Lifespan with Dr. David Sinclair
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Lifespan with Dr. David Sinclair is a health and science show on how to live longer and stay healthier - grounded in the latest longevity research.
A Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, Dr. Sinclair breaks down the latest studies into clear, applicable insights so that you can perform at your best and live your longest, healthiest life.
Season 1 ranked #1 in Health & Wellness podcasts. Season 2 is now live, starting with two Rewind episodes, followed by new episodes detailing the latest breakthroughs in aging science.
Become a Lifespan member at lifespan.com.
New episodes every two weeks.
Afleveringen
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Prevent Alzheimer's with Peptides? | Lifespan with Dr. David Sinclair - S2, Ep. 12
1 november 2026 · 52 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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Could peptides help us heal faster, protect our brains, and even live longer?
In this episode, David and Matt ask the questions we all want to ask. Could peptides such as humanin help protect the brain against Alzheimer’s disease? Can they accelerate healing, repair damaged tissues, ease arthritis, or improve muscle and gut health? Might they eventually offer new ways to treat age-related diseases? They also separate promising science from hype, examining which peptides have credible evidence from human studies, which remain experimental, and what we know about their safety. The conversation also looks at the first FDA-approved medicine designed to target mitochondria.__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it easy for the Lifespan audience to access tools and technologies featured in this episode – from Ketone-IQ’s exogenous ketones as an alternative brain fuel, to WHOOP’s wearable tracking of recovery, strain, and sleep, to Sunlighten’s patented, high-heat infrared saunas designed to support mitochondrial function, heart health, and energy.
If you’d like to learn more or try these tools:
○ Sunlighten: Save up to $2,500 on a sauna plus free shipping, or get $50 off red light products, at get.sunlighten.com/lifespan with code LIFESPAN.
○ Ketone-IQ: Get 30% off your first monthly order at ht…
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Younger Skin with Peptides? | Lifespan with Dr. David Sinclair - S2, Ep. 11
18 oktober 2026 · 56 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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Peptides are everywhere – from collagen supplements to experimental longevity therapies. But can they really help us age better?
In this episode, David and Matt dive into the rapidly evolving science of peptides—and their potential to transform longevity medicine. They explore promising compounds like GHK-Cu, MOTS-c, Epitalon, and apelin, examining what the research reveals about cellular repair, stem cells, telomeres, and the hallmarks of aging.
Along the way, David separates scientifically promising treatments from unproven hype and unpacks the potential benefits, risks, and unanswered questions surrounding these increasingly popular compounds. As David puts it, “We're going to have going forward a bunch of different peptides that hopefully will help us with our longevity.”
__________________________________________Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP…
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Could Ozempic Help You Live Longer? | Lifespan with Dr. David Sinclair - S2, Ep. 10
4 oktober 2026 · 1 uur 1 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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Ozempic and GLP-1s transformed weight loss. Could they also extend lifespan?
In this episode, David and Matt look at the emerging science behind that question. They examine a recent study in which semaglutide extended lifespan in female mice, evidence that GLP-1s may influence multiple hallmarks of aging, plus early human research examining biological aging. They also explore how these drugs work, the potential role of the brain, the promise and unanswered questions around microdosing, and what the next generation of GLP-1 therapies could mean for longevity medicine. As David puts it, this class of drugs “might be the world’s first effective longevity medicines."
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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off…
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This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 9
19 september 2026 · 49 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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Could an amino acid sweet enough to replace sugar also help us live longer? In this episode, David and Matt explore Glycine, one of life’s simplest building blocks, and why it’s attracting attention in aging research. From building collagen to blood sugar control, heart health, memory, and recovery after stroke, its potential reaches surprisingly far. They unpack studies linking glycine to multiple hallmarks of aging and longer lifespans in animal models and ask what it would take to show these benefits in humans.
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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
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Legal & Medical Disclaimers
The Lifespan show and al…
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How to Eat for Gut Health & Longevity | Lifespan with Dr. David Sinclair - S2, Ep. 8
11 september 2026 · 31 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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This Lifespan episode explores how what we eat shapes how we age - from inflammation and blood sugar to the trillions of microbes living in our gut. Dr. Sinclair explains how diet affects key biological processes tied to metabolism, health, and longevity.
Dr. Sinclair breaks down what sugar does inside the body, including glycation - the process by which sugar attaches to proteins and disrupts their function. The conversation also explores why inflammation rises with age, how the gut microbiome changes over time, and why our ability to sense and respond to nutrients can decline as we get older.
Most importantly, Dr. Sinclair explains what we can do about it - from reducing dietary drivers of inflammation and excess sugar to supporting gut health and the nutrient-sensing pathways linked to longevity.
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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
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Why We Age | Lifespan with Dr. David Sinclair - S2, Ep. 7
4 september 2026 · 31 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and longevity scientist - and co-host Matthew LaPlante explore why we age, how aging begins long before its visible signs appear, and what we can do to slow aspects of cellular aging.
