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Sep 20 2024 This Week in Cardiology
20 september 2024 · 23 min
Listener feedback, K levels post cardiac surgery, cardiac device safety, disparities in preventive care, stopping trials early, and a SHAM-PVI update are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Listener Feedback
Sep 13, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1001596
Sripal Bangalore Tweet on Yusef Meta-analysis https://x.com/SripalBangalore/status/1750116964893094125
II. Post Cardiac Surgery AF
TIGHT K Trial https://jamanetwork.com/journals/jama/fullarticle/2823246
III. Evidence Base for New Cardiac Devices
Annals of IM Survey Observational Study https://www.acpjournals.org/doi/10.7326/ANNALS-24-00724
IV. Disparities in Care
JAMA Network Open Paper on Insurer Denials of Preventive Care https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2823677
V. Stopping Trials Early
Kaul and Butler; Insights on Recent CKD Trials https://doi.org/10.1016/j.jacc.2024.07.026
Bassler Systematic Review https://jamanetwork.com/journals/jama/fullarticle/185591
VI. Sham PVI
AF Ablation Works…But: The Positive SHAM-PVI Trial
https://www.medscape.com/viewarticle/af-ablation-works-positive-sham-pvi-trial-2024a1000gzl?&icd=login_success_email_match_fpf
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
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Sep 13 2024 This Week in Cardiology
13 september 2024 · 26 min
More from ESC: the SCOFF trial and fasting before cardiac cath, MATTERHORN, humbling data with AI, plus a reflection on the work of being a patient are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Fasting Before Cardiac Procedures
The SCOFF Trial https://doi.org/10.1093/eurheartj/ehae573
II. MV repair for Functional MR
Large Trials Support Mitral Valve Repair in Heart Failure
MATTERHORN https://www.nejm.org/doi/full/10.1056/NEJMoa2408739
III. AI in Medicine
Rapidx AI Project https://healthtranslationsa.org.au/project/rapid-x-ai/
PROTEUS Trial Rationale paper https://pubmed.ncbi.nlm.nih.gov/37192698/
IV. Time Toxicity
Time Toxicity https://link.springer.com/article/10.1007/s00520-024-08844-1
Thread X https://x.com/EnriqueSoto8/status/1833587144256065859
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Sep 06 2024 This Week in Cardiology
6 september 2024 · 30 min
Feedback on ABYSS and beta-blockers, more ESC recap, including SHAM-PVI, FINEARTS-HF, and RESHAPE HF2 trials are the topics John Mandrola, MD, discusses in today's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Feedback on ABYSS
Setbacks After Stopping Beta-Blockers
https://www.medscape.com/viewarticle/setbacks-after-stopping-beta-blockers-2024a1000fv7
Beta-Blockers Post-MI? No for Me, Even After the ABYSS Trial
https://www.medscape.com/viewarticle/beta-blockers-post-mi-no-me-even-after-abyss-trial-2024a1000fva
ABYSS trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
REDUCE AMI https://www.nejm.org/doi/full/10.1056/NEJMoa2401479
QOL paper REDUCE AMI https://doi.org/10.1093/ehjcvp/pvae062
Atenolol ED paper 10.1016/j.ehj.2003.08.016
II. SHAM-PVI
JAMA SHAM-PVI paper https://jamanetwork.com/journals/jama/article-abstract/2823283
Gupta QOL paper https://pubmed.ncbi.nlm.nih.gov/33952593/
III. FINEARTS HF
Finerenone Benefits Heart Failure With Preserved EF
https://www.medscape.com/viewarticle/finerenone-benefits-heart-failure-preserved-ef-2024a1000fza
Topline Finerenone Results Point to Advance in Heart Failure
https://www.medscape.com/viewarticle/topline-finerenone-results-point-advance-heart-failure-2024a1000fq2
FINEHEARTS -HF NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
FIDELIO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2025845
FIGARO-DKD https://www.nejm.org/doi/full/10.1056/NEJMoa2110956
Why Have We Not Been Able to Demonstrate Reduced Mortality in Patients With HFmrEF/HFpEF? https://doi.org/10.1016/j.jacc.2024.08.033
IV. RESHAPE HF
TEER in Functional MR: Data Deluge, but No Easy Answers
https://www.medscape.com/viewarticle/teer-functional-mr-data-deluge-no-easy-answers-2024a1000fvg
Mitra FR https://www.nejm.org/doi/full/10.1056/NEJMoa1805374
COAPT https://www.nejm.org/doi/full/10.1056/NEJMoa1806640
RESHAPE- H…
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Aug 30 2024 This Week in Cardiology
30 augustus 2024 · 26 min
From ESC: post-MI beta blockers, a new therapy for ATTR-CM, holding RASi before non-cardiac surgery, good news in HFpEF, and an ESC preview are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. ABYSS
ABYSS trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
REDUCE AMI https://www.nejm.org/doi/full/10.1056/NEJMoa2401479
II. ATTR -CM HELIOS B
Positive Top Line Results for Vutrisiran in Cardiac Amyloidosis
https://www.medscape.com/viewarticle/positive-top-line-results-vutrisiran-cardiac-amyloidosis-2024a1000cjj
HELIOS A https://www.tandfonline.com/doi/full/10.1080/13506129.2022.2091985
HELIOS B https://www.nejm.org/doi/full/10.1056/NEJMoa2409134
III. STOP or NOT Trial
Observational Study Showing Benefits of Holding RASi https://doi.org/10.1097/ALN.0000000000001404
STOP or NOT Protocol Paper -- https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3247-1
JAMA STOP or NOT https://jamanetwork.com/journals/jama/fullarticle/2823118
IV. GLP1a in HFpEF
The GLP-1 Agonist Semaglutide in HFpEF Cleared a Low Bar https://www.medscape.com/viewarticle/995872
STEP-HFpEF https://www.nejm.org/doi/full/10.1056/NEJMoa2306963
STEP-HFpEF-DM https://www.nejm.org/doi/full/10.1056/NEJMoa2313917
SELECT https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
FLOW https://www.nejm.org/doi/full/10.1056/NEJMoa2403347
Lancet Meta-analysis https://doi.org/10.1016/S0140-6736(24)01643-X
V. ESC Preview
Mandrola's Five Big Trials to Look for at ESC 2024
https://www.medscape.com/viewarticle/mandrolas-five-big-trials-look-esc-2024-2024a1000fkt
Topline Finerenone Results Point to Advance in Heart Failure
https://www.medscape.com/viewarticle/topline-finerenone-results-point-advance-heart-failure-2024a1000fq2
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Aug 23 2024 This Week in Cardiology
23 augustus 2024 · 33 min
Suicidal ideation and GLP-1 agonists, a repeat of PARADIGM HF in Chagas CM, CASTLE HTx critical appraisal, and primary prevention of SCD in HF are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Suicidal ideation with GLP-1
Signal of Suicidality With GLP-1 RA Semaglutide, but Experts Urge Caution
https://www.medscape.com/viewarticle/signal-suicidality-glp-1-ra-semaglutide-experts-urge-caution-2024a1000fa7
Disproportionality Analysis from World Health Organization Data on Semaglutide, Liraglutide, and Suicidality
Variability in Disproportionality paper https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.668765/full
II. PARACHUTE HF: Repeating the Mistakes in PARADIGM HF
PARACHUTE HF https://www.jacc.org/doi/10.1016/j.jchf.2024.05.021
SOLVD https://www.nejm.org/doi/full/10.1056/NEJM199108013250501
CONSENSUS trial https://www.nejm.org/doi/full/10.1056/NEJM198706043162301
Meta-analysis of Low vs High Dose ACE/ARB https://doi.org/10.1161/CIRCHEARTFAILURE.117.003956
Meta-analysis of Sac/Val vs ARB/ACE Inhibitors https://link.springer.com/article/10.1007/s00228-024-03686-6
PARADISE MI https://www.nejm.org/doi/full/10.1056/NEJMoa2104508
III. CASTLE HTx Critical Appraisal
Critical Appraisal of CASTLE HTx https://doi.org/10.1016/j.jacc.2024.06.020
CASTLE HTx https://www.nejm.org/doi/10.1056/NEJMoa2306037
CASTLE AF https://www.nejm.org/doi/full/10.1056/NEJMoa1707855
IV. More Data Suggesting Modest Benefits of the Primary Prevention ICD
First and Recurrent ICD Shocks: JICE Paper from Denmark https://link.springer.com/article/10.1007/s10840-024-01873-0
HF trialists https://www.nejm.org/doi/full/10.1056/NEJMoa1609758 PROFID Trial https://profid-project.eu/
DANISH https://www.nejm.org/doi/full/10.1056/NEJMoa1608029
SCD-HeFT https://www.nejm.org/doi/full/10.1056/NEJMoa043399
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Aug 16 2024 This Week in Cardiology
16 augustus 2024 · 29 min
Diuretic therapy in HFrEF, AF ablation, TACT 2 and the story of subgroups, and SGLT2 inhibitor underuse are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Diuretic Therapy in HF
Dapa vs Metolazone Trial https://doi.org/10.1093/eurheartj/ehad341 ADVOR https://www.nejm.org/doi/10.1056/NEJMoa2203094
II. Rapid Medication Titration for Acute HF
ACC Decision Pathway https://www.jacc.org/doi/10.1016/j.jacc.2024.06.002
III. SGLT2 Inhibitor Use in the US
Shin and Colleagues; JACC https://www.sciencedirect.com/science/article/abs/pii/S0735109724076332
Editorial https://doi.org/10.1016/j.jacc.2024.07.001
IV. AF Ablation: General Anesthesia vs Conscious Sedation
Da Riis-Vestergaard and Colleagues https://doi.org/10.1093/europace/euae203
V. TACT 2 Published
TACT 1 https://jamanetwork.com/journals/jama/fullarticle/1672238
TACT 1 DM https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.113.000663
TACT 2 https://jamanetwork.com/journals/jama/fullarticle/2822472
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Questions or feedback, please contact news@medscape.net
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Aug 09 2024 This Week in Cardiology
9 augustus 2024 · 28 min
Prediction models vs clinical judgement, CCTA quantification of atherosclerosis, AF ablation plus LAAO, atrial shunt devices, and HF medical therapy are topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I.Clinical Prediction Models vs Clinical Judgement
Did Statin Decision-Making Just Get Harder?
