/10.1016/j.eclinm.2024.102835
Clear-Synergy Rationale https://pubmed.ncbi.nlm.nih.gov/38936755/
COLCOT (post MI) https://www.nejm.org/doi/full/10.1056/NEJMoa1912388
LoDoCo (Chronic CAD) https://www.nejm.org/doi/full/10.1056/NEJMoa2021372
III. TRISCEND II Trial
TRISCEND II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2401918
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Oct 25 2024 This Week in Cardiology
25 oktober 2024 · 24 min
Listener feedback on PFA and STEMI/NSTEMI paradigm, oral semaglutide, symptomatic vs asymptomatic AF, and the win-ratio are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Listener Feedback
Oct 18, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1001769
Pulsed Field Ablation
https://www.hrsonline.org/guidance/safety-alerts/boston-scientific-cardiac-cryoablation-system
STEMI/NSTEMI https://doi.org/10.1016/j.jacadv.2024.101314
II. Oral Semaglutide
Press Release: https://www.novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=171480
Rationale Paper SOUL trial
III. Symptomatic vs Asymptomatic AF
Meta-analysis in EHJ
Meta-analysis of rate vs rhythm-control strategies https://doi.org/10.1016/j.jacep.2024.03.006
IV. The Win Ratio
Pocock and colleagues https://doi.org/10.1093/eurheartj/ehae647
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Oct 18 2024 This Week in Cardiology
18 oktober 2024 · 29 min
Listener feedback on the c-statistic, atherosclerotic plaque imaging, WATCHMAN implant decisions in the US, and deprescribing are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I.Listener Feedback
Oct 11, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1001735
Nancy Cook; C-statistic https://doi.org/10.1161/CIRCULATIONAHA.106.672402
II. Plaque Imaging
New Evidence That Plaque Buildup Shouldn't Be Ignored
https://www.medscape.com/viewarticle/new-evidence-plaque-buildup-shouldnt-be-ignored-2024a1000ihw
Fuster and colleagues; Imaging vs CAC
III. WATCHMAN Decisions
Zeitler and colleagues. Long-term Outcomes
IV. Deprescribing
Cognitive Decline and Antihypertensive Use: New Data
https://www.medscape.com/viewarticle/cognitive-decline-and-antihypertensive-use-new-data-2024a1000isw?form=fpf
Jing and colleagues.
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Oct 11 2024 This Week in Cardiology
11 oktober 2024 · 30 min
Reader feedback on cardiac devices and PFA, a new paradigm in the language of MI, sudden cardiac death, and measuring blood pressure are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Listener Feedback
Sep 20, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1001631
Cardiac Devices
https://www.acpjournals.org/doi/10.7326/ANNALS-24-00724
Impact of PFA on Intraluminal Esophageal Temperature https://onlinelibrary.wiley.com/doi/10.1111/jce.16096
II. Towards a New Classification of MI
McLaren and colleagues; From STEMI to OMI https://doi.org/10.1016/j.jacadv.2024.101314
III. Sudden Death After MI.
EHJ Paper; SCD After MI https://doi.org/10.1093/eurheartj/ehae326
Barsheshet and colleagues; Risk Score to Predict Benefit of ICD https://doi.org/10.1016/j.jacc.2012.02.036
Zegard and colleagues; Myocardial Fibrosis and SCD 10.1016/j.jacc.2020.10.046
MADIT RIT https://www.nejm.org/doi/full/10.1056/NEJMoa1211107
IV. BP Readings
Poor Arm Position May Significantly Skew BP Readings
https://www.medscape.com/viewarticle/poor-arm-position-may-significantly-skew-bp-readings-2024a1000icv?form=fpf
ARMS Crossover RCT
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Oct 04 2024 This Week in Cardiology
4 oktober 2024 · 27 min
Reader feedback on LGE pre-ICDs, PFA for AF ablation, CTO-PCI, endovascular ablation of the greater splanchnic nerve in HFpEF, and data sharing are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Listener Feedback
Sept 27, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1001666
JAMA Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2823869/
II. Pulsed Field Ablation for AF
Feb 02, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/999995
ADMIRE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.070333
ADVENT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307291
III. PCI for CTO
EuroCTO One Year SAQ Results https://doi.org/10.1093/eurheartj/ehy220
EuroCTO Hard Outcomes https://eurointervention.pcronline.com/article/three-year-outcomes-of-eurocto-a-randomized-multicentre-trial-comparing-revascularization-and-optimal-medical-therapy-for-chronic-total-coronary-occlusions
Faith Healing and Subtraction Anxiety https://doi.org/10.1161/CIRCOUTCOMES.118.004665
DECISION CTO trial https://doi.org/10.1161/CIRCULATIONAHA.118.031313
ISCHEMIA CTO Rationale and Design https://doi.org/10.1016/j.ahj.2022.11.016
IV. Greater Splanchnic Nerve Ablation for HFpEF
REBALANCE HF https://jamanetwork.com/journals/jamacardiology/fullarticle/2823999
V. Data Sharing
The Pros and Cons of Clinical Trial Data Sharing
https://www.medscape.com/viewarticle/862815
Kramer and Nallamothu, Caution in Data Sharing https://www.ahajournals.org/doi/full/10.1161/CIRCOUTCOMES.124.010257
Nosek, Variability in Analytic Methods https://journals.sagepub.com/doi/10.1177/2515245917747646
Zeraatker, Variability in Analytic Methods
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Sep 27 2024 This Week in Cardiology
27 september 2024 · 35 min
Surgical clearance, NICM assessment, dueling perspectives on PCI as first-line therapy for angina, GDMT in HFrEF are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. New ACC Peri-operative Guidelines Released
ACC Guideline document https://www.jacc.org/doi/10.1016/j.jacc.2024.06.013
J Vasc Surg https://www.jvascsurg.org/article/S0741-5214(21)00335-9/fulltext
McFalls and colleagues; CARP https://www.nejm.org/doi/full/10.1056/NEJMoa041905
II. NICM – We may be doing it wrong in Selecting ICDs
JAMA Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2823869/
German CMR ICD Trial https://www.clinicaltrials.gov/study/NCT04558723
BRITISH CMR trial https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/britishusing-cmr-scar-as-risk-indication-tool-in-nicm-and-severe-lvsd/
III. When Should PCI be Used in Chronic Stable CAD?
Rajkumar and Al-Lamee; PCI First https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.124.011201
Boden and De Caterina; Meds First https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.124.011268
ORBITA 10.1016/S0140-6736(17)32714-9
ORBITA 2 trial https://www.nejm.org/doi/full/10.1056/NEJMoa2310610
IV. GDMT Underuse in HFrEF
Greene and colleagues https://doi.org/10.1016/j.jchf.2024.08.002
DAPA HF https://www.nejm.org/doi/full/10.1056/NEJMoa1911303
RALES https://www.nejm.org/doi/full/10.1056/NEJM199909023411001
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