They break down key drivers - or “hallmarks” - of aging, including mitochondrial dysfunction, stem cell exhaustion, and declining communication between cells, and explain how these changes can affect energy, inflammation, and the body’s ability to repair itself.
They also explore practical strategies including exercise, cold exposure, and molecules such as berberine, curcumin, metformin, and resveratrol, alongside emerging research into mitochondrial replacement and stem cells.
Along the way, they tackle intriguing questions: When does biological aging begin? Why can identical twins age at different rates? Why does energy decline with age? And what can we do today to stay healthier for longer?
__________________________________________Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral …
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Why Exercise Slows Aging | Lifespan with Dr. David Sinclair
21 augustus 2026 · 1 uur 11 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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This episode explores why humans are biologically built to move and what happens to the aging process when we don’t.
Drawing on evolutionary biology and the latest research, Dr. Sinclair traces physical activity back millions of years, explaining how humans evolved for endurance, why modern sedentary life creates a profound mismatch with our biology, and how exercise activates ancient cellular pathways involved in repair, resilience, metabolism, and longevity.
Dr. Sinclair breaks down what happens inside the body when we exercise, including the molecular responses that help us adapt to stress and influence the brain, immune system, metabolism, cardiovascular health, and even the way our cells age.
He also tackles some of the biggest questions in exercise science: Can exercise offset sitting all day? Do we compensate for calories burned during exercise? Why did humans evolve such extraordinary endurance? And could exercising with others provide benefits beyond physical fitness?
From our evolutionary past to the molecular machinery inside our cells, this episode reveals why movement is so deeply embedded in human biology – and why staying active may be one of the most powerful ways to keep that biology working as we age.
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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan a…
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How to Exercise to Live Longer | Lifespan with Dr. David Sinclair - S2, Ep. 5
7 augustus 2026 · 1 uur 9 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and longevity scientist – details how to exercise for a longer, healthier life.
Drawing on the latest research, Dr. Sinclair explains why exercising for longevity isn’t the same as training for peak athletic performance – including how much exercise you really need, which types matter most as you age, and whether more exercise is always better.
He also breaks down the key fitness metrics for longevity – including VO2 max, grip strength, resting heart rate, and heart rate variability (HRV) – and why cardiorespiratory fitness may predict mortality more strongly than smoking, diabetes, or hypertension.
Lastly, Dr. Sinclair tackles some of the most common questions about exercise science: What’s the best time of day to work out? Should you drink coffee beforehand? Should men and women train differently? How should exercise change as you age?
Whether you're just getting started or already exercise regularly, this episode offers a practical, evidence-based guide on what to do to stay healthier for longer.
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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-I…
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Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4
23 juli 2026 · 1 uur 12 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of eye aging, vision loss, and emerging strategies to preserve vision throughout life.
Dr. Sinclair shares an exclusive update on ER-100, including his team's successful restoration of vision in non-human primates and the launch of the world's first FDA-cleared age reversal human clinical trial. This Phase 1 clinical trial will evaluate the safety of epigenetic cellular restoration as a therapy.
Additionally, drawing on decades of research, Dr. Sinclair explains why the eyes may offer one of the earliest windows into biological aging, how everyday factors such as sleep position, alcohol consumption, and intraocular pressure influence long-term eye health, and what the latest evidence reveals about nutrition, supplements, and the connection between the eyes and the brain.
Whether you're interested in longevity, brain health, or protecting your eyesight, this episode provides an evidence-based look at the biology of vision and the future of regenerative medicine.
00:00 AI & the First Human Clinical Trial to Reverse Aging
08:30 How the Eye Works
16:00 How Light Sets Your Body Clock
20:18 Your Eyes Are Part of Your Brain
21:34 Can Your Eyes Estimate Your Biological Age?
23:43 Can Eye Exams Help Predict Alzheimer's Disease?
24:43 ER-100: Restoring Vision Through Age Reversal
33:17 Why We Lose Vision as We Age
39:32 How to Keep Your Eyes Healthy as You Age
41:53 The Best Foods & Supplements for Eye Health
49:15 Can Diet … -
What to Eat & When to Eat for Longevity: New Science | Lifespan with Dr. David Sinclair - S2, Ep. 3
12 juli 2026 · 1 uur 8 min
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives - while supporting medical research into breakthroughs to improve all lives. Lees meer
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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In this second installment of Lifespan's two-part series on calorie restriction and fasting, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and a pioneer in longevity research – explores how to fast effectively for health and longevity.
Drawing on decades of research and the latest scientific evidence, Dr. Sinclair explains how to approach fasting effectively, what happens inside your body at the 12-, 24-, and 48+-hour marks, how to overcome common plateaus, and the key considerations for women, men, and people at different stages of life.
Whether you're new to fasting or looking to refine your approach, this episode provides a practical, evidence-based guide to using fasting to support metabolism, cellular repair, and healthy longevity.
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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP …
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