https://www.medscape.com/viewarticle/did-statin-decision-making-just-get-harder-2024a1000egl
Colunga-Lozano and colleagues
https://doi.org/10.1016/j.jclinepi.2023.10.016
Aug 02, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1001429
II. CCTA Quantification of Atherosclerosis
Atherosclerosis Quantification and Cardiovascular Risk: the ISCHEMIA Trial https://doi.org/10.1093/eurheartj/ehae471
Circulation ISCHEMIA sub study 2021 – Severity of CAD and Outcomes https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.049755
ISCHEMIA Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1915922
III. Combined AF Ablation and LAAO
Review from Mills and colleagues https://doi.org/10.1016/j.tcm.2023.11.003
Link to CMS Rule on AF Ablation and LAAO https://hrs2.informz.net/z/cjUucD9taT05MjU3ODgyJnA9MSZ1PTkwMDQ2MTk4MCZsaT04NTU1OTQxMg/index.html
IV. Atrial Shunt Devices
No Net HF Benefit for Interatrial Shunt Device
https://www.medscape.com/viewarticle/no-net-hf-benefit-interarterial-shunt-device-2024a10006kk
Original REDUCE-LAP-HF-II https://doi.org/10.1016/S0140-6736(22)00016-2
Two-year results of REDUCE-LAP-HF-II https://doi.org/10.1016/j.jchf.2024.04.011
Apr 19, 2024 This Week in Cardiology Podcast
V. Optimal HF Therapy
Rao and colleagues; CHAMP HF https://doi.org/10.1016/j.jchf.2024.05.026
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Aug 02 2024 This Week in Cardiology
2 augustus 2024 · 29 min
Two downsides of PFA including autonomic tone and hemolysis, a bad surrogate in AF care, and controversies in defining cardiac risk are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I.PFA and Its (lack of) Effect on Autonomic Tone
Pulsed Field Ablation for AF: Are US Electrophysiologists Too Easily Impressed?
https://www.medscape.com/viewarticle/pulsed-field-ablation-af-are-us-electrophysiologists-too-2024a1000d2v
Autonomic Tone Paper https://doi.org/10.1016/j.jacep.2024.05.005
ADVENT https://www.nejm.org/doi/full/10.1056/NEJMoa2307291
II. Second PFA Study JACC-EP—on Hemolysis
Hemolysis study https://doi.org/10.1016/j.jacep.2024.05.001
MANIFEST 17K https://www.nature.com/articles/s41591-024-03114-3
Defaye Editorial https://www.jacc.org/doi/abs/10.1016/j.jacep.2024.06.007
III. A Self-serving Surrogate Marker: Diagnosis to Ablation Time.
CAPLA Study https://jamanetwork.com/journals/jama/fullarticle/2800186
CAPLA Substudy https://doi.org/10.1016/j.jacep.2024.05.031
EHJ RCT Early vs Late https://doi.org/10.1093/eurheartj/ehad247
LOOP; Diederichsen and colleagues 10.1016/j.jacc.2019.09.050
Groningen and Maastricht Group study https://heart.bmj.com/content/109/3/186
IV. Future Cardiac Risk
Diao and colleagues Study of AHA PREVENT Risk Equations https://jamanetwork.com/journals/jama/fullarticle/2821624
JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821542
Another JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821628
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Jul 26, 2024 This Week in Cardiology Podcast
26 juli 2024 · 24 min
Health and income, high BP in the hospital, and more on subclinical AF and when to use anticoagulants are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Health and Income
A Cash Giveaway to Improve Health
https://www.medscape.com/viewarticle/cash-giveaway-improve-health-2024a1000dhf?form=fpf
JAMA RCT https://jamanetwork.com/journals/jama/fullarticle/2821454
NBER RCT https://www.nber.org/papers/w32711
Have We Missed the Hidden Cause of Medical Overuse? https://www.medscape.com/viewarticle/908309
Mar 17, 2023 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/989775
Other References
Health Care Access and Management of Cardiovascular Risk Factors Among Working-Age Adults With Low Income by State Medicaid Expansion Status https://jamanetwork.com/journals/jamacardiology/article-abstract/2793120
Rand Link https://www.rand.org/pubs/reports/R3055.html
The Oregon Health Insurance Experiment https://www.healthaffairs.org/do/10.1377/hpb20150716.236899/full/
Effect of Health Insurance in India: A Randomized Controlled Trial https://www.nber.org/papers/w29576
Full Coverage for Preventive Medications after Myocardial Infarction https://www.nejm.org/doi/full/10.1056/nejmsa1107913
Effect of Medication Co-payment Vouchers on P2Y12 Inhibitor Use and Major Adverse Cardiovascular Events Among Patients With Myocardial InfarctionThe ARTEMIS Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2720024
II. Elevated BP in the hospital
JAMA-IM https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2821364
III. Short-duration Subclinical AF
Apixaban Cuts Stroke but Ups Bleeding in Subclinical AF: ARTESIA
https://www.medscape.com/viewarticle/998379
ARTESiA https://www.nejm.org/doi/full/10.1056/NEJMoa2310234
ARTESiA CHADSVASC Subgroup https://www.jacc.org/doi/1…
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Jul 19 2024 This Week in Cardiology
19 juli 2024 · 25 min
Vulnerable plaque and scientific method; industry payments to trainees; tirzepatide or semaglutide; trial interpretation; and PFA are the topics John Mandrola, MD, covers in today's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Non-invasive Imaging for Vulnerable Plaque
PET Imaging Finds Vulnerable Plaques That Cause MI
https://www.medscape.com/viewarticle/pet-imaging-finds-vulnerable-plaques-cause-mi-2024a1000cm2
JACC paper https://doi.org/10.1016/j.jacc.2024.03.419
Original JAMA-Card paper https://jamanetwork.com/journals/jamacardiology/fullarticle/2806690
II. Industry Payments to Fellows
JAMA Network Letter https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2821267
III. GLP-1a Class Effect?
Semaglutide Significantly Improves Chronic Kidney Disease
https://www.medscape.com/viewarticle/semaglutide-significantly-improves-chronic-kidney-disease-2024a10009w9
Mounjaro Beats Ozempic, So Why Isn't It More Popular?
https://www.medscape.com/viewarticle/mounjaro-beats-ozempic-so-why-isnt-it-more-popular-2024a1000ckd
JAMA-Internal Medicine: Semaglutide vs Tirzepatide https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2821080
SELECT trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
FLOW trial https://www.nejm.org/doi/full/10.1056/NEJMoa2403347
SURPASS-CVOT – Rationale https://doi.org/10.1016/j.ahj.2023.09.007
IV. Colchicine and Trial Interpretation in the Lancet
CONVINCE https://doi.org/10.1016/S0140-6736(24)00968-1
V. PFA
Pulsed Field Ablation for AF: Are US Electrophysiologists Too Easily Impressed?
https://www.medscape.com/viewarticle/pulsed-field-ablation-af-are-us-electrophysiologists-too-2024a1000d2v
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Jul 12 2024 This Week in Cardiology
12 juli 2024 · 29 min
Venous closure devices, GLP1-s linked to blindness and cancer, resisting the urge to do an ECG, and transcatheter edge-to-edge repair (TEER) for secondary mitral regurgitation are the topics discussed this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Venous vascular closure system vs. figure-of-eight suture following atrial fibrillation ablation: the STYLE-AF Study https://doi.org/10.1093/europace/euae105
II GLP1-s and Blindness
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2820255
Locke Twitter https://x.com/doc_BLocke/status/1808972226655629610
When to Start a Statin Is a Preference-Sensitive Decision https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.029808
III GLP1-s and Cancer
Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820833
IV Screening ECG
Routine Electrocardiogram Screening and Cardiovascular Disease Events in Adultshttps://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2820721
Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP) https://doi.org/10.1016/S0140-6736(21)01637-8
Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study) https://doi.org/10.1016/S0140-6736(21)01698-6
IV TEER for Secondary Mitral Regurgitation
Randomized investigation of the MitraClip device in heart failure: Design and rationale of the RESHAPE-HF2 trial design https://doi.org/10.1002/ejhf.3247
Percutaneous repair of moderate-to-severe or severe functional mitral regurgitation in patients with symptomatic heart failure: Baseline characteristics of patients in the RESHAPE-HF2 trial and comparison to COAPT and MITRA-FR trials https://…
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Jun 28 2024 This Week in Cardiology
28 juni 2024 · 25 min
Screening echo, multivitamins, wasteful research, another PA sensor for HF, vascular closure devices, and GLP-1 marketing as science research are the topics John Mandrola, MD, discusses this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Screening for Valvular HD in the Elderly
EHJ-CV Imaging Paper https://doi.org/10.1093/ehjci/jeae127
II. Vitamins and Wasteful Research
Is Red Meat Healthy? Multiverse Analysis Has Lessons Beyond Meat https:// www.medscape.com/viewarticle/red-meat-healthy-multiverse-analysis-has-lessons-beyond-meat-2024a10008qv
May 10, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1000772
Multivitamin Paper https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820369
Physicians Health Study II https://jamanetwork.com/journals/jama/fullarticle/1389615
III. FDA Has Approved Another PA Sensor
Link to slides https://c212.net/c/link/?t=0&l=en&o=4104690-1&h=4197477262&u=https%3A%2F%2Fendotronix.com%2FEndotronix-PROACTIVE-HF-LBCT-THT-2024.pdf&a=here
IV. Vascular Closure Devices in Electrophysiology.
Vascular Closure Devices Study https://onlinelibrary.wiley.com/doi/full/10.1111/jce.16345
V. SURMOUNT-OSA
SURMOUNT OSA Paper https://www.nejm.org/doi/full/10.1056/NEJMoa2404881
SELECT https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
June 21, 2024 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1001237
JAMA Systematic Review and Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2643307
SAVE https://www.nejm.org/doi/full/10.1056/NEJMoa1606599
Norwegian study https://doi.org/10.1016/j.hrthm.2022.06.016
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Jun 21 2024 This Week in Cardiology
21 juni 2024 · 27 min
MRAs in HF with renal dysfunction, coronary autoregulation, the hubris of US doctors, NSTEMI in older patients, survival after STEMI, and new leaders at JACC are discussed by John Mandrola, MD. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
Combined analysis (Matsumoto)
II Coronary artery autoregulation with increasing stenosis
NEJM Paper https://www.nejm.org/doi/full/10.1056/NEJMc2402216
III RECOVER IV Trial
Gregg Stone, MD Tweet https://x.com/GreggWStone/status/1803583552354742416
DANGER-Shock Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2312572
Impella Saves Lives in Cardiogenic Shock, but Patient Selection Key https://www.medscape.com/viewarticle/1000659
IV NSTEMI Elderly
Main Paper
Datamethods https://discourse.datamethods.org/t/random-vs-fixed-effects-meta-analysis/7361
O'Fee Paper https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560
V MI Survival
Danish Paper https://doi.org/10.1016/j.jacc.2024.04.025
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Jun 14 2024 This Week in Cardiology
14 juni 2024 · 31 min
Listener feedback, statin eligibility and Yogi Berra, evidence-based medicine and heterogenous treatment effects, and MRAs in HF are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Listener Feedback
ASPIRE AF https://classic.clinicaltrials.gov/ct2/show/NCT03968393
Butala paper: Stroke After TAVR With and Without EPD https://www.ahajournals.org/doi/abs/10.1161/CIRCINTERVENTIONS.123.013697
PROTECTED TAVR
Heuts meta-analysis: EPD During TAVR https://heart.bmj.com/content/110/11/757
II. Statin Eligibility
JAMA-IM: Data Analytic Choices and Predicting Vascular Events https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2819821
Zeraatker Specification Analysis Paper https://doi.org/10.1016/j.jclinepi.2024.111278
PCE https://www.mdcalc.com/calc/3398/ascvd-atherosclerotic-cardiovascular-disease-2013-risk-calculator-aha-acc
III. Heterogenous Treatment Effect
Weisberg and Dailey-Higgs
DANISH
IV. Heart Failure and MRAs
RALES https://www.nejm.org/doi/full/10.1056/NEJM199909023411001
EMPHASIS https://www.nejm.org/doi/full/10.1056/NEJMoa1009492
Combined analysis (Matsumoto)
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Jun 07 2024 This Week in Cardiology
7 juni 2024 · 28 min
Cannabis and CV outcomes, post-CABG AF, embolic protection devices, emulation of randomization, and a preview heterogenous treatment effects are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Cannabis
It Sure Looks Like Cannabis Is Bad for the Heart, Doesn't It?
https://www.medscape.com/viewarticle/1000250
Cannabis Use Tied to Increased Cardiovascular Risk
https://www.medscape.com/viewarticle/cannabis-use-tied-increased-cardiovascular-risk-2024a10003yr
Medical Cannabis for Chronic Pain Tied to Arrhythmia Risk
https://www.medscape.com/viewarticle/medical-cannabis-chronic-pain-tied-arrhythmia-risk-2024a10000sc
Cannabis for Chronic Pain and CV Safety https://doi.org/10.1093/eurheartj/ehad834
Editorial https://academic.oup.com/eurheartj/article/45/6/485/7500073
Response to Letter https://doi.org/10.1093/eurheartj/ehae314
UCLA paper https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2819559
Lifetime Cannabis Use and Mortality https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2819635
II. Post Cardiac Surgery AF
Meta-analysis https://doi.org/10.1093/eurheartj/ehae267
III. Embolic Protection devices
Clear Stroke Benefit Eludes Embolic Protection: PROTECTED TAVR
https://www.medscape.com/viewarticle/980978
Embolic Protection and Stroke Prevention With TAVR https://www.ahajournals.org/doi/abs/10.1161/CIRCINTERVENTIONS.123.013697
PROTECTED TAVR https://www.nejm.org/doi/full/10.1056/NEJMoa2204961
IV. Preview of HTE
Paper https://doi.org/10.1016/j.ahj.2024.04.020
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May 31 2024 This Week in Cardiology
31 mei 2024 · 33 min
The FLOW trial of semaglutide, the DANCAVAS CV screening trial, non-invasive tests for chest pain, and conflicts of interest on social media are the topics John Mandrola, MD, discusses this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Semaglutide for CKD
Semaglutide Significantly Improves Chronic Kidney Disease
https://www.medscape.com/viewarticle/semaglutide-significantly-improves-chronic-kidney-disease-2024a10009w9
FLOW Trial
II. CV Screening
Judicious CVD Screening May Work in Men: DANCAVAS
https://www.medscape.com/viewarticle/980153
DANCAVAS 6-Year Outcomes https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004403
DANCAVAS Main Trial NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2208681
III. Non-invasive Cardiac Testing in Chest Pain
Circulation Outcomes Paper https://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.123.010457
Scot Heart https://www.nejm.org/doi/full/10.1056/NEJMoa1805971
IV. COI and Social Media
JAMA letter https://jamanetwork.com/journals/jama/fullarticle/2816900
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May 24 2024 This Week in Cardiology
24 mei 2024 · 29 min
Clues in SCAF, a DOAC antidote trial, another negative lytic trial in stroke, JAMA changes to observational studies, and BP in stroke care are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. ARTESIA Substudy
Sadly, ARTESIA Doesn't Answer a Common Question in Cardiology
https://www.medscape.com/viewarticle/998215
ARTESIA Substudy
NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062
ARTESIA https://www.nejm.org/doi/10.1056/NEJMoa2310234
II. DOAC Reversal
ANNEXA-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2313040
III. Lytic Therapy in Acute Stroke
Thrombolysis Offers No Benefit for Mild Stroke
https://www.medscape.com/viewarticle/iv-thrombolysis-offers-no-benefit-mild-stroke-2024a10009p7
TEMPO-2 Trial https://doi.org/10.1016/S0140-6736(24)00921-8
The Case Against Thrombolytic Therapy in Stroke
IV. Observational Research
JAMA Special Communication https://jamanetwork.com/journals/jama/fullarticle/2818746
JAMA editors note https://jamanetwork.com/journals/jama/fullarticle/2818747
V. Aggressive BP Control in Stroke
Guidelines on Rapid BP Reduction in Acute Ischemic Stroke Challenged
https://www.medscape.com/viewarticle/guidelines-rapid-bp-reduction-acute-ischemic-stroke-2024a10009pe
TRUTH Trial https://doi.org/10.1016/S1474-4422(24)00177-7
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May 17 2024 This Week in Cardiology
17 mei 2024 · 30 min
An Impella update, another TAVI vs SAVR trial, two studies on angina and PCI, another null substudy from REVIVED-BCIS, and semaglutide are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Impella Update
CHRIP BCIS 3 https://classic.clinicaltrials.gov/ct2/show/NCT05003817
Danger-Shock Podcast https://www.medscape.com/viewarticle/1000675
II. TAVI vs SAVR
Notion 2 Trial EHJ https://doi.org/10.1093/eurheartj/ehae331
DEDICATE-DZHK6
III. Angina and PCI
Orbita 2 Sub-analysis
Orbita Star https://www.jacc.org/doi/10.1016/j.jacc.2024.04.001
IV. Complete Revascularization
Main REVIVED trial https://www.nejm.org/doi/full/10.1056/NEJMoa2206606
JACC Substudy https://www.jacc.org/doi/10.1016/j.jacc.2024.04.043
V. Semaglutide
Semaglutide CV Benefits Irrespective of Weight Loss: 4-Year SELECT Data
https://www.medscape.com/viewarticle/semaglutide-cv-benefits-irrespective-weight-loss-4-year-2024a100095z
Nature Med substudy https://www.nature.com/articles/s41591-024-02996-7
SELECT Main paper https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
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May 10 2024 This Week in Cardiology
10 mei 2024 · 32 min
Inclisiran, sodium-channel blocker safety, analytic flexibility, the work-up of patients with HF, and BP in older patients are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Inclisiran Update
ORION 4 https://classic.clinicaltrials.gov/ct2/show/NCT03705234
II. Sodium-Channel AADs
UPenn Paper https://doi.org/10.1016/j.jacep.2024.01.021
Three Questions Editorial https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381
EAST Post-hoc Review https://doi.org/10.1093/europace/euae121
III. Analytic Flexibility
Is Red Meat Healthy? Multiverse Analysis Has Lessons Beyond Meat
https://www.medscape.com/viewarticle/red-meat-healthy-multiverse-analysis-has-lessons-beyond-meat-2024a10008qv
Specification Curve Analysis of Red Meat Data https://doi.org/10.1016/j.jclinepi.2024.111278
IV. The Work-up of Patients With HF
Durstenfeld and colleagues, UCSF https://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.123.010800
REVIVED BCIS2 https://www.nejm.org/doi/full/10.1056/NEJMoa2206606
V. BP Therapy in Older Patients
Haring and colleagues; Women's Health Initiative BP Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067302
SPRINT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1511939
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May 03 2024 This Week in Cardiology
3 mei 2024 · 21 min
The DEDICATE trial of TAVR vs SAVR, more on renal denervation, inclisiran, and marketing disguised as science are the topics John Mandrola, MD, discusses in today's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. TAVR vs SAVR
TAVI Comparable With SAVR in Lower-Risk Aortic Stenosis
https://www.medscape.com/viewarticle/tavi-comparable-savr-lower-risk-aortic-stenosis-2024a100074o?form=fpf
DEDICATE https://www.nejm.org/doi/full/10.1056/NEJMoa2400685
Partner 3 https://www.nejm.org/doi/full/10.1056/NEJMoa1814052
Evolut Low Risk https://www.nejm.org/doi/full/10.1056/NEJMoa1816885
Barili meta-analysis https://doi.org/10.1093/ejcts/ezab516
II. Renal Denervation
Alcohol-Mediated Renal Denervation Promising in Hypertension
https://www.medscape.com/viewarticle/alcohol-mediated-renal-denervation-promising-hypertension-2024a10007eg
TARGET 1 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.069291
III. Inclisiran
Earlier Inclisiran Gives Better Long-Term LDL Reductions
https://www.medscape.com/viewarticle/earlier-inclisiran-gives-better-long-term-ldl-reductions-2024a10007d6
VICTORIAN INITIATE Trial https://www.jacc.org/doi/10.1016/j.jacc.2024.03.382
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Apr 26 2024 This Week in Cardiology
26 april 2024 · 28 min
A listener defends colored boxes in guidelines; mysteries of non-culprit coronary lesions during PCI, and of AF ablation; and surrogate markers are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Mystery of What to Do in the Cath Lab after Fixing the Culprit Lesion – The FULL REVASC Trial
Complete Revascularization Not Superior to Culprit-Only PCI After MI
https://www.medscape.com/viewarticle/complete-revascularization-not-superior-culprit-only-pci-2024a10007ik
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
FIRE Trial https://www.nejm.org/doi/10.1056/NEJMoa2300468
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
Cohen Tweet on FULL REVASC https://x.com/djc795/status/1781361606238085532
II. AF Ablation Mysteries
New Expert Consensus on Ablation Strategies for AF
https://www.medscape.com/viewarticle/new-expert-consensus-ablation-strategies-af-2024a1000851
Bern Study of Remapping https://doi.org/10.1016/j.jacep.2024.02.026
Natural History of SCAF https://doi.org/10.1016/j.jacc.2019.09.050
Liverpool Study: Thermal PV Isolation in Persistent AF https://doi.org/10.1016/j.hrthm.2024.04.061
III. Surrogate Markers
JAMA: Surrugate Markers and Clinical Outcomes https://jamanetwork.com/journals/jama/fullarticle/2817850
BP Surrogate Meta-analysis https://doi.org/10.1016/S0140-6736(21)00590-0
JAMA: Nonfatal MI as Surrogate for Mortality https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560
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Apr 19 2024 This Week in Cardiology
19 april 2024 · 29 min
ACC Part 2: The TACT2 trial of chelation, inter-atrial shunts for HF, and triglyceride lowering; plus diltiazem and Factor Xa anticoagulants are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. TACT 2
Chelation Therapy Provides No Benefit Post-MI
https://www.medscape.com/viewarticle/chelation-therapy-provides-no-benefit-post-mi-2024a10006l5
Chelation Therapy and CV Risk: Why TACT2 Showed No Benefit https://www.medscape.com/viewarticle/chelation-therapy-and-cv-risk-why-tact2-showed-no-benefit-2024a1000761?src=
JAMA TACT 1 paper https://jamanetwork.com/journals/jama/fullarticle/1672238
Diabetes Subgroup paper https://pubmed.ncbi.nlm.nih.gov/24254885/
A New Look at P-values https://evidence.nejm.org/doi/abs/10.1056/EVIDoa2300003
PARAGON HF https://www.nejm.org/doi/full/10.1056/NEJMoa1908655
II. Interatrial Shunts for HF
No Net HF Benefit for Interarterial Shunt Device
https://www.medscape.com/viewarticle/no-net-hf-benefit-interarterial-shunt-device-2024a10006kk
REDUCE LAP HF II https://doi.org/10.1016/S0140-6736(22)00016-2
III. Triglyceride Lowering
Early Olezarsen Results Show 50% Reduction in Triglycerides
https://www.medscape.com/viewarticle/early-olezarsen-results-show-50-reduction-triglycerides-2024a10006oz
Is It Time to Stop Treating High Triglycerides?
https://www.medscape.com/viewarticle/990126
NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2402309
Substantial Triglyceride Reduction With Plozasiran
https://www.medscape.com/viewarticle/substantial-triglyceride-reduction-plozasiran-2024a10006wf?icd=login_success_email_match_norm
JAMA Cardiology https://jamanetwork.com/journals/jamacardiology/article-abstract/2817469
IV. Diltiazem and Factor Xa inhibitors
JAMA Vanderbilt University Paper https://jamanetwork.com/journals/jama/fullarticle/2817546
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Apr 12 2024 This Week in Cardiology
12 april 2024 · 29 min
ACC Recap #1: DanGer Shock (plus a sobering JAMA research letter on Impella use), REDUCE-AMI, PREVENT, and EMPACT-MI are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. DanGer-Shock Trial
Impella CP Improves Survival in STEMI, Cardiogenic Shock https://www.medscape.com/viewarticle/impella-cp-improves-survival-stemi-cardiogenic-shock-2024a10006kz
Impella Saves Lives in Cardiogenic Shock, but Patient Selection Key https://www.medscape.com/viewarticle/1000659
Published DanGer Shock Study https://www.nejm.org/doi/full/10.1056/NEJMoa2312572
JAMA Research letter https://jamanetwork.com/journals/jama/article-abstract/2817457
II. REDUCE-AMI Trial
New Data Question Beta-Blockers Post-MI With Preserved EF https://www.medscape.com/viewarticle/new-data-question-beta-blockers-post-mi-preserved-ef-2024a10006y8
Beta-Blockers Post-MI Past Their Expiration Date: REDUCE-AMI https://www.medscape.com/viewarticle/1000663
REDUCE-AMI paper https://www.nejm.org/doi/full/10.1056/NEJMoa2401479
Meta-analysis: Beta Blockers for MI https://doi.org/10.1016/j.amjmed.2014.05.032
III. PREVENT Trial
Preventive PCI for Vulnerable Plaques Reduces Cardiac Events
https://www.medscape.com/viewarticle/preventive-pci-vulnerable-plaques-reduces-cardiac-events-2024a10006tc
Preventive Coronary Stents: Not There Yet
https://www.medscape.com/viewarticle/preventive-coronary-stents-not-there-yet-2024a10006yr
PREVENT https://doi.org/10.1016/S0140-6736(24)00413-6
IV. EMPACT MI trial of Empagliflozin in the Post-MI setting
Empagliflozin Fails to Reduce Events After Acute MI
https://www.medscape.com/viewarticle/empagliflozin-fails-reduce-events-after-acute-mi-2024a10006kn
EMPACT-MI: Another SGLT2 Inhibitor Miss in Post-MI Care https://www.medscape.com/viewarticle/1000684
EMPACT MI https://www.nejm.org/doi/10.1056/NEJMoa2314051
DAPA MI ht…
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Apr 05 2024 This Week in Cardiology
5 april 2024 · 27 min
Statins and diabetes, AAD in patients with heart disease, tricuspid valve interventions, and an ACC preview are the topics John Mandrola, MD, discusses in this week's podcast.This podcast is intended for healthcare professionals only. Lees meer
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Statins and Diabetes
Meta-analysis in Lancet-Diabetes https://doi.org/10.1016/S2213-8587(24)00040-8
Editorial https://doi.org/10.1016/S2213-8587(24)00059-7
NEJM Paper on Gene Variants and DM https://www.nejm.org/doi/full/10.1056/nejmoa1604304
JAMA Paper on Gene Variants and DM https://jamanetwork.com/journals/jama/fullarticle/2565289
II. Anti-arrhythmic Drugs in Patients With Serious Heart Disease
UPenn Paper on AADs for PVC Suppression https://doi.org/10.1016/j.jacep.2024.01.021
Three Questions for Evidence-Based Cardiac EP https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381
CAST trial https://www.nejm.org/doi/full/10.1056/NEJM199103213241201
III. Tricuspid Valve Interventions
FDA Clears TriClip for Tricuspid Regurgitation
https://www.medscape.com/viewarticle/fda-clears-triclip-tricuspid-regurgitation-2024a100068o
FDA Panel in Favor of TriClip for Tricuspid Regurgitation
https://www.medscape.com/viewarticle/fda-panel-favor-triclip-tricuspid-regurgitation-2024a100037n
Slides for Trisend II
TRILUMINATE https://www.nejm.org/doi/full/10.1056/NEJMoa2300525
IV. ACC Preview
Mandrola's Three Trials to Look for at the 2024 American College of Cardiology Scientific Sessions
https://www.medscape.com/viewarticle/1000613
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Mar 29, 2024 This Week in Cardiology Podcast
29 maart 2024 · 29 min
Intermittent fasting, anticoagulation decisions, heterogenous treatment effects, frailty in HF, the importance of the ECG, and industry conflicts are the topics John Mandrola, MD, covers this week. Lees meer
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Intermittent Fasting
No, Intermittent Fasting Won't Kill You
https://www.medscape.com/viewarticle/1000544
NEJM Paper on Time-Restricted Eating https://www.nejm.org/doi/full/10.1056/NEJMoa2114833
JAMA TREAT Clinical Trial https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2771095
II. Stroke Prevention with OAC
Shah Meta analysis of Vitamin K Agonists in AF https://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.123.010269
III. Heterogenous Treatment Effects in Trials
Pivotal CV Trials May Not Apply to Complex Patients
https://www.medscape.com/viewarticle/989129
Analysis of 8 Trials of Multimorbidity and Treatment Response https://doi.org/10.1016/j.amjmed.2024.01.028
IV. Frailty and HF
Circulation Outcomes: Multidomain Frailty and Mode of Death in HF https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.123.010416
V. ECG in LBBB
JAMA Cardiology: Revised Definition of LBBB https://jamanetwork.com/journals/jamacardiology/fullarticle/2816973
VI. Industry Payments to Doctors
JAMA: Payments to US Physicians by Specialty https://jamanetwork.com/journals/jama/fullarticle/2816900
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Mar 22 2024 This Week in Cardiology
22 maart 2024 · 26 min
p>Obesity drugs as ASCVD-modifiers, HR monitors, when journals publish obvious facts, and effect scores and sorting out signals from RCTs are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Denmark Notes
II. FDA approval of Semaglutide
FDA Approves Semaglutide for Cardiovascular Risk Reduction
https://www.medscape.com/viewarticle/fda-approves-semaglutide-cardiovascular-risk-reduction-2024a10004ix
Select Trial
III. PPG Monitor Accuracy
Research Letter https://doi.org/10.1016/j.jacc.2024.01.024
IV. AAD and Bradycardia
Anti-arrhythmic Drugs Linked to Bradycardia in Patients With AF
https://www.medscape.com/viewarticle/anti-arrhythmic-drugs-linked-bradycardia-patients-af-2024a10004vw
JACC paper on AAD Adverse Effects https://doi.org/10.1016/j.jacc.2024.01.013
V. Finding Signals in RCTs
JAMA paper on Treatment Effects of Oxygen Targets
DANISH trial https://www.nejm.org/doi/full/10.1056/nejmoa1608029
LAFFLIN et al. Scoring System to Assess Generalizability of Trial Results https://doi.org/10.1177/2047487318815967
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Mar 08 2024 This Week in Cardiology
8 maart 2024 · 27 min
Plastics and heart disease, MINT trial letters-to-the-editor and Bayes theorem, and Brugada syndrome are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Plastics and Heart Disease
Plastic Particles in Carotid Plaques Linked to CV Events
https://www.medscape.com/viewarticle/plastic-particles-carotid-plaques-linked-cv-events-2024a10004ge
Plastics and ASCVD Study https://www.nejm.org/doi/full/10.1056/NEJMoa2309822
Review https://www.nejm.org/doi/full/10.1056/NEJMra2300476
Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2400683
II. MINT trial LTE and Bayes Theorem
In MI With Anemia, Results May Favor Liberal Transfusion: MINT https://www.medscape.com/viewarticle/998376
The MINT Study https://www.nejm.org/doi/full/10.1056/NEJMoa2307983
Letter-to-the-Editor https://www.nejm.org/doi/full/10.1056/NEJMc2400982
Likelihood Ratio https://www.cebm.ox.ac.uk/resources/ebm-tools/likelihood-ratios
III. Brugada Syndrome
The EHJ paper: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehae133/7623123
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Mar 1 2024 This Week in Cardiology
1 maart 2024 · 29 min
The Western AF meeting, aspirin, cannabis use, LVEF in athletes, and shared decision making before ICD implantation are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. ASA in Primary Prevention
Campbell Meta-analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065420
Swedish Observational study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.028321
ASPREE https://www.nejm.org/doi/full/10.1056/NEJMoa1805819
II. Cannabis
Cannabis Use Tied to Increased Cardiovascular Risk
https://www.medscape.com/viewarticle/cannabis-use-tied-increased-cardiovascular-risk-2024a10003yr
It Sure Looks Like Cannabis Is Bad for the Heart, Doesn't It?
https://www.medscape.com/viewarticle/1000250
Journal of the AHA Observational Study https://www.ahajournals.org/doi/full/10.1161/JAHA.123.030178
III. Low EF in Athletes
Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.063777
IV. ICDs and Shared Decision-Making
Association of a Medicare Mandate for Shared Decision-Making With Cardiac Device Utilization https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2815017
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Feb 23 2024 This Week in Cardiology
23 februari 2024 · 29 min
Reading incidental CAC on chest CT scans, exercise benefits in women vs men, PCI with or without imaging, and trial non-reporting are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Incidental CAC on Chest CT
Incidental CAC
Tweet
When Does a Calcium Score Equate to Secondary Prevention?: Insights From the Multinational CONFIRM Registry https://doi.org/10.1016/j.jcmg.2023.03.008
II. Exercise
Health Gains of Exercise Greater in Women?
https://www.medscape.com/viewarticle/health-gains-exercise-greater-women-2024a10003fv
Sex Differences in Association of Physical Activity With All-Cause and Cardiovascular Mortality
III. PCI With or Without Imaging
Intravascular Imaging in PCI: Time for a Guideline Update?
https://www.medscape.com/viewarticle/995677
Meta-analysis paper Lancet https://doi.org/10.1016/S0140-6736(23)02454-6
Imaging uptake paper https://doi.org/10.1093/eurheartj/ehad430
IV. Trial Non-reporting
The Ghost Research Haunting Nordic Medical Trials
https://www.medscape.com/viewarticle/ghost-research-haunting-nordic-medical-trials-2024a10003gz
Manuscript/preprint https://www.medrxiv.org/content/10.1101/2024.02.04.24301363v1#T10
Nissen (Rosiglitazone) https://www.nejm.org/doi/10.1056/NEJMoa072761
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Feb 16 2024 This Week in Cardiology
16 februari 2024 · 24 min
An update in trial interpretation, CI, and P-values; percutaneous tricuspid Interventions; and news on HDL and humility in Medicine are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Evidence of Absence Is not Absence of Evidence
Feb 09, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1000101
ARCADIA Trial https://jamanetwork.com/journals/jama/fullarticle/2814933
FOURIER Trial https://www.nejm.org/doi/full/10.1056/nejmoa1615664
Sample Size Calculator https://clincalc.com/stats/samplesize.aspx
II. Tricuspid Valve Interventions
FDA OKs First Transcatheter Tricuspid Valve Replacement
https://www.medscape.com/viewarticle/fda-oks-first-transcatheter-tricuspid-valve-replacement-2024a10002dq
FDA Panel in Favor of TriClip for Tricuspid Regurgitation
https://www.medscape.com/viewarticle/fda-panel-favor-triclip-tricuspid-regurgitation-2024a100037n
Cardiothoracic Surgical Trials Network Study https://www.nejm.org/doi/full/10.1056/NEJMoa2115961
TRILUMINATE https://www.nejm.org/doi/full/10.1056/NEJMoa2300525
KAUL Tweet on ATTR Cardiomyopathy https://twitter.com/kaulcsmc/status/1753552603534016622?s=20
APOLLO B trial https://www.nejm.org/doi/full/10.1056/NEJMoa2300757
Al-Lamee Tweet on Sham Controls https://x.com/rallamee/status/1758236588570562736
III. HDL Cholesterol
Rationale paper — AEGIS https://doi.org/10.1016/j.ahj.2020.10.052
Press Release AEGIS II https://www.prnewswire.com/news-releases/csl-announces-top-line-results-from-the-phase-3-aegis-ii-trial-evaluating-the-efficacy-and-safety-of-csl112-apolipoprotein-a-i-human-302059156.html
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Feb 09 2024 This Week in Cardiology
9 februari 2024 · 26 min
Beta-blocker withdrawal in HFpEF, the ARCADIA trial, food as medicine, and bariatric surgery are the topics John Mandrola, MD, discusses in today's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. HFpEF and Heart Rate
PRESERVE HF Substudy https://jamanetwork.com/journals/jamacardiology/fullarticle/2814596
PRESERVE HF Original https://doi.org/10.1016/j.jacc.2021.08.073
II. ARCADIA trial
ARCADIA Main Paper: Apixaban vs ASA https://jamanetwork.com/journals/jama/fullarticle/2814933
KAMEL's AF and Stroke Paper 10.1161/STROKEAHA.115.012004
AVERROES Substudy -- 10.1016/S1474-4422(12)70017-0
III. Food as Medicine
Food-As-Medicine Trial results: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2812982
NPR Story https://www.npr.org/sections/thesalt/2017/05/08/526952657/fresh-food-by-prescription-this-health-care-firm-is-trimming-costs-and-waistline
IV. Bariatric Surgery
Weight Loss Surgery Yields Long-Term BP Control in Obesity
https://www.medscape.com/viewarticle/weight-loss-surgery-yields-long-term-bp-control-obesity-2024a10002le
Gateway RCT https://doi.org/10.1016/j.jacc.2023.11.032
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Feb 02 2024 This Week in Cardiology
2 februari 2024 · 28 min
FDA approves PFA for AF ablation, flawed comparisons of TEER vs MV surgery and PCI vs CABG, and cardiologists struggling with board exams are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. PFA
FDA Okays Boston Scientific PFA System for Paroxysmal AF
https://www.medscape.com/viewarticle/fda-okays-boston-scientific-pfa-system-paroxysmal-af-2024a1000275
Pulsed-Field Ablation for AF: The Promise and the Reality
https://www.medscape.com/viewarticle/995675
ADVENT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307291
EU-PORIA Registry https://doi.org/10.1093/europace/euad185
Tomlinson/Mandrola Editorial https://www.jacc.org/doi/10.1016/j.jacc.2020.07.032
II. TEER vs MV Surgery
EHJ Paper https://doi.org/10.1093/eurheartj/ehae046
III. ISCHEMIA Post-Hoc Studies
JACC Post-Hoc ISCHEMIA Trialhttps://doi.org/10.1016/j.jacc.2023.11.002
Main ISCHEMIA paper https://www.nejm.org/doi/full/10.1056/nejmoa1915922
FAME 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2112299
IV. Board Exams
More Cardiologists Failing the Boards, Why and How to Fix?
https://www.medscape.com/viewarticle/more-cardiologists-failing-boards-why-and-how-fix-2024a10001oi
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Jan 26 2024 This Week in Cardiology
26 januari 2024 · 30 min
LAAO, more evidence that stable CAD is stable, CRT benefit over the long-term, and AF monitoring after stroke are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. LAAO
This Week in Cardiology Podcast, Dec 15, 2023 https://www.medscape.com/viewarticle/999282
European Heart Journal paper https://academic.oup.com/eurheartj/article/45/3/214/7471675
LAAOS 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2101897
II. CAD after Transcatheter Aortic Valve Implantation
Cleveland Clinic Observational study https://doi.org/10.1093/eurheartj/ehae019
ACTIVATION trial https://doi.org/10.1016/j.jcin.2021.06.041
III. Cardiac Resynchronization Therapy
Original RAFT 2010 https://www.nejm.org/doi/full/10.1056/nejmoa1009540
Long-term RAFT https://www.nejm.org/doi/full/10.1056/NEJMoa2304542
Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2312419
IV. AF Monitoring After Stroke
Japanese Observational Study https://www.ahajournals.org/doi/10.1161/JAHA.123.031508
ARTESIA https://www.nejm.org/doi/full/10.1056/NEJMoa2310234
NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062
LOOP substudy https://jamanetwork.com/journals/jamaneurology/fullarticle/2795865
CRYSTAL AF https://www.nejm.org/doi/full/10.1056/nejmoa1313600
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Jan 19 2024 This Week in Cardiology
19 januari 2024 · 30 min
Listener feedback on antiplatelet therapy after PCI, bempedoic acid, off-Label PFO Closure, and palliative care are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Listener Feedback on Antiplatelet Therapy After PCI
Long-term Clopidogrel Has Advantages After Coronary Stenting
https://www.medscape.com/viewarticle/long-term-clopidogrel-has-advantages-after-coronary-stenting-2024a10000c8
Host Exam Study; Extended FU of Host-Exam https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062770
II. Bempedoic Acid
This Week in Cardiology July 7, 2023 https://www.medscape.com/viewarticle/994089
NEJM: Bempedoic Acid and CV Outcomes
JAMA: Primary Prevention Analysis https://jamanetwork.com/journals/jama/fullarticle/2806646
JAMA-Cardiology: Total Events Analysis https://jamanetwork.com/journals/jamacardiology/fullarticle/2813647/
III. Off-Label PFO Closure
Circulation Outcomes Paperhttps://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.123.010200
IV. Palliative Care
JAMA: Palliative Care Consultation
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Jan 12 2024 This Week in Cardiology
12 januari 2024 · 27 min
GLP-1s and BaroStim Neo revisited, a new drug for transthyretin amyloid CM, clopidogrel vs ASA years after PCI and stent, and statins are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. GLP-1s and Obesity, BaroStim Neo Revisited
FDA Expands Label for CVRx Barostim System in HF https://www.medscape.com/viewarticle/fda-expands-label-cvrx-barostim-system-hf-2023a1000wsx
JAMA Cardiology Special Communication – BDP https://jamanetwork.com/journals/jamacardiology/fullarticle/2810726
II. ATTR Cardiomyopathy
ATTRibute-CM NEJM paper https://www.nejm.org/doi/full/10.1056/NEJMoa2305434
Circulation Review of TTR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.111.078915
ATTR-ACT (Tafadimis) https://www.nejm.org/doi/10.1056/NEJMoa1805689
III. Clopidogrel vs ASA Years After PCI
Long-term Clopidogrel Has Advantages After Coronary Stenting
https://www.medscape.com/viewarticle/long-term-clopidogrel-has-advantages-after-coronary-stenting-2024a10000c8
Stop DAPT Original Trial
STOP DAPT at 5 Years https://doi.org/10.1016/j.jacc.2023.10.013
Network Meta-analysis of P2Y12-I vs ASA https://doi.org/10.1016/j.jcin.2022.08.009
IV. Statin Use
Statin Use Remains Low for At-Risk Patients
https://www.medscape.com/viewarticle/999043
Annals of Internal Medicine Observational Study https://doi.org/10.7326/M23-1915
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Jan 05 2024 This Week in Cardiology
5 januari 2024 · 25 min
Neuro-modulation in HF, private equity owned hospitals, HCM, SCD and ICD re-evaluated, and peer review are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Neuromodulation for HFrEF
FDA Expands Label for CVRx Barostim System in HF
https://www.medscape.com/viewarticle/fda-expands-label-cvrx-barostim-system-hf-2023a1000wsx
BeAT HF trial https://doi.org/10.1016/j.jacc.2020.05.015
II. Private Equity Takeover of US Hospitals
Hospital Adverse Events Rise After Private Equity Acquisition
https://www.medscape.com/viewarticle/hospital-adverse-events-rise-after-private-equity-2023a1000wya
Changes in Hospital Adverse Events and Patient Outcomes Associated With Private Equity Acquisition: https://jamanetwork.com/journals/jama/article-abstract/2813379
RSS audio: https://bi.medscape.com/pi/editorial/studio/audio/2024/core/999557.mp3
III. Hypertrophic Cardiomyopathy
Positive Topline Results for SEQUOIA-HCM Trial in OHCM
https://www.medscape.com/viewarticle/positive-topline-results-sequoia-hcm-trial-ohcm-2023a1000wu9
IV. The ICD gets a ReLook
Study to Examine Routine ICD Implantation Post Heart Attack
https://www.medscape.com/viewarticle/study-examine-routine-icd-implantation-post-heart-attack-2023a1000wmd
PROFID Site https://profid-project.eu/profid-ehra-trial/
Declining Risk of Sudden Death in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1609758
V. Peer Review
Prevalence of Short Peer Reviews in 3 Leading General Medical Journals -- https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2812883
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Dec 15 2023 This Week in Cardiology
15 december 2023 · 29 min
FDA approves PFA, breakthrough in PAH, residual leaks after percutaneous LAAO, OAC in low to intermediate risk people are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. FDA Approves PFA
FDA Approves First Pulsed Field Ablation System for AF https://www.medscape.com/viewarticle/fda-approves-first-pulsed-field-ablation-system-af-2023a1000vit
- PULSED AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064329
- ADVENT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307291
- MANIFEST https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064959
II. Pulmonary HTN
Positive Topline Data for Sotatercept in PAH: STELLAR
https://www.medscape.com/viewarticle/982407
- STELLAR https://www.nejm.org/doi/10.1056/NEJMoa2213558
- Editorial on STELLAR https://www.nejm.org/doi/full/10.1056/NEJMe2300324
III. Peri-Device Leaks
- Greek Meta-analysis https://doi.org/10.1093/eurheartj/ehad828
IV. Intermediate Risk AF – Norwegian Study
- Stroke and bleeding risk in atrial fibrillation with CHA2DS2-VASC risk score of one: the Norwegian AFNOR study AFNOR Study https://doi.org/10.1093/eurheartj/ehad659
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Dec 08 2023 This Week in Cardiology
8 december 2023 · 28 min
Three aspects of the recent AF guideline documents and a possible new treatment of POTS are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I AF Guidelines
ACC/AHA Issue Updated Atrial Fibrillation Guideline
https://www.medscape.com/viewarticle/998956
- Guideline doc: https://www.ahajournals.org/doi/10.1161/CIR.0000000000001193
- CASTLE AF https://www.nejm.org/doi/full/10.1056/nejmoa1707855
- Analysis of US Inpatient Sample https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-14-73
- RAFT AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057095
- Beta Blockers in AF https://pubmed.ncbi.nlm.nih.gov/25193873/
Section 2 AF Guidelines – EARLY Rhythm Control Gets Emphasis
- STOP AF https://www.nejm.org/doi/full/10.1056/NEJMoa2029554
- EARLY AF https://www.nejm.org/doi/full/10.1056/nejmoa2029980
- EAST https://www.nejm.org/doi/full/10.1056/NEJMoa2019422
- Natural History of AF https://www.jacc.org/doi/abs/10.1016/j.jacc.2019.09.050
Section 3 AF Guidelines – Dubious Upgrade of percutaneous LAAC
- PROTECT and PREVAIL Meta-analysis 5-year https://doi.org/10.1016/j.jacc.2017.10.021
- PINNACLE FLX https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.120.050117
II. Postural Orthostatic tachycardia Syndrome
Vagus Nerve Stimulation Promising In POTS
https://www.medscape.com/viewarticle/998913
- Stavrakis et al. Noninvasive VNS for POTS https://doi.org/10.1016/j.jacep.2023.10.015
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Dec 01 2023 This Week in Cardiology
1 december 2023 · 28 min
More from AHA including SGLT2 inhibitors, blood transfusion after MI; cracks in the armor of Factor XI inhibitors; and renal denervation are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. DAPA MI
Potential Dapagliflozin Benefit Post-MI Is Not a 'Mandate'
https://www.medscape.com/s/viewarticle/998378
- NEJM Evidence: Dapagliflozin After MI https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300286
II. Blood Transfusion Strategy Post MI
In MI With Anemia, Results May Favor Liberal Transfusion: MINT
https://www.medscape.com/viewarticle/998376
- MINT NEJM -- https://www.nejm.org/doi/full/10.1056/NEJMoa2307983
- REALITY https://jamanetwork.com/journals/jama/fullarticle/2776201
- PROTECTED TAVR - https://www.nejm.org/doi/full/10.1056/NEJMoa2204961
III. FACTOR XI
Impressive Bleeding Profile With Factor XI Inhibitor in AF: AZALEA
https://www.medscape.com/viewarticle/998418
Asundexian Phase 3 AF Study Halted for Lack of Efficacy
https://www.medscape.com/viewarticle/998665
- Abelacimab for VTE https://www.nejm.org/doi/full/10.1056/NEJMoa2105872
IV. Renal Denervation
FDA Panel Split on Efficacy of Spyral Renal Denervation
https://www.medscape.com/viewarticle/995800
FDA OKs Symplicity Renal Denervation System for Hypertension
https://www.medscape.com/viewarticle/998664
- SPYRAL HTN OFF MED -- https://doi.org/10.1016/S0140-6736(20)30554-7
- SPRYAL HTN On Meds (Pilot Lancet 2018 ) https://doi.org/10.1016/S0140-6736(18)30951-6
- SPRYAL HTN ON Meds (Expansion Pilot) https://doi.org/10.1016/j.jacc.2023.08.045
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Nov 17 2023 This Week in Cardiology
17 november 2023 · 26 min
An AHA Recap: SELECT, ORBITA2, and ARTESIA are the trials John Mandrola, MD, reviews in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
American Heart Association 2023 on theHeart.org | Medscape Cardiology
https://www.medscape.com/viewcollection/37277
I. SELECT Trial
Semaglutide 'A New Pathway' to CVD Risk Reduction: SELECT
https://www.medscape.com/viewarticle/998373
Positive Results From SELECT Begins a New Era in Cardiology
https://www.medscape.com/viewarticle/998217
Is It Time for Cardiologists to Treat Obesity?
https://www.medscape.com/viewarticle/998391
- SELECT trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
- SUSTAIN 6 https://www.nejm.org/doi/full/10.1056/nejmoa1607141
II. ORBITA 2
Angioplasty Finally Proven Beneficial in Stable Angina: ORBITA-2
https://www.medscape.com/s/viewarticle/998375
ORBITA-2 Saves Interventional Cardiology and Challenges Current Guidance
https://www.medscape.com/viewarticle/998213
PCI, the Antianginal 'Pill': ORBITA-2 in Detail
https://www.medscape.com/viewarticle/997777
- ORBITA-2; NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2310610
- ORBITA 1 https://doi.org/10.1016/S0140-6736(17)32714-9
III. ARTESIA
Apixaban Cuts Stroke but Ups Bleeding in Subclinical AF: ARTESIA
https://www.medscape.com/viewarticle/998379
Sadly, ARTESIA Doesn't Answer a Common Question in Cardiology
https://www.medscape.com/viewarticle/998215
- NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062
- ARTESIA https://www.nejm.org/doi/10.1056/NEJMoa2310234
- AVERROES https://www.nejm.org/doi/full/10.1056/NEJMoa1007432
- McIntyre Meta-analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067512
- TRENDS https://www.ahajournals.org/doi/10.1161/circep.109.849638
- ASSERT https://doi.org/10.1093/eurheartj/ehx042
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Nov 10 2023 This Week in Cardiology
10 november 2023 · 24 min
Renal denervation, a potential deadly decision in the ED, GLP-1 agonists, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Renal Denervation
FDA OKs Paradise Renal Denervation System for Hypertension
https://www.medscape.com/viewarticle/998237
- Company Press Release https://www.recormedical.com/recor-medical-and-otsuka-medical-devices-announce-first-fda-approved-renal-denervation-system-for-the-treatment-of-hypertension/
- Six-month Meta-analysis of RDN Studies https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.123.066941
- March This Week in Cardiology with RDN Discussion https://www.medscape.com/viewarticle/989014
II. Potential Deadly Decisions in the ED
Even One Night in the ED Raises Risk for Death
https://www.medscape.com/viewarticle/998080
- JAMA Internal Medicine Study
III. Tirzepatide Approval
FDA Approves Tirzepatide for Treating Obesity
https://www.medscape.com/viewarticle/998225
- SURMOUNT 2 https://doi.org/10.1016/S0140-6736(23)01200-X
- SURMOUNT 1 https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
IV. AHA Preview
Mandrola's Top Trials to Look for at AHA 2023
https://www.medscape.com/viewarticle/998123
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Nov 03 2023 This Week in Cardiology
3 november 2023 · 26 min
Tricuspid regurgitation therapy, two more left atrial appendage trials, and reflections on being too soft on medical science are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Tricuspid Regurgitation
Trilogy TAVR Safe, Effective in Aortic Regurgitation
https://www.medscape.com/viewarticle/997782
The TRILUMINATE Transcatheter Tricuspid Repair Trial: Positive but No Benefit?
https://www.medscape.com/viewarticle/989105
Transcatheter Tricuspid Valve Repair Effective, Safe for Regurgitation: TRILUMINATE
https://www.medscape.com/s/viewarticle/989103
- TRILUMINATE NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2300525
II. LAA Occlusion
Different Strengths for LAA Closure Devices?
https://www.medscape.com/viewarticle/962893
- Swiss Apero – Original paper https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057859
- Swiss Apero – One-year https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067599
Peri-device Leaks After Watchman https://pubmed.ncbi.nlm.nih.gov/35902169/
TAVR With Left Atrial Appendage Occlusion Non-inferior to TAVR Plus Medical Therapy https://www.medscape.com/viewarticle/997725
- WATCH TAVR Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067312
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Oct 27 2023 This Week in Cardiology
27 oktober 2023 · 30 min
More on the Million Hearts RCT, ENRICH AF, TAVI vs SAVR, the Partner 3 and Evolut-low-risk trials, and myocardial viability are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Listener Feedback Million Hearts
CMS 'Million Hearts' CVD Risk Reduction Model Works
https://www.medscape.com/viewarticle/997551
- RCT JAMA - https://jamanetwork.com/journals/jama/fullarticle/2810696
AC in ICH - ENRICH AF
Oral Anticoagulation in ICH Patients With AF: New Data https://www.medscape.com/viewarticle/997547
- Lancet Neurology Meta-analysis https://doi.org/10.1016/S1474-4422(23)00315-0
- ENRICH AF letter https://doi.org/10.1016/S0140-6736(23)02025-1
II. TAVI vs SAVR
Low-Risk TAVR Studies: Divergent Long-Term Results
https://www.medscape.com/viewarticle/997784
- Partner 3 Main Results
- Partner 3 – Five Year
- Original EVOLUT -LR https://www.nejm.org/doi/10.1056/NEJMoa1816885
- EVOLUT 3-year https://doi.org/10.1016/j.jacc.2023.02.017
- EVOLUT -LR 4-year https://doi.org/10.1016/j.jacc.2023.09.813
III. Myocardial Viability
Viability-Guided PCI Doubted in Stable Severe CAD: REVIVED-BCIS2
https://www.medscape.com/viewarticle/989101
- Revived BCIS – Original paper https://www.nejm.org/doi/10.1056/NEJMoa2206606
- JAMA Cardiology Viability paper https://jamanetwork.com/journals/jamacardiology/fullarticle/2810727
- STICH Viability Paper - https://www.nejm.org/doi/full/10.1056/NEJMoa1100358
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Oct 20 2023 This Week in Cardiology
20 oktober 2023 · 26 min
Listener feedback, oral anticoagulation in patients with ICH, an example of statistical significance but not clinical significance, and statins and diabetes are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Listener Feedback
October 13, 2023 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/997281
- European Heart Journal: IVI for PCI https://doi.org/10.1093/eurheartj/ehad430
- Elgendy Meta-analysis of Imaging in PCI: https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.116.003700
- ULTIMATE: https://www.jacc.org/doi/10.1016/j.jacc.2018.09.013
- ILUMEIN IV: https://www.nejm.org/doi/full/10.1056/NEJMoa2305861
- OCTOBER: https://www.nejm.org/doi/full/10.1056/NEJMoa2307770
- Main STEP-HFpEF paper
- Letter to the Editor on Lack of Obesity Paradox https://doi.org/10.1016/j.amjcard.2019.04.037
II. Anticoagulation in ICH
Oral Anticoagulation in ICH Patients With AF: New Data https://www.medscape.com/viewarticle/997547
- Lancet Neuro Meta-analysis https://doi.org/10.1016/S1474-4422(23)00315-0
- ENRICH AF letter https://doi.org/10.1016/S0140-6736(23)02025-1
III. Million Hearts
CMS 'Million Hearts' CVD Risk Reduction Model Works https://www.medscape.com/viewarticle/997551
- RCT JAMA
IV. Statin Choice and Diabetes
April 7, 2023 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/990542
- LODESTAR Main Study
- LODESTAR Substudy
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Oct 13 2023 This Week in Cardiology
13 oktober 2023 · 22 min
Three stories regarding GLP-1 agonists, imaging during PCI, and the power of sham controls in procedure trials are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. FLOW Trial Positive
Novo Nordisk Stops Ozempic Kidney Trial After Early Signs of Success https://www.medscape.com/s/viewarticle/997237
- FLOW Trial – press release https://www.novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=166327
II. STEP HFpEF
Semaglutide Win in HFpEF With Obesity Regardless of Ejection Fraction: STEP-HFpEF
https://www.medscape.com/viewarticle/997185
The GLP-1 Agonist Semaglutide in HFpEF Cleared a Low Bar
https://www.medscape.com/viewarticle/995872
- STEP HFpEF substudy
- STEP HFpEF main paper
III. GLP-1 Agonist Adverse Effects
GLP-1 Agonists Linked to Higher Risk for Rare but Serious GI Complications
https://www.medscape.com/viewarticle/997128
- GI Adverse Effects of GLP-1 Agonists https://jamanetwork.com/journals/jama/fullarticle/2810542
IV. Imaging in PCI
Intravascular Imaging in PCI: Time for a Guideline Update?
https://www.medscape.com/viewarticle/995677
- Intravascular imaging during percutaneous coronary intervention: temporal trends and clinical outcomes in the USA https://academic.oup.com/eurheartj/article/44/38/3845/7226277
- HEART Review of Studies of Intracoronary Imaging During PCI https://heart.bmj.com/content/107/9/755
V. The Power of Placebo (Sham) control
Hopeful Insights, No Overall HFpEF Gains From Splanchnic Nerve Ablation: REBALANCE-HF
https://www.medscape.com/viewarticle/997318
- Transvenous Right GSN Ablationin HFpEF https://doi.org/10.1016/j.jchf.2022.05.009
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Oct 06 2023 This Week in Cardiology
6 oktober 2023 · 24 min
Coated vs uncoated ASA, a new trial in CAD, conflicts of interest, first AF in the hospital, and changing HTN scoring and CHADSVASC are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. ASA
No Benefit of Enteric-Coated Aspirin vs Uncoated in CVD https://www.medscape.com/viewarticle/997119
- JAMA Cardiology: Coated vs Uncoated ASA https://jamanetwork.com/journals/jamacardiology/fullarticle/2809795
- ADAPTABLE https://www.nejm.org/doi/10.1056/NEJMoa2102137
II. RECHARGE
- Revascularization Choices Among Under-Represented Groups Evaluation (The RECHARGE Program) https://www.pcori.org/research-results/2023/revascularization-choices-among-under-represented-groups-evaluation-recharge-program
- Gaudino/Stone: Reconsidering Coronary Revascularization Trials
III. Conflicts of Interest
- Financial Conflicts of Interest in Public Comments on Medicare National Coverage Determinations of Medical Devices https://jamanetwork.com/journals/jama/fullarticle/2808721
IV. First AF in the Hospital
Decoding AFib Recurrence: PCPs' Role in Personalized Care https://www.medscape.com/viewarticle/997011
- Annals of Internal Medicine: AF Recurrence https://doi.org/10.7326/M23-1411
V. Changing CHADSVASC Score
- JAMA Network Open: HTN Guidelines and CHADSVASC Up-Scoring https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809933
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Sep 29 2023 This Week in Cardiology
29 september 2023 · 26 min
Reader feedback, leadless pacing, ABIM, SGLT2 inhibitors, peri-operative MI after cardiac surgery, and. AHA late-breakers are the topics John Mandrola, MD, covers in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Reader Feedback
Sep 22, 2023 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/996694
- ODYSSEY OUTCOMES trial https://www.nejm.org/doi/full/10.1056/nejmoa1801174
- FOURIER https://www.nejm.org/doi/full/10.1056/nejmoa1615664
II. Leadless Pacing
- Leadless vs Transvenous Pacemaker Study https://doi.org/10.1093/europace/euad269
III. ABIM News
Heart Societies Ready to Split From ABIM Over Long-Standing MOC Disputes
https://www.medscape.com/viewarticle/996747
IV. SGLT2 inhibitors
Empagliflozin Gets FDA Nod for CKD Without T2D or HF
https://www.medscape.com/viewarticle/996873
- EMPA-Kidney https://www.nejm.org/doi/full/10.1056/NEJMoa2204233
V. Peri-Op MI after Cardiac Surgery
Cardiac Troponin Predicts Mortality Post Surgery
https://www.medscape.com/viewarticle/996877
- Austrian Perioperative MI study https://doi.org/10.1016/j.jacc.2023.07.011
- Vision https://www.nejm.org/doi/10.1056/NEJMoa2000803
VI. AHA Late Breakers
- Link to Late-Breakers https://professional.heart.org/en/meetings/scientific-sessions/programming/late-breaking-science#late-breaking
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Sep 22 2023 This Week in Cardiology
22 september 2023 · 25 min
Coronary calcium, cardiac arrest survival, Factor XI drug findings, APCs and a potential new board certification in cardiology are the topics discussed by John Mandrola, MD in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Coronary Artery Calcium
- CONFIRM Registry - https://doi.org/10.1016/j.jcmg.2023.03.008
- CURE -- https://www.nejm.org/doi/full/10.1056/nejmoa010746
II Cardiac Arrest
Cardiac Arrest Centers No Benefit in OHCA Without STEMI
https://www.medscape.com/viewarticle/995885
- Cycling coverage https://velo.outsideonline.com/road/road-racing/nathan-van-hooydonck-forced-to-end-to-racing-career-due-to-heart-condition/
- ARREST https://doi.org/10.1016/S0140-6736(23)01351-X
- SCD in Athletes Bob Harrington and Manesh Patel https://www.medscape.com/viewarticle/995575
III Factor XI
Trial Halted for Bleeding Reduction With Abelacimab vs Rivaroxaban in AF
https://www.medscape.com/viewarticle/996587
- Press Release - https://anthostherapeutics.com/wp-content/uploads/2023/09/2023-09-18-Anthos-Press-Release-final.pdf
- Abelacimab, a Factor XI Inhibitor, Prevents VTE With Low Bleeding Risk in Knee Replacement
- NEJM proof-of-concept https://www.nejm.org/doi/full/10.1056/NEJMoa2105872
- OCEANIC-AF https://classic.clinicaltrials.gov/ct2/show/NCT05643573
- Will Factor XI Be the Goldilocks Anticoagulant Target? https://www.medscape.com/viewarticle/979634
IV APC Care
NPs and PAs Handling Increasingly More Primary Care Visits: New Studies https://www.medscape.com/viewarticle/996709
BMJ paper -- https://www.bmj.com/content/382/bmj-2022-073933
V Possible Cardiology Board Certification Changes
- Heart Societies Ready to Split From ABIM Over MOC Disputes https://www.medscape.com/viewarticle/996747
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Sep 15 2023 This Week in Cardiology
15 september 2023 · 24 min
Reader feedback, imaging in the cath lab, AF ablation to relieve anxiety, and some possible help in hypertension are the topics John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I. Reader Feedback
Sep 08, 2023 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/996233
First Clinical Trial of CTO Procedures Fails to Deliver https://www.medscape.com/viewarticle/877405
- DanGerShock trial https://pubmed.ncbi.nlm.nih.gov/31176289/
II. Imaging in the Cath Lab
Should Intravascular Imaging Be Almost Routine in PCI? https://www.medscape.com/viewarticle/996375
- ILUMIEN IV https://www.nejm.org/doi/full/10.1056/NEJMoa2305861
- OCTOBER https://www.nejm.org/doi/full/10.1056/NEJMoa2307770
III. AF Ablation to Relieve Anxiety
- REMEDIAL Trial https://jamanetwork.com/journals/jama/fullarticle/2809419
- Sohaib and Francis; Meta analysis of Symptomatic Response Effect of CRT Pacing https://pubmed.ncbi.nlm.nih.gov/24259043/
IV. HTN
'New Dawn' for Aldosterone as Drug Target in Hypertension? https://www.medscape.com/viewarticle/996316
- TARGET HTN - https://jamanetwork.com/journals/jama/fullarticle/2809625
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Sep 08 2023 This Week in Cardiology
8 september 2023 · 26 min
ESC Recap Part 2: ECLS-SHOCK, FIRE, MULTISTARS-AMI, HEART FID, and DANPACE II are the trials John Mandrola, MD, discusses in this week's podcast. Lees meer
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit: https://www.medscape.com/twic
I. Cardiogenic Shock
ECMO for Shock in Acute MI Won't Help, May Harm: ECLS-SHOCK https://www.medscape.com/viewarticle/995882
- ECLS-SHOCK trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307227
- ECMO-CS trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062949
II. FIRE TRIAL
FIRE a Win for Physiology-Guided MI Complete Revascularization in Older Patients https://www.medscape.com/viewarticle/995875
- FIRE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2300468
- COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
III. Immediate vs Staged Revascularization
Parity for Prompt vs Staged STEMI Complete Revascularization: MULTISTARS-AMI https://www.medscape.com/viewarticle/995961
- MULTISTARS AMI trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307823
- Complete Revascularization Now Compulsory? MULTISTARS-AMI and FIRE in Context https://www.medscape.com/viewarticle/995676
IV. Iron-Supplementation in Heart Failure
IV Iron Shows Only Modest Benefit in HF: HEART-FID https://www.medscape.com/viewarticle/995874
- HEART-FID https://www.nejm.org/doi/full/10.1056/NEJMoa2304968
- EHJ meta-analysis of Iron Supplementation https://doi.org/10.1093/eurheartj/ehad586
V. AF Prevention with Pacing
Minimizing Atrial Pacing No Benefit in Sinus Node Disease: DANPACE II https://www.medscape.com/viewarticle/996076
- DANPACE II https://doi.org/10.1093/eurheartj/ehad564
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